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PENGGUNAAN METODE RASIO ABSORBAN DALAM PENETAPAN KADAR PARASETAMOL DAN SALISILAMIDA BERBENTUK SEDIAAN CAMPURAN Armin, Fithriani; Dantes, Ehrlich Von
Jurnal Sains dan Teknologi Farmasi Vol 17, No 2 (2012)
Publisher : Universitas Andalas

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A study on the determination of paracetamol and salicylamide in a mixture by absorbance ratio method has been done. The absorption spectrum of both compounds crossing one each other at isoabsorption point. The maximum wavelength of paracetamol, salicylamide, and wavelength of isoabsorpsi line which show the relation of paracetamol fractions in a mixture containing paracetamol and salicylamide in various proportions and absorbances at isoabsorption wavelength was constructed. The measurement of absorbance was done at 247,2 nm and 300,3 nm. The experiment showed that the absorbancy ratio method can be used to determine paracetamol and salicilamyde. The percent recovery of paracetamol was 101,31 % with 0,642 % of standard deviation and coefficient of variation 0,616 %. The salicylamide content was then calculated and found to be 99,66 % with 0,863 % of standard deviation and 0,861 % of coefficient variation.

Penggunaan Metode Rasio Absorban dalam Penetapan Kadar Parasetamol dan Salisilamida Berbentuk Sediaan Campuran Dantes, Ehrlich Von; Armin, Fithriani; Rusdi, Rusdi
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar

A study on the determination of paracetamol and salicylamide in a mixture by absorbance ratio method has been done. The absorption spectrum of both compounds crossing one each other at isoabsorption point. The maximum wavelength of paracetamol, salicylamide, and wavelength of isoabsorpsi line which show the relation of paracetamol fractions in a mixture containing paracetamol and salicylamide in various proportions and absorbances at isoabsorption wavelength was constructed. The measurement of absorbance was done at 247,2 nm and 300,3 nm. The experiment showed that the absorbancy ratio method can be used to determine paracetamol and salicilamyde. The percent recovery of paracetamol was 101,31 % with 0,642 % of standard deviation and coefficient of variation 0,616 %. The salicylamide content was then calculated and found to be 99,66 % with 0,863 % of standard deviation and 0,861 % of coefficient variation.

Identifikasi dan Penetapan Kadar Merkuri (Hg) dalam Krim Pemutih Kosmetika Herbal Menggunakan Spektrofotometri Serapan Atom (SSA) Armin, Fithriani; Zulharmita, Zulharmita; Firda, Dinda Rama
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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Telah dilakukan penelitian analisis kandungan merkuri dalam 3 sampel krim pemutih kosmetika herbal. Sampel diekstraksi dengan cara digesti basah selama 3 jam pada suhu Â±95Â°C sampai diperoleh larutan bening. Selanjutnya merkuri ditentukan secara kualitatif dan kuantitatif dengan pereaksi warna dan menggunakan metoda spektrofotometri serapan atom. Hasil analisis kualitatif menunjukkan bahwa semua sampel mengandung merkuri. Kadar merkuri pada sampel 1, 2, 3 berturut-turut adalah sebesar 0,56%; 0,28% dan 0,45 %. Kadar Hg pada sampel tersebut melanggar Peraturan Menkes RI No.376/MenKes/Per/VIII/1990 dan PerMenKes RI No.445/MenKes/Per/V/1998 yang isinya melarang penggunaan merkuri dalam sediaan kosmetika.

Penentuan Kadar Senyawa Fenolat Dan Uji Aktivitas Antioksidan Pada Buah Terung Belanda (Cyphomandra betacea (Cav.) Sendtn) Secara Spektrofotometri Visibel Fithriani Armin; Yuli Yani Dewi; Mahyuddin Mahyuddin
Jurnal Farmasi Higea Vol 3, No 1 (2011)
Publisher : STIFARM Padang

Levels Determination of phenolic compounds and antioxidant activity assay of eggplant belanda fruit (Cyphomandra betacea (Cav.) Sendtn) with visible spektofotometri has been done. Determination of phenolic compounds performed by the method of Folin ciocalteu, while DPPH is used as an antioxidant. The antioxidant activity is determined by its IC50 value. In this treatment gallic acid used as a comparison. The results showed that the levels of phenolic compounds from the sample extract solution is 0.288845 mg / g; 0.29678 mg / g and 0.28964 mg / g respectively. The antioxidant activity determined by IC50 values, where the value of its IC50 was 240.0811 µg / mL; 204.5010 µg / mL; 196.8531 µg / mL.

Pembuatan Kalsium Glukonat Dari Batu Kapur Bukit Tui Padang Panjang Zulharmita Zulharmita; Sri Indah Kesuma; Fithriani Armin
Jurnal Farmasi Higea Vol 6, No 1 (2014)
Publisher : STIFARM Padang

A study concerning the manufacture of calcium gluconate limestone hill Tui Leopold. Previous limestone samples were identified and determined the levels of calcium. 1 g sample of limestone calcium levels obtained 36,0812 %. In the manufacture of calcium gluconate used limestone samples of 20 g were dissolved in 6 M HCl, filtered and the filtrate was added 6 M NH4OH to pH 10 . Then added gluconic acid 1 M. The precipitate is filtered, washed, dried in an oven at a temperature of 1050 C. The results obtained as 6,2084 g of calcium gluconate. Examination of limestone calcium gluconate include organoleptic examination, solubility, qualitative identification, examination and the melting point of the assay by the method complexometry. In the assay of calcium gluconate from the manufacture of natural limestone samples carefully weighed approximately 0,5 g , 1 g, and 2 g. Of the three differences in weight percentage of calcium gluconate calcium results obtained, weighing 0,5 g to as much as 62,2708 % , 1 g weight as much as 79,9048 %, while the weight of as much as 2 g 101,7232 %. From the results of the assay of calcium gluconate with a sample of 6,2084 g drying results have percentage 101,7232 % with the results of testing the melting point is 2000 C calcium gluconate. It can be concluded natural limestone hill Tui Leopold has a high purity calcium levels that can be made of calcium gluconate.

Analisis Senyawa Fenolat Dan Uji Aktivitas Antioksidan Buah Markisa (Passiflora Edulis Sims) Secara Spektrofotometri Visibel Fithriani Armin; Ermadanis Ermadanis; Roslinda Rasyid
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

Has done research on the analysis of phenolic compounds and antioxidant activity test on passion fruit (Passiflora edulis Sims) by visible spectrophotometry method. To determine the presence of phenolic compounds in the sample to be identified with iron (III) chloride is characterized by the formation of dark blue color on the sample. Samples were macerated with 96% ethanol, performed three repetitions and the filtrate was concentrated using a rotary evaporator at a temperature of 400 C. Extracts were obtained determined the levels of phenolic compounds using Folin-ciocalteau method and test the antioxidant activity using DPPH method. Standard solution used is gallic acid. Equation linearity gallic acid used in the determination of phenolic compounds in the sample is y = 0.004x + 0.1366 with correlation coefficient (r) = 0.9956 measured at λ max 761.5 nm. the levels of phenolic compounds were obtained on average at the sample was 0.0377% w / w. The average percent inhibition of passion fruit sample solution were counted against the maximum wavelength of 512.0 nm DPPH is 19.8763%. The antioxidant activity of the sample solution of 10 mg is equivalent to 618.9760 mg gallic acid and gallic acid solution IC50 of 1.5604 mg / mL of the sample solution while the IC50 14.4751 mg / mL.

Pembangan dan Validasi Metode Kromatografi Lapis TipisDensitometri untuk Analisis Pewarna Merah Sintentik pada Beberapa Merek Saus Sambal Sachet Fithriani Armin; Bita Revira; Adek Zamrud Adnan
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Chili sauce sachet A, B and C containing synthetic red coloring agent were taken from three fast food premises in Padang. Synthetic red coloring agent were a food additives used by food manufacturers to enhance color of food products. The use of food coloring agent in Indonesia were regulated in The Rule of Head of the Supervisory Food Board of the Republic of Indonesia Number 37 Year 2013 about the Limit Use of Food Coloring Agent. Thin-layer chromatography (TLC) -densitometry was a precision method for the analysis of food additives. Development and validation of TLC method for chromatographic separation used GF254 silica plate eluted with a mixture of ethanol: butanol: distilled water (4: 5: 5) and spots were detected visually. A red spots on the sample B was identified as Ponceau 4R with Rf value of 0.76. It was then followed by quantitative analysis using densitometry. The linearity of the method was found in the range of 2-10μg/ml with a correlation coefficient of 0.994. Precision intra-day and inter-day relative standard deviation was shown from 1.11% and 2.69% respectively. Accuracy of the method was shown on the percentage of recovery of the 3 different concentrations of solution which gave the average percentage of 108.17%. Limit of detection and limit quantitation was 0.8306μg/ml and 2.7687μg/ml. The concentration of Ponceau 4R in the sample B was 11.9520mg/kg of material. This value was not exceeded the maximum concentration of food coloring agent as stated in the rule which should not be above 70mg/kg of material.

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