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All Journal Journal of Tropical Pharmacy and Chemistry Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Kedokteran Komunitas (Journal of Community Medicine)
Tilaqza, Andri
Pharmacy Department, Faculty Of Medicine, University Of Islamic Malang, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Environmental Science Immunology & microbiology Medicine & Pharmacology Public Health

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Studi In silico Potensi Anti Hipertensi dan Prediksi Profil Farmakokinetika Daun Jati Belanda (Guazuma ulmifolia. Lamk) Andri Tilaqza; Merlita Herbani
Jurnal Kesehatan Islam : Islamic Health Journal Vol 10, No 2 (2021): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v10i2.13821

Abstract

Abstract. Hypertension is a disease that is often occurred in every country, including Indonesia. Hypertension is one of the risk factors that lead to cardiovascular disease. Guazuma ulmifolia Lamk are one of the plants used empirically as antihypertensive in Indonesia, but research on the antihypertensive potential of its leaves has never been done before.The purpose of this study was to predict the potential activity and predict the pharmacokinetic of several compounds contained in Guazuma ulmifolia leaves. The Guazuma ulmifolia leaves compounds and captopril were docked to the Angiotensin-Converting Enzyme protein (PDB ID: 1O86). Mole­cular docking tests were performed using PyRx software while the visuali­zation analysis of molecular anchoring results was performed using Biovia Discovery Studio Visualizer software. Prediction of phar­macokinetic and physicochemical properties of the tested compounds was carried out using the pkCSM web page. Based on the molecular docking test, all compounds in Guazuma ulmifolia leaves have lower energy than the captopril. Kaempferitrin (-9.9 k/mol) and beta-sitosterol (-9.2 kcal/mol) had the lowest energy among other test compounds compared to captopril (-5.5 kcal/mol). Quercetin, kaempferol, and beta-caryophyllene were compounds that had similar interactions to the captopril based on the chemical interaction. All compounds had varied pharmacokinetic profiles but still had a fairly good profile.
In Silico Study of Pulutan (Urena lobata) Leaf Extract as Anti Inflammation and their ADME Prediction Doti Wahyuningsih; Yudi Purnomo; Andri Tilaqza
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 1 (2022): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i1.323

Abstract

Inflammation is the basic for the pathogenesis of several diseases both of degenerative and non-degenerative disease. Urena lobata is a medicinal plant that can be found in Indonesia and has been used traditionally to cure influenza, inflammation and fever. However, there have been few reports about their anti-inflammatory activity and their mechanism action are still unclear. The aim of study to evaluate the anti-inflammatory activities of active substances from U.lobata leaf and their pharmacokinetic property through in silico study. lobata leaf was extracted by digeration methods using ethanol solvent. Therefore, the active substances in the extract was analyzed by Liquid Chromatography-Mass Spectra (LC-MS). Pharmacokinetic property and physicochemical of active compounds were evaluated using pkCSM online tool. Anti-inflammatory activity of U. lobata active compound on phospholipase-A2 (PLA-2), cyclooxygenase-2 (COX-2) and lipoxygenase-5 (LOX-5) were evaluated by in silico study. Ethanolic extract of U. lobata contained five active compound, there are stigmasterol, ?-sitosterol mangiferin, gossypetin and chrysoeriol. Molecular docking study indicated stigmasterol and ?-sitosterol of U. lobata have a strong activity as anti-inflammatory based on the estimation of inhibition constant (Ki) value against PLA2 and COX-2. Meanwhile, mangiferin and gossypetin have a stronger anti-inflammatory effect on LOX-5 among others compound. U. lobata has anti-inflammatory activity through inhibition on COX-2 greater than on PLA2 and LOX-5.
Pengaruh Stadium HIV terhadap Infeksi Oportunistik, Penggunaan Antiretroviral dan Antibiotik pada Pasien HIV di Rumah Sakit X Kota Malang Nurma Puspita Asis; Andri Tilaqza; Hardadi Airlangga
Jurnal Kedokteran Komunitas Vol 8, No 2 (2020)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (776.436 KB)

Abstract

Introduction: Human Immunodeficiency Virus (HIV) is a retrovirus group in the family Retroviridae, a genus of lentiviruses that attack white blood cells that cause a decrease in immunity in humans.The immunity of HIV patients can be assessed based on CD4 levels and clinical symptoms which are divided into four clinical stages of HIV. Each level of HIV stage can affect the use patterns of antiretrovirals and antibiotics used by HIV patients during treatment. This study aims to determine the relationship between the effect of HIV staging on antiretroviral profiles, types of opportinistic infections that accompany, antibiotics used for opportunistic infections and the duration of antibiotic administration used by HIV patients in one hospital in Malang.Method: Non-experimental research was carried out in a Analytic Observational Cross Sectional Retrospective study using a Descriptive Analytic design, using a total sampling method by taking secondary data or medical records on HIV patients at Hospital X Malang in 2015-2018.Results: The total population are 112 medical records and data that inclusion criteria are 73 medical records obtained by the HIV stadium did not affect the use of ARVs  HIV stage did not affect the use of antiretroviral drugs (p = 0.473) (p> 0.05), opportunistic infections (p = 0.135) (p> 0.05), antibiotic use (p = 0.175) (p> 0.05) and duration of antibiotic administration (p = 0.864) (p> 0.05).Conclusion: HIV stage does not affect the pattern of ARV use, opportunistic infections that accompany patients, patterns of antibiotic use and duration of antibiotic administration of HIV patients at VCT Hospital X Malang in 2015-2018.Keywords: HIV stage, ARVs, opportunistic infections, antibiotics
Co-Authors Doti Wahyuningsih Hardadi Airlangga Merlita Herbani Nurma Puspita Asis Yudi Purnomo