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All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JURNAL ILMU KEFARMASIAN INDONESIA Proceeding of Mulawarman Pharmaceuticals Conferences
Wiwi Winarti
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Formulasi Curcuma zedoaria Sebagai Emulgel Antioksidan Yesi Desmiaty; Wiwi Winarti; Fahleni Fahleni; Lindawati Lindawati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (677.062 KB) | DOI: 10.35814/jifi.v18i1.711

Abstract

Curcuma zedoaria has a high antioxidant activity and potential to be made a topical antioxidant preparation. Emulgel is a combination of O/W emulsion with a gel base, and it has many advantages, including convenience in use. In this study, an emulgel formulation was made using Sepigel 305® with various concentrations (3%, 4%, and 5%). The emulgel formulation, the ethanol extract of C. zedoaria, was added with concentrations 1%, 2%, and 5%. The preparation was evaluated for physical quality and antioxidant activity using the DPPH method. In the selected formula, had been observing the accelerated stability tests were carried out for three months. Ethanol extract of C. zedoaria has antioxidant activity with IC50 49.72 ± 0.32 ppm. The best emulgel preparation is F2, which contains Sepigel 305® 4% and extract 2%. The F2 emulgel formulation was found to be stable physicochemical properties (organoleptic, homogeneity, viscosity, flow properties, dispersion ability, and emulsion type test) upon the accelerated stability tests, and pH met the requirements with antioxidant activity gave IC50 135.8 ppm. Ethanol extract of C. zedoaria can be made emulgel preparations using Sepigel 305®, physically and chemically stable, and has an excellent antioxidant activity for the three months of storage.
PENGHAMBATAN AKTIVITAS ENZIM α-GLUKOSIDASE DARI EKSTRAK AIR TANAMAN RARU (Vatica pauciflora) SECARA IN VITRO eris septiana; wiwi winarti; partomuan simanjuntak
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 4 No. 1 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.706 KB) | DOI: 10.22236/farmasains.v4i1.96

Abstract

Diabetes mellitus is a metabolic disorder that leading the blood sugar levels become higher than normal. In Indonesia, one of the plants that traditionally used to cure hyperglycemic is raru plant (Vatica pauciflora). The objectives of this research was to investigate α-glucosidase inhibitory activity from stem bark, root, and leaf of raru plant. Extraction of stem bark, root, and leaf was conducted with reflux at 70 °C by using water as a solvent. In vitro anti-diabetic activity was tested using the method of α-glucosidase inhibition. The results show that water extracts of raru’s stem bark, root, and leaf have α-glucosidase inhibitory activity. The stem bark water extract has the highest activity than leaf and root with IC50 values were 13.53, 16.96, and 41.91 ppm respectively. All extracts is categorized as active in inhibiting the activity of α-glucosidase enzyme by having IC50≤100 ppm. The results obtain in this research clearly indicate a promising potential as anti-diabetic properties of raru plant.
Identifikasi Senyawa Kimia yang Memiliki Aktivitas Antioksidan Dalam Fase Etilasetat Endokarpium Bawang Hutan Wiwi Winarti; Yatri Hapsari; Fransiska Kurniati
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 3 (2016): Spesial Issue of Mulawarman Pharmaceuticals Conference Proceeding (Prosiding Semnas T
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (367.761 KB) | DOI: 10.25026/mpc.v3i2.146

Abstract

Berdasarkan hasil penelitian sebelumnya mengenai aktivitas antioksidan dari ekstrak metanol dalam fase etil asetat kulit kayu bawang hutan yang diperoleh secara refluks dan maserasi, diketahui bahwa nilai IC 50 dari ekstrak tersebut adalah 39,66 bpj dan 87,08 bpj. Penelitian ini bertujuan untuk mengidentifikasi senyawa kimia pada fase etilasetat dari ekstrak etanol endokarpium bawang hutan. Pada peneltian ini dilakukan pembuatan ekstrak secara maserasi kinetik menggunakan pelarut etanol 96%, kemudian ekstrak kental etanol dipartisi dengan n-heksana, etil asetat dan air. Selanjutnya pada ekstrak etilasetat dilakukan penapisan fitokimia dan uji aktivitas antioksidan dengan metode peredaman radikal bebas menggunakan DPPH, kemudian difraksinasi dengan kromatografi kolom pertama. Fraksi yang diperoleh diuji aktivitas antioksidan pada konsentrasi 100 bpj. Fraksi yang mempunyai nilai % inhibisi tertinggi difraksinasi kembali dengan kromatografi kolom kedua. Selanjutnya dilakukan pemurnian dengan KLT preparatif dan hasil KLT preparatif diidentifikasi menggunakan spektrofotometri UV-Vis, FTIR dan KG-SM. Hasil penapisan fitokimia menunjukkan ekstrak etil asetat mengandung golongan senyawa kimia flavonoid, steroid, triterpenoid, minyak atsiri dan kumarin. Uji aktivitas antioksidan terhadap ekstrak dari fraksi etil asetat diperoleh nilai IC50 sebesar 51,52 bpj. Hasil fraksinasi kromatografi kolom pertama isolat-2 dengan nilai % inhibisi sebesar 42,86%. Isolat terpilih dari hasil pemurnian dengan KLT preparatif adalah isolat 2.7.2 Berdasarkan analisis spektra UV-Vis, FTIR dan KG-SM diduga senyawa yang mempunyai aktivitas antioksidan adalah kolesta-3,5-dien.
Co-Authors Eris Septiana Fahleni Fahleni Fransiska Kurniati Lindawati Lindawati Partomuan Simanjuntak Yatri Hapsari Yesi Desmiaty, Yesi