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All Journal Jurnal Florea JCPS (Journal of Current Pharmaceutical Sciences) Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Ilmiah Farmasi Akademi Farmasi Jember

Asa Falahi

Akademi Farmasi Jember

Author-ID : 3732596

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Public Health

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Pengaruh Propilen glikol dan Menthol sebagai Enhancer terhadap Sifat Fisik serta Indeks Iritasi Kulit dalam Sediaan Gel Meloksikam Asa Falahi
JCPS (Journal of Current Pharmaceutical Sciences) Vol 3 No 2 (2020): March 2020
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.841 KB)

ABSTRAK Meloksikam adalah obat golongan anti inflamasi non-steroid (AINS) yang banyak digunakan untuk mengobati nyeri dan inflamasi. Penggunaan oral Meloksikam dapat menimbulkan berbagai efek samping sistemik. Pemakaian transdermal diketahui mampu mencapai konsentrasi efektif pada jaringan target, dengan konsentrasi plasma yang lebih rendah dibanding penggunaan oral, sehingga dapat mengurangi resiko efek samping sistemiknya. Penelitian ini bertujuan untuk membuat sediaan emulgel untuk penghantaran transdermal Meloksikam. Propilenglikol 10% dan menthol 3% digunakan sebagai peningkat penetrasi. Sediaan dievaluasi meliputi pengamatan organoleptik, pH, viskositas, daya sebar serta pengujian stabilitas fisik menggunakan metode freeze thaw. Sediaan emulgel memenuhi persyaratan sifat fisik yang ditentukan baik sebelum maupun setelah kurun waktu penyimpanan 3 siklus pada suhu freeze dan thaw. Efektifitas anti inflamasi paling baik ditunjukan pada formula 3 yaitu emulgel dengan enhancer menthol.

OPTIMASI FORMULA TABLET BUKAL MUKOADHESIVE GLIBENKLAMID MENGGUNAKAN MATRIKS CMC NA SERTA ASAM OLEAT SEBAGAI ENHANCHER ASA FALAHI; DEWI RASHATI
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 4, No 1 (2021): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Glibenclamide is a sulfonylurea class of antidiabetic drugs that works by stimulating insulin secretion in the pancreas so that it is effective only when the β-cells of the pancreas can still produce. The glibenclamide dosage form that is on the market is a conventional oral tablet which has various disadvantages in terms of pharmacokinetics. Based on this, it is necessary to develop a more effective drug delivery system for glibenclamide in order to avoid first-pass metabolism so as to increase the bioavailability of glibenclamide, namely by making mucoadhesive buccal tablets. This glibenclamide mucoadhesive buccal tablet is formulated using a variety of mucoadhesive polymers, namely CMC Na and oleic acid as enhancers. The manufacture of four mucoadhesive buccal tablet formulas used the direct compression method. The results of the weight uniformity test showed that they did not meet the NP requirements specified, all formulas had an NP of more than 15. The tablet hardness test also showed results that did not meet the test requirements. However, the results of the physical properties of the brittleness, pH and swelling index showed the results that met the test requirements. In this research, the optimum variation of CMC Na polymer and oleic acid as enhancers to physical properties (hardness, brittleness, pH, swelling ability) and the release of glibenclamide mucoadhesive tablets were CMC Na of 37.5 mg and oleic acid of 3.5. ml.

STABILITAS FISIK EMULGEL MELOKSIKAM MENGGUNAKAN METODE FREEZE THAW ASA FALAHI
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 4, No 2 (2021): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Emulgel is a semi-solid preparation, in the form of an emulsion where the viscosity is increased by the addition of the gelling agent. Emulgel can be used for formulations of active substances that are difficult to dissolve in water. Meloxicam is a first-line treatment to treat rheumatoid arthritis and osteoarthritis. The aim of the study was determine the stability of the physical properties of emulgel meloxicam with the Freeze thaw test. The research design used was quasi experimental. In this study there were 2 storage temperatures, the freeze temperature of 4-8oC and thaw temperature of 40-48oC. The treatment was carried out in 3 cycles for 6 days. Physical stability test of organoleptic (color, odor, and dosage form) showed no difference during storage. Physical stability test of homogenity also showed no difference during storage. Physical stability of the emulsion type showed that there was no phase separation in the emulsifying gel during storage. Significance of pH is 0,083 (p 0,05), viscosity is 0,083 (p0,05), and spreadabilityis 0,102 (p 0,05) can be interpreted that the physical stability of pH, viscosity and dispersion power has no significant difference. From all research data, it can be seen that the meloxicam emulgel preparation did notchanges in physical stability after passing 3 cycles.

PENGARUH VARIASI KONSENTRASI CARBOPOL 934 SEBAGAI PENGENTAL TERHADAP SIFAT FISIK SEDIAAN SAMPO INFUSA DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) ASA FALAHI
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 5, No 1 (2022): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

The purpose of this study was to determine the effect of variation concentration carbopol 934 934 to the characteristics of physical shampoo from anti-dandruff infusion of pandan leaves (Pandanus amaryllifolius roxb). Pre-experiment one shot case study was used as a research design. Variation in carbopol 934 concentration were 1% (F1), 1.5% (F2), and 2% (F3) The result stowed that variation concentration of carbopol 934 affect organoleptic shape and smell, pH, and viscosity of shampoo. But didn’t affect color, homogenity, and foam height oh shampoo. The viscosity of the shampoo increases with the increase in the concentration of carbopol 934 used.

Pengaruh Variasi Suhu Sebelum dan Setelah Penyimpanan terhadap Stabilitas Fisik dan Kontaminasi Bakteri Suspensi Antasida Generik Rica Laily Istighfarin; Siti Nur Azizah; Asa Falahi; Amaliyah Nurul Hidayah
Florea : Jurnal Biologi dan Pembelajarannya Vol 9, No 2 (2022)
Publisher : UNIVERSITAS PGRI MADIUN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/florea.v9i2.11904

The purpose of this study was to determine the effect of temperature variations before and after storage on physical stability and bacterial contamination of the antacid suspension. The samples in this study were generic antacid suspensions with variations in storage temperature stored at 15-30Â°C (room), 2-8Â°C (cold), and 30-40Â°C (warm). Physical evaluations were carried out in the form of organoleptic tests, pH tests, viscosity tests and there was a bacterial contamination test. The results of the organoleptic test showed that the generic antacid suspension before and after storage had no change in smell, color and taste. The pH test has a stable pH and meets the requirements, namely pH between 7.3 and 8.5, the statistical test results obtained were 0.589> 0.05, which means that the pH before and after storage there was no significant difference. The viscosity test met the requirements, namely viscosity from 0.37 to 3.9 dpas. statistical test results obtained 0.023 <0.05, which means that the viscosity before and after storage there was a significant difference. The results of the Total Plate Number test before storage there was no contamination with ALTB values, namely 1.3x101 colonies/ml, 1,3x101 colonies/ml, and 1x101 colonies/ml, based on The International Pharmacopeia-7th edition the requirement for suspension bacterial contamination â‰¤ 1x102 colonies/ml, the result showed that contamination happened in all samples after storage. It can be concluded that bacterial contaminatios occured in all samples with temperature variations before and after storage but not affected on physical stability of antacid suspension.

TINGKAT PENGETAHUAN MASYARAKAT PERUMAHAN PONDOK GEDE JEMBER TERHADAP PENGGUNAAN ANTIBIOTIK TANPA RESEP DOKTER (Periode Juni 2022) Asa Falahi; Novia Ananta Budiono; Amaliyah Nurul Hidayah; Rosida Rosida
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 5, No 2 (2022): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53864/jifakfar.v5i2.108

Antibiotics are drugs used to treat bacterial infections and including in a group of strong drugs that are only purchased at pharmacies with doctor's prescription. Inappropriate use of antibiotics can lead to less effective treatment, an increased risk of patient death, widespread resistance, and high treatment costs. The purpose of this study was to know the society knowledge level in Perumahan Pondok Gede RT 06 RW 33 Kaliwates Jember about using antibiotics without a doctor's prescription. The type of this study was a descriptive survey research with a cross-sectional method. Sampling technique used purposive sampling with an inclusion criteria and obtain 60 samples. Based on research and data analysis obtain the percentage level of knowledge in 3 domains, in the know realm was 61% (enough category), in the understanding realm was 52% (less category), and 58% in the application realm (enough category). It can be concluded that the society knowledge level in Perumahan Pondok Gede RT 06 RW 33 is enough category about using antibiotics without doctor’s prescription.

PENGARUH VARIASI KONSENTRASI NATRIUM HIDROKSIDA TERHADAP SIFAT FISIK SEDIAAN SABUN PADAT EKSTRAK DAUN NANGKA (Artocarpus heterophyllus Lam.) Mikhania Christiningtyas Eryani; Hadi Barru Hakam Fajar Siddiq; Asa Falahi; Noer Layla Fitri Ani
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 12 No 1 (2023): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v12i1.161

The aim of this study was to determine the variataion concentration effect of sodium hydroxide (NaOH) on the physical properties of jackfruit leaf extract solid soap (Artocarpus heterophyllus Lam.). The concentration of NaOH used were 2.5% (F1); 5% (F2) and 7.5% (F3). The physical evaluation was carried out in the form of an organoleptic test, homogeneity test, pH test, water content test, and foam height test. The results showed that variations in NaOH concentration had no effect on the organoleptic physical properties (odor, shape, color) and homogeneity of solid soap but had an effect on the physical properties of pH, water content, and foam height of solid soap

EVALUASI SIFAT FISIK TABLET FLOATING FUROSEMIDE DENGAN MATRIKS CARBOPOL ASA FALAHI
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 6, No 1 (2023): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53864/jifakfar.v6i1.132

Furosemide is a sulfonamide-derived diuretic drug which is an alternative treatment for heart failure. Furosemide was made into slow-release tablets to improve the criteria for poor furosemide and maximize its absorption in the stomach. The purpose of this study was to determine whether floating furosemide tablets with a concentration of 23% carbopol matrix could meet the requirements for evaluating the physical properties of tablets compared theoretically with the literatur. The research design used was pre-experimental. In this study, the results of the weight uniformity test showed that there were no deviations from column A and column B, tablet hardness test with an average of 5.4 kg, tablet friability test with a % friability value of 0.08%, floating lag time test with an average time of 184 seconds, and the floating duration time test is with an average time of 8 hours. From the research data, it can be concluded that the floating furosemide tablet with a carbopol matrix concentration of 23% fulfills all evaluations of the physical properties of the tablet

Co-Authors Dewi Rashati Eryani, Mikhania Christiningtyas Hadi Barru Hakam Fajar Siddiq Noer Layla Fitri Ani Novia Ananta Budiono Rica Laily Istighfarin Rosida Rosida Siti Nur Azizah

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