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Correlation of Malignancy in the Hepato-Pancreato-Biliary System with Serum Bilirubin Levels in Extrahepatic Cholestasis Patients Rizqy Tansa; M. Iqbal Rivai; Avit Suchitra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.566

Background: The incidence of hepato-pancreato-biliary system cancer is increasing worldwide, which has been recognized as a disease that is difficult to diagnose early and has a poor prognosis. No research has yet been conducted in areas with limited resources and health facilities. There is an urgent need for diagnostic methods to recommend further diagnostic modalities in the selection of curative or palliative management. Methods: Retrospective data from all cholestatic patients at Dr. M. Djamil General Hospital were collected during the period July 2020-May 2022. The data included demographic characteristics such as age, gender, preoperative, results of bilirubin fraction, and final diagnosis. Data analysis was done by bivariate and multivariate. Results: A total of 132 patients were included in this study. 35.6% of them are HPB system malignancies, with Pancreatic Adenocarcinoma being the most common diagnosis (34.4%), more in males (51.06%), and in the age group, 50 years (61.71%) is the most. Only 52.27% of patients underwent preoperative radiological imaging. Bivariate analysis showed a significant relationship between HPB system malignancies with age >50 years (p=0.024) and all bilirubin fractions (p<0.001). Multivariate analysis showed that only the bilirubin fraction was significant for the diagnosis of malignant HPB (p<0.001). Conclusion: The bilirubin fraction is a good initial indicator for predicting malignancy in the HPB system in order to increase the effectiveness of the diagnostic modality and reduce the referral duration.

Correlation of Malignancy in the Hepato-Pancreato-Biliary System with Serum Bilirubin Levels in Extrahepatic Cholestasis Patients Rizqy Tansa; M. Iqbal Rivai; Avit Suchitra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.566

Background: The incidence of hepato-pancreato-biliary system cancer is increasing worldwide, which has been recognized as a disease that is difficult to diagnose early and has a poor prognosis. No research has yet been conducted in areas with limited resources and health facilities. There is an urgent need for diagnostic methods to recommend further diagnostic modalities in the selection of curative or palliative management. Methods: Retrospective data from all cholestatic patients at Dr. M. Djamil General Hospital were collected during the period July 2020-May 2022. The data included demographic characteristics such as age, gender, preoperative, results of bilirubin fraction, and final diagnosis. Data analysis was done by bivariate and multivariate. Results: A total of 132 patients were included in this study. 35.6% of them are HPB system malignancies, with Pancreatic Adenocarcinoma being the most common diagnosis (34.4%), more in males (51.06%), and in the age group, 50 years (61.71%) is the most. Only 52.27% of patients underwent preoperative radiological imaging. Bivariate analysis showed a significant relationship between HPB system malignancies with age >50 years (p=0.024) and all bilirubin fractions (p<0.001). Multivariate analysis showed that only the bilirubin fraction was significant for the diagnosis of malignant HPB (p<0.001). Conclusion: The bilirubin fraction is a good initial indicator for predicting malignancy in the HPB system in order to increase the effectiveness of the diagnostic modality and reduce the referral duration.

Comparison of Incident of Chronic Pain Post Operations of Preperitoneal Transabdominal Herniorafi Laparoscopy (TAPP) and Totally Extraperitoneal (TEP) in General Hospital Dr. M. Djamil Padang Yudi Ichsan Ramata; M.Iqbal Rivai; Avit Suchitra
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.278

Introduction : Inguinal herniation is a protrusion of peritoneal component through abdominal wall caused by the weakness of aponeurotica tissue of abdomen. Inguinal herniation is the most common herniation cases in which 291.145 patient registered in Indonesia at 2012 and 87 patients in General Government Hospital of M. Djamil Padang at 2017-2018. Herniation treatment is consisted of herniorrhapy laparoscopy using the TEP or TAPP techniques and both of them are related to the incidence of chronical post-operative pain that was defined by IASP as an uncomfortable sensation lasting for more than 3 months. Method: This research was using retrospective study design. The research was conducted at RSUP Dr. M. Djamil Padang in August – October 2020 with 54 samples. Result: The study found there was 54 cases of inguinal herniation fit to the inclusion criteria with peak age of 82 years old and average of 59.1 years old. Most patients were male (79.62 %). There were 2 patients having chronic pain (7.41%) after herniorrhapy using the TAPP technique and 1 more (3.71%) having chronic pain with TEP technique. Bivariate analysis was done by Fisher Exact Test and the study concluded there was no statistical significance in relationship of chronic post-operative pain incidence with the particular technique chosen at herniorrhapy laparoscopy (p=1.000). Conclusion:There was no significant relationship between the incidence of postoperative chronic pain in patients undergoing laparascopic hernioraphy and TEP or TAPP procedure.

The Effect of Giving Fermented Milk Starter Lactococcus lactis D4 Dadih on Obstructive Jaundice: An In Vivo Study Syahriandra; M. Iqbal Rivai; Irwan; Ade Sukma; Tofrizal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 15 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i15.691

Background: Every 1 person out of 3 people with obstructive jaundice will die from complications of obstructive jaundice. The absence of bile salts causes the loss of the protective layer of the intestinal mucosa, which causes an increase in the permeability of the intestinal wall, triggering the process of translocation of various bacteria from the intestinal tract to the blood circulation so that it can trigger septicemia and sepsis. Dadih or commonly known as ampiang dadih is a fermented buffalo milk product. Dadih contains lactic acid bacteria microbiota, which can function as probiotics fermented milk starter Lactococcus lactis D4 dadih to small intestine in obstructive jaundice in vivo. Methods: This study was an in vivo experimental study using 30 wistar rats, which were divided into 3 test groups. Observation of the condition of the small intestine was carried out histopathologically to assess the inflammatory process and the condition of the intestinal mucosa. Data analysis was performed using SPSS version 25 using univariate and bivariate methods. Results: Group 3 showed minimal histopathological inflammation compared to the control and was statistically different, p<0.05. Conclusion: Giving fermented milk starter Lactococcus lactis D4 dadih was able to reduce the inflammatory response and repair the intestinal mucosa in conditions of obstructive jaundice in vivo studies.

The Effect of Giving Fermented Milk Starter Lactococcus lactis D4 Dadih on Obstructive Jaundice: An In Vivo Study Syahriandra; M. Iqbal Rivai; Irwan; Ade Sukma; Tofrizal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 15 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i15.691

Background: Every 1 person out of 3 people with obstructive jaundice will die from complications of obstructive jaundice. The absence of bile salts causes the loss of the protective layer of the intestinal mucosa, which causes an increase in the permeability of the intestinal wall, triggering the process of translocation of various bacteria from the intestinal tract to the blood circulation so that it can trigger septicemia and sepsis. Dadih or commonly known as ampiang dadih is a fermented buffalo milk product. Dadih contains lactic acid bacteria microbiota, which can function as probiotics fermented milk starter Lactococcus lactis D4 dadih to small intestine in obstructive jaundice in vivo. Methods: This study was an in vivo experimental study using 30 wistar rats, which were divided into 3 test groups. Observation of the condition of the small intestine was carried out histopathologically to assess the inflammatory process and the condition of the intestinal mucosa. Data analysis was performed using SPSS version 25 using univariate and bivariate methods. Results: Group 3 showed minimal histopathological inflammation compared to the control and was statistically different, p<0.05. Conclusion: Giving fermented milk starter Lactococcus lactis D4 dadih was able to reduce the inflammatory response and repair the intestinal mucosa in conditions of obstructive jaundice in vivo studies.

Lactococcus Lactis D4 Starter Fermented Milk’s Effect on Liver Function of Obstructive Jaundice Model Hannan Khairu Anami; M. Iqbal Rivai; Avit Suchitra; Irwan Irwan; Rini Suswita; Juni Mitra
Indonesian Journal of Multidisciplinary Science Vol. 2 No. 5 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Obstructive jaundice can cause liver function damage which exacerbates patient morbidity and mortality. Fermented milk starter Lactococcus Lactis D4 derived from dadih is a probiotic that has the potential to improve liver function through the enterohepatic pathway. The research would like to determine the effect of Lactococcus Lactis D4 starter fermented milk on liver function of obstructive jaundice. This study was an experimental study with a post test only randomized control group design in 3 groups of Rattus Novergicus strain Wistar rats with obstructive jaundice model which got ligation of biliary ducts and given Lactococcus lactis D4 starter fermented milk for 7 days. Liver function was assessed by looking at the levels of total bilirubin, SGOT, SGPT, ALP, and GGT in each treatment group. Administration of Lactococcus Lactis D4 starter fermented milk caused a decrease in SGOT levels (LDB + BAL vs LDB: 51.12 ± 1.77 U/L vs 64.63 ± 0.10 U/L, p<0.05) and SGPT (LDB + LAB vs LDB: 60.60±0.85 U/L vs 67.77±2.60 U/L, p<0.05) which was significant. However, there was no significant effect on total bilirubin levels (LDB + BAL vs LDB: 3.21±0.11 mg/dl vs 3.18±0.10 mg/dl, p>0.05), ALP (LDB + LAB vs LDB: 108.20 ± 2.78 U/L vs 115.38 ± 5.08 U/L, p>0.05), and GGT (LDB + LAB vs LDB: 12.57 ± 0.45 U/L vs 12.78±0.31 U/L, p>0.05). Lactococus Lactis D4 starter fermented milk can improve liver function which is indicated by a decrease in SGOT and SGPT levels in experimental animals.

Panduan Pelayanan Bedah Digestif Selama Masa Pandemi COVID-19: Perhimpunan Dokter Spesialis Bedah Digestif Indonesia (IKABDI) Adianto Nugroho; Fransicus Arifin; Perwira Widianto; Agung Ari Wibowo; A. Yuda Handaya; Iwan Kristian; M Iqbal Rivai; Made Mulyawan; Mohammad Niam; Parish Budiono; Mamiek Dwi Putro; Warsinggih
Majalah Kedokteran Indonesia Vol 70 No 6 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.6-2020-239

Digestive surgery service including surgical management of gastrointestinal disease and digestive cancers are experiencing the impact of COVID-19 pandemic. Therefore it is necessary to formulate recommendation for digestives surgery service, as guidelines to engage in case-by-case assessment of particular patients with digestive diseases. We are aware that the knowledge and science of COVID-19 are still evolving, with new progression every day. This recommendation reflect actual condition and are subject for future adjustment in the future.

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