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Hubungan Variasi Genetik Gen FADS pada Suku Sasak Terhadap Angka Kecukupan Gizi Ridha Sasmitha Ajiningrum; Luh Gde Sri Adnyani; Andi Agung Riatmojo; Vira Eka Trie Sanggita; Siti Rahmah
Jurnal Syntax Fusion Vol 2 No 01 (2022): Jurnal Syntax Fusion: Jurnal Nasional Indonesia
Publisher : Rifa' Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/fusion.v2i01.137

Abstract

One of the macronutrients needed by the human body is fat. Fatty acids are divided into two, namely saturated and unsaturated fatty acids. Based on the source of unsaturated fatty acids are divided into two, namely non-essential and essential. Essential fatty acids consist of omega-3 and omega-6 which are part of PUFAs. To determine the relationship of genetic variation of the FADS gene to the nutritional adequacy of long-chain polyunsaturated fatty acids (LC-PUFA) in children of the Sasak ethnic. Systematic reviews were carried out through scientific journals, government guidelines, online portals for journal publications such as Medscape, Google Scholar, PubMed, and Science Direct, with the keyword “Polyunsaturated Fatty Acid (PUFA)” There was a significant relationship between the FADS2 index (DHA: EPA ratio) and MDI score (r = 0.648, p < 0.059) in AG but not in GG genotype. Two genotype models were found, namely homozygous major allele (GG) of rs 174468 which was dominant and heterozygous allele (AG) of Sasak ethnicity. The levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in infants in the Sasak ethnic were found to be higher than infants in other areas. Sasak ethnic children get EPA and DHA from breast milk which contains a lot of DHA. Sources of omega-3 and 6 on the island of Lombok are sea fish, seaweed, and full-blooded shellfish.
Pemeriksaan Fungsi Penghidu Pada Rinitis Alergi Vira Eka Trie Sanggita
Jurnal Syntax Fusion Vol 2 No 01 (2022): Jurnal Syntax Fusion: Jurnal Nasional Indonesia
Publisher : Rifa' Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/fusion.v2i01.140

Abstract

Rhinitis is an inflammation of the lining membrane or nasal mucosa characterized by one or more symptoms such as sneezing, nasal congestion, itchy nose, and rhinorrhea or runny nose. Allergic rhinitis (hay fever) is clinically a disorder of nasal function resulting from an allergic reaction to allergen exposure through an inflammatory process mediated by specific IgE in the nasal mucosa. Allergic rhinitis can also be regarded as a chronic inflammatory disease of the upper respiratory tract with a reported prevalence of around 40% of the general population. The writing of this article was obtained from various sources in the form of scientific journals and guidelines for related institutions. Source searches were carried out on various online portals such as Medscape, NCBI Google Scholar and other health websites with the keyword “Allergic Rhinitis”. Allergic rhinitis is an inflammatory disease of the nasal mucosa caused by exposure to allergens. The prevalence of rhinitis in Indonesia is around 3-4% at the age of 6-7 years and 4-5% at the age of 13-14 years. Allergic rhinitis can occur when a person's immune system reacts to allergens such as dust mites, pollen, pet dander, mold spores, and insects such as cockroaches. Symptoms and signs that can occur in allergic rhinitis include runny nose, nasal congestion, itching in the nose, ears, throat, and palate, sneezing, coughing, headache, snoring due to nasal obstruction, and decreased sense of smell and taste. Allergic rhinitis that occurs in childhood worsens with age. The diagnosis of olfactory function in allergic rhinitis begins with anamnesis, physical examination and supporting examinations such as imaging and olfactory chemosensory examinations such as the UPSIT (University of Pennsylvania Small Identification) test, The Connectitut Chemosensory Clinical Research Center (CCCRC) test, and the "Sniffin Sticks test".