This study was conducted to assess the factors (age, gender, education, workplace, working experience and training) associated with the nurses anesthetists’ knowledge of Cardiac Pulmonary Resuscitation (CPR) in the COVID-19 pandemic era. This descriptive correlation study used a cross-sectional approach involved 109 nurses anesthetist as a sample. This study employed total sampling technique. The questionnaire used was adapted from the American Heart Association (2020). Based on the Chi square test, There was a significant relationship between age (p value = 0,044) and working experience (year) (p value = 0.024) with the nurses anesthetists’ knowledge of CPR in the COVID-19 pandemic era. Otherwise There was no significant relationship between gender (p value = 0,613), education (p value = 0,350), workplace (p value = 0,408), and training (p value = 0,632) with the nurses anesthetists’ knowledge of CPR in the COVID-19 pandemic era. The factors that significantly related to the nurses anesthetists’ knowledge of CPR in the COVID-19 pandemic era are age and working experience. The factors which unrelated are gender, education, income, workplace, and training.