Garuda - Garba Rujukan Digital

Potency of Black Soybean (Glycine max L. Merr) and Jati Belanda Leaves (Guazuma ulmifolia Lamk) for Dyslipidemia Treatment In Vivo Prahastuti, Sijani; Hidayat, Meilinah; Kurniadi, Michael W.; Christiany, Selvina
Journal of Medicine and Health Vol 1, No 3 (2016)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Soybean Detam 1 and Jati Belanda leaves are potential alternative medicines for treating dyslipidemia. The purpose of this study is to explore Â the potential of the combination of Ethanolic Extract Soybean Detam 1 (EEKD) and Jati Belanda (EEJB) in lowering LDL cholesterol and triglycerides compared to single extract and Simvastatin. Using a real laboratory experimental method with CRD, a total of 36 male Wistar rats were divided into 6 groups and administrated for treatment of 28 days. The results showed a significant decrease of LDL cholesterol as well as triglyceride in NCÂ as compared to P1, P2, P3 (p <0.05) and no significant difference with PC (p> 0.05). The highest suppression of LDL cholesterol between P1 with P2 and P3 is (p <0.05) while the triglyceride is between P1 and P2 (p <0.05). This study concludes that the combination of EEKD 10 mg, 20 mg EEJB, EEKD 30 mg and EEJB 30 mg is significantly lowering LDL cholesterol and triglyceride. The combination of EEKD 10 mg, 20 mg EEJB is the highest compression of LDL cholesterol and triglyceride, and has an equivalent effect with simvastatin in lowering LDL cholesterol and triglycerides in male Wistar rats induced with high fat diet.Â Keywords: LDL cholesterol, triglycerides

Subchronic Treatment of Combination Extract Detam 1 Soybean and Jati Belanda Leaves has No Toxic Effect on Function, Weight, and Histopathological of Wistar Rat Kidney Hidayat, Meilinah; Prahastuti, Sijani; Chikita, Vibiola; Safitri, Dewi; Rahmawati, Siti F.; Soemardji, Andreanus A.
Journal of Medicine and Health Vol 1, No 4 (2016)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar

The combination of Detam 1 soybean and Jati Belanda leaves proved to have effect of weight loss. Since it will become longterm using, toxicity effectvresearch is needed.Â This study was conducted to determine the effect of subchronic combination of ethanol extract of soybean Detam 1 (EEDS) and Jati belanda (EEJB) on kidney function, with parameters: urea and creatinine, macroscopic and histopathological of kidney. This study were conducted on 120 Wistar rats (60 males, 60 females), 90 days (treatment group) and 120 days (satellite group). Rats were divided into six treatment groups. Test results of urea and creatinine levels of all treatment groups was lower than control group (p <0.05). The treatment turned out to have a good effect on kidney function. Kidney weight of all groups showed no significant difference with the control group (p> 0.05). Histopathological score interpretationâs result of low dose group male and female kidney rats were not disturbed. In conclusion, the combination of EEDS and EEJBÂ have a good effect on kidney function, didÂ not lead to changes in organ weight and at low doses did not cause disturbance ofÂ renal histopathology.Â Key words: combination of soybean jati Belanda, subchronic treatment, kidney function, kidneyâsÂ weight, kidneyâs histopathology

Effect of Chewing Xylitol Gum on Salivary Volume and Acidity Angwarmase, Alfonsa; Tih, Fen; Hidayat, Meilinah
Journal of Medicine and Health Vol 1, No 5 (2017)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Dental caries or tooth decay is a result of the production of acid from fermentation ofbacteria that destroy tooth tissue. It can be prevented by maintaining the stability of salivaryvolume and acidity. Chewing xylitol gum is beneficial for increasing salivary volume andacidity. The aim of the study is to determine the effect of chewing xylitol gum on salivary volumeand acidity. The study is a quasi experiment conducted to 30 males aged between 17-25 yearsold. Pre and post treatmentâs salivary volume are measured with measuring cup. Pre and posttreatmentâs salivary acidity are measured using a pHmeter with 0,1 accuracy. Data areanalyzed with paired âtâ test (a = 0,05). Average salivary volume after chewing xylitol gumincreased very significantly from 0,26 mL to 13,37mL (p=0,000). Average salivary acidity afterchewing xylitol gum increased very significantyly from 6,47 to 7,36(p=0,000). The researchconcludes that chewing xylitol gum increases salivary volume and acidity.Keywords : dental caries, xylitol, salivary volume, salivary acidity

Blood Calcium Level and Its Correlation with Calcium Daily Intake, Calcium Supplementation & Clinical Symptoms in Women with Premenstrual Syndrome Hidayat, Meilinah; Wardani, Komang RP; Purba, Bertha M; Apreza, Rendhy T
Journal of Medicine and Health Vol 1, No 6 (2017)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Premenstrual syndrome (PMS) is complex of symptoms that occur during the luteal phase of the menstrual cycle. This study aimed to observe blood calcium levels differences between the patient and not the PMS, list the average intake of calcium / day among subjects, statistically analyze the relationship between calcium intake and blood calcium levels, and examine the effect of calcium supplementation on blood calcium levels and symptoms of PMS. We examined blood levels of calcium, analytical survey method using a cross-sectional study, experimental methods and PMS symptom questionnaires. The results showed that in the group of subjects SPM average blood calcium level, and the mean intake of calcium / day were lower than in non-PMS and showed a fairly correlation between the intake of calcium per day with blood calcium levels in SPM subjects. There is a significant relationship between increased calcium blood calcium levels and symptoms of PMS. The conclusions: 1. there are differences in blood calcium levels and 2. intake of calcium per day between patients with PMS and not PMS, 3. Calcium intake is significantly associated with calcium level in the PMS and 4. calcium supplementation affects blood calcium levels and reduce symptoms of PMS.Keywords : average calcium intake, blood calcium, calcium supplementation, Premenstrual Syndrome (PMS)

PENGUJIAN AKTIVITAS INHIBITOR LIPASE EKSTRAK ETANOL DAN HASIL FRAKSIONASI DARI KEDELAI DETAM 1 DAN DAUN JATI BELANDA Hidayat, Meilinah; Soeng, Sylvia; Prahastuti, Sijani
Chimica et Natura Acta Vol 2, No 1 (2014)
Publisher : Departemen Kimia

Salah satu pilihan pengelolaan obesitas adalah memperlambat absorbsi asam lemak dengan cara menginhibisi enzim lipase dalam saluran pencernaan. Inhibitor lipase pankreas dilaporkan telah berhasil dalam pengelolaan terapi obesitas. Senyawa aktif dalam Jati Belanda dan kedelai dapat berfungsi sebagai inhibitor lipase. Tujuan penelitian ini adalah mengetahui aktifitas lipase dari ekstrak etanol kedelai Detam 1 (EEKD), daun Jati Belanda (EEJB), kombinasi serta hasil fraksionasinya menggunakan metode standar dan modifikasi. Uji aktifitas lipase terhadap EEKD, EEJB, kombinasinya serta fraksi etil asetat, air dan n-heksana menggunakan kit Lipase Liquicolor (HUMANÂ®) dengan prinsip kolorimetri, menggunakan spektrofotometer 580 nm. Metode modifikasi menggunakan 96 well plate, microplate reader 630 nm. Penelitian ini menyimpulkan bahwa aktifitas inhibitor lipase tertinggi didapatkan pada sampel kombinasi EEKD:EEJB perbandingan 1:2, baik menggunakan metode standar maupun metode modifikasi; fraksi yang mengandung aktifitas inhibitor lipase paling tinggi adalah fraksi air kedelai Detam 1 (KD-1) dan air Jati Belanda (JB) pada 100 ppm, serta aktifitas lipase dalam fraksi air JB lebih tinggi dari fraksi air KD-1.

Potency of Black Soybean (Glycine max L. Merr) and Jati Belanda Leaves (Guazuma ulmifolia Lamk) for Dyslipidemia Treatment In Vivo Prahastuti, Sijani; Hidayat, Meilinah; Kurniadi, Michael W.; Christiany, Selvina
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

Soybean Detam 1 and Jati Belanda leaves are potential alternative medicines for treating dyslipidemia. The purpose of this study is to explore Â the potential of the combination of Ethanolic Extract Soybean Detam 1 (EEKD) and Jati Belanda (EEJB) in lowering LDL cholesterol and triglycerides compared to single extract and Simvastatin. Using a real laboratory experimental method with CRD, a total of 36 male Wistar rats were divided into 6 groups and administrated for treatment of 28 days. The results showed a significant decrease of LDL cholesterol as well as triglyceride in NCÂ as compared to P1, P2, P3 (p <0.05) and no significant difference with PC (p> 0.05). The highest suppression of LDL cholesterol between P1 with P2 and P3 is (p <0.05) while the triglyceride is between P1 and P2 (p <0.05). This study concludes that the combination of EEKD 10 mg, 20 mg EEJB, EEKD 30 mg and EEJB 30 mg is significantly lowering LDL cholesterol and triglyceride. The combination of EEKD 10 mg, 20 mg EEJB is the highest compression of LDL cholesterol and triglyceride, and has an equivalent effect with simvastatin in lowering LDL cholesterol and triglycerides in male Wistar rats induced with high fat diet.Â Keywords: LDL cholesterol, triglycerides

Subchronic Treatment of Combination Extract Detam 1 Soybean and Jati Belanda Leaves has No Toxic Effect on Function, Weight, and Histopathological of Wistar Rat Kidney Hidayat, Meilinah; Prahastuti, Sijani; Chikita, Vibiola; Safitri, Dewi; Rahmawati, Siti F.; Soemardji, Andreanus A.
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

The combination of Detam 1 soybean and Jati Belanda leaves proved to have effect of weight loss. Since it will become longterm using, toxicity effectvresearch is needed.Â This study was conducted to determine the effect of subchronic combination of ethanol extract of soybean Detam 1 (EEDS) and Jati belanda (EEJB) on kidney function, with parameters: urea and creatinine, macroscopic and histopathological of kidney. This study were conducted on 120 Wistar rats (60 males, 60 females), 90 days (treatment group) and 120 days (satellite group). Rats were divided into six treatment groups. Test results of urea and creatinine levels of all treatment groups was lower than control group (p <0.05). The treatment turned out to have a good effect on kidney function. Kidney weight of all groups showed no significant difference with the control group (p> 0.05). Histopathological score interpretationâ€™s result of low dose group male and female kidney rats were not disturbed. In conclusion, the combination of EEDS and EEJBÂ have a good effect on kidney function, didÂ not lead to changes in organ weight and at low doses did not cause disturbance ofÂ renal histopathology.Â Key words: combination of soybean jati Belanda, subchronic treatment, kidney function, kidneyâ€™sÂ weight, kidneyâ€™s histopathology

Effect of Chewing Xylitol Gum on Salivary Volume and Acidity Angwarmase, Alfonsa; Tih, Fen; Hidayat, Meilinah
Journal of Medicine and Health Vol. 1 No. 5 (2017)
Publisher : Universitas Kristen Maranatha

Dental caries or tooth decay is a result of the production of acid from fermentation ofbacteria that destroy tooth tissue. It can be prevented by maintaining the stability of salivaryvolume and acidity. Chewing xylitol gum is beneficial for increasing salivary volume andacidity. The aim of the study is to determine the effect of chewing xylitol gum on salivary volumeand acidity. The study is a quasi experiment conducted to 30 males aged between 17-25 yearsold. Pre and post treatmentâ€™s salivary volume are measured with measuring cup. Pre and posttreatmentâ€™s salivary acidity are measured using a pHmeter with 0,1 accuracy. Data areanalyzed with paired â€œtâ€ test (a = 0,05). Average salivary volume after chewing xylitol gumincreased very significantly from 0,26 mL to 13,37mL (p=0,000). Average salivary acidity afterchewing xylitol gum increased very significantyly from 6,47 to 7,36(p=0,000). The researchconcludes that chewing xylitol gum increases salivary volume and acidity.Keywords : dental caries, xylitol, salivary volume, salivary acidity

Blood Calcium Level and Its Correlation with Calcium Daily Intake, Calcium Supplementation & Clinical Symptoms in Women with Premenstrual Syndrome Hidayat, Meilinah; Wardani, Komang RP; Purba, Bertha M; Apreza, Rendhy T
Journal of Medicine and Health Vol. 1 No. 6 (2017)
Publisher : Universitas Kristen Maranatha

Premenstrual syndrome (PMS) is complex of symptoms that occur during the luteal phase of the menstrual cycle. This study aimed to observe blood calcium levels differences between the patient and not the PMS, list the average intake of calcium / day among subjects, statistically analyze the relationship between calcium intake and blood calcium levels, and examine the effect of calcium supplementation on blood calcium levels and symptoms of PMS. We examined blood levels of calcium, analytical survey method using a cross-sectional study, experimental methods and PMS symptom questionnaires. The results showed that in the group of subjects SPM average blood calcium level, and the mean intake of calcium / day were lower than in non-PMS and showed a fairly correlation between the intake of calcium per day with blood calcium levels in SPM subjects. There is a significant relationship between increased calcium blood calcium levels and symptoms of PMS. The conclusions: 1. there are differences in blood calcium levels and 2. intake of calcium per day between patients with PMS and not PMS, 3. Calcium intake is significantly associated with calcium level in the PMS and 4. calcium supplementation affects blood calcium levels and reduce symptoms of PMS.Keywords : average calcium intake, blood calcium, calcium supplementation, Premenstrual Syndrome (PMS)

Hypolipidemic Effects of Pea Protein Hydrolysates on Lipid Profile and Uric Acid in Cisplatin-Induced Nephropathy Rats Hidayat, Meilinah; Prahastuti, Sijani; Soemardji, Andreas A; Hasan, Khomaini; Audrey, Gabriella; Gabriella, Janifer; Luvina, Petrisia; Liempapas, Cicilia; al, et
Journal of Medicine and Health Vol. 2 No. 3 (2019)
Publisher : Universitas Kristen Maranatha

The usage of Cisplatin (CP) can cause side effects such as toxicity and impaired kidneyfunction. Poor kidney function causes dyslipidemia and hyperuricemia. Researchers in Canadastate that pea protein hydrolysates can improve kidney function. The aim was to examine thehypolipidemic effect of 8 types of pea protein hydrolysate on lipid profiles and uric acid in CPinduced rats in purpose to find protein sources origin of Indonesia for kidney therapy. This is atrue experimental study using fifty female Wistar rats divided into 10 treatment groups.Weadministered 8 types of pea protein hydrolysate for 30 days. On day 7 all rats (except negativecontrol) were induced CP intraperitoneally. Study parameters was evaluated on days 12 and30. In general, all treatments showed good hypolipidemic effects, and differed significantly fromCP group (p <0.01). The group that showed lowest total cholesterol, LDL and triglycerideresults is yellow pea protein hydrolysate Neutrase; HDL: green peas protein hydrolysatebromelain, uric acid: protein hydrolysate of pea protein isolate bromelain. As conclusion,protein hydrolysates of pea has good hypolipidemic effects on Lipid profile and Uric Acid inCP-induced nephropathy Rats. Keywords: protein hydrolysates, green peas, neutrase, bromelain, lipid profiles

Title

Found 16 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 16 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 16 Documents
Search