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All Journal Jurnal Penelitian Farmasi Indonesia Jurnal Sains dan Teknologi Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) JFIOnline
Nofri Hendri Sandi
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Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Medicine & Pharmacology

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Pengaruh Ekstrak Etanol Daun Tampa Badak (Voacanga foetida (Bl.) K Schum) Terhadap Klirens Kreatinin Mencit Putih (Mus musculus L.) Jantan Susanty, Adriani; Sandi, Nofri Hendri; M, Wewen Sista
Jurnal Penelitian Farmasi Indonesia Vol 1, No 2 (2013)
Publisher : Jurnal Penelitian Farmasi Indonesia

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Abstract

A research on effect of ethanol extract of tampa badak (Voacanga foetida) to renal function of male white mice at doses 100, 200 and300mg/kgBW of weight has been studied. The employed parameter was measuring creatinine clearence and the kidney weight ratio of malewhite mice in the 61st day. In this study, four group of male white mice, each of which consisted of five mice, were utilized. Three groups weregiven suspension of ethanol extract of tampa badak and the other group as a control was simply given suspension of NaCMC 1% orally. Themeasurement method used was the method of chemical reaction with using reagent Diasys and by using ultraviolet-visible spectrophotometry(Microlab 200) at wavelength 505 nm. The result showed that application of ethanol extract of tampa badak did not give significant effect(p>0,05) to 24 hour urine volume, urinary creatinie quantity, serum creatinine, cretinine clearance as well as kidney weight ratio of malewhite mice.
Uji Efek Antipiretik Ekstrak Etanol, Fraksi N-Heksana dan Fraksi Etil Asetat Daun Beringin (Ficus Benjamina L.) pada Tikus Putih Jantan (Rattus Norvegicus) Hasti, Syilfia; Sandi, Nofri Hendri; Srianti, Teti
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Banyan plant has been used by communities as a traditional medicine in order to heal heat cramps in children but it has not been scientifically tested. A study has been conducted to observe an antipyretic effect of the ethanolic extract, the fraction of n-hexane and ethyl acetate fraction of the leaves of banyan (Ficus benjamina. L) in male white rats (Rattus norvegicus) with fever induction method using a solution of peptone 2% as much as 0.5 mL / 200 g body weigt intra peritonially, with the dose of ethanol extract, the fraction of n-hexane and ethyl acetate fractions 100, 200, and 400 mg / kg orally. Respectively as a positive control, asetosal was administered at a dose 117 mg / kg and the negative control was 1% CMC Na. Temperature observations of mice performed at 30, 60, 90, 120, 150, and 180 minutes, then percent protection was calculated. Data analysis was done using Two-way Analysis of Variance (ANOVA) and Tukey test. Results showed that the fraction of n-hexane at a dose of 400 mg/kg had an antipyretic effect as significantly (p<0.05).
Uji Aktivitas Antidiabetes Ekstrak Etanol dari Akar dan Batang Tumbuhan Sekunyit (Fibraurea Tinctoria Lour) Utami, Rahayu; Sandi, Nofri Hendri; Hasti, Syilfia; Delvia, Sutri
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 4 (2015)
Publisher : Indonesian Research Gateway

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Sekunyit (Fibraurea tinctoria Lour) is a species plant that has been used as traditional medicine for treating several diseases including jaundice, dysentery, headache, eye infection as well as anti diabetic drug. This research aims to evaluate antidiabetic activity of ethanol extract of roots and stem of sekunyit on white male mice (Mus musculus L) using glibenclamide as positive control. The experimental animals were induced with alloxan 175 mg/Kg BW i.p and devided into six groups, each group consisted of five mice. Group one served as negative control which was given NaCMC 1%, group second was positive control, given  glibenclamide 0,65 mg/KgBW, while group third, fourth, fifth were administered orally with etanol extract with doses of 100, 200 and 300 mg/KgBW, respectively. The observed parameter were measurement of blood glucose levels, urine volume and volume of drinking water as well as ratio of relative organ weight. The treatment was conducted for 15 days. The result showed that administration of ethanol extract of roots and stem of sekunyit can lowered significantly blood glucose levels (p<0,05) of alloxan induced-diabetic mice, decreased urine volume (p<0,05), decreased volume of drinking water (p<0,05), and did not affect relative organ weight of heart, liver and kidney (p>0,05).
Uji Aktivitas Antidiabetes Ekstrak Etanol dari Akar dan Batang Tumbuhan Sekunyit (Fibraurea Tinctoria Lour) Utami, Rahayu; Sandi, Nofri Hendri; Hasti, Syilfia; Delvia, Sutri
Jurnal Farmasi Indonesia Vol 7, No 4 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.003 KB) | DOI: 10.35617/jfi.v7i4.198

Abstract

Sekunyit (Fibraurea tinctoria Lour) is a species plant that has been used as traditional medicine for treating several diseases including jaundice, dysentery, headache, eye infection as well as anti diabetic drug. This research aims to evaluate antidiabetic activity of ethanol extract of roots and stem of sekunyit on white male mice (Mus musculus L) using glibenclamide as positive control. The experimental animals were induced with alloxan 175 mg/Kg BW i.p and devided into six groups, each group consisted of five mice. Group one served as negative control which was given NaCMC 1%, group second was positive control, given  glibenclamide 0,65 mg/KgBW, while group third, fourth, fifth were administered orally with etanol extract with doses of 100, 200 and 300 mg/KgBW, respectively. The observed parameter were measurement of blood glucose levels, urine volume and volume of drinking water as well as ratio of relative organ weight. The treatment was conducted for 15 days. The result showed that administration of ethanol extract of roots and stem of sekunyit can lowered significantly blood glucose levels (p<0,05) of alloxan induced-diabetic mice, decreased urine volume (p<0,05), decreased volume of drinking water (p<0,05), and did not affect relative organ weight of heart, liver and kidney (p>0,05).
UJI EFEK ANALGETIK, TOKSISITAS AKUT DAN TERTUNDA EKSTRAK ETANOL DAUN BERINGIN (Ficus benjamina L.) PADA MENCIT PUTIH JANTAN (Mus musculus) Syilfia Hasti; Elka Yuslinda; Nofri Hendri Sandi; Wan Liawati
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peranan dan Kontribusi Herbal dalam Terapi Penyakit Degeneratif"
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (56.119 KB) | DOI: 10.31942/jiffk.v0i0.376

Abstract

Salah satu tumbuhan yang telah digunakan oleh masyarakat sebagai obat tradisional yaitu daun beringin guna mengatasi rasa nyeri dan dari penelusuran pustaka belum ada dilakukan pengujian secara ilmiah begitu juga dengan penelitian tentang toksisitasnya. Berdasarkan hal tersebut, telah dilakukan penelitian untuk mengetahui efek analgetik ekstrak etanol daun beringin yang diberikan secara oral pada hewan coba mencit putih jantan yang diberi asam asetat 1% v/v sebanyak 0,1 ml sebagai penginduksi nyeri. Penelitian dilakukan menurut metode writhing test, menggunakan pembanding asetosal dengan dosis 65 mg/kgBB. Bahan uji diberikan secara oral dalam bentuk suspensi dalam Na CMC 1%, diberikan tiga puluh menit sebelum pemberian asam asetat. Pengamatan jumlah geliat dilakukan setelah penyuntikan asam asetat. Jumlah geliat dihitung dengan selang waktu 10 menit selama 90 menit kemudian dihitung persen proteksinya. Penelitian toksisitas akut (LD50) dihitung sebagai dosis yang memberikan kematian hewan sebanyak 50% dari jumlah hewan percobaan selama 24 jam setelah penyuntikan dan toksisitas tertunda dilakukan pada dosis 1000, 2000, 4000, 8000, dan 16000 mg/kgBB terhadap parameter volume air minum, volume urin, perubahan berat badan, konsumsi makanan, berat feses, rasio organ ginjal dan jantung. Hasil penelitian menunjukkan bahwa ekstrak etanol pada dosis 100, 200, dan 400 mg/kgBB memberikan efek analgetik p < 0,05 terhadap kontrol negatif (analisis varian dua arah dan analisis Tukey). Berdasarkan hasil pengujian toksisitas akut, ekstrak etanol daun beringin digolongkan praktis tidak toksik. Hasil penelitian yang menunjukkan adanya gejala toksisitas akut, ekstrak etanol daun beringin digolongkan praktis tidak toksik. Hasil penelitian yang menunjukkan adanya gejala toksisitas tertunda terhadap parameter perubahan berat badan, konsumsi makanan, berat feses, organ ginjal dan jantung signifikan pada dosis 16000 mg/kgBB.   Kata kunci : Analgetik, Ficus benjamina, writhing test.
Co-Authors Adriani Susanty Delvia, Sutri Delvia, Sutri Elka Yuslinda Rahayu Utami Syilfia Hasti Teti Srianti Wan Liawati Wewen Sista M