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PROFIL PENDERITA KANKER GINEKOLOGI DI RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JULI 2015 SAMPAI JULI 2016 Potes, Velisitas Ana Maria; Suparman, Erna; Laihad, Joel Bismarck
JKK (Jurnal Kedokteran Klinik) Vol 1, No 3 (2017): JURNAL KEDOKTERAN KLINIK
Publisher : FAKULTAS KEDOKTERAN UNSRAT

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AbstractÂ Reproductive health is a state of complete physical, mental, social intact in all matters relating to the systems, functions, and, in the process of reproduction. Women's reproductive health issues has become an international agenda. One of the female reproductive health problems that their femininity or gynecological disease. This studyâ€™s goal is to identify and obtain data about the profile of cancer patients in the department of gynecology Prof. Dr. R. D. Kandou Manado period July 2015 to July 2016. This research uses descriptive retrospective study. Data retrieved from the registration records medical records of all patients in the department of gynecology Prof. Dr. R. D. Kandou period July 2015 - July 2016. The results showed that in July 2015 until July 2016 there were 276 cases of gynecologic cancers. Most of gynecologic cancers are cervical cancer with the number of 179 cases (64.9%), followed by 74 cases of ovarian cancer (26.8%), endometrial cancer were 21 cases (7.6%) and vaginal cancer as much as 2 cases ( 0.72%). Conclusion: The profile of cancer patients in the department of gynecology Prof. Dr. R. D. Kandou Manado period July 2015 to July 2016 as many as 276 cases of gynecologic cancers with four types of cancer that most cervical cancer, ovarian cancer, endometrial cancer, and vaginal cancer.Keywords: gynecological cancerÂ AbstrakÂ Kesehatan reproduksi adalah keadaan kesejahteraan fisik, mental, sosial yang utuh dalam segala hal yang berkaitan dengan sistem, fungsi, dan, proses reproduksi. Masalah kesehatan reproduksi wanita sudah menjadi agenda internasional. Salah satu masalah kesehatan reproduksi wanita yaitu adanya penyakit kewanitaan atau ginekologi. Penelitian ini bertujuan untuk mengetahui dan mendapatkan data mengenai profil penderita kanker ginekologi di RSUP Prof. Dr. R. D. Kandou Manado periode Juli 2015 sampai Juli 2016. Penelitian ini menggunakan metode penelitianÂ deskriptif retrospektif. Data diambil dari catatan registrasi rekam medik seluruh pasien ginekologi yang ada di RSUP Prof. Dr. R. D. Kandou Periode Juli 2015 - Juli 2016. Hasil penelitian menunjukkan bahwa pada Juli 2015 sampai Juli 2016 terdapat 276 kasus kanker ginekologi. Kanker ginekologi terbanyak terdapat pada kanker serviks dengan jumlah 179 kasus (64,9%), kemudian diikuti kanker ovarium sebanyak 74 kasus (26,8%), kanker endometrium sebanyak 21 kasus (7,6%) dan kanker vagina sebanyak 2 kasus (0,72%). Simpulan: profil penderita kanker ginekologi di RSUP Prof. Dr. R. D. Kandou Manado periode Juli 2015 sampai Juli 2016 sebanyak 276 kasus kanker ginekologi dengan empat jenis kanker terbanyak yaitu kanker serviks, kanker ovarium, kanker endometrium dan kanker vagina.Kata kunci : kanker ginekologi

Levels of 25 Hydroxyvitamin D in Normotensive Pregnancy and Severe Preeclampsia Palinoan, Meynita; Kaeng, Juneke J; Suparman, Erna
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 2 April 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

  Objective: To determine the ratio of 25-hydroxyvitamin D levels innormotensive pregnancy and severe preeclampsia.   Methods: This study was an analytic cross-sectional study witht-test. The subject of this study consists of 17 samples normotensivepregnancy and 17 samples severe preeclampsia. This study wasconducted and evaluated from August 2016 until December 2016 atDepartment of Obstetrics and Gynecology Faculty of MedicineUniversitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manadoand satellite hospital in Manado. Samples were taken from serumas much as 5 ccs and were analyzed using CLIA at Prodia clinicallaboratory. Data were analyzed with SPSS version 20.0.   Results: By using the t- test, there were significant differences in25-hydroxyvitamin D levels between normotensive pregnancygroup (24.771  6.9567ng/ml) and severe preeclamptic group(17.712  3.7513ng/ml), p = 0.001.   Conclusion: Levels of 25-hydroxyvitamin D in normotensive pregnancysignificantly higher compared to severe preeclampsia so it canbe concluded that the levels of 25-hydroxyvitamin D were associatedwith preeclampsia.   Keywords: 25-hydroxyvitamin D, normotensive, severe preeclampsia

Levels of 25 Hydroxyvitamin D in Normotensive Pregnancy and Severe Preeclampsia Palinoan, Meynita; Kaeng, Juneke J; Suparman, Erna
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 2 April 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

  Objective: To determine the ratio of 25-hydroxyvitamin D levels innormotensive pregnancy and severe preeclampsia.   Methods: This study was an analytic cross-sectional study witht-test. The subject of this study consists of 17 samples normotensivepregnancy and 17 samples severe preeclampsia. This study wasconducted and evaluated from August 2016 until December 2016 atDepartment of Obstetrics and Gynecology Faculty of MedicineUniversitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manadoand satellite hospital in Manado. Samples were taken from serumas much as 5 ccs and were analyzed using CLIA at Prodia clinicallaboratory. Data were analyzed with SPSS version 20.0.   Results: By using the t- test, there were significant differences in25-hydroxyvitamin D levels between normotensive pregnancygroup (24.771  6.9567ng/ml) and severe preeclamptic group(17.712  3.7513ng/ml), p = 0.001.   Conclusion: Levels of 25-hydroxyvitamin D in normotensive pregnancysignificantly higher compared to severe preeclampsia so it canbe concluded that the levels of 25-hydroxyvitamin D were associatedwith preeclampsia.   Keywords: 25-hydroxyvitamin D, normotensive, severe preeclampsia

Correlation between Body Mass Index and Lipid Profile in Second Trimester with Incidence of Hypertension in Third Trimester Prasetyo, Ananto; Wantania, John J E; Suparman, Erna
Indonesian Journal of Obstetrics and Gynecology Volume 7 No. 2 April 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Abstract Objective : to determine the relationship of BMI (Body Mass Index) and lipid profile (total cholesterol, triglycerides, HDL, LDL, VLDV) in the second trimester of pregnancy with the incidence of hypertension in the third trimester of pregnancy Methods :this study is a prospective cohort. The research subjects were the second trimester pregnant women group which examined by BMI and lipid profile, then assessed the incidence of hypertension in third trimester. The study was conducted in Department of Obstetric and Gynecology and Prof.DR.RDKandou General Hospital, and affiliated hospital from January 2017 until May 2017. Data analyzed with SPSS version 2.0 Results:from 49 research subjects, based on age,most subject with age 20-34 years with 42 subjects (85.8%). Based on the parity obtained 27 subjects (55.2%) with multigravida. By education level, most are high school with 19 subjects (38,7%). From the occupation, most are housewives with 30 subjects (61.3%). Based on BMI, most were subjects with normal BMI with 21 subjects (42.9%). Pearson test showed a significant association between BMI with total cholesterol (r = 0,500 and p = 0,000), whereas Spearman test showed significant relation between BMI with LDL cholesterol (r = 0,416 and p = 0,003) and significant relation between second trimester LDL cholesterol with third trimester diastolic blood pressure(r = 0.303 and p = 0.034). Conclusions:there was a significant correlation between BMI with total cholesterol & LDL in second trimester  and there was significant correlation between LDL in second trimester and third trimesterdiastolic blood pressure. Keywords:BMI,total cholesterol, VLDL, TG, LDL, HDL, hypertension.   Abstrak Tujuan : Untuk mengetahui hubungan IMT (Index Massa Tubuh)danprofil lipid ( kolesterol total, trigliserida, HDL, LDL, VLDV)  pada trimester kedua kehamilan dengan kejadian hipertensi pada trimester ketigak ehamilan. Metode : Penelitian ini merupakan kohort prospektif. Subjek penelitian adalah kelompok ibu hamil trimester kedua yang diperiksa IMT dan profil lipidnya, kemudian dinilai kejadian hipertensi pada trimester ketiga. Penelitian dilakukan di Departemen Obstetri dan Ginekologi  Rumah Sakit Umum Pusat (RSUP) Prof.DR.R.D Kandou, dan RS jejaring mulai Januari 2017 sampai Mei 2017. Data dianalisa dengan SPSS versi 2.0 Hasil : Dari 49 subjek penelitian, berdasarkan usia paling banyak usia  20 – 34 tahun dengan 42  subjek (85,8%). Berdasarkan paritas didapatkan 27 subjek (55,2%) dengan multigravida. Berdasarkan pendidikan, paling banyak adalah SMA dengan 19 subjek (38,7%). Dari jenis pekerjaan, paling banyak adalah ibu rumah tangga dengan 30 subjek (61,3%). Berdasarkan IMT, paling banyak adalah subjek dengan IMT normal dengan 21 subjek (42,9%). Uji Pearson menunjukkan hubungan bermakna antara IMT dengan kolesterol total (r = 0,500 dan p = 0,000), sedangkan Uji Spearman menunjukkan hubungan bermakna antara IMT dengan kolesterol LDL (r = 0,416 dan p = 0,003) dan hubungan bermakna antara kolesterol LDL trimester kedua dengan tekanan darah diastol trimester ketiga  (r = 0,303 dan p = 0,034). Kesimpulan : Terdapat hubungan bermakna antara IMT dengan kolesterol total, LDL trimester kedua dan terdapat hubungan bermakna antara LDL trimester kedua dengan tekanan darah diastol trimester ketiga. Kata kunci :IMT, kolesterol total, VLDL, TG, LDL, HDL, hipertensi.

KARAKTERISTIK PENDERITA KANKER SERVIKS DI BLU RSUP PROF. DR. R. D. KANDOU Lasut, Edwin; Rarung, Max; Suparman, Erna
e-CliniC Vol 3, No 1 (2015): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v3i1.6519

Abstract: Cervical cancer is still the most frequent type of cancer among women in Indonesia. For ASEAN region, the incidences of cervical cancer in Singapore are: around 25.0% among the Chinese and 17.8% among the Malayan. In Thailand the incidence is around 23.7 per 100.000 civilians. In Indonesia, it is estimated that there are 40.000 new cases of cervical cancer in every year. This study aimed to obtain the characteristics of mothers with cervical cancer in the Department of Obsterics and Gynaecology in the Prof. Dr. R. D. Kandou General Hospital, Manado from January 1 to December 31,2013.Keywords: cervical cancer, age, pap smear history, parity, age of first maritalAbstrak: Kanker serviks masih menjadi penyakit yang terbanyak pada wanita di Indonesia. Untuk wilayah ASEAN, insidens kanker serviks di Singapura sebesar 25,0 pada ras Cina; 17,8 pada ras Melayu; dan di Thailand sebesar 23,7 per 100.000 penduduk. Di Indonesia diperkirakan ditemukan 40.000 kasus baru kanker serviks setiap tahunnya. Penelitian ini bertujuan untuk mengetahui karakteristik ibu dengan kanker serviks di Bagian Obstetri dan Ginekologi BLU RSUP Prof. Dr. R. D. Kandou Manado periode 1 Januari 2013 sampai dengan 31 desember 2013.Kata kunci: Kanker serviks, usia, paritas, riwayat pap smear, usia kawin pertama kali

Hubungan Anemia pada Ibu Hamil dengan Kejadian Persalinan Prematur di RSUP Prof Dr. R. D. Kandou Manado Larumpaa, Florensia S.; Suparman, Erna; Lengkong, Rudy
e-CliniC Vol 5, No 1 (2017): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v5i1.14700

Abstract: Preterm labor is a labor that occurs at 20-<37 weeks of gestational age calculated from the first day of the last menstrual. Until now the mortality and morbidity of preterm labor is still high. This matter is related with the maturity of the organs in the newborn such as lungs, brain and gastrointestinal tract. There are several factors that cause preterm labor inter alia maternal factor. Pregnant women with anemia potentially have preterm labors. World Health Organization (WHO) estimates that 35â€“37% of pregnant women in developing countries are anemic during pregnancy. In pregnant women it is important to meet iron needs during pregnancy by supplementation of iron and folic acid. The aim of this study was to determine the correlation between anemia in pregnant women and preterm labor. This was an analytical observational study with a cross-sectional design. Samples were mothers delivered in Obstetrics and Gynecology department at Prof. Dr. R. D. Kandou General Hospital Manado from September until November 2015. The results showed correlation between anemia in pregnant women with preterm labor from 168 samples that met the inclusion criteria (p value = 0.000). Conclusion: There was a significant correlation between anemia in pregnant women and preterm labor.Keywords: anemia, preterm labor, pregnant womenÂ Abstrak: Persalinan prematur adalah persalinan yang terjadi antara usia kehamilan 20-<37 minggu dihitung dari hari pertama haid terakhir. Sampai saat ini mortalitas dan morbiditas persalinan prematur masih sangat tinggi. Hal ini berkaitan dengan maturitas organ pada bayi baru lahir seperti paru, otak, dan gastrointestinal. Beberapa faktor dapat menyebabkan terjadinya persalinan prematur diantaranya faktor ibu, dimana ibu hamil dengan anemia berpotensi mengalami persalinan prematur. World Health Organization memperkiran bahwa 35-37% ibu hamil di negara berkembang mengalami anemia selama kehamilannya. Pada ibu hamil penting untuk memenuhi kebutuhan zat besi selama kehamilan dengan suplementasi zat besi dan asam folat. Penelitian ini bertujuan untuk mengetahui hubungan antara anemia pada ibu hamil dengan kejadian persalinan prematur. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Sampel penelitian yaitu ibu yang bersalin di Bagian Obstetri dan Ginekologi RSUP Prof. Dr. R. D. Kandou Manado pada bulan September hingga November 2015. Hasil penelitian dari 168 sampel ibu bersalin yang memenuhi kriteria inklusi menunjukkan terdapat hubungan bermakna antara anemia pada ibu hamil dengan kejadian persalinan prematur (p=0,000). Simpulan: Terdapat hubungan bermakna antara anemia pada ibu hamil dengan kejadian persalinan prematur.Kata kunci: anemia, persalinan prematur, ibu hamil

KARAKTERISTIK PENDERITA PREEKLAMSIA DI RSUP PROF. Dr. R. D. KANDOU MANADO Warouw, Patricia C.; Suparman, Erna; Wagey, Freddy W.
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i1.10986

Abstract: Worldwide there are about 76,000 pregnant women die each year due to preeclampsia and other hypertensive disorders in pregnancy. The incidence rate of preeclampsia in the United States, Canada, and Western Europe ranges from 2-5%. In developing countries, the rate ranges from 4-18% of all pregnancies. In Indonesia, the Maternal Mortality Ratio (MMR) of the period of 2008 to 2012 was 359 deaths per 100,000 live births. The occurrence of preeclampsia in Indonesia is about 3-10% of all pregnancies. This study aimed to determine the characteristics of patients with preeclampsia. This was a retrospective descriptive study. Samples were pregnant women with preeclampsia and had complete medical records at Prof. Dr. R. D. Kandou Hospital during the period of January 1, 2014 until December 31, 2014. The results showed that the number of pregnant women with preeclampsia were 201 people. Mild preeclampsia and severe preeclampsia were most prevalent in the age group of 20-35 years (70% and 61.46%) meanwhile superimposed preeclampsia in the age group of >35 years (78.13%). Preeclampsia was mostly among multiparity. Superimposed preeclampsia was found in 32 cases. Most pregnant women with preeclampsia had a BMI â‰¥ 30.00. Conclusion: Most preeclampsia cases occured in the age group of 20-35 and> 35 years with multiparity, some had hypertension, and mostly were obese. Keywords: mild preeclampsia, severe preeclampsia, superimposed preeclampsia, age, parity, nutritional status (obesity).Â Abstrak: Diseluruh dunia sekitar 76.000 wanita hamil meninggal setiap tahun akibat preeklamsia dan gangguan hipertensi lainnya pada kehamilan. Insiden preeklamsia di Amerika Serikat, Kanada, dan Eropa Barat berkisar 2-5% sedangkan di negara berkembang berkisar 4-18% dari semua kehamilan. Di Indonesia Maternal Mortality Ratio (MMR) periode 2008 sampai 2012 sebesar 359 kematian per 100.000 kelahiran hidup. Frekuensi kejadian preeklamsia di Indonesia sekitar 3-10% dari semua jumlah kehamilan. Penelitian ini bertujuan untuk mengetahui karakteristik penderita preeklamsia. Jenis penelitian ini deskriptif retrospektif. Sampel penelitian ialah ibu hamil dengan preeklamsia dan mempunyai data rekam medis lengkap di RSUP Prof. Dr. R.D. Kandou periode 1 Januari 2014 sampai 31 Desember 2014. Hasil penelitian menunjukkan bahwa jumlah ibu hamil dengan preeklamsia 201 orang. PER dan PEB terbanyak ditemukan pada kelompok usia 20-35 tahun (70% dan 61,46%) sedangkan superimposed PE pada kelompok usia >35 tahun (78,13%). Preeklamsi terbanyak pada paritas multigravida. Superimposed PE berjumlah 32 kasus. Ibu hamil dengan preeklamsia terbanyak memiliki IMT â‰¥30.00. Simpulan: Preeklamsia terjadi pada kelompok usia 20-35 dan >35 tahun dengan paritas multipara, sebagian dengan riwayat hipertensi, dan sebagian besar disertai obesitas.Kata kunci: preeklamsia ringan, preeklamsia berat, superimposed preeklamsia, usia, paritas, status gizi (obesitas).

Profil Persalinan dengan Plasenta Previa di RSUP Prof. Dr. R. D. Kandou Manado periode 1 Januari 2015 â€“ 31 Desember 2015 Pawa, Alif F.; Mewengkang, Maya; Suparman, Erna
e-CliniC Vol 5, No 1 (2017): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.5.1.2017.14762

Abstract: Placenta previa is a complication of pregnancy in which the placenta is located at the bottom of the uterus, partially or completely covering the cervix. This causes painless vaginal bleeding and some leads to bleeding. The bleeding may be intense enough to threaten motherâ€™s life leading to labor immediately, either elective or emergency. This study was aimed to obtain the profile of labor with placenta previa at Prof. Dr. R. D. Kandou Hospital Manado period 1 January 2015-31 December 2015. The results showed that of 27 cases, the most incidents were in the age group more than equal with 35 years (48.1%). The most parity was 2-4 (74.1%). The incidence of placenta previa with SC history was 25.9%. Based on types of the management, the highest was placenta previa that got expectative management (63%). Based on the classification, total placenta previa amounted to 88.9%. Based on gestational age, aterm was 55.6%. All labors with placenta previa used SCTP. The most indication of labor was inpartu (96.3%). The most labor complication was pre eclampsia (11.1%). Most of the babies were born alive (96.3%). Conclusion: Women who had placenta previa symptoms like bleeding without pain had to be immediately checked into hospitals or Obstetrics and Gynecology specialists to get the optimum management as soon as possible.Keywords: placenta previa, laborAbstrak: Plasenta previa adalah komplikasi kehamilan di mana plasenta terletak di bagian bawah rahim, sebagian atau seluruhnya menutupi leher rahim. Hal ini menyebabkan perdarahan vagina tanpa rasa sakit dan beberapa mengarah ke perdarahan. Perdarahan yang mungkin cukup besar untuk mengancam kehidupan ibu janin membuat persalinan segera, baik secara elektif maupun darurat. Penelitian ini bertujuan untuk mengetahui gambaran persalinan dengan plasenta previa di RSUP Prof. Dr. R. D. Kandou Manado periode 1 Januari 2015 â€“ 31 Desember 2015. Hasil penelitian mendapatkan dari 27 kasus, didapatkan insiden terbanyak pada kelompok usia lebih dari dan sama dengan 35 tahun sebanyak 48,1 % kasus. Paritas terbanyak ialah paritas 2-4 sebanyak 74,1%. Kejadian plasenta previa dengan riwayat SC sebanyak 25,9%. Berdasarkan jenis tatalaksana, terbanyak pada plasenta previa yang mendapatkan tatalaksana ekspektatif sebanyak 63%. Berdasarkan klasifikasi, plasenta previa totalis sebanyak 88,9%. Berdasarkan usia kehamilan, aterm sebanyak 55,6%. Semua persalinan pada plasenta previa menggunakan cara SCTP. Indikasi persalinan terbanyak ialah inpartu sebanyak 96,3%. Penyulit persalinan terbanyak ialah preeklampsia dengan 11,1%. Luaran bayi terbanyak ialah lahir hidup sebanyak 96,3%. Simpulan: Wanita yang memiliki gejala plasenta previa seperti perdarahan tanpa nyeri harus segera memeriksakan ke rumah sakit atau dokter spesialis Obstetri dan Ginekologi untuk mendapatkan penanganan optimal sesegera mungkin.Kata kunci: plasenta previa, persalinan

PEMBERIAN PROGESTERON PADA KEGUGURAN BERULANG Suparman, Erna; Suparman, Eddy
Jurnal Biomedik : JBM Vol 5, No 2 (2013): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.5.2.2013.2588

Abstract: Recurrent pregnancy loss (RPL) occurs in 0.5-1% of partners. The pathophysiology of this RPL is complex. The causes include anatomical, genetic and molecular abnormalities, endocrine disorders, thrombophilia, and the anti-phospholipid syndrome, meanwhile in 50% of cases no cause can be identified. Progesterone is needed to create a suitable environment for the implantation. Low progesterone level during early pregnancy may reflect corpus luteum defects or abnormal products of conception. Besides that, low progesterone is a sign of a coming miscarriage; an administration of progesterone can only delay the onset of bleeding.. Even with a normal plasma progesterone levels, endometrial progesterone deficiency can still result from receptor defects; this finding supports the existence of absolute or relative progessterone deficiency as a cause of spontaneous abortion. Women who suffer from relative progesterone deficiency probably will not get any benefit from progesterone therapy. Almost all current research states that there is no difference in the rates of miscarriages in women treated and not treated with progesterone. Therefore, all medical organizations do not recommend progesterone supplementation to recurrent miscarriage, except in women who use reproductive technologies such as in vitro fertilization (IVF). Keywords: recurrent pregnancy loss, progesterone. Â Â Abstrak: Keguguran berulang terjadi pada 0,5-1% pasangan dengan patofisiologi yang kompleks. Sebagai penyebab ialah kelainan anatomi, genetik dan molekuler, gangguan endokrin, thrombofilia, dan sindrom anti-fosfolipid, tetapi pada 50% kasus tidak jelas. Progesteron sangat diperlukan dalam menciptakan lingkungan yang cocok untuk implantasi endometrium. Konsentrasi progesteron yang rendah selama awal kehamilan mencerminkan defek korpus luteum atau hasil konsepsi yang abnormal. Progesteron yang rendah merupakan tanda dari keguguran akan datang namun pemberian progesteron hanya dapat menunda timbulnya perdarahan. Walaupun tingkat progesteron plasma normal, endometrium masih dapat mengalami kekurangan progesteron akibat defek reseptor. Temuan ini mendukung adanya defisiensi progesteron absolut atau relatif sebagai penyebab keguguran spontan. Wanita yang menderita kekurangan progesteron relatif tidak akan mendapatkan keuntungan dari pemberian progesteron. Hampir semua penelitian saat ini menyatakan bahwa tidak terdapat perbedaan tingkat keguguran pada wanita yang diberikan progesteron dan yang tidak; oleh karena itu semua organisasi medis tidak menganjurkan pemberian progesteron pada keguguran berulang, kecuali pada wanita yang menggunakan teknologi reproduksi seperti IVF. Kata kunci: keguguran berulang, progesteron.

TOKSOPLASMOSIS DALAM KEHAMILAN Suparman, Erna
Jurnal Biomedik : JBM Vol 4, No 1 (2012): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.4.1.2012.744

Abstract: Toxoplasmosis in pregnancy causes the Toxoplasma gondii infection in the fetus via the uteroplacental route. There is a very significant positive correlation between the isolation of Toxoplasma from placental tissues and neonatal infection. Laboratory tests commonly performed are anti-Toxoplasma IgG and IgM, and anti-Toxoplasma IgG avidity. Examination should be done in women who are suspected of being infected of Toxoplasma gondii before or during pregnancy, as well as in newborns of mothers infected with Toxoplasma gondii. Food and Drug Administration (FDA) recommends interpreting the results of an anti-Toxoplasma IgM serology test carefully. Doctors can not confirm the diagnosis based solely on one type of toxoplasmosis test. The use of spiramycin during pregnancy causes a decrease in the frequency of vertical transmission. Spiramycin is given to women who are suspected of having acute Toxoplasma infection in the first trimester or in the early second trimester until labor. Spiramycin should not be used as a monotherapy in suspected cases of fetal infection. In pregnant women who have a high likelihood of infection of Toxoplasma gondii or in cases of fetal infection, treatment with spiramycin should include pyrimethamine, sulfadiazine, and folic acid after 18 weeks of gestation.Key words: Toxoplasmosis, pregnancy, fetal infection.Â Abstrak: Toksoplasmosis dalam kehamilan menyebabkan transmisi Toxoplama gondii melalui sirkulasi uteroplasenta ke janin. Terdapat korelasi positif yang sangat bermakna antara isolasi toksoplasma dari jaringan plasenta dan infeksi neonatus. Pemeriksaan laboratorium yang lazim dilakukan ialah anti toksoplasma IgG dan IgM, serta aviditas anti-Toksoplasma IgG. Pemeriksaan tersebut perlu dilakukan pada ibu yang diduga terinfeksi Toxoplasma gondii sebelum atau selama masa kehamilan, serta pada bayi baru lahir dari ibu yang terinfeksi Toxoplasma gondii. Food and Drug Administration (FDA) merekomendasikan untuk menginterpretasikan hasil tes serologi IgM anti toksoplasma dengan cermat. Para dokter tidak boleh menegakkan diagnosis toksoplasmosis hanya berdasarkan satu jenis pemeriksaan. Penggunaan spiramisin selama kehamilan menyebabkan penurunan frekuensi transmisi vertikal. Spiramisin diberikan pada wanita yang diduga mengalami infeksi toksoplasma akut pada trimester pertama atau awal trimester kedua, dan akan diberikan hingga persalinan. Sebaiknya spiramisin tidak digunakan sebagai menoterapi pada kasus yang diduga terjadi infeksi pada janin. Untuk ibu hamil yang memiliki kemungkinan infeksi yang tinggi atau telah terjadi infeksi janin, pengobatan dengan spiramisin harus dibantu setelah usia kehamilan 18 minggu dengan pirimetamin, sulfadiazin, dan asam folat. Kata kunci: Toksoplasmosis, kehamilan, infeksi fetal.

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