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All Journal AL KAUNIYAH Jurnal Biologi dan Pembelajarannya (JBP) Scientiae Educatia: Jurnal Pendidikan Sains Journal Syifa Sciences and Clinical Research (JSSCR) JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Indonesian Journal of Pharmaceutical Education Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Jurnal Pengabdian Harapan Ibu (JPHI)
Nurul Istiqomah
Institut Ilmu Kesehatan Bhakti Wiyata Kediri
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Journal : Indonesian Journal of Pharmaceutical Education

 1 
The Correlation between Leukocytes and Bacterial Number from Urine of Type 2 Diabetes Mellitus Patients Using Urine Analyzer Novia Agustina; Diana Pratiwi; Nurul Istiqomah
Indonesian Journal of Pharmaceutical Education Vol 3, No 1 (2023): Januari-April 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i1.19008

Abstract

Diabetes Mellitus (DM) is a chronic metabolic disorder. DM can occur if the pancreas does not produce enough insulin or the insulin that is produced isn’t effectively used. Patients with diabetes mellitus have a high risk for chronic microvascular complications, including infection. This research aimed to determine the correlation between leukocytes and bacterial number from urine of patients with Type 2 Diabetes Mellitus at the X Hospital Blitar. This research used a cross sectional method, with 47 urine samples of Type 2 Diabetes Mellitus patients by purposive sampling, were tested with urine analyzer. The result showed that the number of high leukocytes was 13 (28%) respondents and normal leukocytes was 34 (72%) respondents. While the number of bacteria from respondents  was normal 21 (45%) and high number was 26 (55%). Based on the Spearman-rho correlation test on SPSS, it can be concluded that there was a significant relationship between leukocytes with bacterial number of urine from Type 2 Diabetes Mellitus patients, with sig = 0,000 (0,05) and the correlation coefficient = 0,515.
Kajian in Silico Daun Sungkai (Peronema canescens) dalam Menghambat Enzim lanosterol 14-α demethylase Jamur Candida albicans Nurul Istiqomah; Safitri Fatikasari; Ariani H. Hutuba
Indonesian Journal of Pharmaceutical Education Vol 3, No 1 (2023): Januari-April 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i1.19135

Abstract

Candida albicans (C. albicans) is a fungus that causes candidiasis. C. albicans has the enzyme Lanosterol 14- α demethylase. Lanosterol 14-α-demethylase has bioactivity in converting lanosterol to ergosterol, a special sterol found in fungal membranes, which mediates membrane permeability and fluidity. One way to treat candidiasis is to use traditional medicinal plants. Sungkai (Peronema canescens) can be used as an anti-fungal medicine. Drug development efforts can be done using the In silico method. Objectives of this study was to determine the interaction between terpenoid, flavonoid, and phenol compounds in Sungkai leaves against Lanosterol 14-α demethylase in Candida albicans. The research design used was a pre-experimental one-shot case study. Toxtree software was used to test the toxicity of compounds. Test for compound potency using the Pass Online webserver. Docking molecular using PyRx software. Visualization of docking results using Discovery Studio 2019 Software. Physicochemical test of compounds using Lipinski Test. The results showed that the compounds that had a low risk of toxicity were butanoic, catechol, guaiacol, hydroquinone, isopropanol, methanoic acid, palmitic acid, and phytol. Compounds that have anti-fungal activity based on Pharma-expert analysis are butanoic acid, genkwanin, guaiacol, hydroquinone, isopropanol, palmitic acid, and phytol. Compounds that have hydrogen bonds and binding affinity value 10 and RMSD value 2 are butanoic acid, catechol, genkwanin, guaiacol, hydroquinone, isopropanol, methanoic acid, palmitic acid, and quinic acid compounds. These compounds are thought to inhibit the Lanosterol 14-alpha demethylase enzyme in C. albicans. Compounds that comply with Lipinski's rules are anthocyanin and genkwanin compounds. The groups of compounds found in Sungkai leaves that have antifungal activity are the terpenoids, flavonoids, and phenols.
Co-Authors Aisyah Hadi Ramadani Ariani H. Hutuba Diana Pratiwi Durroh Humairoh Fera Suwitasari Herlinda Mawardika, Herlinda Inayah Fitri Indra Sabban Intan Puspitasari Ismiy Wahyuni Juliyanti Akuba Muh. Shofi Muhammad Taupik Novia Agustina Novia Agustina Novia Agustina Safitri Fatikasari Salsa Bellamilenia Putri