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All Journal Medical Sains : Jurnal Ilmiah Kefarmasian Medical Sains : Jurnal Ilmiah Kefarmasian
Nia Kurniasih
Sekolah Tinggi Kesehatan Muhammadiyah Ciamis
Medicine & Pharmacology

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Journal : Medical Sains : Jurnal Ilmiah Kefarmasian

 1 
HUBUNGAN PENGETAHUAN DAN EFEK SAMPING OBAT TERHADAP KEPATUHAN PENGOBATAN PASIEN TUBERKULOSIS DI PUSKESMAS SUKARATU TASIKMALAYA: THE RELATIONSHIP OF KNOWLEDGE AND SIDE EFFECTS OF MEDICINE ON TREATMENT COMPLIANCE IN TUBERCULOSIS PATIENTS IN PUSKESMAS SUKARATU TASIKMALAYA Nia Kurniasih; Nina Muthoharoh; Nurhidayati Harun; Siti Rahmah Kurnia Ramdan; Marlina Indriastuti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 2 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i2.301

Abstract

Tuberkulosis merupakan masalah kesehatan masyarakat yang serius di dunia. Pada tahun 2019 sekitar 1,4 juta penduduk dunia meninggal karena Tuberkulosis. Ketidakpatuhan terhadap pengobatan Tuberkulosis merupakan hambatan penting dalam pencegahan dan pengendalian penyakit Tuberkulosis. Kepatuhan yang buruk dapat menyebabkan penyakit menular yang berkepanjangan, resistensi obat, kekambuhan ulang dan kematian. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan dan efek samping obat terhadap kepatuhan pengobatan pasien Tuberkulosis di Puskesmas Sukaratu, Tasikmalaya. Metode yang       digunakan adalah survei analitik dengan rancangan cross sectional. Pengambilan data menggunakan kuesioner dengan teknik purposive sampling. Analisis data menggunakan Chi Square. Hasil penelitian menunjukkan  responden yang memiliki tingkat pengetahuan baik sebanyak 23 responden dari total 31 responden (74,2%) dan responden  yang mengalami efek samping obat sebanyak 24 responden dari total 31 responden (77,4 %). Sebagian besar responden memiliki tingkat kepatuhan sedang yaitu sebanyak 22 responden (71,0%). Pada penelitian ini menunjukkan adanya hubungan antara tingkat pengetahuan dengan kepatuhan pengobatan pasien Tuberkulosis dengan nilai p-value sebesar 0,046 < 0,05 dan terdapat hubungan terjadinya efek samping obat dengan kepatuhan pengobatan pasien Tuberkulosis dengan nilai p-value sebesar 0, 010 < 0,05.
TEST ANTINFLAMMATION CAPSULE COMBINATION OF MORINGA LEAVES (Moringa oleifera L) AND KARUK LEAVES (Piper sarmentosum Roxb. Ex. Hunter) EXTRACT TEST AGAINST MICE (Mus musculus) Nia Kurniasih; Nurhidayati Harun; Ade Egie Prayogi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.837

Abstract

Empirically utilized medicinal plants include Moringa leaves (Moringa oleifera L) and Karuk leaves (Piper sarmentosum Roxb. Ex. Hunter). Moringa leaves contain active compounds, such as vitamins, carotenoids, polyphenols, phenolic acids, flavonoids, alkaloids, glucosinolates, isothiocyanates, tannins, saponins, and oxalates. The leaves of karuk contain polyphenols, flavonoids, saponins, and tannins. This study aimed to assess the anti-inflammatory activity of combination capsules of Moringa and Karuk leaf extracts in mice (Mus musculus). Anti-inflammatory agents are drugs that can suppress or reduce inflammation. The aim of the experimental method used in this study was to determine the optimal concentration for anti-inflammatory activity. Carrageenan as an inflammatory mediator in mouse paws. The anti-inflammatory test involved five groups of animals, each consisting of five mice. The negative control group received Na-CMC, the positive control group was administered diclofenac sodium, and the test samples involved a combination capsule of Moringa and Karuk leaf extract at doses of 350, 700, and 1,050 mg. Measurements were performed every hour for 6 hours after carrageenan induction. Data analysis employed the One-way ANOVA method to ascertain whether variations in the dose of the combination capsule of Moringa and Karuk leaf extracts affected anti-inflammatory activity in mice. The results indicate that the greatest inflammation inhibition occurs with the 1,050 mg dose, resulting in 23% inhibition, followed by 22% at 700 mg and 13% at 350 mg. Statistical analysis yielded a p-value of 0.048, which was less than 0.05. This suggests a significant difference in the anti-inflammatory activity among the test groups ...
Co-Authors Ade Egie Prayogi Indriastuti, Marlina Nina Muthoharoh Nurhidayati Harun Siti Rahmah Kurnia Ramdan Siti Rahmah Kurnia Ramdan