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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana
Budi Utomo
Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Immunology & microbiology Public Health Other

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Longer Lag Time in Early-Stage Retinoblastoma Anindya Citra; Budi Utomo; Hendrian Dwikoloso Soebagjo
Folia Medica Indonesiana Vol. 58 No. 2 (2022): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (720.645 KB) | DOI: 10.20473/fmi.v58i2.24975

Abstract

Highlights: Patients with IRSS I stage have the longest lag time than IVB stage. Lag time is no significant with stage retinoblastoma.   Abstract: Retinoblastoma is a rare neoplasm disease that occurs in children, generally under the age of two. Retinoblastoma is more prevalent in developing countries and is often associated with a late diagnosis. Such delays can lead to a poor prognosis. The time from the appearance of symptoms of retinoblastoma (onset) to the time of diagnosis is called lag time. Early diagnosis of retinoblastoma by paying attention to factors such as age, clinical symptoms, and laterality can help improve retinoblastoma survival rates, especially in developing countries. The purpose of this study was to analyze the relationship between the lag time to the stage of retinoblastoma patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. This study was a retrospective analytical observational study using secondary data from retinoblastoma patients at the Ophthalmology Outpatient Unit at Dr. Soetomo General Academic Hospital, Surabaya, from January 2014 to December 2018. The data were analyzed using Kendall's tau-C test. No significant correlation was found between lag time and stage (p = 0.339). Patients with International Retinoblastoma Staging System (IRSS) I stage had the longest lag time (on average 28 months), and patients with stage IVB had the shortest lag time (on average four months). There was no correlation between lag time and retinoblastoma stage. However, there was a trend of patients with early stages delaying hospital visits, while patients with advanced stages in earlier to the hospital.
Optimal Dose of Vitamin D For Covid-19 Treatment Dita Mega Utami; Muhammad Abdurrahman Rasyid Ash-Siddiq; Desi Rianti Rahmahani; Muhammad Iqbal Mubarok; Muhammad Zulkifly Tasman; Jeremy Nicolas Sibarani; Habibah Teniya Ariq Fauziyah; Budi Utomo; Shifa Fauziyah
Folia Medica Indonesiana Vol. 58 No. 4 (2022): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (838.38 KB) | DOI: 10.20473/fmi.v58i4.36474

Abstract

Highlights: Vitamin D supplementations in different doses yield different outcomes. Multi-day vitamin D administration of 1000-6000 IU in patients with COVID-19 has more positive impacts than a single high dose of vitamin D. Patient morbidity, length of hospitalization, and patient mortality improved with multi-day vitamin D administration.   Abstract: This meta-analysis aimed to determine whether there is any optimal dose of vitamin D for morbidity, length of hospitalization, and mortality in patients with COVID-19. We conducted a comprehensive search in three online databases for eligible studies until February 28, 2022. Odds ratio (OR) and standardized mean difference (SMD) were applied as summary statistics of primary outcomes. The study quality of the literatures collected was assesed using the Cochrane risk of bias tool version 2 (RoB 2). Eight randomized clinical trials (RCT) were included in the study. In our analysis, we found that there was no significant difference in morbidity when vitamin D was administered to COVID-19 patients [OR=0.50 (95% CI=0.13-1.96); SMD=-0.14 (95% CI=-0.55-0.28)]. Duration of hospitalization [SMD=-0.12 (95% CI=-0.39-0.15)] and mortality [OR 0.47 (95% CI=0.19-1.17)] of COVID-19 patients in five studies also showed no significant difference compared to patients who do not take vitamin D. However, when we analyzed two other studies, we found that in patients who did not take vitamin D, mortality was lower [SMD=0.43 (95% CI=0.29, 0.58)]. Compared to a single high dose of vitamin D, the multi-day vitamin D administration of 1000-6000 IU in patients with COVID-19 resulted in improved patient morbidity, length of hospitalization, and patient mortality.
Antifungal Activity of Rosemary (Rosmarinus officinalis L.) Emulsion Gel Compared to Nystatin on Candida albicans Stored Isolate from HIV/AIDS Patients with Oral Candidiasis Maya Wardiana; Astindari; Evy Ervianti; Afif Nurul Hidayati; Diah Mira Indramaya; Pepy Dwi Endraswari; Budi Utomo; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 2 (2023): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.2.2023.88-92

Abstract

Background: Oral candidiasis (OC), frequently caused by Candida albicans, is the most common opportunistic infection in HIV/AIDS patients. Topical treatment for OC is limited. In vitro study revealed rosemary (Rosmarinus officinalis L.) essential oil has an antifungal effect. However, the essential oil is volatile and is not recommended to be applied to the skin and mucosa; therefore, emulsion gel (emulgel) is made. Purpose: This study was conducted to evaluate the antifungal activity of rosemary emulgel 6.25%, 25%, 37.5%, and 50% compared to nystatin. Methods: This study is an in vitro test using the disk diffusion method to d  etermine the antifungal activity shown by the inhibitory zones of rosemary emulgel at 6.25%, 25%, 37.5%, and 50% compared to nystatin to stored isolates of C. albicans from HIV/AIDS patients with OC. Result: Rosemary emulgel 6.25% dan 25% did not show antifungal activity because no inhibitory zone was shown. The inhibitory zone diameter provided by rosemary emulgel 37.5%; 50%; and nystatin against C. albicans isolates were 3.17±3.763 mm; 7.00±4.107 mm; and 30.13±5.319 mm respectively. Significant differences in antifungal activity were shown by the inhibitory zone diameter provided between rosemary emulgel 37.5%, 50%, and nystatin (p<0,05). Conclusion: Rosemary emulgel 37.5% dan 50% had antifungal activity showed by the formation of inhibitory zone against Candida species isolates in disk diffusion method even though it was weaker compared to nystatin as a standard antifungal.
The Use of Comics as a Tuberculosis Learning Medium for Junior High School Students Budi Utomo; Widati Fatmaningrum; Sulistiawati; Shifa Fauziyah; Teguh Hari Sucipto; Chan Chow Khuen
Folia Medica Indonesiana IN-PRESS ISSUE
Publisher : Universitas Airlangga

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Abstract

Highlights:  1. Comics centered around tuberculosis offer a novel method tailored for specific audiences, specifically children or those of school age, to learn about the disease. 2. The tuberculosis comics feature the etiology, prevention, and treatment of tuberculosis conveyed through their unique design. 3. Comics can be an innovative promotional method to support the preventive campaign against tuberculosis.    Abstract As a tropical country, Indonesia continues to grapple with the prevalence of tuberculosis. This study, conducted by the Department of Public Health and Preventive Medicine at Universitas Airlangga, Surabaya, Indonesia, presents a novel approach to preventive measures that is tailored to the socio-cultural context of the population. Specifically, it involves the use of tuberculosis comics. This study aimed to assess the effectiveness of comics as an educational tool to inform junior high school students about tuberculosis. This research was quasi-experimental, with a one-group pretest-posttest design. This study was carried out in Dukun District, Gresik, Indonesia, in 2022. As many as 70 junior high school students participated in this study. Each participant received a questionnaire consisting of ten questions about tuberculosis. Afterward, tuberculosis education was implemented through the use of comics. The post-test was carried out using the same questions as the pretest. The data were analyzed using the R Program for Windows, version 4.1.3 (Auckland University, New Zealand). The analysis revealed a significant difference between the pretest and posttest results (p<0.0001). As indicated by the data, comics proved to be an effective method of educating people about infectious diseases, specifically tuberculosis. Here, we introduce an educational tool designed to revitalize the educational method for disseminating knowledge about infectious diseases. Ultimately, comics can increase students' interest in learning about tuberculosis, including its etiology, prevention, and treatment strategies. 
Co-Authors Afif Nurul Hidayati Anindya Citra Astindari Chan Chow Khuen Desi Rianti Rahmahani Diah Mira Indramaya Dita Mega Utami Dwi Murtiastutik Evy Ervianti Habibah Teniya Ariq Fauziyah Hendrian Dwikoloso Soebagjo Jeremy Nicolas Sibarani Maya Wardiana Muhammad Abdurrahman Rasyid Ash-Siddiq Muhammad Iqbal Mubarok Muhammad Zulkifly Tasman Pepy Dwi Endraswari Shifa Fauziyah Shifa Fauziyah Sulistiawati Teguh Hari Sucipto Widati Fatmaningrum