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All Journal JURNAL ILMU KEFARMASIAN INDONESIA
Ginna Sri Nuryani
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Medicine & Pharmacology

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Uji In Vitro dan Studi In Silico Senyawa Turunan n’-benzoylisonicotinohydr Ruswanto Ruswanto; Nur Rahayuningsih; Nur Laeli Dwi Hidayati; Ginna Sri Nuryani; Richa Mardianingrum
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (704.686 KB) | DOI: 10.35814/jifi.v17i2.703

Abstract

There have been in silico and in vitro studies of N-Benzoylisonicotinohydrazide derivatives as antituberculosis candidates. The aims of this research were determined that the N'-benzoylisonicotinohydrazide derivatives could inhibit the activity of gram-positive, gram-negative and Mycobacterium tuberculosis, as well as having good interactions with Enoyl-Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis. From the in vitro test it was found that the N'-benzoylisonicotinohydrazide compound had a Minimum Inhibitor Concentration (MIC) of 0.33 µg / ml against the Basillus subtilis, while the Minimum Inhibitor Concentration (MIC) of N '- (2-chlorobenzoyl) isonicotinohydrazide against Mycobacterium tuberculosis (H37Rv) was 3.125 µg / ml. From the in silico study, it was found that the binding affinity value between N '- (2-chlorobenzoyl) isonicotinohydrazide enzyme Enoyl-Acyl Carrier Protein Reductase (2X23) had the smallest binding affinity so that it could be predicted that it had a stable interaction than other compounds so that the N '- (2-chlorobenzoyl) isonicotinohydrazide could be used as a more potent antituberculosis candidate.
Co-Authors Nur Laeli Dwi Hidayati Nur Rahayuningsih Richa Mardianingrum Ruswanto, Ruswanto