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All Journal As-syifaa Jurnal Farmasi Jurnal BALIRESO JCES (Journal of Character Education Society) Journal of Tropical Pharmacy and Chemistry Jurnal farmasi UIN Alauddin Makassar Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Journal of Experimental and Clinical Pharmacy (JECP) Mejuajua Indonesian Community Journal Jurnal Pengabdian Masyarakat Bangsa Journal of Pharmaceuticals and Natural Sciences
Asni Amin
Fakultas Farmasi Universitas Muslim Indonesia Makassar
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Journal of Experimental and Clinical Pharmacy (JECP)

 1 
Standarisasi Ekstrak Etanol Daun Sirsak (Annona muricata Linn.) Asal Daerah Gowa dan Takalar Amin, Asni; Rasyid, Faradiba Abdul; Syarif, Rezki Amriati; A.M, Sinta Faradilla; Saputri, Dicka; Sukmawati, Sukmawati
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 1 (2024): February 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i1.972

Abstract

Tumbuhan sirsak (Annona muricata Linn.) memiliki aktivitas sebagai antikanker dan antiinflamasi. Bahan baku ekstrak daun sirsak yang akan dikembangkan menjadi obat modern Indonesia asli harus terstandardisasi untuk menjaga mutu ekstrak yang dapat dipengaruhi oleh tempat tumbuh. Penelitian ini bertujuan melakukan standarisasi ekstrak daun sirsak asal daerah Gowa dan Takalar. Masing-masing ekstrak daun sirsak dilakukan standarisasi dengan parameter spesifik dan non spesifik. Hasil penelitian diperoleh data untuk pengujian parameter spesifik berupa uji organoleptik ekstrak yaitu bentuk kental, warna coklat kehitaman, dan berbau khas. Kadar senyawa larut air dan etanol  sebesar 7, 560% dan 13,94%untuk Gowa, sedangkan Takalar sebesar 6,64% dan 10,1%. Hasil uji parameter non spesifik untuk daerah Gowa dan Takalar sebagai berikut, susut pengeringan 0,289% dan 0,293%, bobot jenis 0,814 g/mL dan 0,818 g/mL, kadar air 4,488% dan 7,436%, kadar abu total 4,467% dan 6,560%, kadar abu tidak larut asam 0,499% dan 0,248%, cemaran mikroba < 1,0 x 101 koloni/g, cemaran logam berat cadmium < 0,0001 µg/g,  cemaran logam timbal sebesar 0,0390 µg/g dan < 0,0471 μg/g, residu pestisida < 0,001 mg/kg. Penelitian ini menunjukkan ekstrak daun sirsak asal daerah Gowa dapat digunakan menjadi sumber bahan baku daun sirsak.Annona muricata Linn. has anticancer and anti-inflammatory activity. The raw material for soursop leaf extract, which will be developed into authentic modern Indonesian medicine, must be standardized to maintain the quality of the extract, which can be influenced by the place of growth. This research aims to standardize soursop leaf extract from the Gowa and Takalar areas. Each soursop leaf extract was standardized with specific and non-specific parameters. The results of the research obtained data for testing specific parameters in the form of an organoleptic test of the extract, namely thick form, blackish brown color, and distinctive smell. The levels of water-soluble compounds and ethanol were 7,560% and 13.94% for Gowa, while for Takalar they were 6.64% and 10.1%. The results of non-specific parameter tests for the Gowa and Takalar areas are as follows: drying loss 0.289% and 0.293%, specific gravity 0.814 g/mL and 0.818 g/mL, water content 4.488% and 7.436%, total ash content 4.467% and 6.560%, acid insoluble ash content 0.499% and 0.248%, microbial contamination < 1.0 x 101 colonies/g, heavy metal cadmium contamination < 0.0001 µg/g, lead metal contamination 0.0390 µg/g and < 0.0471 μg/g, pesticide residue < 0.001 mg/kg. This research shows that soursop leaf extract from the Gowa area can be used as a source of raw material for soursop leaves.
Toxicity Activity and Total Phenolic Content of Soursop Leaves from Three Regions in South Sulawesi, Indonesia Rasyid, Faradiba Abdul; Amin, Asni; Sukmawati, Sukmawati; Djakariani, Kurnia Putri; Riska, Riska; Aliansyah, Moch. Rayhan; Sari, Cindy Artika
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 2 (2023): August 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i2.674

Abstract

The fruit plant known as the soursop (Annona muricata L.) is indigenous to the Caribbean, Central America, and South America. The leaves of soursop contain substances with the potential to be cytotoxic, such as phenols and anonaceous acetogenins. Numerous variables, including geographic location, climatic conditions, and pest or disease disturbance factors, might impact a compound's phenol levels and toxicity. This study aims to investigate whether there are variations in the phenolic content and toxicity of the ethanol extract of soursop leaves that are grown in Gowa, Takalar, and Pinrang, three distinct regions in South Sulawesi, Indonesia. The Folin-Ciocalteu reagent was used to evaluate the total phenolic content, whereas Artemia salina Leach larvae were used for the BSLT method of the toxicity test. The results showed that the extracts of soursop leaves from Gowa, Pinrang, and Takalar had total phenolic contents of 3.7588% mg GAE/g, 0.9686% mg GAE/g, and 1.3832% mg GAE/g, respectively. Gowa, Pinrang, and Takalar have LC50 values of 38.19 µg/mL, 34.35 µg/mL, and 70.95 µg/mL, respectively, indicating their toxicity. The conclusion is that there were differences in the phenolic content and toxicity level of the ethanol extract of soursop leaves. All of these areas could source raw materials of soursop for the development of herbal medicines with cytotoxicity, i.e., anticancer, because they have LC50< 1,000 µg/mL.
Co-Authors A. Amalia Dahlia A.M, Sinta Faradilla Abdul Rasyid, Faradiba Ade Dede Ahmad Najib Aliansyah, Moch. Rayhan Andi Maulana Kamri Andini Zabrina Aqilah Alviola Bani Aslinda Septinia Dina Izza Djakariani, Kurnia Putri Faradiba Farizah Dhaifina Amran Fawwaz , Muammar Hidrawati, Hidrawati Hilman Erwin Iriani, Rahma Irmayani Irmayani Karman, Nurliani Martati Martati Melly Amanda Muzakkir Baits Nur Azizah, Rizqi Nurhudayah Nurhudayah Nurlina Nurmaya Effendi Rachmat Kosman Rahayu Lestari Rezki Amriati Syarif, Rezki Amriati Risda Waris Risda Waris Riska Riska Rosmayanti Rosmayanti Rugayyah Alyidrus Rusli rusli Rusli Saputri, Dicka Sari, Cindy Artika Selpida Handayani Sri Wahyuni Sri Wahyuninsih Subehan Subehan Sukmawati Sukmawati Zainal Abidin Zakinah , Yuni