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All Journal Jurnal Ilmu Komputer dan Agri-Informatika
Chamdan L Abdulbaaqiy
Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Computer Science & IT

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Pemodelan Berbasis Jaringan untuk Pengklasifikasian Kanker Payudara Berdasarkan Data Molekuler Mushthofa; Chamdan L Abdulbaaqiy; Sony Hartono Wijaya; Muhammad Asyhar Agmalaro; Lailan Sahrina Hasibuan
Jurnal Ilmu Komputer dan Agri-Informatika Vol 9 No 1 (2022)
Publisher : Departemen Ilmu Komputer, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jika.9.1.101-113

Abstract

Cancer is a disease characterized by uncontrolled cell growth. One of the characteristics of uncontrolled growth is the presence of estrogen-receptor-positive (ER+). About 67% of breast cancer test results have ER+. Breast cancer profiles are divided into 4 subtypes, namely: Luminal A, Luminal B, basal-like, and HER-2 enriched. Each category has a different effect on adjuvant chemotherapy. In this study, a network-based approach was used to select features/molecular biomarkers that have the potential to assist modeling and classifying sub-types of breast cancer. The molecular features used are Copy Number Alteration (CNA) and gene expression. The feature selection results were compared with the PAM50 feature-based accuracy from the literature study. The results indicate that the features selected from this network-based approach can obtain a comparable performance w.r.t the original PAM50 features, and can be used as alternative to perform breast cancer subtyping.
Co-Authors Hasibuan, Lailan Sahrina Muhammad Asyhar Agmalaro Mushthofa Mushthofa Sony Hartono Wijaya