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All Journal Jurnal Layanan Masyarakat (Journal of Public Service) Berkala Ilmiah Kimia Farmasi
Nuzul Wahyuning Diyah
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Environmental Science Medicine & Pharmacology Social Sciences Other

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Analgesic Activity of Acyl-Salicylic Acid Derivatives And In Silico Docking Study For Their Potency As Cyclooxygenase-2 Inhibitors Nuzul Wahyuning Diyah; Anindi Lupita Nasyanska; Bambang Tri Purwanto; Siswandono Siswandono
Berkala Ilmiah Kimia Farmasi Vol. 7 No. 2 (2020): DESEMBER
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (805.626 KB) | DOI: 10.20473/bikfar.v7i2.29302

Abstract

A series of acyl salicylic acid derivatives were screened to investigate their analgesic activities and their potency as cyclooxygenase-2 (COX-2) inhibitors. Fourteen compounds (BS1–14) were assayed by acetic acid induced writhing test. Their ability for interaction with COX-2 was studied through a docking simulation at the COX-2 active site (PDB. 5IKQ). The results of the analgesic activity test gave 3 compounds that produce ED50< 0.39 mmol/kg body weight, lower than aspirin as a positive control. The compounds BS3 and BS4 showed excellent analgesic activity and the tert-butyl substituted molecule BS3 (O-(4-tert-butylbenzoyl)-salicylic acid analog) showed the highest analgesic activity with ED50 of 0.26 mmol/kg. Based on in silico molecular docking, it is known that almost all of the tested ligands (12 compounds) showed a higher binding affinity for COX-2 than meclofenamic acid which is a COX-2 inhibitory NSAID. The results of in vivo analgesic activity were justified with the outcome of in silico investigation. Molecular docking of acyl-salicylates confirmed in vivo experiments and it was found that BS3 was the most active compound as an analgesic agent and the most potent as a COX-2 inhibitor among the evaluated compounds.a
PHARMACIST COMPETENCY IMPROVEMENT IN STERILE DISPENSING AT HEALTH FACILITY SERVICES IN LAMPUNG Prof. Dr. Retno Sari, M.Sc., Apt.; Dewi Isadiartuti; Muhammad Agus Syamsur Rijal; Dini Retnowati; Dinda Monika Nusantara Ratri; Nuzul Wahyuning Diyah; Tutik Sri Wahyuni
Jurnal Layanan Masyarakat Vol. 7 No. 1 (2023): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v7i1.2023.114-122

Abstract

Sterile dosage forms are pharmaceutical preparations that require to be free of microorganisms and particles. In health services, sterile preparations often undergo a series of changes in form from their original conditions to new products through dissolution or mixing with other sterile preparations. To maintain sterility, sterile preparation dispensing skills are needed. Regulation of the Minister of Health of the Republic of Indonesia No. 72 of 2016 and No. 74 of 2016 concerning Pharmaceutical Service Standards in Hospitals and Health Centers are intended to improve the quality of pharmaceutical services, guarantee legal certainty for pharmacists and protect patients and the public from irrational drug use in the context of patient safety. Pharmaceutical service standards in hospitals cover the management of pharmaceutical preparations, medical devices, consumable medical materials and clinical pharmacy services. One of the standards in clinical pharmacy services is aseptic/sterile dispensing sterile. The community service aims to increase the knowledge and skills of pharmacists at Bandar Lampung health facilities and its surroundings in managing sterile preparations.The community service is held through a webinar with a zoom platform followed by discussion and aseptic dispensing demonstration. The sterile dispensing demonstration are carried out by dividing the participants into four groups in the breakout room and each group was guided by a facilitator. In this activity, participants were provided with material on formulation, compatibility, and stability of pharmaceutical preparations, dispensing sterile preparations, aseptic techniques, and problems in sterile dispensing sterile at the hospital. The activity was attended by 63 pharmacists from 25 hospitals in Bandar Lampung and its surroundings, also academics in Tanjung Karang. The evaluation results showed an increase in participants' knowledge of 19,3% and participants expected that activities could be carried out periodically with various topics. The activities are expected to improve the patient's health status and enhance the role of the Faculty of Pharmacy, Airlangga University in the National Health System.
Co-Authors Anindi Lupita Nasyanska Bambang Tri Purwanto Dewi Isadiartuti Dinda Monika Nusantara Ratri Dini Retnowati Muhammad Agus Syamsur Rijal Prof. Dr. Retno Sari, M.Sc., Apt. Siswandono, Siswandono Tutik Sri Wahyuni