Article Per Year (5 Year)
p-Index From 2019 - 2024
0.659
P-Index
This Author published in this journals
All Journal Journal of Tropical Pharmacy and Chemistry Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Kedokteran Komunitas (Journal of Community Medicine)
Tilaqza, Andri
Pharmacy Department, Faculty Of Medicine, University Of Islamic Malang, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Environmental Science Immunology & microbiology Medicine & Pharmacology Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Jurnal Kesehatan Islam : Islamic Health Journal

 1 
Studi In silico Potensi Anti Hipertensi dan Prediksi Profil Farmakokinetika Daun Jati Belanda (Guazuma ulmifolia. Lamk) Andri Tilaqza; Merlita Herbani
Jurnal Kesehatan Islam : Islamic Health Journal Vol 10, No 2 (2021): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v10i2.13821

Abstract

Abstract. Hypertension is a disease that is often occurred in every country, including Indonesia. Hypertension is one of the risk factors that lead to cardiovascular disease. Guazuma ulmifolia Lamk are one of the plants used empirically as antihypertensive in Indonesia, but research on the antihypertensive potential of its leaves has never been done before.The purpose of this study was to predict the potential activity and predict the pharmacokinetic of several compounds contained in Guazuma ulmifolia leaves. The Guazuma ulmifolia leaves compounds and captopril were docked to the Angiotensin-Converting Enzyme protein (PDB ID: 1O86). Mole­cular docking tests were performed using PyRx software while the visuali­zation analysis of molecular anchoring results was performed using Biovia Discovery Studio Visualizer software. Prediction of phar­macokinetic and physicochemical properties of the tested compounds was carried out using the pkCSM web page. Based on the molecular docking test, all compounds in Guazuma ulmifolia leaves have lower energy than the captopril. Kaempferitrin (-9.9 k/mol) and beta-sitosterol (-9.2 kcal/mol) had the lowest energy among other test compounds compared to captopril (-5.5 kcal/mol). Quercetin, kaempferol, and beta-caryophyllene were compounds that had similar interactions to the captopril based on the chemical interaction. All compounds had varied pharmacokinetic profiles but still had a fairly good profile.
Co-Authors Doti Wahyuningsih Hardadi Airlangga Merlita Herbani Nurma Puspita Asis Yudi Purnomo