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All Journal Medical Journal of Indonesia Majalah Sainstekes
Marzuki Suryaatmadja
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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The influence of lipoprotein(a) on fibrinolytic activity Setiabudy, Rahajuningsih D.; Suryaatmadja, Marzuki; Henrika, Fifi
Medical Journal of Indonesia Vol 13, No 3 (2004): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (132.948 KB) | DOI: 10.13181/mji.v13i3.142

Abstract

Lipoprotein(a) is a plasma lipoprotein whose structure and composition are similar with low density lipoprotein (LDL) with an addition of apo(a) that is bound to apo B100. The structure of apo(a) is similar with plasminogen, a proenzym in fibrinolytic system. Due to this similarity, it is assumed that Lp(a) can inhibit plasminogen activity and decreases fibrinolytic activity. The purpose of this study is to prove that addition of Lp(a) to normal plasma can inhibit fibrinolytic activity. Four healthy people whose fibrinogen levels, plasminogen activities and euglobulin clot lysis time were within normal range were enrolled in this study. Fibrinolytic activity were assessed by euglobulin clot lysis time (ECLT). In the first experiment, the addition of Lp(a) was done before centrifugation to obtain euglobulin precipitates, while in the second experiment, Lp(a) was added to the euglobulin precipitates. As a control, ECLT was performed in the plasma with the addition of NaCl 0.9% in the same volume with Lp(a). The results of the study showed that in the first experiment, there was no clot formation. It is assumed that Lp(a) can bind fibrinogen and both of them floated in the supernatant, so there was no fibrinogen in the euglobulin precipitate that can be clotted by thrombin. In the second experiment, the clot did not dissolve until the fourth day. In conclusion, the addition of Lp(a) to normal plasma can inhibit the activity of fibrinolytic system. (Med J Indones 2004; 13: 135-9) Keywords: plasminogen, fibrinogen, apo(a), euglobulin clot lysis time (ECLT)
The association of plasminogen activator inhibitor-1 level with ischemic stroke (preliminary study) Surjawan, Yenny; Setiabudy, Rahajuningsih D.; Suryaatmadja, Marzuki; Ranakusuma, Teguh A.S.
Medical Journal of Indonesia Vol 19, No 3 (2010): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.414 KB) | DOI: 10.13181/mji.v19i3.403

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Aim Recently, increased plasminogen activator inhibitor-1 (PAI-1) has been known a risk factor for ischemic heart disease. However, the association of increased PAI-1 level with ischemic stroke remains unclear. The aim of this study was to analyze the association of PAI-1 level with ischemic stroke.Methods By case control design we involved 38 ischemic stroke and 38 risky-matched control subjects who fulfilled the criteria. The PAI-1 level was determined by ELISA method using Asserachrom PAI-1 from Stago.Results High PAI-1 level was found more frequent in ischemic stroke subjects than in control subjects (21.1% vs. 7.9 % with OR 3.1; 95 % CI 0.757 – 12.790). The analysis of all studied subjects showed that there was a weak negative correlation between PAI-1 level and age (r = -0.4; P = 0.000). High PAI-1 level was found more frequent in younger (40 – 58 years old) than in the older subjects (60 – 84 years old) (20% vs. 9.8 %) (p=0.004).Conclusion The result of this preliminary study suggested an association between PAI-1 level and ischemic stroke in younger age. Further study with larger subjects is recommended to confirm this association. (Med J Indones 2009;19:158-63)Key words: ischemic stroke, plasminogen activator inhibitor-1, stroke risk factors
Protein S100 sebagai Petanda Kerusakan Otak pada Cedera Otak Ringan dan Sedang Aditarahma Imaningdyah; Marzuki Suryaatmadja; Lyna Soertidewi Kiemas
Majalah Sainstekes Vol 4, No 1 (2017): Juni 2017
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.021 KB) | DOI: 10.33476/ms.v4i1.899

Abstract

Brain injury becomes worldwide public health issue since it may cause disability and mortality. The diagnosis of brain injury is made based on clinical neurology examination, and CT scan or MRI. Serum S100 protein examination in mild and moderate brain injury patients is needed to detect and evaluate the presence of post traumatic brain injury. This research subject is healthy people and patients with mild and moderate brain injury, based on their GCS grade, clinical neurologic examination, and CT scan. On these patients, the blood for S100 protein examination is taken at admission, 6 and 24 hours post trauma, and last day of hospitalization. Examination of a serum S100 protein is conducted using ECLIA method. There is significant difference (p value 0,001) in mild or moderate brain injury patients in all serum S100 protein. The peak level of serum S100 protein reached at 6 hours post trauma. Serum S100 protein in moderate brain injury patients at admission is significantly higher than the mild ones, and serum S100 protein in mild brain injury patients is also significantly higher than healthy people. Serum S100 protein can be used as brain injury biomarker  to  detect  and  evaluate  the  presence  of  post  traumatic  brain injury.
Co-Authors Aditarahma Imaningdyah Fifi Henrika Lyna Soertidewi Kiemas Rahajuningsih D. Setiabudy Teguh A.S. Ranakusuma Yenny Surjawan