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Efficacy of N-Acetylcysteine (NAC) Against Malondialdehyde (MDA) Levels in Diabetic Cataracts: In vivo Study Dining Pratidina; M. Hidayat; Andrini Ariesti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.558

Background: Diabetes mellitus is a systemic condition that affects various organs, including the eyes. N-acetylcysteine (NAC) functions as an antioxidant because it belongs to a thiol group synthesis glutathione. However, the availability of cysteine in the body is only 15%, so cysteine supplementation can help with oxidative stress in diabetic cataracts. That it will prevent the reaction of lipid peroxidase and the formation of PUFA in the lens membrane, which causes damage to lens cells and is characterized by an increase in malondialdehyde. This study aims to determine the comparison of malondialdehyde levels in the lenses of diabetic cataract rats given or without topical NAC. Methods: 36 rats were divided into the control group (received streptozotocin) and treatment group (received streptozotocin and topical NAC. Intraperitoneal injection of streptozotocin was given 90 mg/kg BW and performed once a week for 3 weeks. GDP examination was performed the next day after the rats fasted for 16 hours from the vein. In the tail, GDP > 110 mg/dl categorized as diabetes. Topical NAC was given 4 times per day for 3 weeks. At the end of the study, the lens was extracted for the measurement of malondialdehyde. Results: The mean MDA levels in the control group were higher (2.90±0.71nmol/ml) than in the treatment group (2.33±0.38nmol/ml), p<0.05. Conclusion: NAC was effective in reducing oxidative stress levels in diabetic cataract lenses by lowering MDA levels better than the group that did not receive MDA in vivo.

Efficacy of N-Acetylcysteine (NAC) Against Malondialdehyde (MDA) Levels in Diabetic Cataracts: In vivo Study Dining Pratidina; M. Hidayat; Andrini Ariesti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.558

Background: Diabetes mellitus is a systemic condition that affects various organs, including the eyes. N-acetylcysteine (NAC) functions as an antioxidant because it belongs to a thiol group synthesis glutathione. However, the availability of cysteine in the body is only 15%, so cysteine supplementation can help with oxidative stress in diabetic cataracts. That it will prevent the reaction of lipid peroxidase and the formation of PUFA in the lens membrane, which causes damage to lens cells and is characterized by an increase in malondialdehyde. This study aims to determine the comparison of malondialdehyde levels in the lenses of diabetic cataract rats given or without topical NAC. Methods: 36 rats were divided into the control group (received streptozotocin) and treatment group (received streptozotocin and topical NAC. Intraperitoneal injection of streptozotocin was given 90 mg/kg BW and performed once a week for 3 weeks. GDP examination was performed the next day after the rats fasted for 16 hours from the vein. In the tail, GDP > 110 mg/dl categorized as diabetes. Topical NAC was given 4 times per day for 3 weeks. At the end of the study, the lens was extracted for the measurement of malondialdehyde. Results: The mean MDA levels in the control group were higher (2.90±0.71nmol/ml) than in the treatment group (2.33±0.38nmol/ml), p<0.05. Conclusion: NAC was effective in reducing oxidative stress levels in diabetic cataract lenses by lowering MDA levels better than the group that did not receive MDA in vivo.

Comparison of Central Corneal Thickness and Lamina Cribrosa Thickness in Ethnic Indians and Ethnic Malays as Predictors of Glaucomatous Optic Neuropathy Meironi Waimir; Andrini Ariesti; Ardizal Rahman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.655

Background: Glaucoma poses a public health problem because it is the second leading cause of blindness after cataracts. A thinner central corneal thickness (CCT) is also a contributor to the development of primary open-angle glaucoma (POAG). Lamina cribrosa (LC) is a structure of the optic nerve head (ONH). LC structural changes such as thinning, posterior displacement, and connective tissue deficiency are associated with the mechanism of retinal nerve fiber layer (RNFL) thickness damage, leading to glaucomatous optic neuropathy. Methods: Cross-sectional analytic observational study. A total of 36 eyes from 36 research subjects participated in this study. Data analysis was carried out using SPSS version 25. Then, univariate and bivariate analyzes were carried out to see the difference in CCT and LC thicknesses. Results: The average CCT in ethnic Indians is 514.33 ± 14,142 μm and in ethnic Malays, 542.06 ± 17,234 μm. In this study, there were differences in the average CCT in Indian ethnicity and Malay ethnicity, which was statistically meaningful with a p-value = 0.000. Conclusion: There are differences in the average central corneal thickness and lamina cribrosa thickness in ethnic Indians compared to ethnic Malays, where the central corneal thickness and lamina cribrosa thickness in ethnic Indians are thinner than ethnic Malays.

Comparison of Central Corneal Thickness and Lamina Cribrosa Thickness in Ethnic Indians and Ethnic Malays as Predictors of Glaucomatous Optic Neuropathy Meironi Waimir; Andrini Ariesti; Ardizal Rahman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.655

Background: Glaucoma poses a public health problem because it is the second leading cause of blindness after cataracts. A thinner central corneal thickness (CCT) is also a contributor to the development of primary open-angle glaucoma (POAG). Lamina cribrosa (LC) is a structure of the optic nerve head (ONH). LC structural changes such as thinning, posterior displacement, and connective tissue deficiency are associated with the mechanism of retinal nerve fiber layer (RNFL) thickness damage, leading to glaucomatous optic neuropathy. Methods: Cross-sectional analytic observational study. A total of 36 eyes from 36 research subjects participated in this study. Data analysis was carried out using SPSS version 25. Then, univariate and bivariate analyzes were carried out to see the difference in CCT and LC thicknesses. Results: The average CCT in ethnic Indians is 514.33 ± 14,142 μm and in ethnic Malays, 542.06 ± 17,234 μm. In this study, there were differences in the average CCT in Indian ethnicity and Malay ethnicity, which was statistically meaningful with a p-value = 0.000. Conclusion: There are differences in the average central corneal thickness and lamina cribrosa thickness in ethnic Indians compared to ethnic Malays, where the central corneal thickness and lamina cribrosa thickness in ethnic Indians are thinner than ethnic Malays.

Risk Factors Associated with Intraocular Pressure and the Correlation of Central Corneal Thickness to Actual Intraocular Pressure in Myopia Patients Hadwer Wicaksono Pandjaitan; Andrini Ariesti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1112

Background: Myopia, a prevalent refractive error, is associated with an increased risk of glaucoma, a leading cause of irreversible blindness. Central corneal thickness (CCT) is a key factor in glaucoma assessment, as thinner corneas can lead to underestimation of intraocular pressure (IOP). This study aimed to investigate the correlation between CCT and actual IOP in myopic patients, considering various risk factors that may influence IOP. Methods: This cross-sectional study included myopic patients aged 20-25 years. Participants underwent comprehensive ophthalmic examinations, including visual acuity assessment, autorefraction, CCT measurement using optical coherence tomography (OCT), and Goldmann applanation tonometry for IOP measurement. IOP values were corrected for CCT. Statistical analysis was performed using ANOVA, Pearson correlation tests, and multivariate regression analysis to identify independent risk factors for elevated IOP. Results: A total of 78 eyes from 78 participants were analyzed. The mean CCT was significantly thinner in moderate myopia compared to mild myopia and emmetropia (p = 0.000). While IOP was lower in moderate myopia, the actual IOP, after CCT correction, was not significantly different among the groups (p = 0.078). A strong positive correlation was found between CCT and IOP (r = 0.737, p = 0.000), and a moderate negative correlation was observed between CCT and actual IOP (r = -0.492, p = 0.000). Multivariate regression analysis identified axial length (p = 0.021) and family history of glaucoma (p = 0.038) as independent risk factors for elevated IOP. Conclusion: This study highlights the importance of CCT assessment in myopic patients, as thinner corneas can mask elevated IOP. Regular eye examinations, including CCT and IOP measurements, are crucial for early detection and management of glaucoma in this high-risk population. Axial length and family history of glaucoma were identified as independent risk factors for elevated IOP, emphasizing the need for comprehensive risk assessment in myopic individuals.

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