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Wiryatun Lestariana
Bagian Biokimia Faluktas Kedokteran Universitas Gadjah Mada
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Swamedikasi diabetes mellitus dengan daun ceplikan (Ruellia tuberosa L.): kajian kemanfaatan pada profil lipid serum secara praklinik Ety Yuni Ristanti; Wiryatun Lestariana; Lily Arsanti Lestari
Jurnal Gizi Klinik Indonesia Vol 5, No 3 (2009): Maret
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.17569

Abstract

Background: Self-medication by using ceplikan leaves (Ruellia tuberosa L.) has been practiced in society for many times in the after-boiled form. It had been proved that liquid extract of ceplikan leaves (Ruellia tuberosa L.) was able to reduce blood glucose level on diabetic rat. It is also well known among diabetes mellitus patient that it has following effect on increasing triglyceride and reducing HDL-cholesterol level.Objective: This research was aimed to give scientific evidence on the society habit on self-medication by using ceplikan leaves (Ruellia tuberosa L.) by examining its oral administration on serum lipid profile pre-clinically.Method: Two months old Rattus novergicus within average weight of 150-200 g were divided into experimental and control groups. The control group consisted of 6 normal rats; while the experimental group consisted of 24 alloxan induced-diabetic rats. The experimental groups were divided into four groups i.e. non-treatment group and oral administrations of Ruellia tuberosa L. liquid extract with different concentrations that were 1.6 mg, 3.2 mg, and 6.4 mg, respectively. The feeds were given ad libitum. The oral administrations of Ruellia tuberosa L. liquid extract were given everyday for 30 days. In the end of the treatment, all rats were fastened and the blood was taken from the eye and being observed for its serum lipid profile. The data were analyzed statistically by using ANOVA and Tukey’s HSD mean difference tests.Results: The results showed that oral administration of 3.2 mg Ruellia tuberosa L. liquid extract was significantly reduced triglyceride and LDL-cholesterol level (p < 0,05) and increased HDL-cholesterol level (p < 0,05).Conclusion: The 3.2 mg of Ruellia tuberosa L. liquid extract was able to reduce triglyceride and LDL-cholesterol level and increase HDL-cholesterol level. Moreover, ceplikan leaves (Ruellia tuberose L.) could be taken as traditional drugs in a non-formal way with control on dietary intake and regular physical exercise.
Ekstrak air daun Ceplikan (Ruellia tuberosa L) berpengaruh terhadap kadar SGOT, SGPT dan gambaran histologis hepar tikus DM Fitri Ardiani; Wiryatun Lestariana; Emy Huriyati
Jurnal Gizi Klinik Indonesia Vol 8, No 2 (2011): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (410.218 KB) | DOI: 10.22146/ijcn.17775

Abstract

Background: Diabetes Mellitus (DM) is a chronic metabolic disorder as indicated by hiperglycemia caused by insulin defciency produced by pancreatic islet ß cell which triggers metabolic disorder of carbohydrate, protein and fat, and tends to cause complications. One of the complications is liver damage caused by DM which is probably due to lipid peroxydation, subsequent to free radical production. The common biochemistry signs of liver damage are increasing activities of some enzym such as transaminase pyruvat glutamate serum in the blood. Ruellia tuberosa L is a traditional plant and used by people as diabetic traditional drug. Flavonoid, saponin, zink as antioxidant can decreased of blood glucose in diabetic.Objective: The study aimed to identify the effect of Ruellia tuberosa L extract on glutamate oxaloacetate and glutamate pyruvat transaminases as well as liver histology of diabetic white mice (Rattus norvegicus).Method: The study was pure experimental that used a pre-post test control group design. The study used 30 male Rattus norvegicus. They were divided into 5 groups, each group consisting of 6 rats. Group I rats served as the normal control. Groups II to V consisted of rats with DM induced with alloxan 170 mg/kgBB subcutaneously. The experiment made was as followed. Group I served as control, group II was DM+aquades, group III was DM+Ruellia tuberosa L extract 1.6 mg/ kgBB/day, group IV was DM+Ruellia tuberosa L extract 3.2 mg/kgBB/day, and group V was DM+Ruellia tuberosa L extract 6.4 mg/kgBB/day. Glutamate oxaloacetate and glutamate pyruvat transaminases was measured before beginning and end of the treatment. The blood was taken from sinus orbitalis. At day 30 (end of the study) the rats were sacrifced for their liver. Data of transaminase oxaloacetate glutamate serum and transaminase pyruvat glutamate serum level were analyzed using one way ANOVA. The result of liver histology was analyzed descriptively.Results: The effect of Ruellia tuberosa L extract within 30 days of study could minimize level of transaminase oxaloacetate glutamate serum and transaminase pyruvat glutamate serum of DM rats. Maximal decreasing in extract 3,2 mg. Histologically there was no damage of the liver.Conclusion: Ruellia tuberose L extract could minimize level of transaminase oxaloacetat glutamate serum and transaminase pyruvat glutamate serum of DM and liver histology is normal.
Co-Authors Emy Huriyati Fitri Ardiani Lestari, Lily Arsanti Ristanti, Ety Yuni