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All Journal Majalah Obat Tradisional PROSIDING SEMINAR KIMIA Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Journal of Tropical Pharmacy and Chemistry JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Jamu Indonesia Jurnal Janata
Yesi Desmiaty, Yesi
Fakultas Farmasi, Universitas Pancasila, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Transportation Other

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FORMULASI SEDIAAN LOSION ANTIOKSIDAN EKSTRAK AIR DAUN TEH HIJAU (Camellia sinensis L.) Faramayuda, Fahrauk; Alatas, Fikri; Desmiaty, Yesi
Majalah Obat Tradisional Vol 15, No 3 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (585.308 KB) | DOI: 10.14499/mot-TradMedJ15iss3pp105 – 111

Abstract

Penelitian tentang formulasi dosis ekstrak air daun teh hijau dengan konsentrasi 0,0002%, 0,002%, 0,02% dan 8,6% telah dilakukan. Penetapan nilai EC50 dilakukan berdasarkan perhitungan persamaan regresi linier antara larutan uji dan persentase peredamanl. Formulasi losion dimulai berdasarkan orientasi basis dengan parameter organoleptik, homogenitas, pH dan viskositas. Diketahui bahwa losion dengan5,5% glyceryl monostearate mempunyai stabilitas pH, viskositas dan konsistensi yang terbaik. Evaluasi formulasi termasuk evaluasi fisik (organoleptis, homogenitas, viskositas dan stabilitas) dan evaluasi kimia (pH dan stabilitas aktivitas anti oksidan). Evaluasi aktivitas antioksidan formula yang mengandung larutan 1,1-diphenyl-2-picrylhidrazyl menggunakan spektrofotometri UV-Vis menunjukkan bahwa formula yang mengandung 0.02% dan 8,6% ektrak air daun teh memberikan aktivitas anti oksidan terbaik dan stabilitas selama penyimpanan.
UJI AKTIVITAS PENANGKAP RADIKAL BEBAS DAUN CERME (Phyllanthus acidus (L.) Skeels) UJI AKTIVITAS PENANGKAP RADIKAL BEBAS DAUN CERME (Phyllanthus acidus (L.) Skeels) Desmiaty, Yesi; R, Julia; R., Ika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 2 (2008)
Publisher : Indonesian Research Gateway

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Abstract

The leaves of Phyllanthus acidus (L.) Skeels)  has been use in many ways as traditional medicine. It is use as expectorant, diuretic, laxative,  as component of anti-obesity mixture, and anti cancer. In this work we examine the antioxidant activity  of Phyllanthus acidus (L.) Skeels) leaves using in vitro method base on free radical scavanger effect of 1,1-diphenyl-picrylhydrazil (DPPH) solution. Screening test of ethanolic extract of Phyllanthus acidus (L.) Skeels)  leaves using TLC with 0.2% DPPH solution in methanol as spot marker, showed positive result. Ethanol, ethyl acetate, and water fraction were also showed positive results. Free radical scavanger activity was tested  by determined the EC50 of those extracts using uv-vis spectrophotometry with 40 ug/ml DPPH solution. Result showed that among those extract, ethyl acetate fraction has the least EC50, i.e. 56.82 µg/ml.  ABSTRAK Penggunaan daun cerme (Phyllanthus acidus (L.) Skeels)  secara tradisional sangat beragam, terutama daun yang masih muda. Daun cerme diyakini berkhasiat sebagai ekspektoran, diuretik, urus-urus, campuran teh pelangsing hingga obat kanker. Oleh karena itu dilakukan pengujian awal aktivitas antioksidan secara in vitro yang didasarkan pada efek peredaman radikal bebas larutan 1,1-difenil-pikrilhidrazil (DPPH). Pada uji penapisan terhadap ekstrak etanol daun cerme menggunakan KLT dengan penampak bercak DPPH 0,2 % dalam metanol menunjukkan reaksi positif. Kemudian dilanjutkan dengan proses fraksinasi cair-cair menggunakan n-heksan & etil asetat, ternyata ekstrak etanol, fraksi etil asetat & fraksi air yg menunjukkan reaksi positif. Aktivitas penangkap radikal bebas diuji dengan menentukan EC50 ekstrak etanol, fraksi etil asetat & fraksi air secara spektrofotometri uv-vis dengan pereaksi larutan DPPH 40µg/ml. Hasil menunjukkan fraksi etil asetat memiliki EC50 terkecil sebesar 56,82 µg/ml.
UJI AKTIVITAS PENANGKAP RADIKAL BEBAS DAUN CERME (Phyllanthus acidus (L.) Skeels) UJI AKTIVITAS PENANGKAP RADIKAL BEBAS DAUN CERME (Phyllanthus acidus (L.) Skeels) Desmiaty, Yesi; R, Julia; R., Ika
Jurnal Farmasi Indonesia Vol 4, No 2 (2008)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i2.12

Abstract

The leaves of Phyllanthus acidus (L.) Skeels)  has been use in many ways as traditional medicine. It is use as expectorant, diuretic, laxative,  as component of anti-obesity mixture, and anti cancer. In this work we examine the antioxidant activity  of Phyllanthus acidus (L.) Skeels) leaves using in vitro method base on free radical scavanger effect of 1,1-diphenyl-picrylhydrazil (DPPH) solution. Screening test of ethanolic extract of Phyllanthus acidus (L.) Skeels)  leaves using TLC with 0.2% DPPH solution in methanol as spot marker, showed positive result. Ethanol, ethyl acetate, and water fraction were also showed positive results. Free radical scavanger activity was tested  by determined the EC50 of those extracts using uv-vis spectrophotometry with 40 ug/ml DPPH solution. Result showed that among those extract, ethyl acetate fraction has the least EC50, i.e. 56.82 µg/ml.  ABSTRAK Penggunaan daun cerme (Phyllanthus acidus (L.) Skeels)  secara tradisional sangat beragam, terutama daun yang masih muda. Daun cerme diyakini berkhasiat sebagai ekspektoran, diuretik, urus-urus, campuran teh pelangsing hingga obat kanker. Oleh karena itu dilakukan pengujian awal aktivitas antioksidan secara in vitro yang didasarkan pada efek peredaman radikal bebas larutan 1,1-difenil-pikrilhidrazil (DPPH). Pada uji penapisan terhadap ekstrak etanol daun cerme menggunakan KLT dengan penampak bercak DPPH 0,2 % dalam metanol menunjukkan reaksi positif. Kemudian dilanjutkan dengan proses fraksinasi cair-cair menggunakan n-heksan & etil asetat, ternyata ekstrak etanol, fraksi etil asetat & fraksi air yg menunjukkan reaksi positif. Aktivitas penangkap radikal bebas diuji dengan menentukan EC50 ekstrak etanol, fraksi etil asetat & fraksi air secara spektrofotometri uv-vis dengan pereaksi larutan DPPH 40µg/ml. Hasil menunjukkan fraksi etil asetat memiliki EC50 terkecil sebesar 56,82 µg/ml.
FORMULASI SEDIAAN LOSION ANTIOKSIDAN EKSTRAK AIR DAUN TEH HIJAU (Camellia sinensis L.) Fahrauk Faramayuda; Fikri Alatas; Yesi Desmiaty
Majalah Obat Tradisional Vol 15, No 3 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (585.308 KB) | DOI: 10.22146/tradmedj.8134

Abstract

The research about lotion dosage formulation that contain green tea leaf water extract with concentration 0.0002%, 0.002%, 0,02%, and 8.6% had been done. The basic of the EC50 value. Which calculated from linierity regression equation between tested solution concentration and scavenging percent. The lotion formulation began with lotion base orientation included organoleptic, homogeinity, pH, and viscosity. It showed that lotion base with glyceryl monostearate 5.5% have the best pH stability, viscosity, and consistency. Evaluation of lotion dosage include physical evaluation (organoleptic, homogeinity, viscosity and stability) and chemical evalution (pH and the stability of lotion antioxidant activity. Antioxidant activity stability evaluation of lotion with 1,1-diphenyl-2-picrylhidrazyl solution using spectrophotometri UV-Visible showed, that formula which contain 0.02% and 8.6% green tea leaf water extract gave the best radical scavenging activity and stable during storage. 
ISOLASI DAN IDENTIFIKASI SENYAWA KIMIA PENGHAMBAT ENZIM - GLUKOSIDASE DARI FRAKSI AIR DAUN SALAM (SYZYGIUM POLYANTHUM (WIGHT) WALP.) Danty Nur Alvionitasari; Lilik Sulastri; Yesi Desmiaty; Syamsudin Syamsudin; Partomuan Simanjuntak
PROSIDING SEMINAR KIMIA Prosiding SNKT Himpunan Mahasiswa Kimia FMIPA UNMUL 2021
Publisher : PROSIDING SEMINAR KIMIA

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Abstract

Diabetes merupakan penyakit kronis dengan gangguan metabolisme akibat pankreas tidak menghasilkan cukup insulin yang ditandai dengan hiperglikemia. Terapi farmakologi yang digunakan untuk menurunkan kadar glukosa dalam darah salah satunya dengan menghambat kerja enzim -glukosidase sehingga menunda penyerapan glukosa di dalam saluranpencernaan. Penggunaan bahan alam yang memiliki potensi sebagai penghambat enzim -glukosidase adalah daun salam (Syzygium polyanthum (Wight) Walp.) yang secara empiris telah banyak digunakan sebagai obat tradisional oleh masyarakat. Tujuan penelitian ini adalah untuk mengetahui senyawa bioaktif dari fraksi air daun salam yangmemiliki aktivitas penghambatan enzim -glukosidase. Penarikan senyawa kimia dilakukan dengan maserasi serbuk daun salam dalam etanol 96%, kemudian ekstrak etanol dipartisi dengan etil asetat dan air. Ekstrak air difraksinasi dengan kromatografi kolom (SiO2 : i). CH2Cl2-MeOH = 10 : 1 ~ 1:1 ii). CH2Cl2 - aseton = 2 : 1 memberikan fraksi 2-1 mempunyai aktivitas penghambatan enzim α-glukosidase paling baik, dengan IC50 21,54 ppm. Identifikasi senyawa kimia menggunakan Liquid Chromathography Tandem Mass Spectrum (LC-MS/MS) memberikan puncak dengan kelimpahan terbesar dengan bobot molekul ion m/z 413 (M+1)+ yang diperkiraan senyawa kimianya adalah Stigmasterol.Kata kunci : Syzygium polyanthum, fraksi air, stigmasterol, enzim -glukosidase, LC-MS/MS
KARAKTERISTIK SENYAWA KIMIA PENGHAMBAT ENZIM α-GLUKOSIDASE DARI FRAKSI ETIL ASETAT DAUN TEH (Camellia sinensis (L) Kuntze) Lilik Sulasti; Yashinta Larasati; Yesi Desmiaty; Syamsudin Syamsudin; Partomuan Simanjuntak
PROSIDING SEMINAR KIMIA Prosiding SNKT Himpunan Mahasiswa Kimia FMIPA UNMUL 2021
Publisher : PROSIDING SEMINAR KIMIA

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Abstract

Teh (Camellia sinensis (L.) Kuntze) adalah salah satu tanaman yang dapat digunakan sebagai inhibitor α-glukosidase. Penelitian ini bertujuan untuk mengetahui senyawa bioaktif dari fraksi etil asetat daun teh yang memiliki aktivitas penghambatan enzim α-glukosidase. Ekstraksi daun teh dilakukan dalam pelarut etanol 96% secara maserasi sebanyak 3 kali, kemudian dipartisi dengan etilasetat - air = 1 : 1. Ekstrak etil asetat difraksinasi dengan kromatografi kolom (SiO2; n-heksan-etilasetat 10 : 1 ~ 1 : 1) memberikan 10 fraksi. Fraksi 6 dimurnikan kembali dengan kromatografi kolom (SiO2; n-heksan - etilasetat = 8 : 1 memberikan 6 fraksi (Fr. 6-1 ~ Fr. 6-6). Hasil uji penghambatan enzim -gluksodase terhadap keenam fraksi menunjukkan bahwa fraksi 6-2 memberikan IC50 sebesar 4,52 ppm. Identifikasi senyawa kimia dalam fraksi 6-2 berdasarkan interpretasi data LC-MS-MS dan infra merah (IR) memberikan senyawa campuran yaitu m/z 194 (kafein); m/z 442 (epikatehin 3-O-galat); m/z 458 (epigallokatehin 3-O-galat dan m/z 620 (dichrostachine F).Kata kunci : inhibisi enzim a-glukosidase, Camellia sinensis (L.) Kuntze, epikatehin 3-O-galat, epigallokatehin 3-Ogalat, kafein, antidiabetes
Uji Aktivitas Penghambatan Enzim α-Glukosidase serta Uji Mutu Ekstrak Etanol Batang Brotowali (Tinospora crispa (L.) Miers.) YESI DESMIATY; RISMA MARISI TAMBUNAN; KARTININGSIH KARTININGSIH; LOLA DYAH PITHALOKA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 2 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

In attempt to develop Indonesian traditional medicine (Jamu) to become standardize herbal, it is need to examine the extract that can guarantee its efficacy, quality and safety. Brotowali stem (Tinospora crispa (L.) Miers.) known has antidiabetic effect and no toxic activity. In this research, the quality and α-glukosidase inhibitor activity of ethanolic extract of brotowali stem has been determined. In the quality test were determined specific parameters (identity, organoleptic, extractable matter), non specific parameters (loss on drying, water content, total ash content, solvent residue, heavy metal, and microbial contamination), quantification of markers content (total flavonoid content with spectrophotometric UV-Vis and assay of apigenin content with densitometric method). The research showed that the extract was fulfiled the requirement, total flavonoid content was 0.52% and apigenin content was 0.03635%. The result of α-glukosidase inhibitor activity test gave IC50 of 237.26 ppm.
Efek Antioksidan Ekstrak Etanol Biji Pepaya (Carica papaya L.) terhadap Aktivitas Enzim Superoksida Dismutase dan Kadar Malondialdehid pada Mencit Stress Oksidatif dengan Perenangan NI MADE DWI SANDHIUTAMI; YESI DESMIATY; AFIZZA ANBAR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Biji pepaya mengandung vitamin E dan flavonoid yang diketahui memiliki aktivitas sebagai antioksidan. Tujuan penelitian ini untuk mengetahui efek antioksidan ekstrak etanol biji pepaya (Carica papaya L.) terhadap aktivitas SOD sel darah merah dengan metode adenokrom dan kadar MDA plasma dengan metode TBARs pada mencit yang diberi aktivitas fisik perenangan. Mencit diberi ekstrak etanol biji pepaya selama 7 hari dan perenangan selama 65 menit pada hari ke-7. Pengujian ini menggunakan 36 ekor mencit yang dibagi 6 kelompok, yaitu kelompok I (normal), kelompok II (kontrol negatif), kelompok III (kontrol positif vitamin E), kelompok IV (dosis 0,105 g/kg bb), kelompok V (dosis 0,210 g/kg bb) dan kelompok VI (dosis 0,420 g/kg bb). Hasil penelitian kelompok I, II, III, IV, V, VI berturut-turut untuk aktivitas SOD sel darah merah adalah 89±6,4329; 47,37±3,8225; 85,56±3,9210; 46,35±10,0929; 58,89±3,8271 dan 81,59±5,7700 U/mL, kadar MDA plasma berturut-turut adalah 1,6831±0,0942; 6,3567±0,1046; 1,3697±0,2254; 4,7914±0,2139; 3,8231±0,3574 dan 1,7560±0,1215 nmol/mL. Ekstrak etanol biji pepaya dosis 0,420 g/kg bb memberikan efek antioksidan paling tinggi.
Potensi Daun Tembelekan (Lantana Camara Linn.) Sebagai Anti-Agregasi Platelet dan Anti-Infl amasi Secara In Vivo Ni Made Dwi Sandhiutami; Yesi Desmiaty; Nattika Sari Darmastuti; Fahri Muhammad
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.707

Abstract

Atherosclerosis is chronic inflammatory disease that can be prevented with anti-inflammatoryactivity agents and reduce thrombus formation in blood vessels. Tembelekan leaves (Lantana camaraLinn.) contain fl avonoids, saponins, and essential oils which potential to inhibit platelet aggregation andbe anti-inflammatory. This study aimed to test the in vivo anti-platelet aggregation and anti-inflammatoryactivity of tembelekan leaves. Platelet anti-aggregation test was carried out on mice by assessing thedecrease in plasma absorbance after addition of ADP. Mice were divided into normal group, positivecontrol group which was given clopidogrel and 3 test groups which were given Tembelekan leaf extractat a dose of 2.5, 5, 10 g/kgBW. In vivo anti-inflammatory test used the Winter method with intraplantar1% carrageenan as inducer. There was a signifi cant decrease in plasma absorbance after addition ofADP at doses of 2.5 and 5 g/kgBW of tembelekan leaves i.e 5.47% and 12.28% compared to thenormal group. Positive control and dose of 10 g/kgBW gave the same eff ect. In anti-inflammatorytest, the doses of 3.2 and 6.4 g/kgBW of tembelekan leaves gave percentage value of inhibition whichwas not signifi cantly diff erent with diclofenac sodium. Tembelekan leaves potentially as anti-plateletaggregation and anti-inflammatory properties.
Formulasi Curcuma zedoaria Sebagai Emulgel Antioksidan Yesi Desmiaty; Wiwi Winarti; Fahleni Fahleni; Lindawati Lindawati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (677.062 KB) | DOI: 10.35814/jifi.v18i1.711

Abstract

Curcuma zedoaria has a high antioxidant activity and potential to be made a topical antioxidant preparation. Emulgel is a combination of O/W emulsion with a gel base, and it has many advantages, including convenience in use. In this study, an emulgel formulation was made using Sepigel 305® with various concentrations (3%, 4%, and 5%). The emulgel formulation, the ethanol extract of C. zedoaria, was added with concentrations 1%, 2%, and 5%. The preparation was evaluated for physical quality and antioxidant activity using the DPPH method. In the selected formula, had been observing the accelerated stability tests were carried out for three months. Ethanol extract of C. zedoaria has antioxidant activity with IC50 49.72 ± 0.32 ppm. The best emulgel preparation is F2, which contains Sepigel 305® 4% and extract 2%. The F2 emulgel formulation was found to be stable physicochemical properties (organoleptic, homogeneity, viscosity, flow properties, dispersion ability, and emulsion type test) upon the accelerated stability tests, and pH met the requirements with antioxidant activity gave IC50 135.8 ppm. Ethanol extract of C. zedoaria can be made emulgel preparations using Sepigel 305®, physically and chemically stable, and has an excellent antioxidant activity for the three months of storage.
Co-Authors AFIZZA ANBAR Arif Tatak Berna Elya Camalia Hartantrie, Rovida Danty Nur Alvionitasari Deby Faradhila Deni Rahmat Diah Kartika Pratami Evita Maria Simorangkir Fadlina Chany Saputri Fahleni Fahleni Fahrauk Faramayuda Fahrauk Faramayuda, Fahrauk Fahri Muhammad Fauzia Noprima Okta Fikri Alatas Greesty F. Swandiny Gumilar Adhi N Nugroho Gumilar Adhi Nugroho Haura Usna Rahmah Iis Irawatty Dewi Ike Ari Priyanti Kartiningsih Kartiningsih Lilik Sulasti Lilik Sulastri Lindawati Lindawati LOLA DYAH PITHALOKA Muhammad Hanafi Nattika Sari Darmastuti Ni Made Dwi Sandhiutami Nilam Sari Maulidina Partomuan Simanjuntak R, Julia R, Julia R., Ika R., Ika Risma Marisi Tambunan Syamsudin Syamsudin Wiwi Winarti Yashinta Larasati Yati Sumiyati YATI SUMIYATI