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All Journal Jurnal Farmasi Udayana MNJ (Malang Neurology Journal) Journal Pharmasci (Journal of Pharmacy and Science) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan AKSONA
Islamiyah, Wardah Rahmatul
Departemen Neurologi, Fakultas Kedokteran, Universitas Airlangga; RS Universitas Airlangga, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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PROFILE OF SUBJECTIVE SLEEP DISTURBANCE IN PATIENT WITH ANTIEPILEPTIC DRUGS Zahra, Farah Az; Islamiyah, Wardah Rahmatul; Budiono, Budiono
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.2

Abstract

Background: Epilepsy and sleep are well recognized for having bidirectional influences upon one another. The effects of antiepileptic drugs (AEDs) on sleep are of particular concern.
Objective: The objective of this study is to know the profile of AEDs effect in patient’s sleep cycle. Methods: This analytical observational study observed total sleep time, sleep onset latency, sleep efficiency, daytime sleepiness, and insomnia in epileptic patient with AEDs of Neurology Clinic Airlangga University Hospital during May-September 2016. A cross sectional study was done by questionnaire and interview directly to the epileptic patients. Data collected was being analyzed analytically.Results: This research was conducted among 27 patients with epilepsy based on inclusion and exclusion criteria. Sleep disturbances that had been found in patients with phenytoin are prolong sleep onset latency (11.11%), decreased sleep efficiency (11.11%), and excessive daytime sleepiness (66.67%). Sleep disturbances that had been found in patients with valproate are decreased total sleep time (33.33%), prolong sleep onset latency (11.11%), decreased sleep efficiency (11.11%), excessive daytime sleepiness (66.67%), and insomnia (11.11%). Sleep disturbances that had been found in patients with carbamazepine are decreased total sleep time (44.44%), prolong sleep onset latency (33.33%), decreased sleep efficiency (22.22%), excessive daytime sleepiness (77.78%), and insomnia (11.11%).Conclusion: In conclusion, this study shows that epileptic patients who consumed AEDs regularly may have sleep disturbance that vary based on the type of AEDs, patients with carbamazepine may have bigger sleep disturbance than with phenytoin and valproate. It is necessary to give information and education to the epileptic patients who consumed AEDs regularly so that they will become aware of the sign of sleep disturbance.
PROFILE OF TYPE 2 DIABETES MELLITUS IN ACUTE THROMBOTIC STROKE Jordan, Danny Randy; Islamiyah, Wardah Rahmatul; Prayitno, Jongky Hendro
Malang Neurology Journal Vol 5, No 2 (2019): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2019.005.02.6

Abstract

Background: Stroke is a brain disorder in blood circulation that occur suddenly and last more than 24 hours, which is one leading cause of death in the world. One of the main risk factors of stroke is diabetes mellitus type 2. One complication is that when thrombosis occurs in the brain causing a stroke.Objective: This study aimed to determine the profile of type 2 diabetes mellitus in patients with acute thrombotic stroke who were treated in the Neurology Department at the Hospital Dr. Soetomo.Methods: Sampling was done with purposive sampling by observing the medical records of patients in the period of January 2014 to December 2015 based on inclusion and exclusion criterias that havebeen set.Results: Women with a history of type 2 diabetes are more exposed to acute thrombotic stroke; the age group which is most at risk for stroke is between age of 56-60 years; the average duration of DM until the occurence of stroke is 6,54 ± 4,85 years; more than two-thirds of patients come to the hospital when the acute thrombotic stroke occurs with a condition of hyperglycemia; the most common comorbid disease is hypertension; and insulin therapy is the most widely used therapy in acute thrombotic stroke patients with type 2 diabetes.Conclusion: Managing the risk factors of stroke should prolong or prevent the incident of acute thrombotic stroke since most of the patients with type 2 diabetes mellitus came to the hospital with a condition of hyperglycemia and hypertension.
Hubungan Kepatuhan Penggunaan Obat Anti Epilepsi terhadap Kejadian Kejang Pasien Epilepsi menggunakan kuesioner ARMS (Adherence Refill Medication Scale) Ernawati, Iin; Islamiyah, Wardah Rahmatul
Journal of Pharmacy and Science Vol. 4 No. 1 (2019): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v4i1.128

Abstract

ABSTRAKEpilepsi termasuk penyakit kronis otak yang dikarakterisasi dengan kejang berulang (2 kali atau lebih), dimana terjadi gerakan involunter yang melibatkan sebagian tubuh (partial) atau seluruh tubuh (generale), dan seringkali disertai dengan hilangnya kesadaran dan kontrol fungsi saluran cerna atau saluran kemih. Pengobatan epeilepsi sering menggunakan OAE (Obat AntiEpilpsi). Diketahui 70% anak-anak dan dewasa dengan epilepsi berhasil diterapi dengan obat antiepilepsi. Salah satu ukuran manajemen terapi obat pada penyakit epilepsi adalah menurun atau hilangnya kejang, sehingga adanya kejadian kejang menjadi salah satu ukuran pencapaian end outcome. Kejadian kejang dipengaruhi oleh beberapa faktor diantaranya ada tidaknya faktor pemicu kejang dan kepatuhan konsumsi obat antiepilepsi. Penelitian ini merupakan penelitian observasional cross sectional yang dilakukan di poli neurologi Instalasi Rawat Jalan RSUD dr. Soetomo dan Instalasi rawat Jalan RS Universitas Airlangga. Selama penelitian diperoleh 52 pasien epilepsi yang menggunakan obat antiepilepsi. Padapenelitian ini diamati hubungan kepatuhan terhadap adanya kejang pasien epilepsi dalam penggunaan obat anti epilepsi. Pada penelitian ini diketahui nilai koefisien korelasi/ nilai rho (r) sebesar -0,348 dengan nilai p= 0,011 (p<0,05) atau signifikan secara statistik. Hasil tersebut menunjukkan adanya hubungan antara kategori kepatuhan (menggunakan kuesioner ARMS) dengan kejadian kejang, dimana semakin tinggi skor ARMS (dianggap semakin tidak patuh) berbanding lurus dengan peningkatan kejang.Kata kunci: Epilepsi, Kepatuhan, OAE, Kejang, ARMS ABSTRACTEpilepsy is a chronic brain disease characterized by recurrent seizures (2 times or more), in which involuntary movements involve part of the body (partial) or whole body (general). Treatment of epilepsy uses antiepileptic drugs. It is known that 70% of children and adults with epilepsy are successfully treated with antiepileptic drugs. One of measurements of drug therapy management in epilepsy is decreasing or losing seizures, so that the event of seizures is one measure of end outcomes. Seizure events are influenced by severalfactors including the presence or absence of seizure trigger factors and adherence with the consumption of antiepileptic drugs. This study was an observational cross sectional study conducted at the neurology department dr. Soetomo and Airlangga University hospital. This study aims to observe the relationship of adherence of antiepileptic drug consumption with seizures of epilepsy patients. This study observed 52outpatients with epilepsy taking antiepileptic drugs. This study showed that the correlation coefficient / rho value (r) is -0,348 with a value of p = 0.011 (p <0.05). These results indicate that an association between adherence categories (using the arms questionnaire) with the events of seizures, whereas the higher of the arms score (considered to be increasingly disobedient) is directly proportional to the increase in seizures.Keywords: Epilepsy, Adherence, AED, Seizure, ARMS
Korelasi Tingkat Kepatuhan Konsumsi Obat Antiepilepsi Menggunakan Kuesioner MGLS (Morisky, Green, Levine Adherence Scale) dengan Frekwensi Kejang Pasien Epilepsi Iin Ernawati; Wardah Rahmatul Islamiyah
Jurnal Farmasi Udayana Vol. 10, No 2, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i02.p02

Abstract

Epilepsi merupakan penyakit gangguan kronis pada otak yang tidak menular yang dapat mempengaruhi orang dari segala usia. OAE (obat antiepilepsi) merupakan terapi utama kebanyakan pasien epilepsi dengan tujuan keseluruhan adalah secara menyeluruh untuk mencegah terjadinya kejang tanpa menyebabkan efek samping. Salah satu ukuran manajemen terapi obat pada penyakit epilepsi adalah menurunnya/hilangnya kejang, sehingga frekwensi kejang menjadi salah satu ukuran pencapaian end outcome. Penelitian ini merupakan penelitian observasional cross sectional yang dilakukan pada pasien epilepsi rawat jalan poli syaraf Rumah Sakit Universitas Airlangga, yang bertujuan untuk melihat hubungan antara tingkat kepatuhan menggunakan obat antiepilepsi dengan kejadian kejang pada pasien epilepsi. Tingkat kepatuhan konsumsi OAE pada penelitian ini menggunakan kuesioner MGLS (Morisky, Green, Levine adherence Scale). Tingkat kepatuhan berdasarkan kuesioner MGLS dibagi menjadi 3 tingkatan diantaranya patuh rendah, menengah atau sedang dan patuh tinggi. Kejadian kejang pada pasien epilepsi yang diamati adalah ada atau tidaknya kejang selama sebulan terakhir, yang datanya diperoleh dari wawancara pasien atau keluarganya serta dari diary seizure. Hasil penelitian dari 40 responden diketahui terdapat korelasi positif sedang antara tingkat kepatuhan yang diukur menggunakan kuesioner MGLS yang mayoritas patuh sedang dengan adanya kejadian kejang pada pasien epilepsi (r = 0,423 dengan nilai p = 0,006 <0,05).
UJI VALIDITAS DAN RELIABILITAS KUESIONER KEPATUHAN MGLS (MORISKY, GREEN, LEVINE ADHERENCE SCALE) VERSI BAHASA INDONESIA TERHADAP PASIEN EPILEPSI Iin Ernawati; Wardah Rahmatul Islamiyah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.407 KB) | DOI: 10.36387/jiis.v4i2.330

Abstract

Epilepsy is a chronic brain disease that is characterized by seizures spontaneously, recurs and there is no improvement in each seizure. One measure of therapy epilepsy is decreased or loss of seizures. One of the things that still causes the uncontrolled seizure is adherence. Measurement of adherence in epilepsy patients is one of the tool for know related to the type of therapy and intervention provided. One of the adherence questionnaires that can be used is MGLS (Morisky, Green, Levine Scale Adherence Scale). The MGLS questionnaire is a adherence questionnaire with 4 items of questions, where the questionnaire questions can describe the level of patient adherence in drug consumption. The purpose of this study is to test the validity and reliability of the MGLS questionnaire with the intention that the questionnaire can be applied to patients.This study was a descriptive observational study conducted on epilepsy patients at Airlangga University Hospital. Sampling was done through consecutive sampling method, obtained 42 epilepsy patients between May-July 2018. Validity test was carried out using the Pearson correlation method (correction value ≥0.3) and the reliability test using internal cronbach alpha coefficient ≥0.6. Based on the results of the validity test it is known that the correlation score of each question with the total score is known to correlate more than r table (N = 42) 0.3496. These results indicate that all questions on the Indonesian version of the MGLS questionnaire are valid. Reliability test showed cronbach alpha coefficient 0.634> 0.6 (p <0.05). The conclusion of this study is the valid and reliable MGLS Indonesian version of the questionnaire instrument to determine the level of adherence in epilepsy patients.
Nocturnal Epilepsy dan Dislokasi Sendi Bahu Anterior Bilateral Berulang Wardah Rahmatul Islamiyah; Ersifa Fatimah; Kurnia Kusumastuti
AKSONA Vol. 1 No. 2 (2021): JULY 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (197.114 KB) | DOI: 10.20473/aksona.v1i2.151

Abstract

Pendahuluan: Penyandang epilepsi sering mengalami cedera pada saat serangan. Tipe bangkitan tonik dan kontraksi kuat dari anggota gerak pada saat serangan seringkali menyebabkan cedera otot pada sendi dan tulang, sehingga menyebabkan dislokasi dan fraktur. Kontraksi hebat pada sekelompok otot dapat menyebabkan dislokasi dan instabilitas sendi bahu. Kejadian dislokasi sendi bahu bilateral patognomonis disebabkan oleh karena kejang. Akan tetapi pada umunya bentuk dislokasi pascakejang berupa dislokasi bahu posterior bilateral.  Laporan kasus berikut akan menyampaikan kejadian dislokasi sendi bahu anterior bilateral berulang pada penyandang nocturnal epilepsy. Kasus ini jarang terjadi dan diharapkan meningkatkan kewaspadaan klinisi dalam merawat penyandang epilepsi.  Kasus: Laki-laki 22 tahun dikonsulkan oleh spesialis bedah orthopedi dengan diagnosis dislokasi sendi bahu anterior berulang. Pasien sudah mengalami dislokasi sebanyak empat kali dalam satu tahun terakhir. Dislokasi bahu selalu terjadi setelah serangan kejang di malam hari ketika pasien tidur. Pasien rutin mengkonsumsi obat phenytoin dengan frekuensi serangan 3 – 4  bulan sekali setiap tidur malam. Pasien menginginkan kejadian ini tidak terulang lagi. Penggantian obat antiepilepsi yang tepat dan memiliki efek samping minimal pada tulang membantu mencegah terjadinya komplikasi dislokasi seperti ini.  Kesimpulan: Dislokasi sendi bahu anterior bilateral berulang merupakan bentuk cedera pascabangkitan yang jarang terjadi. Pemilihan jenis antikejang yang tepat, upaya kontrol kejang yang baik dan penatalaksanaan multidisiplin dapat membantu mencegah terjadinya komplikasi berulang pada kasus serupa.    
Co-Authors Budiono Budiono Ernawati, Iin Ersifa Fatimah Fatimah, Ersifa Iin Ernawati Iin Ernawati Jordan, Danny Randy Kusumastuti, Kurnia Prayitno, Jongky Hendro Zahra, Farah Az