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All Journal Global Health Management Journal Amalee: Indonesian Journal of Community Research & Engagement
Suharyo Hadisaputro
Poltekkes Kemenkes Semarang, Semarang, Indonesia
Humanities Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The effect of chocolate consumption (Theobroma cacao L.) on level of blood cholesterol and triglyceride in hypertension patients at Jatiroto Health Center, Indonesia Muzaroah Ermawati Ulkhasanah; Suharyo Hadisaputro; Rr. Sri Endang Pujiastuti
GHMJ (Global Health Management Journal) Vol. 3 No. 1 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-31272

Abstract

Background: Hypertension is influenced by lifestyle factors such as high fat intake which has the potential for high blood cholesterol level. Cocoa products, which are rich sources of flavonoids, have been shown to reduce blood pressure and the risk of cardiovascular disease.Aims: The purpose of this research is to examine the dark chocolate consumption in decreasing the level of blood cholesterol and triglyceride in hypertension patients.Methods: This research is a quasi-experiment study with pre and post and control group design. There were thirty two (32) hypertensive patients selected from Jatiroto Health Center in June-July 2018 using a random sampling technique. The respondents were then divided to (1) a control group where patients were prescribed to a popular non-pharmacological therapy Simvastatin and (2) an intervention group where the respondents were prescribed with Simvastatin and also received an additional dark chocolate 60gr/day (given twice a day, each 30gr) for 15 days. A spectrophotometer glycerol phosphate oxidase (GPO-POD) with 546 nm wavelength was employed to measure the levels of blood cholesterol and triglyceride. The significant mean difference between pre and posttest, and the changes between control and intervention group were defined by statistical analysis T-test.Results: This study acknowledged that the prescribed simvastatin alone presents a significant contribution to decrease the cholesterol level at 14.40 point (p value = 0.041), however, the generic is not enough to deliver a significant effect to the decrease of triglyceride level in the hypertension patients (p value = 0.361). A great contribution to the depression of cholesterol and triglyceride level in the hypertensive respondent was observed if simvastatin prescription was combined with a provision of 60 gram dark chocolate, respectively to the level of 57.06 and 38.41 mg/dL with p value = 0.001. The addition of dark chocolate in the simvastatin prescription will significantly reduce the blood cholesterol level (p value = 0.020), but not really effective to reduce the triglyceride (p value = 0.560).Conclusion: The findings suggest that giving dark chocolate to the hypertensive patients who receive simvastatin prescription will decrease the cholesterol and triglyceride levels greater than the consumption of simvastatin drugs alone. Keywords: Dark chocolate, Simvastatin, Hypertension, Cholesterol, Triglyceride
Pengaruh Vitamin D terhadap Faktor Metabolik pada Perempuan dengan Sindroma Ovarium Polikisitik (SOPK): Systematic Review - Meta Analysis Andriana - Andriana; Suharyo Hadisaputro; Aris Santjaka
Amalee: Indonesian Journal of Community Research and Engagement Vol 3 No 2 (2022): Amalee: Indonesian Journal of Community Research and Engagement
Publisher : LP2M INSURI Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/amalee.v3i2.2759

Abstract

Deficiency of Vitamin D is one of the causes of Polycystic Ovary Syndrome (PCOS). Vitamin D deficiency can affect metabolic factors in women with PCOS. The purpose of this study was to analyze the effect of vitamin D on the metabolic factors of women with PCOS. The method used is the Systematic Review-Meta Analysis study design. The databases used for searching articles are Sciencedirect, PubMed, and Proquest. Keywords combined with Boolean Operators Inclusion criteria: publications with RCT designs from 2015 to 2020, women aged 18 to 49 years with PCOS, type of vitamin D intervention. Outcomes measured were levels of FPG, insulin, triglycerides, total kolesterol, LDL, HDL, and HOMA-IR. The results of the research where 12 studies were analyzed because they met the eligibility criteria. Administration of vitamin D significantly affected total kolesterol (WMD, -7.94; 95% CI, -15.74 to -0.13, P = 0.05), and HDL (WMD, ̶ 3.24; 95% CI, ̶ 4.32 to ̶ 2.16, P < 0.00001). Vitamin D intervention had no significant effect on FPG, insulin, triglycerides, LDL, and HOMA-IR levels. The conclusions from this study stated that Vitamin D influenced total kolesterol and HDL levels. Defisiensi Vitamin D merupakan salah satu penyebab terjadinya Sindrom Ovarium Polikistik (SOPK). Defisiensi vitamin D dapat mempengaruhi faktor-faktor metabolik pada perempuan yang mengalami SOPK. Tujuan penelitian ini untuk menganalisis pengaruh vitamin D terhadap faktor metabolik perempuan dengan SOPK. Metode yang digunakan yaitu Desain studi Systematic Review-Meta Analysis. Database yang digunakan untuk pencarian artikel adalah Sciencedirect, PubMed, dan Proquest. Kata kunci dikombinasikan dengan Boolean Operators Kriteria inklusi: publikasi dengan desain RCT tahun 2015 sampai 2020, perempuan usia 18 sampai 49 tahun dengan SOPK, jenis intervensi vitamin D. Hasil yang diukur adalah kadar FPG, insulin, triglycerides, total kolesterol, LDL, HDL, and HOMA-IR. Hasil penelitiannya adalah 12 studi dianalisis karena memenuhi kriteria kelayakan. Pemberian vitamin D berpengaruh secara signifikan terhadap kadar total kolesterol (WMD, -7.94; 95% CI, -15.74 to -0.13, P = 0.05), dan HDL (WMD, ̶ 3.24; 95% CI, ̶ 4.32 to ̶ 2.16, P < 0.00001). Intervensi vitamin D tidak berpengaruh secara signifikan pada kadar FPG, insulin, triglycerides, LDL, dan HOMA-IR. Simpulan dari penelitian ini dinyatakan bahwa Vitamin D berpengaruh terhadap kadar total kolesterol dan HDL.
Co-Authors Andriana - Andriana Aris Santjaka Muzaroah Ermawati Ulkhasanah Rr. Sri Endang Pujiastuti