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All Journal e-GIGI Padjadjaran Journal of Dentistry Jurnal Keperawatan Silampari JURNAL ILMIAH KESEHATAN SANDI HUSADA
Florenly Florenly
Universitas Prima Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Efek Penambahan Nanokitosan 1% Kedalam Berbagai Konsentrasi Ekstrak Kulit Kelengkeng Streptococcus Mutans Titania Aurely Tandra; Sabrina Khairunissa; Mellisa Sim; Florenly Florenly
Jurnal Ilmiah Kesehatan Sandi Husada Vol 9 No 1 (2020): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v11i1.313

Abstract

Longan skin (Dimocarpus longan Lour) contains flavonoid compounds, glycosides, saponins, and tannins, so it has an antibacterial capacity. 1% Nanocitosan mixed into plant extracts can increase the inhibitory growth of bacteria in the oral cavity. This study aims to compare the effectiveness of longan skin extract (Dimocarpus longan Lour) added 1% nano chitosan in inhibiting Streptococcusmutans at various concentrations, namely 40%, 60%, and 80%. Longan skin extract is made by maceration method and made with a concentration of 40%, 60%, and 80%. Whereas 1% of nano chitosan is made by the ionic glass method. The two ingredients were mixed in a ratio of 1: 1, and the effectiveness of inhibition was tested by the disk diffusion method. The results showed the mean and standard deviation of longan skin extract at concentrations of 40%, 60% and 80% with 1% nano chitosan was 6.86 ± 0.471 mm; 7.62 ± 0.533 mm and 8.53 ± 0.395 mm. Inhibition with a diameter> 7 mm indicates medium-strength antibacterial. The Shapiro-Wilk test proves that the data are normally distributed. Statistical analysis with one-way Analysis of Variance (ANOVA) showed longan skin extract (Dimocarpus longan Lour) mixed with 1% nano chitosan most effective in inhibiting Streptococcus mutans at 80% concentration, where p = 0,000 (0 <0.05). This is due to an increase in the concentration of phytochemical compounds
Efektivitas Antibakteri Campuran Nanokitosan 1% dengan Berbagai Konsentrasi Ekstrak Biji Kelengkeng Terhadap Staphylococcus Aureus Sabrina Khairunnisa; Titania Aurelya Tandra; Mellisa Sim; Florenly Florenly
Jurnal Ilmiah Kesehatan Sandi Husada Vol 9 No 1 (2020): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v11i1.319

Abstract

As shown on the qualitative phytochemical examinations, longan seeds contain bioactive compounds of flavonoids, glycosides, saponins, and tannins, hence it has antibacterial potential. Whereas nano chitosan, besides having antibacterial activity, is used as a matrix for various types of drugs and plant extracts. This study aims to compare the effectiveness of nano chitosan 1% mix with longan seed extract in inhibiting the growth of Staphylococcus aureus, between 80%, 60%, and 40% concentration. Longan seed extract was prepared using the maceration method and made into various concentrations, i.e. 80%, 60%, and 40%. The nano chitosan 1% was prepared with the ionic gelation method. The two ingredients were mixed in a ratio of 1: 1. The antibacterial investigations on the different concentrations utilized the disk diffusion method. The results presented the mean inhibition power of a mixture of 80% concentration was 9.38 mm; a concentration of 60% (8.47 mm) and a concentration of 40% (7.10 mm). Statistical analysis using one way ANOVA showed the most effective concentration of the mixture in inhibiting Staphylococcus aureus was seen at 80%, where p = 0,000 (p <0.05). The results of this study indicate that increasing the concentration of longan seed extract strengthens the inhibitory power against Staphylococcus aureus. The outcome was justified as the increment in concentration of longan seed extracts lead to an increase in the number of active compounds, thereby upsurge its effectiveness in damaging Staphylococcus aureus cells.
Nano-Green Betel Leaf Extracts (Piper betle L.) Inhibits the Growth of Streptococcus mutans and Staphylococcus aureus Florenly Florenly; Novelya Novelya; Mizeli Janiar; Miranda Miranda; Le Quang Phan Dang Hai; Phan Minh Quang
e-GiGi Vol. 10 No. 2 (2022): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.v10i2.39014

Abstract

Abstract: Streptococcus mutans is a type of bacterium that initiates plaque formation on the tooth surface causing tooth decay, meanwhile, Staphylococcus aureus causes pyogenic infections such as abscesses to necrosis. Green betel leaf (Piper betle L.) contains secondary meta-bolites that have the potential as antibacterial. This study aimed to investigate the effectiveness of green betel leaf extract (Piper betle L.) in micro and nano sizes against Streptococcus mutans and Staphylococcus aureus. This was an experimental and laboratory study with a post-test-only design. The results showed that nano-green betel leaf extracts had antibacterial activity against Streptococcus mutans and Staphylococcus aureus. Green betel leaf extract had a much larger inhibition zone against Staphylococcus aureus rather than against Streptococcus mutans in all groups (p<0.05), with inhibitory diameters of 13,883±1.1496 mm (micro 10%), 16,767± 1.8779 mm (micro 30%), and 18.667±3.148 mm (nano), respectively. A stable increase in antibacterial activity was derived from micro-green betel leaf extracts (Piper betle L.) concentrations of 10%, 30%, and nanoparticle size. In conclusion, nano-green betel leaf extract (Piper betle L.) showed better antibacterial effectiveness than micro-sizes in inhibiting Streptococcus mutans and Staphylococcus aureus bacteria.Keywords: Piper betle L.; nanoparticles; antibacterial; Streptococcus mutans; Staphylococcus aureus
Analisis Formularium Obat Instalasi Farmasi di Rumah Sakit Umum Royal Prima Medan Nadiyah Santika; Chrismis Novalinda Ginting; Suci Erawati; Florenly Florenly; Ali Napiah Nasution
Jurnal Keperawatan Silampari Vol 6 No 1 (2022): Jurnal Keperawatan Silampari
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.997 KB) | DOI: 10.31539/jks.v6i1.4726

Abstract

This study aims to analyze drug formulations in the pharmaceutical installation at the Royal Prima General Hospital Medan. The method in this research is descriptive qualitative. The results showed that the hospital had prepared formularies, maintained formalities, supervised adherence to formulary use, and proposed formulae in pharmaceutical installations. In conclusion, the hospital has carried out a drug formulary in the pharmaceutical installation. Keywords: Drug Formulary, Pharmacy Installation
Uji Efektivitas Antibakteri Ekstrak Kulit Buah Delima Merah (Punica granatum L.) terhadap Pertumbuhan Lactobacillus acidophilus Secara In Vitro Susanna Halim; Florenly Florenly; Shely Anggriani
e-GiGi Vol. 11 No. 2 (2023): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.v11i2.46515

Abstract

Abstract: Lactobacillus acidophilus is a Gram-positive bacterium that causes caries. It is known that natural ingredients of red pomegranate peel extract (Punica granatum L.) have antibacterial effect. This study aimed to determine the effectiveness of red pomegranate peel extract in inhibiting the growth of Lactobacillus acidophilus. This was a laboratory and experimental study using a post-test only design with a control group design. Samples were Lactobacillus acidophilus bacteria. Sample size was determined using the Federer's formula, and five repetitions were obtained for each group. Data were analyzed with One Way ANOVA and Post Hoc LSD tests. The results showed that the average diameters of the inhibition zones of red pomegranate peel extract (Punica granatum L.) at concentrations of 25%, 50%, 75%, and 0.2%, chlorhexidine (positive control), and DMSO (negative control) on the growth of Lactobacillus acidophilus were 16.08±1.16 mm, 17.66 ±0.60 mm, 18.76±0.54 mm, 14.04±0.90 mm, and 0 mm. Statistic tests showed significant differences between various concentrations of red pomegranate peel extract and the positive control (p<0.05). The secondary metabolite compounds contained in red pomegranate peel extract (Punica granatum L.) were saponins, flavonoids, tannins, triterpenoids, and glycosides. In conclusion, various concentrations of red pomegranate peel extract (Punica granatum L.) have antibacterial effect to inhibit the growth of Lactobacillus acidophilus. Keywords: Lactobacillus acidophilus; red pomegranate peel; antibacterial effect   Abstrak: Lactobacillus acidophilus merupakan bakteri Gram positif penyebab terjadinya karies. Bahan alami dari ekstrak kulit buah delima merah (Punica granatum L.) telah dikenal memiliki efek antibakteri. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak kulit buah delima merah dalam menghambat pertumbuhan Lactobacillus acidophilus. Metode penelitian ialah eksperimental laboratorium dengan post-test only with control group design dengan menggunakan sampel bakteri Lactobacillus acidophilus. Penentuan besar sampel menggunakan rumus Federer dan diperoleh lima kali pengulangan tiap kelompok. Analisis data menggunakan uji One Way ANOVA dan Post Hoc LSD. Hasil penelitian mendapatkan rerata diameter zona hambat pada ekstrak kulit buah delima merah konsentrasi 25%, 50%, 75%, chlorhexidine 0,2% (kontrol positif) dan DMSO terhadap pertumbuhan Lactobacillus acidophilus ialah 16,08±1,16 mm; 17,66± 0,60mm; 18,76±0,54 mm; 14,04±0,90 mm; dan 0 mm. Uji statistik menunjukkan perbedaan bermakna antara ekstrak kulit buah delima merah berbagai konsentrasi dengan kontrol positif (p<0,05). Kandungan senyawa metabolit sekunder yang terdapat pada ekstrak kulit buah delima merah yaitu saponin, flavonoid, tanin, triterpenoid, dan glikosida. Simpulan penelitian ini ialah ekstrak kulit buah delima merah berbagai konsentrasi memiliki kemampuan antibakteri untuk menghambat pertumbuhan Lactobacillus acidophilus. Kata kunci: Lactobacillus acidophilus; kulit buah delima merah; efek antibakteri
Formulation and physical stability analysis of red beetroots (Beta vulgaris l.) effervescent granules Florenly Florenly; Shieny Lokanata; Jovin Friando; Phuong Thao Mai; Hong Hai Le; Cut Cynthia Luzria; Anusak Sintapanont
Padjadjaran Journal of Dentistry Vol 35, No 2 (2023): July 2023
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol35no2.47031

Abstract

ABSTRACTIntroduction: Red beetroots (Beta vulgaris L.) are a natural ingredient rich in nutrients and provide various notable health benefits. In dentistry, red beetroots have the potential to act as a plaque-disclosing agent. Previous studies showed that red beetroot preparation in gelform is more effective compared to chewable tablets, but has significant drawbacks in taste. Effervescent granules have the potential to conceal the unpleasant taste of beetroot substances. This study aims to determine the ideal formula and evaluate the physical properties and stability of effervescent granules made from red beetroot extract. Methods: This was an experimental design study with descriptive analysis. The maceration method was used to extract the red beetroot constituents. Fresh fruits were collected, air-dried, and macerated with 96% ethanol twice. The filtrates were then concentrated. The wet granulation method was used to formulate effervescent granules. The samples were grouped into formula 1 (F1), formula 2 (F2), and formula 3 (F3) using 1%, 3%, and 4% red beetroot extract, respectively. All sample groups were analyzed for physical stability, namely: organoleptic, flowability, density, dissolving time, and pH tests. Results: All samples surpassed the sensory evaluation for physical properties. Formula 1 (1%) and formula 2 (3%) models passed all the physical stability tests. Meanwhile, the 4% formula (F3) failed two physical tests. F1 (1%) samples also showed lighter brown color for its lower beetroot extract concentration, indicating under-qualification as dental plaque staining materials. Therefore, 3% concentration (F2) has the best formulation regarding physical properties and stability. Conclusion: Formulas F1 and F2 have the best physical properties and stability by passing all the tests, while Formula 3 failed the organoleptic and flow rate tests.
Co-Authors Ali Napiah Nasution Anusak Sintapanont Chrismis Novalinda Ginting Cut Cynthia Luzria Hong Hai Le Jovin Friando Le Quang Phan Dang Hai Mellisa Sim Miranda Miranda Mizeli Janiar Nadiyah Santika Novelya Novelya Phan Minh Quang Phuong Thao Mai Sabrina Khairunissa Sabrina Khairunnisa Shely Anggriani Shieny Lokanata Suci Erawati Susanna Halim Titania Aurely Tandra Titania Aurelya Tandra