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All Journal MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Merry Tiyas Anggraini
FK UNIMUS, Semarang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pengaruh Pemberian Etanol Secara Akut Terhadap Memori Kerja Pada Tikus (Rattus norvegicus) Rochman Basuki; Merry Tiyas Anggraini
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 2 (2015): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (42.532 KB) | DOI: 10.26714/magnamed.1.2.2015.96-101

Abstract

Effect of Acute Ethanol Administration on Working Memory in Rats (Rattus norvegicus)Background: Acute administration of ethanol can cause neurological disorders, including the prefrontal cortex (CPF) because ethanol is neurotoxic. One of the disorders is a decrease in memory function.Objectives: This study was to determine the effect of acute ethanol administration on spatial working memory in rats.Methods: This experimental study with a posttest-only-randomized control design involved 20 rats (Rattus norvegicus) which were divided into 4 groups (K, P1, P2 and P3) each of 5 animals. Groups P1, P2 and P3 respectively were given 15% intra-peritoneal ethanol at doses of 1, 2 and 3 g/kg/day for 20 days. Memory performance is measured by 8-arm radial maze with the parameter Number of Error, namely the number of type A errors divided by the number of arms entered.Result : After 20 days of ethanol administration, spatial working memory between groups was tested by Kruskal Wallis. The results showed that there was no significant difference, namely 0.070 (p>0.05).Conclusion: There is no significant relationship between spatial working memory in rats after acute administration of ethanol.Latar belakang: Pemberian etanol secara akut dapat menyebabkan gangguan neurologis, diantaranya cortex prefrontalis (CPF) karena etanol bersifat neurotoksik. Salah satu gangguannya berupa penurunan fungsi memori.Tujuan Penelitian: Penelitian ini untuk mengetahui adanya pengaruh pemberian etanol secara akut terhadap memori kerja spasial pada tikus.Metode Penelitian: Penelitian eksperimen dengan desain posttest-only-randomized control ini melibatkan 20 tikus (Rattus norvegicus) yang dibagi menjadi 4 kelompok (K, P1, P2 dan P3) masing-masing 5 ekor. Kelompok P1, P2 dan P3 secara berurutan diberikan etanol 15% intra peritoneal dengan dosis 1, 2 dan 3 g/kgbb/hr selama 20 hari. Kinerja memori diukur dengan maze radial 8 lengan dengan parameter Number of Error yaitu angka kesalahan tipe A dibagi jumlah lengan yang dimasuki.Hasil Penelitian : Setelah pemberian etanol selama 20 hari, memori kerja spasial antar kelompok diuji dengan Kruskal Wallis. Hasil tidak ada perbedaan yang bermakna, yaitu 0,070 (p>0,05).Kesimpulan: Tidak ada hubungan yang bermakna memori kerja spasial pada tikus setelah pemberian etanol secara akut.
Analisis Letak Sumber Air Rumah Tangga Di Wilayah Kerja Puskesmas Mijen, Semarang Terhadap Bakteri Escherichia Coli Kanti Ratnaningrum; Merry Tiyas Anggraini; Pujangga P.Y. Dahlan
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 2 (2015): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (36.677 KB) | DOI: 10.26714/magnamed.1.2.2015.135-139

Abstract

Analysis of the Location of Household Water Sources in the Working Area of Mijen Health Center, Semarang Against Escherichia Coli Bacteria Background: Case detection rate of diarrhea in Puskesmas Mijen, Semarang is still relatively high. One cause of diarrhea disease is a condition of polluted water sources such fouling proximity of water sources with a septic tank. Escherichia coli is a bacteria that may be found in contaminated water sources fouling. Coverage field of environmental health in terms of supervision and control of water quality in Puskesmas Mijen is still far from the achievement of the target, based on these data it is necessary to do research to analysis within a septic tank with a household water source for the presence of the bacterium Escherichia coli. Methods: This study is a cross-sectional study conducted in Puskesmas Mijen. The study methods using systematic random sampling method in 10 villages and the sample number were included with proportion estimate formula. Laboratory tests Escherichia coli bacteria levels in the water conducted in the laboratories of the Faculty of Medicine, Universitas Muhammadiyah Semarang. Data were analyzed using chi square test. Result: From the 36 samples of water, we get the result there is no significant relationship between the distance of a septic tank with a household water source for the presence of the bacterium Escherichia coli (P-value = 0.2). Conclusion: There is no related between the distance of the septic tank with a household water source within the findings of Escherichia coli bacteria in the household water in Puskesmas Mijen. 
Co-Authors Kanti Ratnaningrum Pujangga P.Y. Dahlan Rochman Basuki