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All Journal Caring : Jurnal Pengabdian Masyarakat Asian Journal of Health Research
Anin Indriani
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Brawijaya Malang, East Java, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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HIGH RISK PREGNANCY DETECTION USING TELEHEALTH-BASED SCREENING Fatmawati Fatmawati; Yulia Silvani; Mustika Dewi; Ningrum Paramita Sari; Rahma Dian Hanifarizani; Anin Indriani; Rahma Ega Prospera Haryunita; Berliana Maduratna Irawati
Caring : Jurnal Pengabdian Masyarakat Vol 1, No 3 (2021): CARING Jurnal Pengabdian Masyarakat (Desember 2021)
Publisher : Caring : Jurnal Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (625.767 KB) | DOI: 10.21776/ub.caringjpm.2021.001.03.3

Abstract

High-risk pregnancy is a pregnancy that is likely to cause harm or complications to the mother and fetus. The high maternal mortality rate (MMR) is one of the indicators in determining the degree of public health. Early detection in pregnancy can be used as an effort to increase mother's knowledge about her pregnancy and can facilitate decision making in management. During the COVID-19 pandemic that has hit Indonesia since March 2020, it has caused changes in various aspects of life, especially having a significant impact on the public health aspect. Given the high rate of disease transmission, the use of telehealth technology can be an effective and efficient way to deal with the spread of the virus. Telehealth is one solution to overcome the problem of access to health, with telehealth it can perform screening to detect high-risk pregnancies early so that pregnant women can get continuous monitoring. The purpose of this activity is to conduct and determine the effectiveness of telehealth-based high-risk detection in pregnant women. The method of activity is in the form of community service through webinars and screenings which are carried out within 6 months online. The result of the activity is an increase in the knowledge of webinar respondents with an average pre-test value of 120 and a post-test 157 out of a total of 200. Based on the results of screening using the SIBIDAN application, from 25 pregnant women in trimesters 1,2, and 3 who became respondents, the results were 52%, low-risk group, 32% high-risk group, and 16% very high-risk group. Therefore, further assistance, monitoring, and referral are needed to minimize pregnancy complications.
Effect of Pravastatin on eNOS and PECAM-1 Expression in the Placenta of Pre-Eclampsia Rat (Rattus norvegicus) Model Bambang Rahardjo; Kunawati Tungga Dewi; Anita Dwi Rahmawati; Fauqo Wildatil Jannah; Mukhamad Nooryanto; Anin Indriani
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (992.174 KB) | DOI: 10.55561/ajhr.v1i2.44

Abstract

Introduction: Preeclampsia has two stages: improper placental and maternal circulation. Abnormal trophoblast invasion causes uteroplacental ischemia and hypoxia. Ischemia in the placenta produces endothelial cell dysfunction, which is defined by a change in endothelial cell activity to a reduced ability to vasodilate (decreased eNOS) and prothrombotic conditions (decreased PECAM-1). Reduced maternal eNOS activity and PECAM-1 can cause preeclampsia. Pravastatin is the statin class's most hydrophilic medication, and it limits placental transfer. Pravastatin can reduce endothelial dysfunction by targeting pleiotropic effects in pregnancy. The aim was to show the effects of pravastatin on the eNOS and PECAM-1 expression in the placenta of preeclampsia rat model. Materials and Methods: This is a true experimental study with only a post-test and a control group design. The sample was biological material in the form of placental tissue from a pravastatin-treated preeclampsia rat model (using L-NAME exposure). This research was divided into five groups, each with five samples. The parameters studied were eNOS and PECAM-1 expression. Results: The Shapiro-Wilk test result was significant (p>0.05). Annova tests on eNOS (p=0.000) and PECAM-1 expression (p=0.000) confirmed the hypothesis. The Tukey test showed significant differences in eNOS (sig. 0.001) and PECAM-1 (sig. 0.000) expression between normal and preeclampsia rats. Positive controls and treatment groups P1, P2, and P3 all showed significant changes in eNOS and PECAM-1 expression. Pravastatin dose considerably increased eNOS (p=0.015; r=0.536) and PECAM-1 (p=0.000; r=0.734) expression.. Conclusion: Pravastatin has been shown to increase eNOS and PECAM-1 expression in the placenta of preeclampsia rat model.
Co-Authors Anita Dwi Rahmawati Bambang Rahardjo Berliana Maduratna Irawati Fatmawati Fatmawati Fauqo Wildatil Jannah Kunawati Tungga Dewi Mukhamad Nooryanto Mustika Dewi Ningrum Paramita Sari Rahma Dian Hanifarizani Rahma Ega Prospera Haryunita Yulia Silvani