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Gestina Aliska

Fakultas Kedokteran Universitas Andalas

Author-ID : 4165600

Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Kandungan Timbal pada Sala Lauak yang Dijual di Pasar Raya Padang Akibat Penggunaan Kertas Ketikan sebagai Pembungkus Habifa Mulya Cita; Asterina Asterina; Gestina Aliska
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 1 (2020): Maret 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Latar Belakang. Timbal merupakan logam berat yang dapat memberikan efek buruk terhadap kesehatan manusia. Timbal masuk ke dalam tubuh manusia melalui saluran pernafasan, saluran cerna, dan kulit. Makanan dapat terkontaminasi oleh timbal apabila pengemasan tidak tepat, misalnya pada sala lauak yang dibungkus menggunakan kertas ketikan dapat masuk ke dalam tubuh. Objektif. Penelitian ini bertujuan untuk membuktikan adanya kandungan timbal pada sala lauak yang dijual di Pasar Raya akibat penggunaan kertas ketikan sebagai pembungkus. Metode. Penelitian ini bersifat deskriptif dan dilakukan di Laboratorium Air Fakultas Teknik Lingkungan Universitas Andalas pada Mei 2018 – November 2018. Jumlah sampel sebanyak 34 sampel terdiri 17 sampel sala lauak yang dibungkus kertas ketikan dan 17 sampel yang tidak dibungkus kertas ketikan dengan menggunakan teknik total sampling. Pemeriksaan sampel menggunakan alat ICP (Inductively Coupled Plasma). Hasil. Hasil penelitian didapatkan seluruh sala lauak yang dijual pedagang di Pasar Raya Padang positif mengandung timbal, baik yang dibungkus kertas ketikan maupun yang tidak dibungkus. Rata-rata kadar timbal pada sala lauak yang dibungkus sebesar 0,172 ppm dan sala lauak yang tidak dibungkus sebesar 0,167 ppm. Kesimpulan. seluruh sampel sala lauak mengandung logam timbal dan terdapat peningkatan kadar timbal akibat pembungkusan. Kata kunci: logam timbal, sala lauak, kertas ketikan

Prevalensi Gen OXA-23 pada Isolat Klinis Bakter Acinetobacter baumanii di RSUP Dr. M. Djamil Padang Mhd. Alzaref; Linosefa Linosefa; Gestina Aliska
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 3 (2020): November 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Acinetobacter baumannii is such a big challenge in this modern era because of their multi-drug resistance (MDR) through their resistance mechanism, namely the production of beta lactamase enzymes, one of them is oxacillinases. Several studies have revealed that the OXA-23 gene has an important role in the production of the beta lactamase enzyme so that these bacteria are resistant to antibiotics, especially carbapenem. This study was conducted to determine the description of the resistance of the Acinetobacter baumannii by looking at the prevalence of the OXA-23 gene in clinical isolates of these bacteria at RSUP Dr. M. Djamil Padang. This study was a descriptive observational study and used a cross-sectional design using polymerase chain reactions (PCR) and electrophoresis techniques. The samples were clinical isolates of Acinetobacter baumannii bacteria stored in the Microbiology Laboratory of the Faculty of Medicine, Andalas University with inclusion and exclusion criteria. Of the 150 clinical isolates of Acinetobacter baumannii studied, most of the bacteria were still sensitive to the antibiotics of Amikacin (84%), Tigecycline (78.76%), and Trimethoprim / Sulfamethoxazole (76.77%). Meanwhile, all of the Acinetobacter baumannii isolates were resistant to cefazolin. In PCR and electrophoresis tests, 50 clinical isolates were positive for the OXA-23 gene. 46 of them were carbapenem resistant, while the other 4 isolates were sensitive to carbapenem. From these results it can be concluded that the prevalence of the OXA-23 gene in Acinetobacter baumannii isolates in RSUP Dr. M. Djamil Padang was 85.18% for carbapenem resistant isolates and 4.30% for carbapenem sensitive isolates. Keywords : Acinetobacter baumannii, carbapenem, OXA-23 gene

Correlation of ApoE Gene Polymorphism with Coronary Heart Disease Severity in Patients with Acute Coronary Syndrome Who Receive Statin Therapy, Padang, Indonesia Elly Usman; Gestina Aliska; Masrul Syafri
Journal of Midwifery Vol 7, No 1 (2022): Published on June 2022
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jom.7.1.1-7.2022

Coronary Heart Disease (CHD) is still the most common cause of death. Ischemic heart disease causes more than 7 million (12.8%) deaths worldwide. It is estimated that 3,750,000 Indonesians have CHD. CHD is a disease with many risk factors. ApoE gene polymorphism is associated with atherosclerosis and plays a role in lipid metabolism, which is 2-16% affecting variability in LDL levels. This study aims to look at the relationship between ApoE gene polymorphism and the severity of coronary heart disease. Data regarding ApoE gene polymorphism was obtained using polymerase chain reaction (PCR). DNA was isolated from white blood cells using DNA purification kit. ApoE2, ApoE3, ApoE4 alleles were detected by DNA sequencing. Data on the severity of coronary heart disease were obtained from angiography and were calculated based on SYNTAX scores. In this study, ApoE was obtained with e2 allele frequencies (4.63%), e3 (78.70%), and e4 (16.67%) with E2 / 2 (0%), E2 / 3 (3.70%), E2 / 4 (5.56%), E3 / 3 (64.81%), E3 / 4 (24.07%), and E4 / 4 (1.85%). The relationship between the SYNTAX score and the ApoE genotype has no significant difference. ApoE3 / 4 genotype has the highest SYNTAX score and the e4 allele has the most influence on CHD despite the influence of statin therapy.

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