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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention JFIOnline
. Sismindari
Fakultas Farmasi UGM Yogyakarta
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Journal : Indonesian Journal of Cancer Chemoprevention

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Antiproliferative Effect and Apoptosis Induced in Human Cell Lines by Bruguiera gymnorhiza Barks Methanol Extract Warsinah, .; Sismindari, .; Susidarti, Ratna Asmah
Indonesian Journal of Cancer Chemoprevention Vol 2, No 3 (2011)
Publisher : Indonesian Research Gateway

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Abstract

The Antiproliferative effects of methanol extract from Bruguiera gymnorhiza (B. gymnorhiza) barks were tested in vitro against three human cell lines: Hela, Raji and Myeloma cells. The extract was found to have antiproliferative effects against Hela, Raji and Myeloma cells with an IC50 value of 133, 504 and 384 µg/mL, respectively. The antiproliferative test was then performed on Hela, Raji,  and  Myeloma  cells.  Cytotoxicity  assay  of  the  extract  was  then  determined  using  MTT method.  There  were  some  indications  of  apoptosis,  such  DNA  fragmentation,  as  assessed  by acrydine orange- ethidium bromide staining. These results indicate that extract from B. gymnorhiza barks can induce apoptosis in human cell lines.Key words: Antiproliferative, Apoptosis, B. gymnorhiza
Co-Authors . Warsinah Achmad Fudholi Aditya Krishar Karim Istriyati, . Istriyati, . Nastiti Wijayanti Nining Sugihartini Peni Indrayudha Ratna Asmah Susidarti Suwidjiyo Pramono Tsutomu Nohno Widya Asmara