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All Journal Jurnal Tumbuhan Obat Indonesia Pharmaciana: Jurnal Kefarmasian Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmascience Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS

Ririn Lispita Wulandari

Universitas Wahid Hasyim Semarang

Author-ID : 420434

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Engineering Medicine & Pharmacology Public Health Social Sciences

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FORMULASI DAN EFEK SALEP EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava,L.) DENGAN BASIS HIDROKARBON TERHADAP LUKA SAYAT PADA TIKUS JANTAN GALUR WISTAR Ririn Lispita Wulandari; Elya Zulfa; Dwara Andriani Astuti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT The ethanol extract of guava leaves (EEGL) is proven to heal various types of wounds.This study aims to determine the physicochemical characteristics of the EEGL ointment with a hydrocarbon base formula and examine the effect of the ointment against cut wounds on wistar male rat. The EEGL was obtained by maceration using 70% ethanol solvent. The ointment made 3 formulas with a ratio of hydrocarbon base composition (cera alba:vaselin album) namely F1 (2.5:92.5)%; F2 (5:90)%; F3 (7.5:87.5)%. The physicochemical characteristics of all ointments examined included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion. Organoleptic, homogeneity and pH data were analyzed descriptively, while viscosity, spreadability and adhesion data were analyzedstatistically. Testing the effect of all ointment formulas on the wound was done by applying 0.5 gram 2x a day for 9 days compared to wound control without treatment and positive control used commercial product.The parameter of effect measured was the length of the cut wound on the 9th day, then analyzed with the Kruskall Wallis test followed by the Mann Whitney test.The physicochemical characteristics of EEGL ointment (F1, F2, F3) are known that all ointment formulas are brown in color, typical of guava, homogeneous, pH according to skin pH, viscosity and adhesion are significantly different, while the spredability is not significant.The EEGL ointment had an effect on the cut wound of the male wistar rats, ie the length of the wound on the 9th day was reduced and compared to wound controlwas differentsignificantly. Keywords :Guava leaves, ointment, cut of wound.

EFEK GASTROPROTEKTIF EKSTRAK ETANOL BUAH LABU KUNING (Cucurbita moschata (Duch.) Poir) PADA TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI ASPIRIN Maulida Shofiatun; Ririn Lispita Wulandari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 2 (2020): Jurnal Ilmu Farmasi & Farmasi Klinik Vol. 17 N0. 02 Desember 2020
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Non-steroidal anti-inflammatory drugs (NSAIDs) can cause side effects of gastric ulcers. Based on previous research, it is known that pumpkin contains flavonoids which can protect the gastric mucosa. The aim of this study was to determine the gastroprotective effect of ethanol extract of Cucurbita moschata (Duch.) Poir fruit in male rats Wistar-induced by aspirin. The study used a randomized matched posttest only control group design. Cucurbita moschata (Duch.) Poir fruit extraction was carried out by ultrasonic method. A total of 24 rats were divided into 6 groups: normal control (CMC Na 0,5%; ulcer control (CMC Na 0,5%); positive control (ranitidine HCl 10 mg/kg BW); treatment group (Cucurbita moschata (Duch.) Poir fruit ethanol extract at dose of 100, 200, and 400 mg/kg BW). Treatments lasted for 14 days. One hour after administering the test solution on the 14th day, all rats were given 200 mg/kg BW of aspirin (except normal controls) orally, then fasted for 12 hours. On the 15th day, all rats were sacrificed, dissected and their stomachs were taken. Gastric histology preparations were made with hematoxylin-eosin staining, microscopically read, discussed the number and severity of ulcers. Both data were processed and analyzed by Kruskal Wallis and Mann Whitney (95% confidence level). The results showed that the administration of EEBLK doses of 100, 200, and 400 mg/kg BW resulted in a score of the number and severity of ulcers that were lower significantly than of ulcer controls (p

FORMULASI SIRUP EKSTRAK ETANOL DAUN PARE (Momordica charantia L.) DENGAN GELATIN SEBAGAI PENGENTAL DAN AKTIVITAS MUKOLITIKNYA Ririn Lispita Wulandari; Eli Mahmud; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTEthanol extract of bitter melon leaves at a concentration of 5% has been shown to have mucolytic activity. For ease of use that is made of dosage forms syrup. Thickening agent serves to increase the viscosity and resist settling process resulting in a stable syrup. Gelatin has the ability to improve settling extract better than other thickening. This study aims to determine the effect of variations in the concentration of gelatin to the physical-chemical properties and activity of ethanol extract syrup mukolitik pare leaves the cow intestine mucus in vitro. Extraction of leaf bitter melon is done by percolation. EEDP was made into three syrup formulas using 1% (FII), 2% (FIII), 3% (FIV) gelatin thickener. There is also syrup without extract and gelatin (FI) as a control. The four syrup formulas were examined for physical chemical properties (organoleptic, homogeneity, pH, viscosity), and tested their mucolytic activity. Data on the results of activity tests in the form of viscosity were analyzed by Kruskal-Wallis followed by Mann-Whitney. Data from organoleptic examination, homogeneity, Ph were analyzed descriptively, while viscosity with Linear Regression. The results showed that EEDP syrup with a gelatin concentration of 1%; 2%; 3% have mucolytic activity. The results of examination of the physico-chemical properties of FII, III, and IV syrups have the same taste and color, sweet and bitter, and are greenish black in color, while FI syrup is sweet and yellowish in color. Homogeneous FI syrup, FIII and FIV syrup are evenly distributed, while FII syrup has coarse particles. Fourth pH normal syrup formula. Increased concentration of gelatin (1%; 2%; 3%) can increase the viscosity of syrupKeywords: ethanol extract of bitter melon leaves, syrup, gelatin

PENGARUH KOMBINASI EKSTRAK ETANOL DAUN SIRSAK DAN GEMFIBROZIL TERHADAP KADAR TRIGLISERIDA DAN HDL TIKUS YANG DIINDUKSI PAKAN TINGGI LEMAK Ririn Lispita Wulandari; Sri Susilowati; Sucyati Amelya
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Soursop leaves ethanol extract (SLEE) has been shown to lower blood levels of total cholesterol. However, it not yet investigated the effects on triglyceride and HDL levels. There is also no research on combining related soursop leaves with gemfibrozil. The purpose of this study is to compare the efficacy of combination therapy SLEE and gemfibrozil to SLEE or gemfibrozil single treatment on decreasing triglyceride levels and increase HDL level in rats induced by high-fat feeding. Thirty male Wistar rats were divided into six groups (normal control, hyperlipidemia control, single gemfibrozil, single SLEE, 1st combination, and 2nd combination groups). Each group treated a high-fat feed two times a day for 14 days, except for the normal control. The test material was treated one time a day for five days. Measurement levels of triglycerides and HDL used GPO-PAP reagent and Direct Enzymatic Colorimetric Test. The data was analyzed by One-Way ANOVA test followed by Tukey's test. The results showed that SLEE can decrease triglyceride’s level and increase HDL levels of male Wistar rats. The combination of SLEE and gemfibrozil also can decrease triglyceride’s level and increase HDL level. However, there are no significances different between the efficacy of combination SLEE and gemfibrozil than SLEE or gemfibrozil single treatment in decreasing triglyceride's level and increase HDL levels of male Wistar rats. Keywords: Hyperlipidemia, triglyceride, HDL, Soursop leaves ethanol extract, gemfibrozil.

TOKSISITAS AKUT INFUSA KULIT ARI KACANG TANAH (Arachis hypogea L.) PADA MENCIT BALB/ C Risha Fillah Fithria; Ririn Lispita Wulandari; Devi Nisa Hidayati; Lilis Rejeki
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTPeanut shell (PS) infusion has been shown to be antithrombocytopenia, but there has been no research on safety standards. This study aims to identify the symptoms of toxic effects, the potency of toxicity and histopathology of liver male Balb/C mice after a single dose of PS infusion. This research uses randomized matched posttest only control group design. Twenty five mice were divided into 5 orally dosage groups, ie, PS infusion with a dose of 0,026; 0.052; 0.104; 0.208 g/20gBW; and negative control of CMC Na 0.5%. The observation period is for 14 days. The results showed that single dose of PS infusion had a pseudo LD50 value ie > 0.208g/20gBW which was practically non toxic. Symptoms to watch out for the BW infusion were passive behavior, bradycnea, hair color change, hair loss, and weight loss at doses of 3 and 4. It is unclear whether liver damage ie inflammation, necrosis, and albuminous degeneration caused by PS infusion or other causes.keywords: acute toxicity, infusion, peanut shell

PENGARUH KOMBINASI EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) DAN SIMVASTATIN TERHADAP KADAR KOLESTEROL TOTAL DAN LOW DENSITY LIPOPROTEIN (LDL) TIKUS YANG DIINDUKSI PAKAN TINGGI LEMAK Ririn Lispita Wulandari; Sri Susilowati; Murnik Asih
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Soursop leaves can be used as a drug hypercholesterolemia. Simvastatin is one of the drugs that can be used to lower total cholesterol and LDL. This study aims to determine the effectiveness of combination therapy EEDS and simvastatin in inhibiting elevated levels of total cholesterol and LDL induced rats a high-fat feed when compared with simvastatin alone or single EEDS. This study is experimental with post-test only control group design. Using the test animals were 30 male rats Wistar strain were divided into 6 groups. Test animals fed a high-fat twice daily for 14 days except for the normal control group, the test preparation administration once a day for 5 days. Measurement of total cholesterol using the reagent kit CHOD-PAP and LDL measurement method Direct Enzymatic Colorimetric Test with a spectrophotometer UV-Visibel. Data were statistically analyzed by One Way Anova followed by Tukey test. The results showed that administration of EEDS can inhibit LDL levels induced rats a high-fat feed. eeds combination and simvastatin can inhibit the increase in total and LDL cholesterol levels did not differ significan (p> 0.05), which means it has the same ability in lowering total cholesterol and LDL induced rats a high-fat feed simvastatin compared with administration of single and single EEDS. Keywords: Hypercholesterolemia, Soursop Leaf Extract Ethanol, Total Cholesterol, LDL.

AKTIVITAS MUKOLITIK FRAKSI METANOL DARI EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocotum Ruiz and Pav.) PADA MUKOSA USUS SAPI DAN KANDUNGAN KIMIANYA Ririn Lispita Wulandari; Yulias Ninik Windriyati; Aqnes Budiarti
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Red betel leaves (Piper crocotum Key words: red betel leaves, mucolitic, cow’s mucous Ruiz and Pav.) can cure many kinds of diseases, including cough. The aim of this research is to determine mucolitic activity of methanol fraction from ethanol extract of red betel leaves on cow’s intestine mucous in vitro and to identify its active compound group. Ethanol extract of red betel leaves was made by maceration method using ethanol 70%. Methanol fraction was made from ethanol extract by partitioned gradually using petroleum eter, ethyl acetate, and methanol. The obtained methanol fraction was made serial concentration started from 0.1%, 0.3%, 0.5%, 0.7%, 0.9% in 80% cow’s mucous. The mucolitic activity was tested using Viscometer Rion, and 0.1% acethylcystein as positive control. Identification the active compound using thin layer chromatography. The viscosity cow’s mucous analyzed statistically. Normality test using Shapiro Wilk, non parametric statistic test using Kruskal Wallis, and then continued using Mann Whitney Test with degree of trust of 95%.The result shows that methanol fraction has mucolitic activity whether at concentration 0.3% is equivalent to 0.1% acethylcystein. Methanol fraction contains saponin, flavonoid, and polyphenol.

Co-Authors Anita Dwi Puspitasari Budiarti, Aqnes Budiarti Devi Nisa Hidayati Dwara Andriani Astuti Eli Mahmud Elya Zulfa Lilis Rejeki Maulida Shofiatun Maulita Cut Nuria Mufrod Mufrod Murnik Asih Nilam Eka Putri Nurahmah Hidayati Pia Annisa Puji Hartati risha fillah fithria SRI SUSILOWATI Sucyati Amelya Yance Anas Yulias Ninik Windriati

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