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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya ISM (Intisari Sains Medis) : Jurnal Kedokteran

Evy Ervianti

Departement Of Dermatology And Venereology, Faculty Of Medicine Universitas Airlangga/Dr. Soetomo General Academic Hospital, Universitas Airlangga Teaching Hospital, Surabaya

Author-ID : 563329

Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Secreted Aspartyl Proteinase[SAP] Enzyme Proï¬le on Vulvovaginalis Candidiasis Patients isolates Nugrahaeni, Diah; Agusni, Indropo; Ervianti, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Vulvovaginalis candidiasis (VVC) is an infection caused by various types of Candida, themost is Candida albicans. Candida produces two main enzymes that play a role in virulence, the secreted aspartyl proteinase (SAP) enzyme and the phospholipase enzyme. SAP is most widely produced by Candida albicans,which is one of the main pathogenicfactor of Candida infection. SAP is often found in cases of recurrent candidiasis vulvovaginalis (RVVC) Purpose: To evaluatethe SAP activity produced by VVC patients isolates. Methods: Descriptive observational cross-sectional study was conducted on 21 VVC patients to determine the SAP enzyme levels in VVC patients in Sexually Transmitted Infection (STI) Division, Outpatient Clinic Of Dermatology and Venerology, Dr. Soetomo General Hospital, Surabaya.Vaginal smear was examined to determine levels of SAP and culture examination to determine the kind of candida spesies that causes VVC. Results: Total subject of study are 21 patients. Twelve ofÂ 21 patients had SAP > 20 mm in diameter, 7 patients with SAP < 20 mm in diameter, and 2 patients with negative results of SAP. Fifty patients due to Candida albicans, 6 patients caused by non-albicans. Nine patients were accompanied by diabetes mellitus (DM), 1 patients by genital affection, 2 patients by condylomata acuminata. Additionally obtained in 10 patients who had previously received treatment with the results diameter SAP > 20 mm and 7 patients with of SAP diameter < 20 mm, 2 patients showed negative results of SAP. Conclusions: SAP was mainly produced by Candida albicans. SAP became more active in VVC patients that accompanied by diabetes melitus, affectiogenitalis, condylomata acuminate, and also in some patients who have received prior antifungal therapy.Key words: secreted aspartyl proteinase, vulvovaginalis candidiasis, Candida albicans,

Studi Retrospektif: Psoriasis Pustulosa Generalisata Gayatri, Lunni; Ervianti, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Latar belakang: Angka kejadian kasus psoriasis pustulosa di Indonesia belum diketahui. Selama ini belum pernah dilakukan penelitian retrospektif terhadap penyakit psoriasis pustulosa generalisata. Tujuan: Mengevaluasi gambaran kasus psoriasis pustulosa generalisata untuk meningkatkan mutu pelayanan terhadap pasien di masa mendatang. Metode: Studi retrospektif pasien psoriasis pustulosa generalisata yang dirawat inap di Instalasi Rawat Inap Kulit dan Kelamin RSUD Dr. Soetomo Surabaya selama periode 1 Januari 2001 sampai 31 Desember 2011. Dilakukan penelitian mengenai jumlah kasus, umur, jenis kelamin, anamnesis, pemeriksaan fisik, diagnosis, pemeriksaan penunjang, dan terapi yang diberikan. Hasil: Didapatkan 21 pasien psoriasis pustulosa generalisata dari pengamatan selama 11 tahun. Kasus terbanyak terjadi pada usia antara 2140 tahun (57,1%), pasien perempuan lebih banyak daripada lakilaki (16:5). Pemeriksaan histopatologi dilakukan pada 15 pasien dengan hasil 80% sesuai dengan gambaran psoriasis pustulosa. Terapi methotrexate diberikan pada seluruh pasien, dengan hasil 52,3% pasien dinyatakan mulai sembuh saat pasien keluar rumah sakit. Simpulan: Kasus psoriasis pustulosa generalisata setiap tahun berjumlah 13 pasien. Diagnosis ditegakkan berdasarkan anamnesis, gejala klinis, kemudian dicocokkan dengan hasil patologi anatomi. Kata kunci: pustula, psoriasis pustulosa generalisata, methotrexate.

Profile of Peanut Spesific-IgE in Atopic Dermatitis L, Indiarsa Arief; Lumintang, Hans; Ervianti, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background : Atopic Dermatitis (AD) is a chronic reccurent disease. One of the environmental factors which possibly involved in the reccurency of AD is food allergy such as peanut. Peanut allergy in the pathogenesis of AD is by induction IgE and T cells. Peanut-spesific IgE allergen are observed in AD patient. Purpose: To identify the distibution of serum IgE concerning the peanut antigens according to AD. Methods:This trial was cross sectional descriptive study, which studied 33 atopic dermatitis patients, which fulfill inclution criterias.We describe the anamnesis, physical examination, peanut-spesific IgEÂ and the severity of AD using SCORAD index. Results: There were 7 patients (21,2%) with positive result of peanut-spesific IgE. The positive result of peanut-spesific IgE were noted most often on AD patients who suffer from severe grade of AD severity score (85,7%) but not found in class 3 or more (where antibody can detect significanly, often clinical manifestasion appeared when had sensitisation). Conclusion: The positive result of peanut-spesific IgE class 1 (0,35- 0,7 IU/mL)Â 5 people (15,1%) andÂ class 2 (0,7-3,5 IU/mL) 2 people (6,1%) were noted most often on AD patients who suffer from severe grade of AD severity scoreKey words: atopic dermatitis, peanut-spesific IgE.

Profile of Malassezia Folliculitis Pravitasari, Dwi Nurwulan; Suyoso, Sunarso; Ervianti, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Malassezia folliculitis (MF) is a chronic infection of the pilosebaceous follicles caused by a skin fungus Malassezia sp. most often in teenagers who marked the onset of itchy erythematous perifolicular papules and pustules, especially in the upper body area and rarely on the face. The clinical appearance must be distinguished from acne vulgaris which has a similar clinical picture, so often have the wrong diagnosis that will affect the prognosis of the disease. Objective: To evaluate the profile of MF in Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital. Methods: A cross-sectional, observational, descriptive study, total samplingin three months of forty-five new patients with acne vulgaris appearance visiting Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital according to inclusion and exclusion criteria. Diagnosis based on history, clinical examination, Woods lamp and KOH 20%. Malassezia sp. identification using Mycobiotic culture that is added to the olive oil. Results: Forty five patients with a clinical appearance of acne vulgaris in the upper body and slightly exposed on the face area, the new MF patients showed a total of 36 patients (80%) and the remaining 9 patients (20%) were diagnosed with acne vulgaris. Conclusions:Thirty six MF patients with the highest age range 15-24 years, anamnesis obtained itching is moderate grade, predilection in the area of the upper body, and Woods Lamp examination produces greenish yellow color, KOH 20% examination obtained spores, whereas culture is not required for the diagnosis of MFKey words: Malassezia sp., Malassezia folliculitis, acne vulgaris, Woods lamp, KOH 20%.

Clinical Profile of Psoriasis Vulgaris at Soetomo General Hospital, Surabaya Nadya Kelfinta Hanani; Evy Ervianti; Alphania Rahniayu
Health Notions Vol 4, No 9 (2020): September
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn40902

Psoriasis vulgaris is a progressive chronic inflammatory skin disease. The prevalence of psoriasis vulgaris in the world, and in Indonesia itself. Psoriasis vulgaris brings a negative effect on patient’s physical, emotional and psychosocial aspect. This study as aimed to evaluate the clinical profile of psoriasis vulgaris in the Soetomo General Hospital Surabaya, in the period of 2016-2018. This was a retrospective descriptive study using the medical record data. The results showed that 201 patients with psoriasis vulgaris. The majority of psoriasis vulgaris cases were males (51.24%), aged 46-55 years old patients (26.87%), occupations as private employees (45.27%), triggering factor was hypertension (26.86%), common complaint was red patches (66.17%), common clinical presentation was erythematous macules (90.54%), the occurrence of chronic residif was (61.69%), typically found in the whole body (57.21%), degree of severity was ‘severe’ (21.89%), duration of disease was 3 months (45.27%), the percentage of sharing a similar disease with family was (0.99%), diagnosed by Histopathology examination was (38.31%), the most common employed systemic therapy and topical was cetirizine (25.87%) and desoxymethasone cream (27.36%). Psoriasis vulgaris diagnosis is done by carrying out an anamnesis and clinical symptoms, and the results were then compared to the results of histopathological examination. Keywords: psoriasis vulgaris; retrospective; profile; Surabaya

Studi Retrospektif: Psoriasis Pustulosa Generalisata Lunni Gayatri; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 26 No. 1 (2014): BIKKK APRIL 2014
Publisher : Faculty of Medicine, Universitas Airlangga

Profile of Peanut Spesific-IgE in Atopic Dermatitis Indiarsa Arief L; Hans Lumintang; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 26 No. 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty of Medicine, Universitas Airlangga

Background : Atopic Dermatitis (AD) is a chronic reccurent disease. One of the environmental factors which possibly involved in the reccurency of AD is food allergy such as peanut. Peanut allergy in the pathogenesis of AD is by induction IgE and T cells. Peanut-spesific IgE allergen are observed in AD patient. Purpose: To identify the distibution of serum IgE concerning the peanut antigens according to AD. Methods:This trial was cross sectional descriptive study, which studied 33 atopic dermatitis patients, which fulfill inclution criterias.We describe the anamnesis, physical examination, peanut-spesific IgE and the severity of AD using SCORAD index. Results: There were 7 patients (21,2%) with positive result of peanut-spesific IgE. The positive result of peanut-spesific IgE were noted most often on AD patients who suffer from severe grade of AD severity score (85,7%) but not found in class 3 or more (where antibody can detect significanly, often clinical manifestasion appeared when had sensitisation). Conclusion: The positive result of peanut-spesific IgE class 1 (0,35- 0,7 IU/mL) 5 people (15,1%) and class 2 (0,7-3,5 IU/mL) 2 people (6,1%) were noted most often on AD patients who suffer from severe grade of AD severity scoreKey words: atopic dermatitis, peanut-spesific IgE.

Secreted Aspartyl Proteinase[SAP] Enzyme Proﬁle on Vulvovaginalis Candidiasis Patient's isolates Diah Nugrahaeni; Indropo Agusni; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 1 (2015): BIKKK APRIL 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Vulvovaginalis candidiasis (VVC) is an infection caused by various types of Candida, themost is Candida albicans. Candida produces two main enzymes that play a role in virulence, the secreted aspartyl proteinase (SAP) enzyme and the phospholipase enzyme. SAP is most widely produced by Candida albicans,which is one of the main pathogenicfactor of Candida infection. SAP is often found in cases of recurrent candidiasis vulvovaginalis (RVVC) Purpose: To evaluatethe SAP activity produced by VVC patients isolates. Methods: Descriptive observational cross-sectional study was conducted on 21 VVC patients to determine the SAP enzyme levels in VVC patients in Sexually Transmitted Infection (STI) Division, Outpatient Clinic Of Dermatology and Venerology, Dr. Soetomo General Hospital, Surabaya.Vaginal smear was examined to determine levels of SAP and culture examination to determine the kind of candida spesies that causes VVC. Results: Total subject of study are 21 patients. Twelve of 21 patients had SAP > 20 mm in diameter, 7 patients with SAP < 20 mm in diameter, and 2 patients with negative results of SAP. Fifty patients due to Candida albicans, 6 patients caused by non-albicans. Nine patients were accompanied by diabetes mellitus (DM), 1 patients by genital affection, 2 patients by condylomata acuminata. Additionally obtained in 10 patients who had previously received treatment with the results diameter SAP > 20 mm and 7 patients with of SAP diameter < 20 mm, 2 patients showed negative results of SAP. Conclusions: SAP was mainly produced by Candida albicans. SAP became more active in VVC patients that accompanied by diabetes melitus, affectiogenitalis, condylomata acuminate, and also in some patients who have received prior antifungal therapy.Key words: secreted aspartyl proteinase, vulvovaginalis candidiasis, Candida albicans,

Profile of Malassezia Folliculitis Dwi Nurwulan Pravitasari; Sunarso Suyoso; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Malassezia folliculitis (MF) is a chronic infection of the pilosebaceous follicles caused by a skin fungus Malassezia sp. most often in teenagers who marked the onset of itchy erythematous perifolicular papules and pustules, especially in the upper body area and rarely on the face. The clinical appearance must be distinguished from acne vulgaris which has a similar clinical picture, so often have the wrong diagnosis that will affect the prognosis of the disease. Objective: To evaluate the profile of MF in Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital. Methods: A cross-sectional, observational, descriptive study, total samplingin three months of forty-five new patients with acne vulgaris appearance visiting Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital according to inclusion and exclusion criteria. Diagnosis based on history, clinical examination, Wood's lamp and KOH 20%. Malassezia sp. identification using Mycobiotic culture that is added to the olive oil. Results: Forty five patients with a clinical appearance of acne vulgaris in the upper body and slightly exposed on the face area, the new MF patients showed a total of 36 patients (80%) and the remaining 9 patients (20%) were diagnosed with acne vulgaris. Conclusions:Thirty six MF patients with the highest age range 15-24 years, anamnesis obtained itching is moderate grade, predilection in the area of the upper body, and Wood's Lamp examination produces greenish yellow color, KOH 20% examination obtained spores, whereas culture is not required for the diagnosis of MFKey words: Malassezia sp., Malassezia folliculitis, acne vulgaris, Wood's lamp, KOH 20%.

Increasing of Urinary 8-Hydroxydeoxyguanosine (8-OHdG) Levels in Children with Atopic Dermatitis Shakti Indraprasta; Iskandar Zulkarnain; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a chronic inflammation of the skin occurring in individuals with allergic diathesis. Reactive oxygen species (ROS) is assumed to be involved in the pathogenesis of allergic inflammation. 8-Hydroxydeoxyguanosine (8-OHdG) is a marker of oxidative DNA base damage. Previous research showed a various result in urinary 8-OHdG levels of AD in children. Purpose: To evaluate urinary 8-OHdG level of children with AD in Dermatology and Venereology Outpatient Clinic at Dr. Soetomo general hospital Surabaya. Methods: This is a descriptive observational cross sectional research in children with AD at Dermatology and Venereology Outpatient Clinic Dr. Soetomo hospital who qualified inclusion and exclusion criteria in three months period (March to June 2016). Urine sampling for 8-OhdG examination were underwent from all subjets. Results: Mean urinary 8-OHdG level of children with AD was 17.236 ± 13.596 ng/mL. Mean urinary 8-OHdG level of AD in children with mild, moderate, and severe based on grade of severity were 7.892 ± 5.596 ng/mL, 16.006 ± 13.662 ng/mL, and 27.321 ± 12.668 ng/mL respectively. Conclusion: There is a tendency of increased levels of urinary 8-OHdG in accordance with increasing grade of severity in children with AD which possibly caused by the role of oxidative stress in the pathogenesis of AD. Further research is needed to reveal the role of antioxidant in AD and the connection between the severity of AD and urinary 8-OHdG levels.

Co-Authors Addia Salsabila Ade Fernandes Ade Fernandes Afif Nurul Hidayati Afif Nurul Hidayati Alphania Rahniayu Amanda Gracia Manuputty Anang Endaryanto Andre Yuindartanto Arthur Pohan Kawilarang Astindari Astindari Astindari Astindari Astindari Bagus Bagus Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra Bagus Meurah Suropati Bernadya Yogatri Anjuwita Budi Utomo Budi Utomo Budi Utomo Budi Utomo Budi Utomo Budiono Budiono Chesia Christiani Liuwan Cindy Fransisca Cita Rosita Sigit Prakoeswa Citra Dwi Harningtyas Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Desiana Widityaning Sari Dewi Puspitorini Diah Mira Indramaya Diah Nugrahaeni Diah Nugrahaeni, Diah Dwi Murtiastutik Dwi Murtiastutik Dwi Nurwulan Pravitasari Dyatiara Devy Rahadiyanti Dyatiara Devy Rahadiyanti Eko Budi Koendhori, Eko Budi Ellenita Soebakti Endang Wahyu Fitriani Esthy Yuliana Esti Hendradi Farhat Surya Ningrat Fatma Rosida Hamidah Luthfidyaningrum Hans Lumintang Hans Lumintang, Hans I Gusti Ayu Agung Elis Indira I Gusti Nyoman Darmaputra Indah Purnamasari Indiarsa Arief L Indiarsa Arief L, Indiarsa Arief INDROPO AGUSNI Indropo Agusni Indropo Agusni Irmadita Citrashanty Irmadita Citrashanty Iskandar Zulkarnain Iskandar Zulkarnain Iskandar Zulkarnain Iskandar Zulkarnain Iskandar Zulkarnain Karina Dyahtantri Pratiwi Kurniati Kurniati Linda Astari Lunni Gayatri Lunni Gayatri, Lunni M. Yulianto Listiawan Made Putri Hendaria ManikRetno Wahyunitisari Maria Ulfa Sheilaadji Maria Ulfa Sheilaadji Marsudi Hutomo Maya Wardiana Maylita Sari Maylita Sari Maylita Sari Medhi Denisa Alinda Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Nadya Kelfinta Hanani Natalia Tanojo Nur Khamidah Nyoman Suryawati Pepy Dwi Endraswari Pepy Dwi Endraswari, Pepy Dwi Putri Intan Primasari Putri Intan Primasari Rahmadewi Rahmadewi Regitta Indira Agusni Retha Retha Riezky Januar Pramitha Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri Selvia Yuliani Dwi Ratih Sanggarwati Septiana Widyantari Shakti Indraprasta Silvani Geani Sunarso Suyoso Sunarso Suyoso Sunarso Suyoso Sunarso Suyoso, Sunarso Sylvia Anggraeni Tjokorde Istri Nyndia Vaniari Trisniartami Setyaningrum Wisnu Triadi Nugroho Wisnu Triadi Nugroho Yoana Fransiska Wahyuning Christi Yuri Widia, Yuri Yuri Widya Yusuf Wibisono zahruddin ahmad

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