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All Journal Buletin Veteriner Udayana
Genta Dhamara Adam Putranto
Praktisi Dokter Hewan, Jl. Mekar Baru 1 No. 70 Cireundeu, Ciputat Timur, Tangerang Selatan, Banten
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Standarisasi Cemaran Mikroba Sampel Daun Pegagan sebagai Persyaratan Mutu Bahan Baku Sediaan Obat Luh Made Sudimartini; Genta Dhamara Adam Putranto; I Gusti Ketut Suarjana; I Made Merdana
Buletin Veteriner Udayana Vol. 14 No. 4 August 2022
Publisher : The Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (236.117 KB) | DOI: 10.24843/bulvet.2022.v14.i04.p01

Abstract

Pegagan is an excellent plant used as a raw material for traditional medicine. The bioactive content in pegagan leaves plays a role in the wound healing process, able to cure complex dermatitis in dogs, proven as neuroprotective, and can reduce oxidative stress of body cells. Many efficacies make pegagan leaves have the potential to be produced into various forms of medicinal preparation. This study will calculate the number of microbes’ contamination in pegagan leaves which will be used as various drug preparations and then compare it to the General Standard Parameters for Medical Plant Extracts of the Ministry of Health of Republic Indonesia in 2000 and Regulation of the Head of BPOM RI Number 32 of 2019. The examination of microbial contamination was carried out through the Total Plate Count and Yeast Fungus Test. The research data obtained were quantitative data that were analyzed by counting the number of microbes that grow on PCA and PDA after incubation at the appropriate growth temperatures. The results of this study show that the Total Plate Count from the sample was 3250 CFU/gr and the Yeast Fungus Test was 450 CFU/gr. The number of Total Plate Count has fulfilled the requirements for the Oral Drugs (£105 colony/gr) and required for Semi Solid Drugs (£107 colony/gr). The number of Yeast Fungus Test are required for Oral Drugs (£103 colony/gr) and required for Semi Solid Drugs (£104 colony/gr).
Co-Authors I Gusti Ketut Suarjana I Made Merdana Luh Made Sudimartini