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EFEKTIFITAS IMUNOSTIMULLAN DARI EKSTRAK ETANOL DAUN BENALU KOPI (Loranthus ferrugineus Roxb) PADA TIKUS JANTAN DENGAN METODE TITER ANTIBODI Novandi Purba; Lasma Novita Sari; Radika Ginting
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.372

Abstract

The research in this paper aims to determine the effectiveness of immunostimulants from ethanol extract of coffee parasite leaves (Loranthus ferrugineus Roxb) with four variants of doses of 50mg / kgBB, 100mg / kgBB, 200mg / kgBB, 400mg / kgBB. This study used 18 male white rats with 200 gram BB which were divided into 6 treatment groups. Rats were injected with 0.1ml SDMS 1% for 7 consecutive days intraperitoneal, then on the 7th day each blood sample was taken through veins in the tail, CMC Na 0.5% suspension, and Levamisole suspension 50mg / kgBB as a positive control was administered orally on the 8th day. Then blood samples were collected in a micro tube and then 1900rpm was centrifuged at a temperature of 4oC for 10 minutes. The results of the study of ethanol extract of coffee parasite leaves proved effective as immunostimulants because they have a value close to positive control, starting from a dose of 200mg / kgBB to 400mg / kgBB.
ANTI-INFLAMMATORY ACTIVITY TEST OF LIME LEAF (CITRUS AURANTIIFOLIA) ETHANOL EXTRACT IN MALE MICE (MUS MUSCULUS) INDUCED CARRAGEENAN ON 2022 Novandi Purba; Bulan Andriani Harianja; Khairil Akbar
Jurnal FARMASIMED (JFM) Vol 5 No 1 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i1.1233

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol daun jeruk nipis (Citrus aurantiifolia) sebagai antiinflamasi. Metode yang digunakan adalah udema buatan telapak kaki mencit putih jantan dengan induksi karagenan 1%. Pengujian aktivitas antiinflamasi ekstrak etanol daun jeruk nipis menggunakan 25 hewan uji, dengan 5 kelompok perlakuan. Kelompok terdiri atas kontrol positif yang diberikan na.diklofenak dengan dosis 6,5 mg/kgBB, kontrol negatif yang diberi perlakuan CMC Na 0,5%, dan 3 kelompok ekstrak yang dimana kelopok ektrak dosis 100 mg/kgBB, kelompok ekstrak dosis 200 mg/kgBB, dan kelompok ekstrak dosis 300 mg/kgBB. persen radang pada kelima kelompok uji mengalami penurunan secara terus menerus mulai dari menit ke-60 sampai menit ke-360 setelah induksi karagenan. persen radang terbesar terjadi pada menit ke-120 pada suspensi Na.cmc dan diikuti oleh 100 mg/kgBB, 200 mg/kgBB, 300 mg/kgBB dan Na.diklofenak. nilai persen inhibisi radang terbesar dimiliki oleh kelompok Na.diklofenak dan diikuti oleh 300 mg/kgBB, 200 mg/kgBB dan 100 mg/kgBB. Hal ini berarti, persen hambatan yang baik terdapat pada EEDJN 300 mg/kgBB setelah Na.diklofenak, kemudian diikuti EEDJN 200 dan 100 mg/kgBB dan hal ini menunjukan bahwa kelompok Na.diklofenak, 100, 200 dan 300 mg/kgBB memiliki potensi sebagai agen antiinflamasi sedangkan kelompok Na.Cmc tidak.
SOSIALISASI DAN EDUKASI PEMANFAATAN TANAMAN BERKHASIAT OBAT DAN MAKANAN SEHAT DALAM MENINGKATKAN SISTEM IMUNITAS DI ERA NEW NORMAL Novandi Purba; Nur Ulina Turnip; Amina Syarifuddin; Khairil Akbar
JURNAL PENGMAS KESTRA (JPK) Vol 1 No 2 (2021): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.225 KB) | DOI: 10.35451/jpk.v1i2.897

Abstract

Medicinal plants that can boost the immune system are very much consumed by the public, especially during the current COVID-19 pandemic. Apart from plants, healthy food also has an important role in improving the immune system in this new normal era, one of which we must consume balanced nutritious foods such as staple foods, namely rice, corn, tubers and side dishes as well as vegetables and fruit. Fruits are a source of protein, minerals, fiber and vitamins. In addition, to face new changes requires careful preparation. Health quality is the main component to face the transition from the Covid-19 era to change for the better. Therefore, it is necessary to maintain the body's immune system which is the body's defense to ward off various diseases. The body's immune system can be improved by changing a bad lifestyle. Including physical exercise (sports). The purpose of Community Service (PKM) is to assist the local government in increasing public awareness to prevent and fight the Covid-19 virus in the form of utilizing nutritious plants that can increase the body's immune system and eat healthy food. The activity was carried out in the form of online discussions through whatsapp groups and meetings via zoom with the younger generation of Lubuk Pakam. From this activity, the younger generation has gained a good understanding of what to do in the new normal era, not only complying with health protocols, but also in regulating lifestyle and eating patterns.
WORKSHOP OF TESTING THE EFFECTIVENESS OF ANTIBACTERIAL EXTRACT OF SURUHAN (peperomia pellucida l. Kunth) LEAVES AGAINST staphylococcus epidermidis BACTERIA Novandi Purba; Yanna Rotua
JURNAL PENGMAS KESTRA (JPK) Vol. 2 No. 1 (2022): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.326 KB) | DOI: 10.35451/jpk.v2i1.1120

Abstract

Skin infections or dermatitis are included in the ten most common diseases in Indonesia, so the use of antibiotics is very high. The increasing use of antibiotics will cause an increase in the use of inappropriate antibiotics. The purpose of this research and community service was to find out the leaf extract of suruhan (Peperomia pellucida L. Kunth) with a variety of solvents providing anti-microbial activity against Staphylococcus epidermidis bacteria and conveying information to the public about the leaf extract that can be used as an acne medication. The results showed that the inhibition of ethanol extract and aquadest leaves of suruhan against the growth of Staphylococcus epidermidis bacteria at a concentration of 25 mg/mL clear zone 6.0 mm ethanol extract and 5.4 mm aquadest extract (Potentially Weak), concentration 50 mg/mL diameter of the extract inhibition zone ethanol 8.46 mm and aquadest extract 6.53 mm (medium potential), concentration 75 mg/mL diameter of inhibition zone 12.96 mm ethanol extract and 8.53 mm aquadest extract (strong potential). From the research data obtained, it is socialized to the public regarding the antibacterial activity of the leaves of suruhan against Staphylococcus epidermidis bacteria. The purpose of Community Service (PKM) is to provide information to the public that suruhan leaves can be used as an antibacterial to inhibit bacterial growth even with various types of solvent concentrations used. The conclusion in this study is that there are many plants that can be used to inhibit the growth and development of acne-causing bacteria, one of which is the leaf plant among young people.
ANTIDIABETIC ACTIVITY TEST OF ETHANOL EXTRACT BROCOLI (BRASSICA OLERACEA VAR. ITALICA) IN WHITE MALE RATS Novandi Purba; Diah Tri Handayani; Kristian Cahayani Zebua
Jurnal FARMASIMED (JFM) Vol 5 No 2 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i2.1587

Abstract

Diabetes is a chronic disease characterized by excessive blood glucose levels caused by absolute and relative insulin deficiency. The stages in this study were sampling, identification of samples/plants, simplification, simplification screening, and preparation of extracts by maceration. The method used in the diabetes activity test uses a glucometer to induce alloxan in rats at a dose of 150 mg/kg body weight. The test animals were 25 rats which were divided into 5 treatment groups namely CMC Na 0.5% (negative control), glibenclamide (positive control) 0.45 mg/kg body weight and EEB dose 200 mg/kg body weight, 400 mg/kg body weight and 600. mg/kg body weight. kg B.W. kg body weight as a test material given orally. Measurement of blood glucose values ??according to Allox and on days 3, 5, and 7 after administration of the test substance, namely EEB. The test results data were analyzed statistically using one-way ANOVA at a 95% confidence level followed by Tukey's post hoc test. The results of the phytochemical screening showed that EEB contains alkaloids, flavonoids, tannins, saponins, and glycosides. The results of the diabetes efficacy test showed that EEB doses of 200, 400, and 600 mg/kg BW had an anti-diabetic effect on male white rats. The EEB dose of 600 mg/kg is the most effective. Post hoc Tukey test results showed that EEB doses of 200 mg/kg, 400 mg/kg, and 600 mg/kg were not significantly different from the positive control glibenclamide 0.45 mg/kg (p>0.05) and 200,400 ug. and 600 mg/kg BW were significantly different from the negative control CMC Na 0.5% (p<0.05).
Co-Authors Amina Syarifuddin Bulan Andriani Harianja Diah Tri Handayani Khairil Akbar Kristian Cahayani Zebua Lasma Novita Sari Nur Ulina Turnip Radika Ginting Yanna Rotua Sihombing