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All Journal The Journal of Educational Development Indian Journal of Forensic Medicine & Toxicology AKSONA
Kusumastuti, Kurnia
Departemen Neurologi, Fakultas Kedokteran, Universitas Airlangga; RSUD Dr. Soetomo, Surabaya, Indonesia
Education Medicine & Pharmacology Neuroscience Public Health

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 1 
The Effect of Applying Self- and Family-Oriented Written Education on the Management of Medicamentose, Clinical Exposure, and Quality of Life of Patient with Epilepsy Kustiowati, Endang; Samsudi, Samsudi; Widodo, Joko; Kusumastuti, Kurnia
The Journal of Educational Development Vol 6 No 2 (2018): June 2018
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jed.v6i2.22412

Abstract

Epilepsy is a brain disorder characterized by a tendency to induce a continuous epileptic recurrence and neurobiological, cognitive, psychological, as well as social consequences. Epilepsy seizures are a series of signs and/or symptoms caused by abnormal neuronal activities in the brain. The purpose of this study was to prove the benefits of applying self- and family-oriented educational management to clinical outcomes, self-management, and impact of epilepsy on family, patient’s quality of life, family support, and the role of doctors and family of the epilepsy patient. This is an experimental research using two groups pre and posttest design. The subjects were 80 epilepsy patients ranging from 18 to 70 years of age. All subjects had never had any epilepsy surgery. The subjects were randomly assigned to treatment and control groups; 40 subjects in the treatment group received treatment and self- as well as family-oriented education while the other 40 subjects in the control group received treatment only. Family-oriented education was conducted using written materials on pathophysiology and epilepsy management, psychological effects of epilepsy, and information about the epilepsy community. All of the subjects answered the questionnaires prior to and 3 months after treatment. The questionnaires include information on seizure frequency and seizure-free status, medication adherence, self-management, epilepsy impact on patient and family, and quality of life. The results show that self- and family-oriented education can improve medication adherence, self-management, and family roles. Family-oriented education reduces the frequency of seizures as well as the impact of epilepsy on patients and families. It was concluded that self- and family-oriented education had a positive effect on medical management, clinical outcomes, self-management, and the quality of life of patients with epilepsy.
Effect of Phenytoin Usage Duration Against Hs-Crp Levels in Epilepsy Patients Ratna Wajiayanti1, Kurnia Kusumastuti1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3385

Abstract

Background: Patients with epilepsy have a higher risk of death than the normal population. Epilepsy patients have increased mortality due to cardiovascular disease with standardized mortality ratios ranged between 1.2 and 2.5. The incidence of non-fatal coronary heart disease also increased significantly between 34% and 63%. Atherosclerosis as an inflammatory state has an important biomarker namely hs-CRP. Longterm use of phenytoin will have an effect on hs-CRP. hs-CRP is an atherosclerotic biomarker with a better cardiovascular predictor than blood lipid and homocysteine levels Methods: This study was conducted in epilepsy patients who fulfill ESR the criteria of inclusion and exclusion in Outpatient Unit of Dr. Soetomo General Hospital from October 2014 to April 2015. Patients were divided into a control group and case group. The control group was patients with hs-CRP levels <1.7 meanwhile, control group was >1.7. Tracking of phenytoin usage duration was performed in both groups. Results: Thirty-four subjects were enrolESR in this study which consisted of 21 males (61.76%) and 13 females (38.23%). The mean age of subjects in the case group was 31.6 + 12.6 years and control group was 26.52 + 11.3. Data of phenytoin usage duration and hs-CRP levels were analyzed. Conclusion: There was no significant difference between hs-CRP levels on phenytoin usage duration of >2 years and <2 years with p = 0.290
Correlation of Matrix Metalloproteinase-2 and p21 Expressions with Capsular Invasion of Thymoma AB Santi Maulina1,2, Etty Hary Kusumastuti3,4, Nila Kurniasari3,4
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13484

Abstract

Thymomas are the common neoplasms of mediastinum, and type AB is the most frequent case. All thymomasare potential for invasion to adjacent tissues and considered malignant. Capsular invasion is one of itsprognostic indicators. Matrix metalloproteinase-2 (MMP-2) is a family of proteinases that has the abilityto degrade a component of extracellular matrix and affect tumor invasion and or metastasis. Cytoplasmicexpression of p21 protein can be significantly correlated with invasion and metastasis. The correlation of thesetwo proteins in thymoma has not been widely studied, hence we aimed to analyze the expression of MMP-2and p21 and investigate their correlation with capsular invasion of thymoma AB. This cross-sectional studywas performed on the 24 paraffin-embedded samples of thymomectomy during January 2013-Desember2019 at Anatomical Pathology Laboratory of Dr. Soetomo General Hospital Surabaya. The samples weredevided based on capsular invasion into 2 groups. Immunohistochemical staining was performed to detectexpression of p21 and MMP-2. The correlation was statistically analyzed using Spearman test. There wasno significant difference of MMP-2 expression between thymoma with capsular invasion and withoutcapsular invasion (p=0.839), and also no significant difference of p21 expression between thymoma withcapsular invasion and without capsular invasion (p=0.816). No correlation of MMP-2 and p21 expressionsin thymoma AB was revealed (p=0.255). In thymoma AB, the expression of MMP-2 and p21 were notcorrelate with capsular invasion. These results may contribute to the development of thymoma research.
The Effect of Applying Self- and Family-Oriented Written Education on the Management of Medicamentose, Clinical Exposure, and Quality of Life of Patient with Epilepsy Kustiowati, Endang; Samsudi, Samsudi; Widodo, Joko; Kusumastuti, Kurnia
The Journal of Educational Development Vol 6 No 2 (2018): June 2018
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jed.v6i2.22412

Abstract

Epilepsy is a brain disorder characterized by a tendency to induce a continuous epileptic recurrence and neurobiological, cognitive, psychological, as well as social consequences. Epilepsy seizures are a series of signs and/or symptoms caused by abnormal neuronal activities in the brain. The purpose of this study was to prove the benefits of applying self- and family-oriented educational management to clinical outcomes, self-management, and impact of epilepsy on family, patient’s quality of life, family support, and the role of doctors and family of the epilepsy patient. This is an experimental research using two groups pre and posttest design. The subjects were 80 epilepsy patients ranging from 18 to 70 years of age. All subjects had never had any epilepsy surgery. The subjects were randomly assigned to treatment and control groups; 40 subjects in the treatment group received treatment and self- as well as family-oriented education while the other 40 subjects in the control group received treatment only. Family-oriented education was conducted using written materials on pathophysiology and epilepsy management, psychological effects of epilepsy, and information about the epilepsy community. All of the subjects answered the questionnaires prior to and 3 months after treatment. The questionnaires include information on seizure frequency and seizure-free status, medication adherence, self-management, epilepsy impact on patient and family, and quality of life. The results show that self- and family-oriented education can improve medication adherence, self-management, and family roles. Family-oriented education reduces the frequency of seizures as well as the impact of epilepsy on patients and families. It was concluded that self- and family-oriented education had a positive effect on medical management, clinical outcomes, self-management, and the quality of life of patients with epilepsy.
Nocturnal Epilepsy dan Dislokasi Sendi Bahu Anterior Bilateral Berulang Wardah Rahmatul Islamiyah; Ersifa Fatimah; Kurnia Kusumastuti
AKSONA Vol. 1 No. 2 (2021): JULY 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (197.114 KB) | DOI: 10.20473/aksona.v1i2.151

Abstract

Pendahuluan: Penyandang epilepsi sering mengalami cedera pada saat serangan. Tipe bangkitan tonik dan kontraksi kuat dari anggota gerak pada saat serangan seringkali menyebabkan cedera otot pada sendi dan tulang, sehingga menyebabkan dislokasi dan fraktur. Kontraksi hebat pada sekelompok otot dapat menyebabkan dislokasi dan instabilitas sendi bahu. Kejadian dislokasi sendi bahu bilateral patognomonis disebabkan oleh karena kejang. Akan tetapi pada umunya bentuk dislokasi pascakejang berupa dislokasi bahu posterior bilateral.  Laporan kasus berikut akan menyampaikan kejadian dislokasi sendi bahu anterior bilateral berulang pada penyandang nocturnal epilepsy. Kasus ini jarang terjadi dan diharapkan meningkatkan kewaspadaan klinisi dalam merawat penyandang epilepsi.  Kasus: Laki-laki 22 tahun dikonsulkan oleh spesialis bedah orthopedi dengan diagnosis dislokasi sendi bahu anterior berulang. Pasien sudah mengalami dislokasi sebanyak empat kali dalam satu tahun terakhir. Dislokasi bahu selalu terjadi setelah serangan kejang di malam hari ketika pasien tidur. Pasien rutin mengkonsumsi obat phenytoin dengan frekuensi serangan 3 – 4  bulan sekali setiap tidur malam. Pasien menginginkan kejadian ini tidak terulang lagi. Penggantian obat antiepilepsi yang tepat dan memiliki efek samping minimal pada tulang membantu mencegah terjadinya komplikasi dislokasi seperti ini.  Kesimpulan: Dislokasi sendi bahu anterior bilateral berulang merupakan bentuk cedera pascabangkitan yang jarang terjadi. Pemilihan jenis antikejang yang tepat, upaya kontrol kejang yang baik dan penatalaksanaan multidisiplin dapat membantu mencegah terjadinya komplikasi berulang pada kasus serupa.    
Co-Authors Djoko Widodo Endang Kustiowati Ersifa Fatimah Fatimah, Ersifa Islamiyah, Wardah Rahmatul Samsudi . Sri Andreani Utomo Vatine Adila