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All Journal JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI INDONESIAN JOURNAL OF PHARMACY Indonesian Journal of Chemistry
Antonius R.B. Ola
Department Of Chemistry, Faculty Of Science And Engineering, Universitas Nusa Cendana, Jl. Adisucipto, Penfui-Kupang 85118, NTT, Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Education Medicine & Pharmacology

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ANALISIS SENYAWA ANTIBIOTIK DARI JAMUR SIMBION YANG TERDAPAT DALAM ASCIDIANS Didemnum molle DI SEKITAR PERAIRAN BUNAKEN-SULAWESI UTARA Bara, Robert A.; Kandou, Grace D.; Ola, Antonius R. B.; Posangi, Jimmy
JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI Vol 2, No 2 (2015)
Publisher : JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI

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Abstract

Endosymbiont can be interpreted as microbes that live in colonies in the internal tissues of other higher organisms without causing adverse effects directly on the its host. Endosymbiont organisms have a huge potential to be exploited as a new natural products that are useful in medicine, agriculture, and industry. This research is focused on the antibacterial potential. Ascidians Didemnum moll speciments were collected from Manado waters. The fungal isolates were purified followed by screening their antibacterial activity towards Staphylococcus aureus and Pseudomonas aeruginosa. In this study we isolated 3 fungal specimens Acremonium sp. (ADMB-1, 2 and 3). Three isolates showed potential antibacterial activity. Together with the fungal isolates, we also isolated Bacillus galacosidilyticus from the same host. This bacterial isolate also show antibacterial potency.
Molecular identification and anticancer activity of alkylphenol from cashew nut shell oil (Anacardium occidentale) grown In Timor Island Antonius R B Ola; Zullies Ikawati; Sismindari .; Ermelinda D Meye; Bibiana Dho Tawo
Indonesian Journal of Pharmacy Vol 19 No 3, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1717.444 KB) | DOI: 10.14499/indonesianjpharm0iss0pp137-144

Abstract

Isolation of anacardic acid and cardanol from cashew nut shell liquid and their cytotoxic activity to on ward HeLa cancer cell line has been done. The objective of this research is to isolate and identify anacardic acid and cardanol from CNSL along with their cytototoxic activity towards HeLa cancer cell lines. Anacardic acid was isolated as calcium anacardate. Hydrolisis of this acid with acid chloride yields anacardic acid . Liquor ammonia was added to the acid-free CNSL and extracted with hexane/ethyl acetate (98:2) to isolate cardanol and with ethyl acetate/hexane (80:20) to separate cardol. Cardanol was obtained as the main chemical component of CNSL derived from Kupang district. Anacardic acid and cardanol was analyzed using IR and GC-MS. Anticancer activity of chemical components of CNSL against HeLa cancer cell lines were studied using MTT. Cytotoxic activity test showed that CNSL, anacardic acid and cardanol can be developed as anticancer agent.Key words : CNSL, anacardic acid, cardanol, anticancer.
C-15 ACETOGENINS FROM THE MARINE ALGA Chondria Antonius R.B. Ola; Bruce F. Bowden
Indonesian Journal of Chemistry Vol 8, No 3 (2008)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1460.121 KB) | DOI: 10.22146/ijc.21603

Abstract

(-) Z-Pinnatifidenyne, a novel C-15 acetogenin has been isolated along with the known compound (+)-3Z,6R,7R-obtusenyne and (+) (3Z)-laurenyne from the Australian red alga Chondria armata. The structures of the compounds were elucidated based on spectral data analysis including 2D NMR spectroscopic experiment.
Bioactive Secondary Metabolites from the Mangrove Endophytic Fungi Nigrospora oryzae Antonius Rolling Basa Ola; Titus Lapailaka; Hermania Em Wogo; Julinda Bendalina Dengga Henuk; Agnes Simamora; Lince Mukkun; Peter Proksch; Chong Dat Pham
Indonesian Journal of Chemistry Vol 21, No 4 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.63129

Abstract

Mangrove forest has a distinctive habitat adapting with marine and terrestrial environment. Chemical investigation of the extract from mangrove endophytic fungi Nigrospora oryzae had resulted in the isolation of sterigmatocystin (1) and pestalopyrone (2). The structure of sterigmatocystin (1) and pestalopyrone (2) were elucidated using mass, UV and NMR spectrometers together with the comparison with the literature data. The study also showed that sterigmatocystin displayed moderate cytotoxicity but it could be further developed as antiviral and antibacterial agent based on the SAR information reported from its analogue and derivatives.
Co-Authors Agnes Simamora Bibiana Dho Tawo Bruce F. Bowden Chong Dat Pham Ermelinda D Meye Grace Debbie Kandou Hermania Em Wogo Jimmy Posangi Julinda Bendalina Dengga Henuk Lince Mukkun Peter Proksch Robert A. Bara Sismindari . Titus Lapailaka Zullies Ikawati