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Pengaruh Ekstrak Etanol Daun Sukun (Artocarpus Communis) Terhadap Radang Lokal Dan Il-6 Pada Mencit Model Gout Arthritis Nurfitria, Siti; Sholehah, Diana Nurus
Jurnal Kesehatan Bali Vol 1 No 1 (2017): Bali Health Journal
Publisher : LP2M Institut Ilmu Kesehatan Medika Persada Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Acute arthritis gout is a form of arthritis caused by deposits of crystalline monosodium urate (MSU) in joints, bones and soft tissues. This disease can cause a large socioeconomic impact considering gout attacks the average young adult upwards that in fact is a productive age. Objective: This study aims to prove the effect of breadfruit ethanol extract (Artocarpus communis) on local inflammation through decrease of IL-6 from mice of gout arthritis model. Method: The type and design of this research is laboratory experimental research using post test only control group design. 20 Balb-c female mice were modeled on gout arthritis by injecting MSU dissolved in PBS intraarticularly on tibio-tarsal joint (ankle) and then divided into 5 groups, ie 1 normal group, 1 group of gout arthritis mice who were not given ethanol extract leaves of breadfruit, and 3 groups of treatment that is mice gout arthritis model which was given the extract of ethanol leaves of breadfruit with dose respectively 1.25; 2.5 and 3.75 g / kg bb for 2 weeks. Result: The results showed that the giving of breadfruit ethanol extract (Artocarpus communis) influenced local inflammation in gout arthritis (p = 0,001). The results showed that ethanol extract of breadfruit leaves was able to decrease IL-6 in the synovial fluid of experimental animals and there was significant difference of IL-6 concentration in the five groups of mice (p = 0.000). The results also showed a strong correlation between local inflammation and IL-6 levels (P = 0.000; r = -0.839). Conclusion: From the above it can be concluded that the ability of breadfruit ethanol extract decreased local inflammation through decreased levels of IL-6 in gout arthritis model.

Optimasi Ekstraksi Pati Jagung Madura-3 Berdasarkan Lama Perendaman dan Konsentrasi NaOH Mojiono, Mojiono; Sholehah, Diana Nurus
Rekayasa Vol 13, No 2: August 2020
Publisher : Universitas Trunojoyo Madura

Produksi jagung di Madura memberikan andil besar terhadap total produksi jagung di Jawa Timur. Di tingkat nasional, BPS menunjukkan bahwa produksi jagung di Jawa Timur mencapai 6 juta ton, berkontribusi sebesar 31.3%, atau hampir sepertiga dari total produksi jagung nasional. Produksi jagung yang besar seharusnya didukung dengan kesiapan teknologi produksi untuk mengolahnya menjadi aneka produk turunan, seperti pati. Pati jagung adalah bahan strategis karena digunakan di berbagai sektor, khususnya pangan. Studi ini dilakukan untuk optimasi proses ekstraksi pati jagung Madura-3. Teknik optimasi dilakukan menggunakan desain rancangan d-optimal pada Response Surface Methodology (RSM). Kondisi optimasi meliputi lama perendaman (X1) dan konsentrasi NaOH (X2), dengan rentang sebagai berikut: X1 (12 jam – 36 jam) dan X2 (0.05 – 0.5%). Hasil uji statistik memperlihatkan bahwa model yang berhasil dikonstruksi dinyatakan signifikan, ditunjukkan dengan F value sebesar 7.30, dan Prob lebih dari F sebesar 0.0075 (P kurang dari 0.05). Selain itu, lack of fit adalah 0.45, memperlihatkan bahwa parameter ini tidak signifikan. Lack of fit yang tidak signifikan memang diinginkan. Selain itu, nilai adequate precision dari model mencapai 7.469 (diinginkan lebih dari 4.0) Hasil optimasi menunjukkan bahwa kondisi optimum dapat dicapai pada kondisi X1 = 36 jam dan X2 = 0.05%. Kondisi optimum ini diprediksi mampu menghasilkan nilai rendemen 5.29%, dengan nilai desirability 0.719. Extraction of Madura-3 corn starch by optimizing soaking time and NaOH concentrationCorn production in Madura showed a tremendous contribution to total production in the Province of East Java. Noticeably, the province was recorded to yield 6 million tons of corn, responsible for approximately 31.3% of domestic production in 2018, as reported by BPS-Statistics. For this reason, there is a need for developing technology that enables to convert the corn into other valuable products, such as starch. Corn starch is essential material since it is applied in copious sectors mainly including food and pharmacy. This present work aimed at optimizing conditions for isolating starch of Madura-3 corn carried out using d-optimal design in Response Surface Methodology (RSM). The variables included soaking time (X1) and concentration of NaOH (X2), arranged as follows: X1 (12 – 36 h) and X2 (0.05 – 0.5%) according to preliminary research. The results demonstrated that the model constructed from data was significant, resulting in an F value of 7.30 and Prob more than F of 0.0075 (P less than 0.05). Furthermore, the statistical analysis showed a lack of fit at 0.45, which means that it was insignificance, which is favorable for this experiment. In addition, adequate precision of the constructed model was achieved at 7.469 (more than 4.0). Based on the statistical evaluation, the optimum condition for starch isolation was found at X1 = 36 h and X2 = 0.05%, which was predicted to yield starch at 5.29% with the desirability value of 0.719.

Identifikasi Kadar dan Pengaruh Sifat Kimia Tanah terhadap Metabolit Sekunder Kunyit (Curcuma domestiva Val.) di Bangkalan Sholehah, Diana Nurus; Amrullah, Arief; Badami, Kaswan
Rekayasa Vol 9, No 1: April 2016
Publisher : Universitas Trunojoyo Madura

Respon Pertumbuhan dan Produksi Andrographolida Tanaman Sambiloto (Andrographis paniculata Nees) Akibat Perbedaan Dosis Pupuk Guano Suhartono, Suhartono; Sholehah, Diana Nurus; Murdianto, Rohmad Suci
Rekayasa Vol 13, No 2: August 2020
Publisher : Universitas Trunojoyo Madura

Tanaman sambiloto (Andrographis paniculata Nees.) merupakan salah satu tanaman obat unggulan Indonesia selain temulawak, mengkudu, pegagan, lidah buaya, lada, dan kunyit. Peningkatan produktivitas sambiloto dapat dilakukan dengan perbaikan teknik budidaya melalui sistem pemupukan. Kajian aplikasi pupuk guano terhadap pertumbuhan, produksi dan kandungan andgrographolida pada tanaman sambiloto terbatas, sehingga perlu dilakukan untuk mengetahui pengaruh pupuk guano terhadap pertumbuhan dan kandungan andrographolida pada tanaman sambiloto. Penelitian ini dilaksanakan di kebun percobaan Program Studi Agroteknologi Fakultas Pertanian Universitas Trunojoyo Madura pada bulan Januari - April 2016. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) non faktorial dengan perlakuan 6 taraf dosis pupuk guano dengan 4 ulangan. Perlakuan dosis pupuk guano per hektar meliputi G0 (control/tanpa pupuk guano), G1 (5 ton), G2 (7.5 ton), G3 (10 ton), G4 (12.5 ton), dan G5 (15 ton). Pada setiap percobaan terdapat 6 tanaman dengan rincian 3 tanaman sebagai sampel. Hasil penelitian menunjukan bahwa pemupukan guano pada dosis 15 ton/ha (G5) memberikan hasil terbaik untuk parameter tinggi tanaman, jumlah daun, luas daun, berat basah total dan berat kering total tanaman. Kandungan andrographolida (%) tertinggi diperoleh pada dosis pupuk guano 7.5 ton/ha (G2), sedangkan produksi andrograpolida (mg) tertinggi ditunjukkan oleh perlakuan G4 (dosis pupuk guano 12.5 ton/ha).Response of Growth and Production of Srographic Andrographolida Plants (Andrographis paniculata Nees) Due to Differences in Guano Fertilizer Doses Bitter plant (Andrographis paniculata Nees.) including one featured Indonesian medicinal plants in addition to ginger, noni, gotu kola, aloe vera, pepper, and turmeric. Increased productivity is bitter to do with the improvement of farming techniques through a system of fertilization. Study of guano fertilizer application on the growth, production, and content andrographolide the bitter plant is limited, so it is necessary to know the effect of guano fertilizer on the growth and content of the plant andrographolide bitter. This research was conducted at the experiment station Agrotechnology, Faculty of Agriculture, University Trunojoyo Madura at January-April 2016 by using a completely randomized design (RAL) non-factorial with 4 replications consisting of G0 (control/without guano fertilizer), G1 ( fertilizer guano 5 tons/ha) G2 (7.5 tons/ha), G3 (10 tons/ha), G4 (12.5 tons/ha) and G5 (15 tons/ha) on each trial there are 6 plants with details of 3 plants in the sample. The results showed that the guano fertilizer at a dose of 15 tons/ha (G5) can be increased plant height, leaf number, leaf area, total wet weight, and total dry weight. The highest content of andrographolide obtained at doses of 7.5 tons/ha (G2) of guano fertilizer, while the highest yield of andrographolide obtained at doses 12.5 tons/ha of guano fertilizer (G4).

UJI AKTIVITAS MINYAK CAMPLONG (Callophyllum inophyllum) TERHADAP PERTUMBUHAN JAMUR Colletotrichum sp. PENYEBAB PENYAKIT ANTRAKNOSA PADA TANAMAN CABE Sholehah, Diana Nurus
Rekayasa Vol 5, No 1: April 2012
Publisher : Universitas Trunojoyo Madura

Hama dan penyakit menjadi kendala utama dalam proses budidaya cabe, salah satunya adalah penyakit antraknosa yang dapat menyerang setiap bagian tanaman, memiliki daya rusak yang sangat tinggi dan penularanya juga sangat cepat sehingga sangat merugikan petani. Penelitian ini bertujuan untuk mengetahui potensi minyak camplong terhadap pertumbuhan jamur Colletotrichum sp. penyebab penyakit antraknosa pada tanaman cabe. Hasil isolasi antraknosa pada sampel cabe yang diteliti menunjukkan bahwa colletotrichum sp yang teridentifikasi adalah jenis C. gloeosporiorides. Penelitian ini dirancang dalam bentuk Rancangan Acak Kelompok (RAK) dengan 3 kali ulangan. Hasil uji aktivitas minyak camplong terhadap jamur ini pada konsentrasi 2 %, 6 % dan 10 % menunjukkan bahwa pada konsentrasi 10 % memberikan hambatan pertumbuhan koloni yang nyata pada pengamatan 7 hari setelah inkubasi yaitu 2,20 cm dan persentase penghambatan sebesar 47,20 %.

Pertumbuhan dan Kandungan Minyak Atsiri Tanaman Selasih (Ocimum basilicum L.) pada Naungan dan Dosis Pupuk Fosfat yang Berbeda Diana Nurus Sholehah; Suhartono ,; dan Angga Lesmana
Indonesian Journal of Agronomy Vol. 46 No. 2 (2018): Jurnal Agronomi Indonesia
Publisher : Indonesia Society of Agronomy (PERAGI) and Department of Agronomy and Horticulture, Faculty of Agriculture, IPB University, Bogor, Indonesia

Basil (Ocimum basilicum L.) is a plant that has great potency to be developed. Almost all parts of the plant can be utilized. This study aimed to determine the effect of shade and phosphate fertilizer on growth and essential oil content in basil. This research was conducted at the experimental field of Agrotechnology Departement, Faculty of Agriculture, University of Trunojoyo Madura, during January-April 2015. The research was arranged in a split plot design with 3 replications. Main plot was shading i.e., without shading and 25% shading. The subplots were phosphate fertilizer rate, i.e., 0, 1.5, 3.0, and 4.5 g SP36 per plant that was planted in polybags. The results showed that plants treated with 25% of shading and applied with phosphate 3 g per plant had the highest total dry weight, production of essential oil and eugenol. Shading of 25% give the best results on plant height, leaf area and total fresh weight of the plant. Application of phosphate fertilizer 3 g per plant give the highest content of chlorophyll (chlorophyll b and total chlorophyll), while the highest essential oil and eugenol content of leaves is obtained from application of phosphate fertilizer 3 and 4.5 g per plant. Shading and phosphate fertilizer application did not affect leaf number.

UJI AKTIFITAS ANTI RAYAP TEMBAKAU DAN SALAK MADURA Diana Nurus Sholehah
Agrovigor Vol 4, No 1 (2011): MARET
Publisher : Universitas Trunojoyo Madura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21107/agrovigor.v4i1.276

This study aims to determine the anti-termite potency of agricultural waste material that has not been used optimally, such as root and stem bark of tobacco and snackfruit rind to increase its economic value. The research conducted at the Laboratory of Agricultural Faculty Agroekoteknologi Trunojoyo. The study was designed based on completely randomized design (CRD) with 3 replication. The observation parameter is the number of termite mortality and weight reduction in test paper which is used as termite bait. The results showed that the extract of root and stem bark Madura tobacco and snackfruit rind cause termite mortality was not significantly different ie consecutive 77.3% and 81.3% classified as strong termite. During the activity test, there is no weight reduction test paper so that termite mortality effect could be due to toxic effects of extract contacts.

MORFOLOGI DAN KANDUNGAN MINYAK ATSIRI AKSESI SELASIH (Ocimum basilicum L.) ASAL MADURA Diana Nurus Sholehah
Agrovigor Vol 9, No 2 (2016): September
Publisher : Universitas Trunojoyo Madura

Penelitian ini bertujuan untuk mengetahui karakter morfologi, kadar dan komposisi minyak atsiri selasih asal Madura. Penelitian dilaksanakan di kebun percobaan Program Studi Agroteknologi Fakultas Pertanian Universitas Trunojoyo Madura pada ketinggian 5 m dpl. Penelitian dilakukan dengan mengamati 2 aksesi selasih asal Madura yaitu aksesi Madura 1 dan aksesi Madura 2 yang ditanam dalam polibag. Karakter yang diamati adalah morfologi batang, daun, bunga dan biji, produksi serta kandungan dan komposisi minyak atsiri selasih. Hasil pengamatan menunjukkan bahwa aksesi 1 dan aksesi 2 memiliki banyak persamaan karakter morfologi. Perbedaan karakter morfologi terdapat pada jumlah cabang, panjang dan jumlah kelompok bunga pada rangkaian bunga utama, berat basah dan berat 100 biji. Kandungan minyak atsiri kedua aksesi memiliki kesamaan yaitu mengandung eugenol sebagai senyawa utama diikuti oleh geraniol dan sineol.Kata kunci : selasih, minyak atsiri, Madura

PENGUKURAN KANDUNGAN SKOPOLETIN PADA BEBERAPA TINGKAT KEMATANGAN BUAH MENGKUDU (Morinda citrifolia Linn) DENGAN METODE KLT DENSITOMETRI Diana Nurus Sholehah
Agrovigor Vol 3, No 1 (2010): MARET
Publisher : Universitas Trunojoyo Madura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21107/agrovigor.v3i1.251

Morinda citrifolia fruit has been used as remedies in Indonesia because many diseases could be healed. Scopoletin, one of major component of Morinda citrifolia was chosen as marker compound because of its various activites such as hypotensive, antiinflamatory and antihistamine. The research aimed to determinate scopoletin in some maturations stage of Morinda citrifolia fruit in order to get best fruit for traditional medicine and phytopharmaca with optimal therapeutical effect . A simple and reliable TLC-Densitometry which has been validated before, was choosen to this aim. Fruit at stage 1,2,3 and 4 were taken 20, 45, 105 and 120 days after flowering. TLC was held on silica gel plates as stationary and ether : toluene : acetic acid 10 % (58:45:0,4) as mobile phase of fruit at stage 1, 2 and 4 and also ether : toluene : acetic acid 10 % (58:45:0,8) as mobile phase of fruit at stage 3. Mean concentration of scopoletin at stage 1 was found to be (10,72±0,45) ppm, stage 2 was found to be (19,19±0,68) ppm, stage 3 found to be (57,94±0,79) ppm and stage 4 (14,11±0,39) ppm respectively.

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