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All Journal MANAJEMEN HUTAN TROPIKA Journal of Tropical Forest Management VALENSI JFIOnline Majalah Farmasetika Journal of Tropical Biodiversity
Ernawati Sinaga
Fakultas Biologi Universitas Nasional
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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DAYA ANTIBAKTERI JAMUR ENDOFIT YANG DIISOLASI DARI DAUN DAN RIMPANG LENGKUAS (Alpinia galanga Sw.) Sinaga, Ernawati; Noverita, .; Fitria, Dinah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 4 (2009)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Endophytic fungi has becoming a potensial source of bioactive compounds. In this work we had isolated 10 endophytic fungi isolates from leaves and rhizomes of Alpinia galanga Sw., and investigated its antibacterial properties. Results of the experiments showed that 7 out 10 of endophytic fungi isolates from leaves and rhizomes of Alpinia galanga Sw. had significant antibacterial properties toward Escherichia coli and Staphylococcus aureus. This result suggest that endophytic fungi isolates from leaves and rhizomes of Alpinia galanga Sw. can be further explored as new sources of antibacterial compounds. ABSTRAK Sumber baru bahan bioaktif yang akhir-akhir ini banyak dieksplorasi adalah jamur endofit. Hal ini disebablan karena kemampuan jamur-jamur endofit memproduksi bahan-bahan bioaktif yang potensial untuk dikembangkan menjadi bahan baku obat. Dalam penelitian ini dilakukan percobaan untuk mengisolasi jamur endofit dari daun dan rimpang lengkuas (Alpinia galanga Sw.) dan kemudian menguji daya antibakterinya. Dari percobaan yang dilakukan diperoleh 10 isolat jamur endofit, 7 isolat dari daun lengkuas dan 3 isolat dari rimpangnya. Dari 10 isolat jamur endofit ini, 7 isolat di antaranya menunjukkan daya antibakteri yang cukup tinggi terhadap 2 bakteri uji yang digunakan yaitu Escherichia coli dan Staphylococcus aureus. Hasil penelitian ini menunjukkan bahwa jamur endofit di dalam daun dan rimpang lengkuas memiliki potensi yang cukup baik untuk dikembangkan lebih lanjut menjadi sumber baru bahan baku obat-obat antibakteri.
ISOLASI DAN UJI AKTIVITAS ANTIBAKTERI JAMUR ENDOFIT DARI DAUN DAN RIMPANG Zingiber ottensii Val. Noverita, .; Fitria, Dinah; Sinaga, Ernawati
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 4 (2009)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Endophytic fungi is cluster of fungi lives in the plant tissues for a few time or entire of its life. This kind of fungi usually produces secondary metabolites which have significant bioactivity, such as anti cancer, anti virus, or antibacterial agents. Endophytic fungi can be isolated from many kinds of plants, especially medicinal plant such as Zingiber ottensii Val. (Ghost Bangle), which is abundant in Indonesia. The objective of this research is to isolate endophytic fungi from leaves and rhizomes of Zingiber ottensii Val. and investigate its antibacterial activity towards Escherichia coli and Staphylococcus aureus. From the experiments we could obtain 10 endophytic fungi isolates from leaves and rhizomes of Zingiber ottensii Val., and experiments showed that all of the endophitic fungi have significant antibacterial activity towards Escherichia coli and Staphylococcus aureus.   ABSTRAK Jamur endofit merupakan  sekelompok jamur  yang sebagian atau seluruh hidupnya berada dalam jaringan tumbuhan hidup dan biasanya tidak merugikan pada inangnya. Jamur-jamur endofit umumnya memproduksi metabolit sekunder yang memiliki aktivitas biologis yang bermanfaat seperti misalnya senyawa-senyawa anti kanker, anti virus, atau antibakteri. Jamur endofit dapat ditemukan pada berbagai jenis tumbuhan, terutama pada tumbuhan obat, seperti misalnya Zingiber ottensii Val. (Bangle hantu), salah satu tumbuhan obat yang banyak terdapat di Indonesia. Penelitian ini bertujuan untuk memperoleh isolat jamur endofit dari daun dan rimpang Zingiber ottensii Val., serta menguji aktivitas antibakteri dari isolat jamur yang diperoleh terhadap pertumbuhan bakteri Escherichia coli dan Staphylococcus aureus. Dari penelitian yang dilakukan diperoleh 10 isolat jamur endofit dari daun dan rimpang Zingiber ottensi Val. Kesepuluh  isolat jamur endofit tersebut  memiliki kemampuan menghambat pertumbuhan kedua jenis bakteri uji, dengan kekuatan yang berbeda-beda.
PERBANDINGAN DAYA SITOTOKSIK EKSTRAK RIMPANG 3 JENIS TUMBUHAN ZINGIBERACEAE TERHADAP SEL KANKER MCF-7 Sinaga, Ernawati; Suprihatin, .; Wiryanti, Ida
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 3 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

We investigated and compared the cytotoxic activity of ethanolic extract of the rhizome of 3 species of Zingiberaceae plants that grow abundantly in Indonesia, i.e. Zingiber ottensii, Zingiber zerumbet, and Nicolaia speciosa in an in vitro tetrazolium salt assay using human breast cancer cell line MCF-7. The results showed that 2 out 3 extracts showed significant cytotoxic activity. i.e. Zingiber ottensii and Zingiber zerumbet with IC50 value respectively 60 and 50 ug/mL, while the ethanolic extract of Nicolaia speciosa showed considerable larger IC50, i.e. 625 ug/mL. From the results it can be concluded that the rhizome of Zingiber ottensii and Zingiber zerumbet have a good prospect to be further investigated and developed as raw materials for new cancer drug. ABSTRAK Telah dilakukan penelitian untuk membandingkan daya sitotoksik ekstrak etanol rimpang 3 jenis tumbuhan suku Zingiberaceae yang banyak tumbuh di Indonesia, yaitu bengle hantu (Zingiber ottensii L.), lempuyang gajah (Zingiber zerumbet L.), dan kecombrang (Nicolaia speciosa Horan) menggunakan galur sel kanker payudara MCF-7. Pertumbuhan sel dievaluasi menggunakan metode garam tetrazolium (MTT). Hasil penelitian menunjukkan bahwa 2 di antara 3 ekstrak rimpang yang diuji menunjukkan daya sitotoksik yang kuat, yaitu ekstrak etanol bengle hantu dan lempuyang gajah dengan nilai IC50 masing-masing sebesar 60 dan 50 ug/ml, sedangkan ekstrak etanol rimpang kecombrang memiliki IC50 yang jauh lebih besar, yaitu 625 ug/mL. Dari hasil penelitian ini dapat disimpulkan bahwa ekstrak etanol rimpang bengle hantu dan lempuyang gajah memiliki potensi besar untuk diteliti dan dikembangkan lebih lanjut menjadi sumber bahan baku obat anti kanker baru.
KUALITASDAN AKTIVITAS ANTIBAKTERI MADU Apis dorsata YANG BERKOLONI PADA TIGA POHON BERBEDA DI KALIMANTAN UTARA Widowati, Retno; Camin, Yeremiah Rubin; Suryono, Annisa Nur’aini; Azkawati, Elok; Lusiana, Diana Intan Gabriella; Kusmaryeni, Siti; Sinaga, Ernawati
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.580

Abstract

Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey.
KUALITASDAN AKTIVITAS ANTIBAKTERI MADU Apis dorsata YANG BERKOLONI PADA TIGA POHON BERBEDA DI KALIMANTAN UTARA Widowati, Retno; Camin, Yeremiah Rubin; Suryono, Annisa Nur’aini; Azkawati, Elok; Lusiana, Diana Intan Gabriella; Kusmaryeni, Siti; Sinaga, Ernawati
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2110.257 KB) | DOI: 10.35617/jfi.v10i1.580

Abstract

Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey.
DAYA ANTIBAKTERI JAMUR ENDOFIT YANG DIISOLASI DARI DAUN DAN RIMPANG LENGKUAS (Alpinia galanga Sw.) Sinaga, Ernawati; Noverita, .; Fitria, Dinah
Jurnal Farmasi Indonesia Vol 4, No 4 (2009)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i4.23

Abstract

Endophytic fungi has becoming a potensial source of bioactive compounds. In this work we had isolated 10 endophytic fungi isolates from leaves and rhizomes of Alpinia galanga Sw., and investigated its antibacterial properties. Results of the experiments showed that 7 out 10 of endophytic fungi isolates from leaves and rhizomes of Alpinia galanga Sw. had significant antibacterial properties toward Escherichia coli and Staphylococcus aureus. This result suggest that endophytic fungi isolates from leaves and rhizomes of Alpinia galanga Sw. can be further explored as new sources of antibacterial compounds. ABSTRAK Sumber baru bahan bioaktif yang akhir-akhir ini banyak dieksplorasi adalah jamur endofit. Hal ini disebablan karena kemampuan jamur-jamur endofit memproduksi bahan-bahan bioaktif yang potensial untuk dikembangkan menjadi bahan baku obat. Dalam penelitian ini dilakukan percobaan untuk mengisolasi jamur endofit dari daun dan rimpang lengkuas (Alpinia galanga Sw.) dan kemudian menguji daya antibakterinya. Dari percobaan yang dilakukan diperoleh 10 isolat jamur endofit, 7 isolat dari daun lengkuas dan 3 isolat dari rimpangnya. Dari 10 isolat jamur endofit ini, 7 isolat di antaranya menunjukkan daya antibakteri yang cukup tinggi terhadap 2 bakteri uji yang digunakan yaitu Escherichia coli dan Staphylococcus aureus. Hasil penelitian ini menunjukkan bahwa jamur endofit di dalam daun dan rimpang lengkuas memiliki potensi yang cukup baik untuk dikembangkan lebih lanjut menjadi sumber baru bahan baku obat-obat antibakteri.
PERBANDINGAN DAYA SITOTOKSIK EKSTRAK RIMPANG 3 JENIS TUMBUHAN ZINGIBERACEAE TERHADAP SEL KANKER MCF-7 Sinaga, Ernawati; Suprihatin, .; Wiryanti, Ida
Jurnal Farmasi Indonesia Vol 5, No 3 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i3.47

Abstract

We investigated and compared the cytotoxic activity of ethanolic extract of the rhizome of 3 species of Zingiberaceae plants that grow abundantly in Indonesia, i.e. Zingiber ottensii, Zingiber zerumbet, and Nicolaia speciosa in an in vitro tetrazolium salt assay using human breast cancer cell line MCF-7. The results showed that 2 out 3 extracts showed significant cytotoxic activity. i.e. Zingiber ottensii and Zingiber zerumbet with IC50 value respectively 60 and 50 ug/mL, while the ethanolic extract of Nicolaia speciosa showed considerable larger IC50, i.e. 625 ug/mL. From the results it can be concluded that the rhizome of Zingiber ottensii and Zingiber zerumbet have a good prospect to be further investigated and developed as raw materials for new cancer drug. ABSTRAK Telah dilakukan penelitian untuk membandingkan daya sitotoksik ekstrak etanol rimpang 3 jenis tumbuhan suku Zingiberaceae yang banyak tumbuh di Indonesia, yaitu bengle hantu (Zingiber ottensii L.), lempuyang gajah (Zingiber zerumbet L.), dan kecombrang (Nicolaia speciosa Horan) menggunakan galur sel kanker payudara MCF-7. Pertumbuhan sel dievaluasi menggunakan metode garam tetrazolium (MTT). Hasil penelitian menunjukkan bahwa 2 di antara 3 ekstrak rimpang yang diuji menunjukkan daya sitotoksik yang kuat, yaitu ekstrak etanol bengle hantu dan lempuyang gajah dengan nilai IC50 masing-masing sebesar 60 dan 50 ug/ml, sedangkan ekstrak etanol rimpang kecombrang memiliki IC50 yang jauh lebih besar, yaitu 625 ug/mL. Dari hasil penelitian ini dapat disimpulkan bahwa ekstrak etanol rimpang bengle hantu dan lempuyang gajah memiliki potensi besar untuk diteliti dan dikembangkan lebih lanjut menjadi sumber bahan baku obat anti kanker baru.
ISOLASI DAN UJI AKTIVITAS ANTIBAKTERI JAMUR ENDOFIT DARI DAUN DAN RIMPANG Zingiber ottensii Val. Noverita, .; Fitria, Dinah; Sinaga, Ernawati
Jurnal Farmasi Indonesia Vol 4, No 4 (2009)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i4.26

Abstract

Endophytic fungi is cluster of fungi lives in the plant tissues for a few time or entire of its life. This kind of fungi usually produces secondary metabolites which have significant bioactivity, such as anti cancer, anti virus, or antibacterial agents. Endophytic fungi can be isolated from many kinds of plants, especially medicinal plant such as Zingiber ottensii Val. (Ghost Bangle), which is abundant in Indonesia. The objective of this research is to isolate endophytic fungi from leaves and rhizomes of Zingiber ottensii Val. and investigate its antibacterial activity towards Escherichia coli and Staphylococcus aureus. From the experiments we could obtain 10 endophytic fungi isolates from leaves and rhizomes of Zingiber ottensii Val., and experiments showed that all of the endophitic fungi have significant antibacterial activity towards Escherichia coli and Staphylococcus aureus.   ABSTRAK Jamur endofit merupakan  sekelompok jamur  yang sebagian atau seluruh hidupnya berada dalam jaringan tumbuhan hidup dan biasanya tidak merugikan pada inangnya. Jamur-jamur endofit umumnya memproduksi metabolit sekunder yang memiliki aktivitas biologis yang bermanfaat seperti misalnya senyawa-senyawa anti kanker, anti virus, atau antibakteri. Jamur endofit dapat ditemukan pada berbagai jenis tumbuhan, terutama pada tumbuhan obat, seperti misalnya Zingiber ottensii Val. (Bangle hantu), salah satu tumbuhan obat yang banyak terdapat di Indonesia. Penelitian ini bertujuan untuk memperoleh isolat jamur endofit dari daun dan rimpang Zingiber ottensii Val., serta menguji aktivitas antibakteri dari isolat jamur yang diperoleh terhadap pertumbuhan bakteri Escherichia coli dan Staphylococcus aureus. Dari penelitian yang dilakukan diperoleh 10 isolat jamur endofit dari daun dan rimpang Zingiber ottensi Val. Kesepuluh  isolat jamur endofit tersebut  memiliki kemampuan menghambat pertumbuhan kedua jenis bakteri uji, dengan kekuatan yang berbeda-beda.
A Model of Religious Moral Approach for Peatland Ecosystem Restoration in Indonesia Gugah Praharawati; Fachruddin Majeri Mangunjaya; Hendra Maujana Saragih; Aos Yuli Firdaus; Taufik Mei Mulyana; Fauziah Ilmi; Muhammad Zulham; Haris Gunawan; Suwigya Utama; Ernawati Sinaga
Jurnal Manajemen Hutan Tropika Vol. 27 No. 2 (2021)
Publisher : Institut Pertanian Bogor (IPB University)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.7226/jtfm.27.2.132

Abstract

Efforts to conserve peatlands and prevent forest fires are inseparable from human awareness and behavior. This study aims to find a model for a religious, moral approach by the clerics in supporting the implementation of peatland restoration. The study was carried out in designated Muslim locations with trained clerics. The farmers surveyed also have experienced by the Peatland Restoration Agency (BRG) programs: i.e., physical support, such as a canal dam program and demonstration plot of agriculture without burning (PLTB). The methods used combine quantitative surveys with a Likert scale to explore attitudes, subjective norms, perception, intention, and their impact on behavior. The results obtained show that the community religious leaders can be an important trigger in encouraging the movement. In the model, visible subjective norm (SN) variables contribute directly to intention by 23%. Perceived behavior control (PBC) directly has a positive and significant effect on intention 53% (p-value). This means the individual, in making a decision and intention to participate, is a factor that has a broad impact on the community and gives a positive value of 53% (good enough) on the intention. The individuals' decisions to participate in peatland conservation are prompted by perception of having a wide impact on the community.
Efektivitas Suplementasi Ekstrak Daging Ikan Bujuk (Channa Lucius) dalam Mempercepat Penyembuhan Luka Diabetik Ernawati Sinaga; Suprihatin Suprihatin; Fitri Istiqomah
Majalah Farmasetika Vol. 4, Supl. 1, Tahun 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v4i0.25881

Abstract

Luka diabetik adalah salah satu komplikasi kronis penyakit diabetes melitus yang sangat ditakuti, karena dapat membawa kecacatan seumur hidup bahkan kematian. Jumlah penderita diabetes semakin meningkat. Penelitian ini dilakukan untuk membuktikan efektivitas suplementasi ekstrak daging ikan bujuk dalam mempercepat penyembuhan luka diabetik. Penelitian dilakukan menggunakan tikus putih jantan galur Sprague Dawley yang diinduksi diabetik dengan aloksan 125 mg/kg bb ip, kemudian diberi perlukaan eksisi. Setelah itu tikus diberi suplementasi ekstrak daging ikan bujuk per oral, sekali sehari sampai seluruh luka sembuh, yaitu antara 27-36 hari. Ekstrak ikan bujuk diberikan dalam 3 dosis yang berbeda, antara 2-6 g/kg bb.  Sebagai pembanding diberikan glibenklamid 0,5 mg/kg bb. Suplementasi ikan bujuk secara signifikan dapat mempercepat pengurangan luas luka dan mempercepat waktu epitelialisasi sempurna, yaitu waktu ketika luka sembuh secara total. Penyembuhan luka total pada tikus diabetik yang diberi ekstrak ikan bujuk sebesar 6 g/kg bb, 135% lebih cepat dibandingkan dengan tikus diabetik yang tidak diberi ekstrak, dan 122% lebih cepat dibandingkan dengan tikus diabetik yang diberi glibenklamid. Penyembuhan luka total pada tikus diabetik yang diberi ekstrak ikan bujuk sebesar 6 g/kg bb bahkan 110% lebih cepat dibandingkan dengan tikus sehat non-diabetik. Dari penelitian ini juga terungkap bahwa pemberian ekstrak ikan bujuk ternyata tidak dapat menurunkan kadar glukosa darah pada tikus diabetik. Suplementasi ekstrak ikan bujuk efektif mempercepat penyembuhan luka diabetik, yang ditunjukkan dengan makin cepatnya pengurangan luas luka dan makin pendeknya waktu epitelialisasi sempurna. Namun demikian, suplementasi ekstrak ikan  bujuk tidak menurunkan kadar glukosa darah tikus diabetik. Hal ini menunjukkan bahwa percepatan penyembuhan luka yang disebabkan oleh suplementasi ekstrak ikan  bujuk bukan disebabkan oleh penurunan kadar glukosa darah tikus diabetik.
Co-Authors Ali Husni Aos Yuli Firdaus Azkawati, Elok Camin, Yeremiah Rubin Carles Tambunan Endah Wulandari Fachruddin Majeri Mangunjaya Fauziah Ilmi Fira Kuswandari Fitri Istiqomah Fitria, Dinah Fitria, Dinah Gugah Praharawati Haris Gunawan Hendra Maujana Saragih Ida Wiryanti Kusmaryeni, Siti Lusiana, Diana Intan Gabriella Muhammad Zulham Noverita Noverita, . Nurbaiti Nurbaiti Retno Widowati Suprihatin Suprihatin Suryono, Annisa Nur’aini Suryono, Annisa Nur’aini Suwigya Utama Tami Idiyanti Taufik Mei Mulyana