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All Journal Justek : Jurnal Sains Dan Teknologi Jurnal Ilmiah Medicamento Jurnal Pengabdian Masyarakat Formosa (JPMF) Jurnal Sains dan Teknologi
Diah Miftahul Aini
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Uji Aktivitas Antiradikal Biji Pare (Momordica charantia L) Menggunakan Metode DPPH Serta Analisis Metabolit Sekundernya Baiq Desy Ratnasari; Diah Miftahul Aini; Imam Syahputra Yamin; Gladeva Yugi Antari
Jurnal Ilmiah Medicamento Vol 8 No 1 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i1.3352

Abstract

Momordica charantia L seed is classified as the domestic waste even though it has many health benefits, namely as anti-tumor, anti-virus, and as a medicine to increase the body resistance. Therefore, this study was designed to examine the antioxidant activity of the ethanol extract of the seeds using the DPPH method. Furthermore, a GC-MS analysis will be carried out to determine the chemical compounds that play a role in the bioactivity. Based on the absorbance of DPPH in three repetitions, the average value of DPPH inhibition by 95% ethanol extract of bitter melon seeds was 60.45%, in which classified as a good radical absorbance. The GC-MS results showed that the ethanol extract of bitter melon seeds contained ten chemical compounds consisting of sesquiterpenes, fatty acids, and alkanes, which affecting the radical absorbance of M. charantia extract.
Pemanfaatan Kulit Buah Manggis Sebagai Bahan Campuran dalam Panganan Manyarakat Sebagai Upaya Penanganan Limbah Kulit Manggis di Daerah Desa Gegelang, Lombok Barat Khairul Pahmi Rahmawati; Abdul Muin; Diah Miftahul Aini; Baiq Desy Ratnasri; Faelga Sara Rosiana
Jurnal Pengabdian Masyarakat Formosa Vol. 1 No. 2 (2022): Juni, 2022
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.303 KB) | DOI: 10.55927/jpmf.v1i2.538

Abstract

This activity is presented to handle waste as well as to improve  public health by utilizing medicinal raw materials that have not been used optimally by the community into food or beverages that are pleasant to consume. This service was carried out in Gegelang Village, Lingsar District, West Lombok, in collaboration with the local village PKK driving team. The target of this service is the village community, especially mothers who are the heart of the family who serve food in the middle of the family every day.  This service was carried out in the early months of February 2022. Community service received a positive response from the community, as evidenced by a high level of satisfaction. Furthermore, this service activity succeeded in inviting the community to use mangosteen peel extract for food additives.
Chemical constituents of ripe Momordica charantia by Gas Chromatography Mass Spectrometry (GCMS) Diah Miftahul Aini; Baiq Desy Ratnasari; Zul Hendry
INSOLOGI: Jurnal Sains dan Teknologi Vol. 1 No. 3 (2022): Juni 2022
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (312.429 KB) | DOI: 10.55123/insologi.v1i3.359

Abstract

Momordica charantia, commonly called bitter melon, is a plant belonging to Cucurbitaceae family known for centuries for its nutritional properties. This plant have been used as folklore medicine for the management of hypertensions, cold, cough, and diabetes. The aim of the present study was to characterize the chemical constituents of ripe M. charantia from Lombok, Indonesia by Gas Chromatography Mass Spectrometry (GCMS). The method that used is maseration with ethanol as solvent. The ethanol extract of ripe M. charantia was characterized by gas chromatography-flame ionization detection and gas chromatography coupled with mass spectrometry analyses. The chemical constituent of ripe M. charantia that followed by GCMS were 2,4-Pentanediol (23,61 %), Eucalyptol (1,8-Cineole) (20,41 %), Trans (Beta)-Caryopyllene (10,07 %), 3-Decyn-2-ol  (9.54 %), Epiglobulol (7.82 %), Methyleugenol (7.15%), Beta-Selinene (5.80 %), Alpha-Selinene (5.43 %), and Alpha-Humulene (5.29 %). This is the first report on chemical screening of ethanol extract of ripe M. charantia and GC-MS analysis shows the presence of compounds which have medicinal properties.
Analisis Pengaruh Penambahan Daun Pegagan (Centella asiatica) terhadap Aktivitas Antioksidan Rimpang Jahe (Zingibere officinale ) Baiq Desy Ratnasari; Diah Miftahul Aini; Gladeva Yugi Antari
Justek : Jurnal Sains dan Teknologi Vol 5, No 2 (2022): November
Publisher : Unversitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/justek.v5i2.11821

Abstract

Abstract:  Zingibere officinale is one of the most widely used herbs as traditional medicine. However, Z. officinale has a distinctive odor and spicy taste that are dislike by some people. Therefore, additional herbs are needed to overcome this problem without affecting its bioactive properties. In this study, Centella asiatica leaves was used as the additional herbs, in accordance with the Indonesian Herbal Medicine Formulary. The aim of this study is to study the synergistic effect between Z. officinalle and C. asiatica by analyzing their antioxidant activity and the chemical compound. The antioxidant assay was conducted with DPPH method. The IC50 value of Z. officinale was 1.28, while the IC50 of C. asiatica was 3.68, and the IC50 of the mixture 1:1 was 2.51. On the other hand, the chemical compound of each samples were analyzed using Gas Chromatography Mass Spectroscopy (GC-MS). Based on the GC-MS chromatogram, Z. officinale has distinctive compounds that affect its taste, aroma, and antioxidant activity such as 1,8-cineol, Zingiberene, and farnesene. On the other hand, C. asiatica also has compounds that regulate aroma and taste, namely Oxacycloheptadec-8-en-2-on or Ambrettolid which is predicted to hindered the spicy taste in Z. officinale. To get a more accurate conclusion, further studies are needed on the synergistic effect of the two extracts in terms of formulation to the synergism of their compounds.Abstrak: Zingibere officinale (Jahe) merupakan salah satu tanaman herbal yang paling banyak digunakan sebagai obat tradisional. Namun, jahe memiliki bau khas dan rasa pedas yang tidak disukai oleh sebagian orang. Oleh karena itu, diperlukan tambahan herbal lain untuk menetralisir aroma dan rasa pedas jahe tersebut tanpa mempengaruhi sifat bioaktifnya. Dalam penelitian ini, daun pegagan digunakan sebagai herbal tambahan, sesuai dengan Formularium Jamu Indonesia. Penelitian ini bertujuan untuk mempelajari efek sinergis jahe dan pegagan yang dilihat dari aktivitas antioksidannya dan keselarasan kandungan senyawa kimia di dalamnya. Aktivitas antioksidan dilakukan dengan metode DPPH. Dari analisis antioksidan didapatkan nilai IC50 jahe adalah 1,28, sedangkan IC50 pegagan adalah 3,68, dan IC50 campuran 1:1 adalah 2,51. Untuk melihat potensi lainnya, maka ekstrak jahe dan pegagan dianalisis dengan menggunakan instrument Gas Kromatografi Spektoskopi Massa (GC-MS). Berdasarkan kromatogram GC-MS, jahe memiliki senyawa khas yang mempengaruhi rasa, aroma, dan aktivitas antioksidannya seperti 1,8-cineol, Zingiberene, dan farnesene. Di sisi lain, pegagan juga memiliki senyawa yang mengatur aroma dan rasa, yaitu Oxacycloheptadec-8-en-2-on atau Ambrettolid yang diduga dapat menghambat rasa pedas pada jahe. Untuk mendapatkan kesimpulan yang lebih akurat, diperlukan penelitian lebih lanjut mengenai efek sinergis kedua ekstrak dari segi formulasi terhadap sinergisme senyawanya.       
Co-Authors Abdul Muin Antari, Gladeva Yugi Baiq Desy Ratnasari Baiq Desy Ratnasri Faelga Sara Rosiana Imam Syahputra Yamin Khairul Pahmi Rahmawati Zul Hendry