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All Journal Zenit Journal of Medicine and Health
Fen Tih
Universitas Kristen Maranatha
Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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 1 
Effect of Chewing Xylitol Gum on Salivary Volume and Acidity Angwarmase, Alfonsa; Tih, Fen; Hidayat, Meilinah
Journal of Medicine and Health Vol 1, No 5 (2017)
Publisher : Maranatha Christian University

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Abstract

Dental caries or tooth decay is a result of the production of acid from fermentation ofbacteria that destroy tooth tissue. It can be prevented by maintaining the stability of salivaryvolume and acidity. Chewing xylitol gum is beneficial for increasing salivary volume andacidity. The aim of the study is to determine the effect of chewing xylitol gum on salivary volumeand acidity. The study is a quasi experiment conducted to 30 males aged between 17-25 yearsold. Pre and post treatment’s salivary volume are measured with measuring cup. Pre and posttreatment’s salivary acidity are measured using a pHmeter with 0,1 accuracy. Data areanalyzed with paired “t” test (a = 0,05). Average salivary volume after chewing xylitol gumincreased very significantly from 0,26 mL to 13,37mL (p=0,000). Average salivary acidity afterchewing xylitol gum increased very significantyly from 6,47 to 7,36(p=0,000). The researchconcludes that chewing xylitol gum increases salivary volume and acidity.Keywords : dental caries, xylitol, salivary volume, salivary acidity
Cytotoxic Activity of Red Fruit (Pandanus conoideus Lam.) Oil and Its Effect On Cyclooxygenase-2 Gene Expression in Raji Cells Tih, Fen
Journal of Medicine and Health Vol 1, No 3 (2016)
Publisher : Maranatha Christian University

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Abstract

The number of cancer patient is increasing, while a really effective therapy has not yet been discovered. One concept of carcinogenesis is the relation between chronic inflammation and cancer. Cyclooxygenase-2 (COX-2) has a carcinogenic effect in inflamed and malignant tissues. Red Fruit contains carotenoid that can suppress COX-2 gene expression and tocopherol, which is a potent inhibitor of  COX-2.  The purpose of this study is to determine cytotoxic activity of Red Fruit oil and its effect on COX-2 gene expression. The experiment used 5 dosages of Red Fruit, 100, 200, 300, 400, and 500 µg/mL, exposed to Raji cells. However, unexposed Raji cells were used as control. Cytotoxic activities were evaluated by MTT Assay, while Lethal Concentration50 (LC50) was determined through regression-correlation analysis. Red Fruit oil effect on COX-2 gene expression was evaluated by Reversed Transcriptase Chain Reaction (RT-PCR) method and electrophoresis. Electrophoresis bands were analyzed by Scion Image for Windows. Optical Integrated Density (OID) of unexposed and exposed groups were statistically analyzed with one way Analysis of Variance (ANOVA), followed by Duncan test with α=0.05. The results showed that Red Fruit had a cytotoxic activity on Raji cells with LC50 of331.42 µg/mL. Red Fruit suppressed COX-2 gene expression with an effective dosage obtained at 500 µg/mL.          Keywords: red fruit, cytotoxicity, cox-2 gene expression, raji cells
Black Chocolate Consumption Reduces Subjective Symptoms in 18-22 Years Old Females with Premenstrual Syndrome Nurazizah, Eliza; Tih, Fen; Suwindere, Winny
Journal of Medicine and Health Vol 1, No 1 (2015)
Publisher : Maranatha Christian University

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Abstract

Menstruation is the release of the endometrium with bleeding every month, except during pregnancy. Before or during menstruation, a woman may experience stiffness or abdominal cramps, mood fluctuations and other physical and psychological disorders, which is termed as premenstrual syndrome (PMS). The aim of this research is to observe and value the effect of dark chocolate on clinical symptoms of PMS. This research is an experimental prospective, using experimental design with one group pre and post test. Subjects were 30 women aged 18-22 years. Every day for 2 weeks before menstruation period, subjects took 20 gram of dark chocolate, then were asked to answer questionaire. The data measured is the score as well as individual PMS symptoms before and after eating dark chocolate, was analyzed using a nonparametric Wilcoxon test, followed by McNemar chi square with α=0.05. A highly significant decrease was found in anxiety symptoms, whereas statistically significant reduction was found in fatigue or feeling tired, cramps abdominal, bloating, diarrhea, headache, back pain, change in appetite, muscle or joint pain, and problems in concentration. But the symptom of acne complaint was increased from 73.3% to 76.7%. Consumption of dark chocolate reduces premenstrual syndrome scores on women aged 18-22 years. Keywords: dark chocolate, premenstrual syndrome
Effect of Methanolic Extract in Ointment and Powder of Kalanchoe Pinnata (Lamk) Leaf in Ointment towards Incision Wound Healing in Mice Suprapto, Adi K; Tih, Fen; Evacuasiany, Endang
Journal of Medicine and Health Vol 1, No 1 (2015)
Publisher : Maranatha Christian University

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Wound is a very common thing that can happen to all people around the world. The purpose of this study is to investigate the effect of methanolic extract and powder of Kalanchoe pinnata (Lamk) leaf in ointment. The methodology is laboratoric experimental design. Six groups of mice (n=30) were incised for 8 mm and treated with different treatment: methanolic extract of Kalanchoe pinnata (Lamk) leaves in ointment (SEMDSB) 10%, SEMDSB 20%, Kalanchoe pinnata (Lamk) leaves powder in ointment (SSDSB) 10%, SSDSB 20%, vaseline album (ointment) as negative control, and povidone iodine ointment as positive control. Examination is carried out by measuring the width of wounds in mice every day until the wound interlocked. Data analysis used one way ANOVA continued by Tukey HSD with α=0,05. The result showed the average time for wound healing (in days) are: SEMDSB 10% (7.2), SEMDSB 20% (6.6), SSDSB 10% (8.8), SSDSB 20% (7.6), negative control (10.6), and positive control (7.8). SEMDSB 10%, SEMDSB 20%, and SSDSB 20% showed highly significant difference (p = 0,000) and SSDSB 10% showed significant difference (p=0,021) when compared to negative control. As conclusion, methanolic extract  and powder of Kalanchoe pinnata (Lamk) leaves in ointment can accelerate wound healing time. Keywords: ointment, Kalanchoe pinnata (Lamk), wound healing, mice
Kandungan Logam Timbal, Besi, dan Tembaga dalam Air Minum Isi Ulang di Kota Bandung Tih, Fen; Kusumawardani, Indah; Estevania, Margaret Yosephine; Simanjuntak, Ezra Artur Stefano
Zenit Vol 4, No 3 (2015)
Publisher : Zenit

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Water necessity is mostly fulfilled from drinking water, which should be in adequate quantity and quality. One of the sources of drinking water is refilled drinking water depots. As stated in health department rules (Permenkes RI Nomor 492/Menkes/Per/IV/2010), heavy metal content in drinking water cannot exceed the permitted level, including lead, iron and copper. The aim of this research is to determine whether there is over permitted level of lead, iron and copper content in refilled drinking water from depots throughout Bandung. This research is a descriptive survey with a cross sectional design. Thirty depots have been randomly selected from 150 registered depots in Bandung. Heavy metal contents are analyzed quantitatively with spectrophotometric method. The result shows that 30 samples do not have lead, iron and copper level content above the permitted level. However, some samples show almost a maximal level of heavy metal content which could influence health when consumed in the long termKeywords: refilled drinking water, lead, iron, copper
Effect of Chewing Xylitol Gum on Salivary Volume and Acidity Angwarmase, Alfonsa; Tih, Fen; Hidayat, Meilinah
Journal of Medicine and Health Vol. 1 No. 5 (2017)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.827 KB) | DOI: 10.28932/jmh.v1i5.542

Abstract

Dental caries or tooth decay is a result of the production of acid from fermentation ofbacteria that destroy tooth tissue. It can be prevented by maintaining the stability of salivaryvolume and acidity. Chewing xylitol gum is beneficial for increasing salivary volume andacidity. The aim of the study is to determine the effect of chewing xylitol gum on salivary volumeand acidity. The study is a quasi experiment conducted to 30 males aged between 17-25 yearsold. Pre and post treatment’s salivary volume are measured with measuring cup. Pre and posttreatment’s salivary acidity are measured using a pHmeter with 0,1 accuracy. Data areanalyzed with paired “t” test (a = 0,05). Average salivary volume after chewing xylitol gumincreased very significantly from 0,26 mL to 13,37mL (p=0,000). Average salivary acidity afterchewing xylitol gum increased very significantyly from 6,47 to 7,36(p=0,000). The researchconcludes that chewing xylitol gum increases salivary volume and acidity.Keywords : dental caries, xylitol, salivary volume, salivary acidity
Co-Authors Adi K Suprapto, Adi K Alfonsa Angwarmase, Alfonsa Eliza Nurazizah, Eliza Endang Evacuasiany Ezra Artur Stefano Simanjuntak, Ezra Artur Stefano Indah Kusumawardani, Indah MEILINAH HIDAYAT Winny Suwindere Yundari, Yundari