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All Journal Jurnal Kedokteran Brawijaya Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Journal of Tropical Pharmacy and Chemistry JIMR - Journal of Islamic Medicine Research Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Journal of Pharmaceutical Care Anwar Medika Jurnal Kedokteran Komunitas (Journal of Community Medicine)
Yudi Purnomo
University Of Islam Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Potensi Toleransi Oral Glukosa Ekstrak Biji Kedelai (Glycine max), Rimpang Jahe (Zingiber officinale) dan Kombinasinya pada Tikus Model Diabetes Purnomo, Yudi
Jurnal Kesehatan Islam : Islamic Health Journal Vol 7, No 01 (2018): JURNAL KESEHATAN ISLAM
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

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Abstract

ABSTRACTDiabetes mellitus (DM) is metabolic syndrome signaled by hyperglycemic chronic and it contribute to several complication risk. Soya(Glycine max) andGingger (Zingiber officinale) are used for the alternative theraphy of DM,however, the potency to regulate blood glucose level especially in it’s combination has not been evaluated.The objective of this study to investigate anti-hyperglycemic effect of Glycine max (G. max) seed extract, Zingiber officinale (Z. officinale) rhizoma and it’s combinationon diabetic rat.This study uses control group post test only with male spraque dawley rats divided into 2 control group and 3 test group (n=5 rats). Diabetic rats was induced by High Fructose and Lipid Diet (HFLD) and multiple dose streptozotocin 25 mg/kg bw (i.p).The rat was administrated orally with G. max seed extract, Z. officinale and it’s combinationin dose of 5000 mg/kb bw, 500 mg/kg bw and 5000 : 500 mg/kg bwrespectively for 4 weeks. Blood sample were collected from the tail vein at 0, 30,60 and 120 minutes after oral glucose administration and thenit were measured using a commercially glucometer. The integrated area under the postprandial glucose curves (AUCs) was calculated by the trapezoidal method.The data was analyzed using ANOVA test continued with LSD test (p < 0,05). The oral administration of G. max seed extract, Z. officinale and it’s combinationwere able to decrease blood glucose AUC about 30 %, 35 % and 35 % respectively compared to diabetic group (p<0.05). In diabetic groups, blood glucose AUC was increased approximately 1.5-fold compared to normal group (p<0.05). Single composition of Z. officinaleextract and its combination with G.maxdecrease blood glucose AUC more compared to the single composisition of G. maxseed extract after glucose stimulation. Key words : AUC, Combination, Diabetic, G. max, Z. officinale
Antidiabetic Effect of Urena lobata: Preliminary Study on Hexane, Ethanolic, and Aqueous Leaf Extracts Wahyuningsih, Doti; Purnomo, Yudi
Jurnal Kedokteran Brawijaya Vol 30, No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2018.030.01.1

Abstract

Chronic hyperglycemia is one of the signs of human type-2 diabetes mellitus due to insulin resistance and depletion. This study aimed to evaluate hexane, ethanolic, and aqueous leaf extracts of Urena lobata as antihyperglycemic agent. Design of this study was a post-test only control group using 25 male Sprague-Dawley rats divided into 5 groups. High fructose diet (HFD) ad libitum and single dose of intraperitoneal streptozocin (STZ) (25 mg/kgBW) were administered to induce diabetes in rats. Three groups of the diabetic rats orally received 500 mg/kgBW of only a type of leaf extract of U. lobata for 4 weeks. Insulin serum levels were measured using enzyme-linked immunosorbent assay (ELISA) method. Size, shape, and density of the islet cells were observed by light microscope. Blood glucose level and the area under curve (AUC) of serial oral glucose tolerance test (OGTT) were measured. The U. lobata leaf extracts of three types of solvent all increased serum insulin level and improved β cells condition, also decreased the AUC of the OGTT series in diabetic rats. Values were compared with untreated diabetic rats (p<0,05). The aqueous leaf extract of U. lobata was the best in increasing insulin serum level, recovering islet cells condition, and correcting blood glucose level. The hexane extract showed poor results when compared to the other soluble agents.
Pengaruh Diet Sambal Tomat Ranti pada Struktur dan Fungsi Hepar Tikus yang Diinduksi Tawas Sulistyowati, Erna; Purnomo, Yudi; Nuri, Sofia; Audra P, Fajar
Jurnal Kedokteran Brawijaya Vol 27, No 3 (2013)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (550.897 KB) | DOI: 10.21776/ub.jkb.2013.027.03.6

Abstract

Masyarakat  Indonesia  mempunyai  kebiasaan  mengkonsumsi  sambal  yang  mengandung  antioksidan.  Paparan  radikal bebas  salah  satunya  tawas  yang  terdapat  pada  air  maupun makanan  bisa  merusak struktur  dan  fungsi  hepar .  Penelitian  ini bertujuan untuk membuktikan pengaruh diet sambal yakni paduan cabe rawit (Capsicum frutescens)  dengan tomat ranti (Lycopersicum  pimpinellifolium  Mill) pada  struktur  hepar  dan  kadar  SGOT  dan  SGPT  tikus  yang  dinduksi  tawas  secara  akut. Penelitian  eksperimental  laboratorium  dilakukan  dengan  post  test  only  with  control  group  design.  Hewan  coba  tikus  dibagi menjadi enam kelompok yaitu kontrol negatif, kontrol positif (induksi tawas 8%), kelompok perlakuan diet tomat ranti 100%,  paduan  tomat  ranti  100,  dengan  cabai  rawit 25%,  50%  dan  100%.  Struktur  hepar  diamati  dengan  menghitung jumlah  nekrosis sel  melalui pulasan Hematoxylin Eosin. Fungsi hepar diamati  melalui pemeriksaan  kadar SGOT dan SGPT. Analisa  data  menggunakan  uji  One  Way  ANOVA,  dilanjutkan  dengan  post  hoc  test  menggunakan  Least  Significant Difference  (LSD).Pemberian  cabai  rawit  dapat  meningkatkan  jumlah  nekrosis  sel  hepar  dan  meningkatkan  kadar  SGOT  dan SGPT  secara  signifikan  bila  dibandingkan  dengan  pemberian tomat  ranti  (tanpa  cabai  rawit). Penambahan  cabai  rawit meningkatkan  kerusakan  struktur  dan  fungsi  hepar  yang  diinduksi  tawas.
Efek kombinasi Amoksisilin dan Kloramfenicol terhadap pertumbuhan bakteri Salmonela thypi Bambang Friambodo; Yudi Purnomo; Ariani Ratri Dewi
JIMR - Journal of Islamic Medicine Research Vol 1, No 1 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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Abstract

AbstractIntroduction :Thypoid fever is one of endemic infection diseases caused bybacteria Salmonela thypi. Occasionally, Thypoid fever is accompanied others infection therefore antibiotic combination is often used to eradicate the infection. Combination of Amoxicillin and Chloramphenicol widely used for treatment of Thypoid fever. Based on theory, the combinationproduces antagonist interaction, however it is still used by Clinicans due to mixed infection. The objective of study to know the antibacterial effect of combination Amoxicillin and Chloramphenicol onSalmonela thypigrowth. Method:The research was done by using disc diffusion methods with Muller Hinton media. Amoxicillin 0,05 µg/ml, 0,1 µg/ml, 0,2 µg/ml , Chloramphenicol 1,25 µg/ml, 2,5 µg/ml, 5 µg/ml and their combinations were tested on Salmonela thypi culture. After 24 hour of administration, antibacterial effect was observed by measuring inhibition zone on bacteria culture. The result of study was tested statistically with One WayANOVA (p=0.05) followed by the test of student-t (t-test) and test of least real difference (LSD) to find out the significance of each groups. Result and discussion: Antibiotic combinationof Amoxicillin and Chloramphenicol have anti-bacterial effect lower than single antibiotic. B-lactam antibiotic like Amoxicillin require that the cell be growing and dividing in order to havea bactericidal action. Chloramphenicolcause slow growth of Salmonella thypiand then impairs bactericidal effect of Amoxicillin. Among combination of antibiotic tested, Amoxicillin 0,5 µg/mland Chloramphenicol 5 µg/ml has antibacterial effect stronger than others. It was caused by the difference dose of bactericide and bacteriostatic used. Conclusion:Combination of Amoxicillin and Chloramphenicol has antibacterial effect lower than the single antibioticgroup on Salmonela thypi.The combination of high dose of Chloramphenicoland low dose of Amoxicillin shows antibacterial effect in the moderate category.Key words:Amoxicillin,Chloramphenicol, Combination, Salmonela thypi.
Ekstrak air Kayumanis (Cinnamomum burmanii) Menurunkan Tingkat Serum INOS Tikus Wistar Diabetes. Alfania Novita Putri Perdana; Doti Wahyuningsih; Yudi Purnomo
JIMR - Journal of Islamic Medicine Research Vol 1, No 1 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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Abstract

Backgound. iNOS enzyme was secreted by immunocompetent cells during pathogenesis of diseases involving inflammation. The enzyme catalized a reaction resulting in nitric oxide radical (NO˙) in large amount. The radical reacts with superoxide (O2 ̅ ) to yield peroxynitrite ( ONOO ̅ ) which are highly reactive and toxic to the tissues. Kayumanis (C.burmanii) was considered rich with compounds overcoming iNOS secretion. This is the initial study of kayumanis potency in reducing iNOS expression. Diabetes is one of many diseases with high level of serum iNOS and was choosen for the study.Purpose. To study kayumanis potency in reducing serum iNOS of a diabetic conditions.Methode.5 groups of rats, each 5, four groups of which were intraperitoneally injected by aloxan at dose of 150 mg/Kg BW to induce hyperglycemia. The another group recieved no treatment. Three groups of diabetic rats were treated with C. Burmanii each day at dose of 0. 5 ml, 1 ml, and 2 ml respectively for 14 days. The remained diabetic group was untreated. Serum iNOS were measured by ELISA. iNOS data were statistically analyzed using ANOVA followed by LSD test (p ≤ 0.05).Results. C.burmanii dose of 1 ml reduced serum iNOS of diabetic rats (p ≤ 0.05). The two other doses of C.burmanii did not reduced the enzyme (p ≥ 0.05).Conclusion. C. Burmanii may have potention of reducing iNOS serum in diabetic condition.Key words: iNOS;Cinnamomum burmanii; diabetes; aloxan
The Combination Effect of Ceftriaxone and Chloramphenicol on Staphylococcus aureus Isolate of Diabetic Gangrene: Efek Kombinasi Seftriakson dan Kloramfenikol pada Staphylococcus aureus Isolat dari Gangren Diabetik Yudi Purnomo; Pasha Chandra; Rahma Triliana
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 8 No. 1 (2022): (March 2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2022.v8.i1.15819

Abstract

Background: Diabetic gangrene is a complication of Diabetes mellitus caused by Staphylococcus aureus. The combination of Ceftriaxone and Chloramphenicol is often used to cure gangrene infection, even though, they produce antagonist interaction based on theory. Objectives: To evaluate the potency of Ceftriaxone, Chloramphenicol and its combination on Staphylococcus aureus isolate of Diabetic gangrene. Material and Methods: The research was done by using disc diffusion methods with Muller Hinton media. Ceftriaxone, Chloramphenicol and its combination dose of 7,5 µg/ml, 15 µg/ml and 30 µg/ml, respectively were tested on Staphylococcus aureus culture taken form the diabetic gangrene patients. Antibacterial effect was observed by measuring inhibition zone on bacteria culture. Type of interaction was analyzed by Ameri-Ziaei Double Antibiotic Synergism Test (AZDAST) method. The results of study were tested statistically with One Way ANOVA (p=0.05) followed by Least Significant Difference (LSD) test. Results: The combination of Ceftriaxone and Chloramphenicol showed an antibacterial effect lower than Ceftriaxone. ß-lactam antibiotic like Ceftriaxone require the cell be growing and dividing in order to have a bactericidal action. Meanwhile, Chloramphenicol causes a slow growth of Staphylococcus aureus and impairs bactericidal effect of Ceftriaxone if they are combined. Conclusions: Ceftriaxone and Chloramphenicol combination has lower antibacterial effect than the single antibiotic groups on Staphylococcus aureus isolate of Gangrene diabetic and the type of interaction is antagonistic.
Potensi Toleransi Oral Glukosa Ekstrak Biji Kedelai (Glycine Max), Rimpang Jahe (Zingiber Officinale) Dan Kombinasinya Pada Tikus Model Diabetes yudi purnomo
Jurnal Kesehatan Islam : Islamic Health Journal Vol 7, No 2 (2018): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v7i2.8923

Abstract

 Diabetes Mellitus (DM) adalah sindrom metabolik yang ditandai peningkatan kadar glukosa darah kronik dan berkontribusi terhadap beberapa resiko komplikasi. Biji Kedelai(G.max) danrimpang Jahe (Z.officinale) digunakan sebagai terapi alternative DM tapi potensi untuk mengendalikan peningkatan kadar glukosa darah khususnya dalam bentuk kombinasinya belum pernah dievaluasi. Penelitian ini bertujuan untuk mengevaluasi efek anti-hiperglikemik biji kedelai, rimpang jahe dan kombinasinya Penelitian ini menggunakan tikus Sprague dawley (SD) jantan berusia 4 minggu berat badan 200 g dibagi menjadi 2 kelompok kontrol dan 3 kelompok uji (n=5 ekor). Tikus DM diinduksi dengan diet tinggi lemak-fruktosa (DTLF) dan streptozotocin 25 mg/kg BB (i.p)multiple dose. Setelah dinyatakan DM diberikan per oral ekstrak biji kedelai 5000 mg/kg BB,rimpang jahe500 mg/kg BB dan kombinasinya 5000 : 500 mg/kgBB   selama 4 minggu. Sampel darah dari vena ekor diambil pada menit ke 0, 30, 60 dan 120 setelah pemberian glucose oral kemudian kadar glukosa darah diukur dengan glucometer. Area Under Curve (AUC) integrasi dihitung dengan metode trapezoidal. Data dianalisa menggunakan one way ANOVA dilanjutkan dengan uji LSD (p<0.05).Pemberian ekstrak biji kedelai, rimpang jahe dan kombinasinya menurunkan AUC glukosa berturut-turut 30 %, 35 %dan 35 % dibandingkan kelompok diabetik (p<0.05). Sedangkan pada kelompok diabetik terjadi peningkatan kadar AUC 1.5 kali dibandingkan kelompok normal (p<0.05). Ekstrak rimpang jahe tunggal dan kombinasinya dengan biji kedelai lebih kuat menurunkan kadar glukosa darah dibandingkan dengan ekstrak biji kedelai tunggal pasca stimulasi glukosa. 
Efek Ekstrak Etanol Daun Gedi Merah (Abelmoschus Manihot (L.) Medik) Terhadap Kadar Sod Dan Mda Pada Aorta Tikus Model Diabetes Melitus Tipe 2 Hendra Putra; Fathia Annis; Yudi Purnomo
Jurnal Kesehatan Islam : Islamic Health Journal Vol 9, No 1 (2020): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v9i1.8861

Abstract

Pendahuluan: Hiperglikemia pada diabetes melitus (DM) meningkatkan produksi reactive oxygen species (ROS) yang berperan terhadap komplikasi makroangiopati diabetik. Daun gedi merah dikenal memiliki efek antioksidan dan antihiperglikemia sehingga diharapkan dapat menghambat kerusakan oksidatif pada DM. Penelitian ini bertujuan untuk mengetahui efek ekstrak etanol daun gedi merah dalam mencegah kerusakan oksidatif pada DM dengan mengamati kadar Superoxide Dismutase (SOD) dan Malondialdehyde (MDA) aorta tikus model DM.Metode: Tikus Sprague Dawley jantan berusia 4-6 minggu dikelompokkan menjadi 2 kelompok kontrol dan 3 kelompok perlakuan (n= 5 ekor). Hewan coba diinduksi diet tinggi lemak-fruktosa (DTLF) dan Stretpzotocin (STZ) 25 mg/kgBB intraperitoneal multiple dose. Selanjutnya kelompok perlakuan diberikan ekstrak etanol daun Gedi merah (EEDGM) dosis 200 mg/kgBB, 400 mg/kgBB dan 800 mg/kgBB. Pengukuran kadar SOD dan MDA aorta menggunakan Elisa SOD rat kit dan Elisa MDA rat kit. Analisa data menggunakan One Way Anova dilanjutkan dengan uji BNT (p<0,05).Hasil: Pemberian EEDGM dosis 200 mg/kgBB, 400 mg/kgBB dan 800 mg/kgBB menghambat penurunan kadar SOD aorta berturut-turut sekitar 10%, 30% dan 50% dibandingkan kelompok kontrol diabetes melitus (KDM) (p<0,05) sementara kadar MDA aorta diturunkan kurang lebih sekitar 20%, 40%, dan 70% (p<0,05). Induksi DTLF dan STZ pada kelompok KDM menurunkan kadar SOD aorta 50% dan meningkatkan MDA aorta 2 kali lipat dibandingkan KN (p<0,05).Kesimpulan: Pemberian EEDGM 200 – 800 mg/kgBB menghambat penurunan kadar SOD aorta dan menghambat peningkatan kadar MDA aorta tikus model DM.
Efek Ekstrak Etanol Daun Gedi Merah (Abelmoschus manihot (l.) medik) Terhadap Persentase Interleukin-10 (Il-10) dan Sel T Sitotoksik (Cd8+) Tikus Model Diabetes Tipe II Nur Kamilah; Reza Hakim; Yudi Purnomo
Jurnal Kesehatan Islam : Islamic Health Journal Vol 8, No 1 (2019): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v8i1.8866

Abstract

Pendahuluan: Inflamasi  akibat kerusakan oksidatif yang dipicu hiperglikemia berperan terhadap progresivitas diabetes melitus (DM). Interleukin-10 (IL-10) dan CD8+ berpengaruh terhadap proses inflamasi. Abelmoschus manihot (L.) Medik memiliki efek antiinflamasi dan antioksidan yang diharapkan dapat menurunkan inflamasi pada patofisiologi DM. Penelitian ini bertujuan untuk mengetahui efek ekstrak etanol Abelmoschus manihot (L.) Medik terhadap persentase IL-10 dan CD8+ tikus model DM.Metode: Tikus Sprague Dawley jantan, 4-6 minggu dikelompokkan menjadi kelompok kontrol normal (KN), kelompok kontrol diabetes melitus (KDM), kelompok ekstrak etanol daun gedi merah (EEDGM) 200 mg/kgBB, EEDGM 400 mg/kgBB dan EEDGM 800 mg/kgBB (n=5). Hewan coba diinduksi diet tinggi lemak-fruktosa (DTLF) selama 10 minggu dan Streptozotocin (STZ) dosis rendah 25 mg/kgBB intraperitoneal dosis ganda pada minggu ke 4. EEDGM 200 mg/kgBB, 400 mg/kgBB dan 800 mg/kgBB diberikan selama 4 minggu. Pengukuran persentase CD8+ dan IL-10 menggunakan flowcytometry. Analisa data menggunakan One Way Anova dilanjutkan dengan uji LSD (p<0,05).Hasil: Induksi DTLF dan STZ pada kelompok KDM menurunkan persentase IL-10 dan meningkatkan persentase CD8+ dibandingkan KN (p<0.05). Pemberian EEDGM dosis 400 mg/kgBB dan 800 mg/kgBB signifikan meningkatkan persentase IL-10 berturut-turut sekitar ½  dan ¾ dibandingkan kelompok KDM (p<0,05). Pemberian EEDGM dosis 200 mg/kgBB, 400 mg/kgBB dan 800 mg/kgBB menurunkan persentase CD8+ berturut-turut 1/5, 1/3 dan 1/10 dibandingkan kelompok KDM (p<0,05).Kesimpulan: Pemberian EEDGM meningkatkan persentase IL-10 dan menurunkan persentase CD8+ tikus model diabetes
Efek Ekstrak Etanol Daun Gedi Merah (Abelmoschus Manihot (L.) Medik) Terhadap Kadar Superoxide Dismutase Dan Malondialdehyde Jaringan Ginjal Tikus Model Diabetes Melitus Tipe 2 ahmad fuadi; yoyon arif; yudi purnomo
Jurnal Kesehatan Islam : Islamic Health Journal Vol 8, No 2 (2019): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v8i2.8889

Abstract

Hiperglikemia pada Diabetes Melitus (DM) meningkatkan produksi Reactive Oxygen Species (ROS) dan berperan terhadap risiko komplikasi nefropati diabetik. Daun gedi merah (Abelmoschus manihot (L.) Medik) berkhasiat sebagai antidiabetik dan antioksidan tetapi penelitian ekstrak etanol daun gedi merah (EEDGM) untuk mencegah nefropati diabetik belum banyak dilaporkan. Penelitian ini bertujuan untuk mengetahui efek EEDGM terhadap kadar SOD dan MDA ginjal tikus model DM.Metode: Tikus Sprague dawley jantan usia 4-6 minggu dikelompokan menjadi 2 kelompok kontrol dan 3 kelompok perlakuan (n=25 ekor). Tikus DM dibuat dengan diet tinggi lemak-fruktosa (DTLF) dan streptozotocin (STZ) 25 mg/kgBB i.p multiple dose. Ekstrak etanol daun gedi merah (EEDGM) diberikan per oral selama 4 minggu. Kadar SOD dan MDA ginjal diukur menggunakan SOD rat kit dan MDA rat kit. Hasil dianalisa dengan One Way Anova dilanjutkan dengan uji BNT (p<0,05).Hasil: Pemberian EEDGM dosis 800 mg/kgBB menghambat penurunan kadar SOD jaringan ginjal dengan persentase sekitar 60% dibandingkan KDM (p<0,05). Pemberian EEDGM dosis 400 mg/kgBB menghambat peningkatan kadar MDA jaringan ginjal dengan persentase sekitar 20% dibandingkan KDM (p<0,05). Induksi DTLF dan STZ menurunkan kadar SOD jaringan ginjal dengan persentase sekitar 40% dan meningkatkan kadar MDA jaringan ginjal dengan persentase sekitar 30%.Kesimpulan: Pemberian EEDGM dapat menghambat penurunan kadar SOD dan peningkatan kadar MDA jaringan ginjal tikus model DM.
Co-Authors Aan Nuraeni Ahmad Fuadi Alfania Novita Putri Perdana Alvian Nur Firdaus Amelia Pramono Ariani Ratri Dewi Aris Rosidah Bagus Kansagis Cahya Bambang Friambodo Daksa Wiladipta Devi Indri Cahyani Dluharrohimah Nur Imami Doti Wahyuningsih Erna Sulistiowati Erna Sulistyowati Fajar Audra P Fathia Annis Fenti Kusumawardhani Hidayah Helmin Elyani Hendra Putra Juliet Tangka Nanda Robby Setyawan Nanda Yunita Ayu Fitriyah Nur Kamilah Pasha Chandra Putri Endrawati Rahma Triliana Rahmadina Putri Meiviani Reza Hakim Ronny Malavia Mardani Sofia Nuri Sri Fauziyah Tilaqza, Andri Yanny Trisyani Yeni Amalia yoyon arif Yoyon Arif Martino Yoyon Arif Martino