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All Journal AL KAUNIYAH Jurnal Biologi dan Pembelajarannya (JBP) Scientiae Educatia: Jurnal Pendidikan Sains Journal Syifa Sciences and Clinical Research (JSSCR) JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Indonesian Journal of Pharmaceutical Education Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Jurnal Pengabdian Harapan Ibu (JPHI)
Nurul Istiqomah
Institut Ilmu Kesehatan Bhakti Wiyata Kediri
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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PENINGKATAN IMUNITAS TUBUH MELALUI KONSUMSI JAMU DI ERA PANDEMI COVID-19 Mawardika, Herlinda; Istiqomah, Nurul
Journal of Community Engagement and Empowerment Vol 3, No 1 (2021)
Publisher : Institut Ilmu Kesehatah Bhakti Wiyata Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pandemi COVID-19 merupakan permasalahan penting yang tengah dihadapi masyarakat saat ini karena memberikan dampak yang besar pada kesehatan individu maupun perekonomian keluarga. Konsumsi jamu tradisional yang merupakan ramuan bahan berupa tanaman herbal diketahui dapat memelihara kesehatan tubuh dan dipercaya oleh masyarakat dapat mencegah agen infeksi. Dengan meningkatnya jumlah pasien terinfeksi virus corona, masyarakat perlu terus dimotivasi untuk memperhatikan kesehatan diri dan keluarga. Salah satu upaya untuk meningkatkan kesadaran masyarakat akan hal ini yaitu dengan pemberian edukasi terkait konsumsi jamu. Kegiatan pengabdian masyarakat ini bertujuan untuk mendukung program pencegahan COVID-19 melalui peningkatan konsumsi jamu oleh masyarakat di Desa Bandar Lor Kediri. Kegiatan ini dilaksanakan melalui beberapa tahapan, yaitu pembuatan dan pembagian jamu ke masyarakat di Desa Bandar Lor, Kediri serta pemberian penyuluhan secara langsung kepada perwakilan masyarakat untuk memberikan pemahaman seputar jamu dengan menerapkan protokol kesehatan. Evaluasi keberhasilan kegiatan ditentukan berdasarkan hasil pengisian kuesioner oleh peserta yang diberikan sebelum dan sesudah sosialisasi. Selama pelaksanaan kegiatan ini, telah dibagikan 2000 botol jamu yang diproduksi secara mandiri kepada masyarakat. Sesuai dengan penilaian kuesioner, kegiatan sosialisasi jamu dapat meningkatkan pengetahuan masyarakat sebesar 60% mengenai khasiat dan pentingnya jamu sebagai minuman kesehatan untuk mendukung sistem imun tubuh selama pandemi COVID-19. Kegiatan pengabdian kepada masyarakat ini dapat meningkatkan wawasan dan memberikan motivasi masyarakat untuk mengkonsumsi jamu di tengah wabah virus corona
Response of Pineapple Callus (Ananas comosus Merr.) through In-Vitro Colchicines Treatment Nurul Istiqomah; Muh. Shofi
Scientiae Educatia: Jurnal Pendidikan Sains Vol 7, No 1 (2018): June (2018)
Publisher : Tadris Biologi Fakultas Ilmu Tarbiyah dan Keguruan IAIN SYEKH NURJATI CIREBON

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.187 KB) | DOI: 10.24235/sc.educatia.v7i1.1919

Abstract

Pineapple Plant (Ananas comosus (L.) Merr) is a fruit plant that has a high economic value. Increased variety of pineapple preparations lead to increased demand for pineapple fruit. Polyploidation is one way to increase the varieties using colchicine. This study aims to know the pineapple explants of callus response after being treated by colchicine using in vitro method. This research used Group Randomized Design (GRD) which variations concentration of Colchicine 0%, 0.01%, 0.05%, and 0.1%. Parameters were observed to response and thickness of callus of pineapple explants. Data were analyzed using F test and DMRT test in which significance level of 5% with SPSS 17 program. The results showed that pineapple plant explant able to respond colchicine concentration marked with thicker callus. The best colchicine treatment to induce pineapple explants callus was concentration 0.1% of colchicine.
Aktivitas Antioksidan Ekstrak Etanol Kamboja Jepang (Adenium obesum) dan Kamboja Putih (Plumeria acuminata) Muh. Shofi; Fera Suwitasari; Nurul Istiqomah
Al-Kauniyah: Jurnal Biologi Vol 13, No 2 (2020): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v13i1.12631

Abstract

AbstrakSenyawa antioksidan adalah senyawa yang dapat menangkal dampak radikal bebas dengan cara menghambat stres oksidatif serta menghentikan kerusakan sel dan induksi penyakit. Tanaman kamboja jepang (Adenium obesum) dan kamboja putih (Plumeria acuminata) termasuk tanaman hias yang memiliki khasiat obat. Tanaman ini banyak mengandung senyawa flavonoid dan senyawa antioksidan alami. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol daun dan bunga tanaman kamboja jepang dan kamboja putih. Ekstrak kamboja diperoleh dengan melakukan maserasi daun dan bunga kamboja dengan menggunakan pelarut etanol 70% dan 96%. Ekstrak kental daun dan bunga kamboja diperoleh dengan cara pemekatan ekstrak menggunakan penangas air. Uji skrining fitokimia ekstrak kental berupa kandungan alkaloid, saponin, tanin, flavonoid, terpenoid, dan steroid secara kualitatif, sementara aktivitas antioksidan diuji dengan metode 2,2-diphenyl-1-picrylhydrazyl (DPPH). Hasil skrining fitokimia ekstrak menunjukkan adanya kandungan alkaloid, tanin, flavonoid, dan saponin dengan nilai IC50 tertinggi ditunjukan oleh ekstrak bunga kamboja putih yang diekstrak dengan etanol 70% yaitu sebesar 98,41 ppm, dan terendah oleh bunga kamboja putih yang diekstrak dengan etanol 96% yaitu 533,13 ppm. Ekstrak etanol tanaman kamboja jepang dan kamboja putih memiliki potensi sebagai antioksidan alami.Abstract Antioxidant compounds are compounds that can counteract the effects of free radicals by inhibiting oxidative stress and stopping cell damage and disease induction. Japanese frangipani plants (Adenium obesum) And white frangipani (Plumeria acuminata), including ornamental plants that have medicinal properties. This plant contains a lot of flavonoid compounds and natural antioxidant compounds. This study aims to determine the antioxidant activity of ethanol extracts of leaves and flowers of japanese frangipani plants  and white frangipani. Frangipani extract is obtained by moderating frangipani leaves and flowers by using 70% and 96% ethanol solvents. Thick extracts of frangipani leaves and flowers are obtained by concentrating the extract using a water bath. Phytochemical screening tests of thick extracts containing alkaloids, saponins, tannins, flavonoids, terpenoids, and steroids qualitatively, while antioxidant activity was tested by the method 2,2-diphenyl-1-picrylhydrazyl (DPPH). Phytochemical screening results showed the presence of alkaloids, tannins, flavonoids, and saponins with the highest IC50 values shown by white frangipani extract extracted with 70% ethanol at 98.41 ppm, and the lowest by white frangipani extracted with 96% ethanol at 533.13 ppm. Ethanol extract of japanese frangipani and white frangipani plants have potential as natural antioxidants.
PROFIL VITAMIN C MANGGA PODANG DI KECAMATAN MOJO, SEMEN, BANYAKAN DAN TAROKAN KABUPATEN KEDIRI nurul istiqomah
Jurnal Biologi dan Pembelajarannya (JB&P) Vol 5 No 1 (2018): JURNAL BIOLOGI DAN PEMBELAJARANNYA (JB&P) APRIL 2018
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/jbp.v5i1.12032

Abstract

Vitamin C berperan sebagai antioksidan dalam tubuh dan juga sebagai kofaktor enzim. Vitamin C bersumber dari buah – buahan, sayuran (tanaman) dan juga ada yang berasal dari hewan. Daerah Kediri merupakan sentra penanaman mangga podang. Kandungan vitamin C pada mangga podang dapat dipengaruhi oleh kondisi mikroklimat dan unsur hara dalam tanah. Sampel mangga podang pada empat kecamatan diambil secara acak, kemudian di frezze dry. Kandungan vitamin C dianalisis dengan HPLC. Hasil pengukuran parameter pada empat kecamatan menunjukkan terdapat beberapa perbedaan yang nyata yaitu pada kondisi suhu udara, kelembapan udara dan tanah, kandungan organik kation transfer kation, komposisi debu dan liat pada komposisi tanah dan tekstur tanah. Kandungan vitamin C tertinggi ada pada mangga podang pada daerah Semen dan Banyakan yang masing – masing sebesar 0.462 + 0.420 dan 0.326 + 0.002. Kata Kunci: Mangga Podang, Vitamin C, Kediri
FORMULASI EMULGEL DARI EKSTRAK DAUN KELOR (Moringa oleifera LAM) SERTA EVALUASI AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH Nurul Istiqomah; Juliyanti Akuba; Muhammad Taupik
Journal Syifa Sciences and Clinical Research Vol 3, No 1 (2021): Volume 3 Edisi 1 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i1.9874

Abstract

Moringa (Moringa oleifera Lam) is one of the plants that has high antioxidant activity, especially in the leaves. Emulgel is one of the topical dosage which dermatologically has several beneficial properties, namely thixotropic, not oily, easy to spread, easy to clean, soft, easy to wash, long lasting, transparent and comfortable when used. The purpose of this research was to formulate moringa (Moringa oleifera Lam) leaves extract into emulgel dosage forms and determine the antioxidant activity of the dosage using DPPH method.The research began with extraction of moringa leaves and optimization of the base by varying the concentration of carbopol 940 as gelling consisting of F1 0.5%, F2 1%, F3 1.5% and F4 2%. The base that met the requirements of good physical stability was F2.  The F2 base was then made into emulgel dosage with 3 concentration variations of the extract, namely F2a 4%, F2b 5% and F2c 6%. The physical stability test result of each formula met the organoleptic test,the pH test, the dispersion test, the adhesion test, the viscosity test, and the freeze-thaw test. The One way ANOVA statistical test result showed that the p value was greater than 0.05, which meant that the emulgel dosage had good physical stability. The IC50values of each antioxidant activity result were F2a (t0 = 120.464 g/mL; t28 = 144.887 g/mL), F2b (t0 = 113.642 g/mL; t28 = 128.407g/mL), F2c (t0 = 74.745 g/mL; t28 = 90.618 g/mL). The statistical results of the t-test showed thep value = 0,027, (0.05), This indicated that there were significant difference results of the antioxidant activity test between the three formulas on the first day (t0) and on the 28th day (t28).
Analisis Kadar Metabolit Sekunder, Histokimia, dan Aktivitas Antioksidan Akar Acalypha indica L. Novia Agustina; Nurul Istiqomah
Journal Syifa Sciences and Clinical Research Vol 3, No 2 (2021): Volume 3 Edisi 2 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i2.11376

Abstract

Acalypha indica L. is a species of wild plant that has secondary metabolites are used as medicine, but the usage is not optimized yet. The objective of of this study was to determine secondary metabolites content, location and distribution of secondary metabolites, and also the capacity for antioxidant. Secondary metabolites content was determined included phenol, flavonoids, tannin of chloroform and methanol extracts from Acalypha indica L. root, using spectrophotometre. Histochemical test was done by making fresh sliced preparation which was reacted with reagent. Antioxidant activity was determined by using DPPH method. The result of this study showed that secondary metabolites content of chloroform extract, were phenol 9,89 ± 0,77 %GAE, flavonoids 5,87 ± 1,40 %QE, and tannin 3,33 ± 1,21 %GAE, while methanol extract were phenol 45,11 ± 4,86 %GAE, flavonoids 19,87 ± 0,61 %QE, and tannin 6,76 ± 0,31 %GAE. Histochemical test showed that phenol, flavonoids, tannin, and alkaloids were found in Acalypha indica L. root. Antioxidant activity showed the IC50 value was 161,81 ± 7,88 μg/mL for chloroform extract and 92,81 ± 4,33 μg/mL for methanol extract.
The Correlation between Leukocytes and Bacterial Number from Urine of Type 2 Diabetes Mellitus Patients Using Urine Analyzer Novia Agustina; Diana Pratiwi; Nurul Istiqomah
Indonesian Journal of Pharmaceutical Education Vol 3, No 1 (2023): Januari-April 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i1.19008

Abstract

Diabetes Mellitus (DM) is a chronic metabolic disorder. DM can occur if the pancreas does not produce enough insulin or the insulin that is produced isn’t effectively used. Patients with diabetes mellitus have a high risk for chronic microvascular complications, including infection. This research aimed to determine the correlation between leukocytes and bacterial number from urine of patients with Type 2 Diabetes Mellitus at the X Hospital Blitar. This research used a cross sectional method, with 47 urine samples of Type 2 Diabetes Mellitus patients by purposive sampling, were tested with urine analyzer. The result showed that the number of high leukocytes was 13 (28%) respondents and normal leukocytes was 34 (72%) respondents. While the number of bacteria from respondents  was normal 21 (45%) and high number was 26 (55%). Based on the Spearman-rho correlation test on SPSS, it can be concluded that there was a significant relationship between leukocytes with bacterial number of urine from Type 2 Diabetes Mellitus patients, with sig = 0,000 (0,05) and the correlation coefficient = 0,515.
Kajian in Silico Daun Sungkai (Peronema canescens) dalam Menghambat Enzim lanosterol 14-α demethylase Jamur Candida albicans Nurul Istiqomah; Safitri Fatikasari; Ariani H. Hutuba
Indonesian Journal of Pharmaceutical Education Vol 3, No 1 (2023): Januari-April 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i1.19135

Abstract

Candida albicans (C. albicans) is a fungus that causes candidiasis. C. albicans has the enzyme Lanosterol 14- α demethylase. Lanosterol 14-α-demethylase has bioactivity in converting lanosterol to ergosterol, a special sterol found in fungal membranes, which mediates membrane permeability and fluidity. One way to treat candidiasis is to use traditional medicinal plants. Sungkai (Peronema canescens) can be used as an anti-fungal medicine. Drug development efforts can be done using the In silico method. Objectives of this study was to determine the interaction between terpenoid, flavonoid, and phenol compounds in Sungkai leaves against Lanosterol 14-α demethylase in Candida albicans. The research design used was a pre-experimental one-shot case study. Toxtree software was used to test the toxicity of compounds. Test for compound potency using the Pass Online webserver. Docking molecular using PyRx software. Visualization of docking results using Discovery Studio 2019 Software. Physicochemical test of compounds using Lipinski Test. The results showed that the compounds that had a low risk of toxicity were butanoic, catechol, guaiacol, hydroquinone, isopropanol, methanoic acid, palmitic acid, and phytol. Compounds that have anti-fungal activity based on Pharma-expert analysis are butanoic acid, genkwanin, guaiacol, hydroquinone, isopropanol, palmitic acid, and phytol. Compounds that have hydrogen bonds and binding affinity value 10 and RMSD value 2 are butanoic acid, catechol, genkwanin, guaiacol, hydroquinone, isopropanol, methanoic acid, palmitic acid, and quinic acid compounds. These compounds are thought to inhibit the Lanosterol 14-alpha demethylase enzyme in C. albicans. Compounds that comply with Lipinski's rules are anthocyanin and genkwanin compounds. The groups of compounds found in Sungkai leaves that have antifungal activity are the terpenoids, flavonoids, and phenols.
Peningkatan Pengetahuan dan Keterampilan Siswa Melalui Pengenalan Proses Penjernihan Air Secara Sederhana Muh. Shofi; Nurul Istiqomah; Aisyah Hadi Ramadani; Durroh Humairoh; Inayah Fitri
Jurnal Pengabdian Harapan Ibu (JPHI) Vol 2 No 1 (2020): Jurnal Pengabdian Harapan Ibu (JPHI)
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (734.428 KB) | DOI: 10.30644/jphi.v2i1.375

Abstract

Air merupakan sumber kehidupan bagi mahluk hidup. Air merupakan kebutuhan yang paling penting dalam kehidupan manusia terutama air tawar yang bersih dan sehat. Namun demikian, kelangkaan dan kesulitan mendapatkan air bersih dan layak pakai menjadi permasalahan yang mulai muncul di banyak tempat dan semakin mendesak dari tahun ke tahun. Salah satu cara untuk mengatasi kendala tersebut dengan menjernihkan air dengan bantuan pasir, sabut air, pecahan genting, pasir, dan arang. Program ini bermaksud memberi edukasi pada siswa mengenai cara penjernihan air secara sederhana. Tujuan dari dilaksanakan program ini yaitu memberikan informasi tentang penjernihan air secara sederhana dengan menggunakan pasir, sabut air, pecahan genting, pasir, dan arang di SD Islamic International School Pesantren Sabilil Muttaqien Kediri. Metode yang digunakan dalam proses penyuluhan yang dilaksanakan di ini yaitu dengan menggunakan tiga metode yaitu: metode ceramah, tanya jawab dan demonstrasi menggunakan pasir, sabut air, pecahan genting, pasir, dan arang. Hasil yang dicapai adalah para siswa mengetahui bahaya air yang tercemar cara menjernihkan air secara sederhana. Antusias para siswa terlihat saat praktik cara menjernihkan air secara sederhana dengan menggunakan pasir, sabut air, pecahan genting, pasir, dan arang.
Hasil Pemeriksaan Telur Soil Transmitted Helminths Pada Kuku Petani Di Desa Wonoayu Kabupaten Madiun Indra Sabban; Intan Puspitasari; Ismiy Wahyuni; Nurul Istiqomah
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 4 No 1 (2023): Juni 2023
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v4i1.97

Abstract

Kecacingan adalah salah satu penyakit yang disebabkan oleh cacing. Soil Transmitted Helminths (STH) adalah suatu kelompok parasit Nematoda yang menyebabkan infeksi pada manusia melalui kontak dengan telur parasit atau larva yang berkembang di dalam tanah. Perilaku hidup bersih dan sehat serta tidak membersihkan kuku dapat memiliki resiko terinfeksi Soil Transmitted Helminths, sehingga menyebabkan terlur cacing yang terselip di kuku, dan ikut tertelan masuk kedalam perut manusia melalui mulut saat orang tersebut melakukan aktivitas makan. Tujuan dari penelitian ini yaitu untuk melihat gambaran hasil pemeriksan telur Soil Transmitted Helminths pada kuku petani di Desa Wonoayu Kabupaten Madiun. Penelitian ini menggunakan teknik total samling dengan jumlah sampel 60 (30 kuku jari dan 30 kuku kaki) dan desain penelitian menggunakan survei deskriptif. Pada penelitian ini menggunakan metode pemeriksaan pengapungan NaCl. Berdasarkan dari hasil penelitian ini terdapat 60 sampel (100%) sampel kuku petani didapatkan hasil negatif atau tidak terinfeksi telur cacing Soil Transmitted Helminths. Peneliti selanjutnya diharapkan untuk mengembangkan penelitian ini, diantaranya dengan cara memilih metode lain selain menggunakan metode pengapungan menggunakan NaCl.
Co-Authors Aisyah Hadi Ramadani Ariani H. Hutuba Diana Pratiwi Durroh Humairoh Fera Suwitasari Herlinda Mawardika, Herlinda Inayah Fitri Indra Sabban Intan Puspitasari Ismiy Wahyuni Juliyanti Akuba Muh. Shofi Muhammad Taupik Novia Agustina Novia Agustina Novia Agustina Safitri Fatikasari Salsa Bellamilenia Putri