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Evida Mainanda
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Medicine & Pharmacology

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Perbandingan Efek Samping Propofol-Fentanil dan Propofol-Fentanil-Midazolam di Instalasi Medis Sentral Rumah Sakit X Bogor Silvi Nurafni; Tri Desminingrum; Evida Mainanda
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.817

Abstract

Propofol is one of the most commonly used intravenous drugs employed to induce and maintain general anesthesia. The effective induction dose of propofol is 1.0-2.5 mg/kg IV caused hemodynamic instability significant as hypotension. Stability hemodynamic in used propofol can optimized with midazolam-fentanyl. The aims of this study was to determine the comparison of side effects propofol-fentanyl and propofol-fentanyl-midazolam in patient undergoing elective surgery with parameter of blood pressure, pulse, respiratory rate (RR). This study was a observational with prospective method in 60 patients undergoing elective surgery with physical status ASA I-II conducted in the period of April to July 2019. The result showed the induction anesthesia used of propofol-fentanyl caused decreased on systolic blood pressure 17,2±3 mmHg, diastolic blood pressure 5,3±1,6 mmHg, pulse 3,9±1,5 beats/minute, and RR 1,4±0,01 breaths/minute. The induction anesthesia used of propofol-fentanyl-midazolam caused decreased on systolic blood pressure 11,8±0,4 mmHg, diastolic blood preasure 4,2±0,4 mmHg, pulse value 5,0±0,9 beats/minute, and RR 2,8±0,9 breaths/minute. Side effects in the form of blood pressure, pulse and respiratory rate from the administration of the combination of propofol-fentanyl and propofol-fentanyl-midazolam were not significantly different.
Co-Authors Silvi Nurafni Tri Desminingrum