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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY JSFK (Jurnal Sains Farmasi & Klinis) Molekul: Jurnal Ilmiah Kimia Pharmaceutical And Biomedical Sciences Journal (PBSJ)

Azrifitria Azrifitria

Pharmacy Department, Faculty Of Health Sciences, UIN Syarif Hidayatullah Jakarta

Author-ID : 4268187

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Published : 6 Documents Claim Missing Document

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Articles

Characteristics of Amino Acid, Fatty Acid and Mineral of Sea Hare Benny Manulang; Sri Purwaningsih; Azrifitria Azrifitria
Jurnal Pengolahan Hasil Perikanan Indonesia Vol 19 No 2 (2016): Jurnal Pengolahan Hasil Perikanan Indonesia
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Dolabella auricularia are found in the waters of Indo - Pacific and has active compound in health,which until now is still limited information about nutritional content from sea hare. The aim of this researchwere to determine morphometric and chemical characteristic D. auricularia which includes the proximate,amino acids, fatty acids and minerals. The composition of fatty acid were measured by gas chromatography(GC), amino acids were measured by high performanced liquid chromatography (HPLC), and mineral wasmeasured by atomic absorption spectrophotometer (AAS). The sea hare contained 9 essential amino acidsand 6 non essential amino acids. The highest essential amino acid was arginine (1.61%) while the highestnon essential amino acids was glycine (3.02%). Sea hare contained 26 fatty acids such as saturated fattyacids 5.33%, monounsaturated fatty acids 2.11% and polyunsaturated fatty acids 4.10%. The high mineralwas calcium 68100 mg/kg.

Optimasi Uji Difusi Kombinasi Testosteron Undekanoat (TU) dan Medroksi Progesteron Asetat (MPA) dalam Sediaan Mikroemulsi Azrifitria Azrifitria; Supandi Supandi; Muhardi Ritonga
MPI (Media Pharmaceutica Indonesiana) Vol. 1 No. 2 (2016): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Uji difusi kombinasi testosteron undekanoat (TU) dan medroksi progesteron asetat(MPA) dalam sediaan mikroemulsi yang telah dilakukan belum menunjukkan profil difusi yang optimal.Penelitian ini bertujuan untuk mengoptimasi medium difusi dan kinetika pelepasan sediaanmikroemulsi TU dan MPA. Parameter yang dioptimasi dalam penelitian ini adalah medium difusiyaitu menggunakan medium NaCl fisiologis, phosphate buffer saline (PBS) dan isopropanol-air (1:9).Pengujian difusi dilakukan dengan menggunakan alat Franz Diffusion Cell dan otot paha tikus jantanSprague-Dawley sebagai membran difusi yang dilakukan selama 18 jam. Hasil uji difusi dianalisisdengan kromatografi cair kinerja tinggi (KCKT) pada kondisi optimum dengan fase gerak metanolasetonitril(90:10), kolom C18, laju alir 1,2 ml/menit, volume injeksi 20 μl dan menggunakan detektorUV-Vis pada panjang gelombang 243 nm. Hasil analisis menunjukkan medium difusi yang palingoptimum adalah isopropanol-air (1:9). Kinetika pelepasan sediaan tersebut mengikuti kinetika ordenol dengan nilai r = 0,9913 untuk TU dan nilai r = 0,9777 untuk MPA.

Antibacterial activity of ethanolic extract of leaves and bulbs of Crinum asiaticum L. against acne-inducing bacteria Azrifitria .; Syaikhul Aziz; Chairul .
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The antibacterial activity of ethanolic extract of leaves and bulbs of Crinum asiaticum L. was tested against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis, pathogenic bacteria that cause acne. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were determined by dilution methods. MIC and MBC of ethanol leaves extract were found for P. acnes (1.25 and 2.5 mg/mL), S. aureus (5 and 10 mg/mL) and S. epidermidis (2.5 and 5 mg/mL). While MIC and MBC of ethanol bulbs extract were found for P. acnes (7.5 and 15 mg/mL), S. aureus (7.5 and 15 mg/mL) and S. epidermidis (3.75 and 7.5 mg/mL). Further study conducted on the ethanol leaves extract against P. acnes to analyze cell leakage (nucleic acid and protein) by ultraviolet spectrophotometry, metal ion (K+ and Ca2+) by atomic absorption spectrometry, and observed alteration of the cell wall by scanning electron microscopy (SEM). The result showed that ethanol leaves extract could damage the cell wall and affect the permeability of cell membrane which marked by release of nucleic acid (absorbance 0.3307-0.4299), protein (absorbance 0.0616-0.101), ion K+ (8.167-15.757 mg/mL), ion Ca2+ (5.47-13.74 mg/L) from the cell and alter morphology of cell wall of P. acnes.Key words: Antibacterial, Crinum asiaticum L., Propionibacterium acnes

The HMG-CoA Reductase Inhibitor Activities of Soy Protein Hydrolysates from Papain Hydrolysis Sandra Hermanto; Aldi Octavio; Azrifitria Azrifitria; Susi Kusumaningrum
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

The search for an HMG-CoA reductase inhibitor agent as a safe and inexpensive alternative treatment for hypercholesterolemia has been carried out using soy protein hydrolysates as one of the bioactive peptide sources. This study was conducted to explore the potency of soy protein hydrolysates as an anti hypercholesterolemia agent by an in vitro assay, through the inhibition capacity of the HMG-CoA (3-hydroxy-3-methyl glutaryl-coenzyme A) reductase enzyme as a key component of cholesterol biosynthesis. Sample preparation started with soy protein isolation through acid precipitation and separated by centrifugation. The samples were analyzed the proximate content and hydrolyzed by papain enzyme at concentration 0.2% (w/v), for 0-6 hours and at 37, 50, and 55 oC. The protein hydrolysates were subsequently evaluated for hydrolysis degree (% DH), hydrolysates profile with SDS-PAGE (Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis), and anti-cholesterol assay through HMG-CoA reductase inhibition tests. The sample with the highest inhibition activity was fractionated using gel filtration chromatography (Sephadex G-10) and the molecular weight of fractions was characterized by LCMS QTOF (Liquid Chromatography-Mass Spectrometry Quadrupole Time-of-Flight) for molecular weight determination. The results indicated the optimum hydrolysis conditions of soy protein isolates were obtained at 3 hours incubation, at 50 °C with DH 33.39% and the inhibition value was 95.65% (protein concentration 39.21 μg / mL). LCMS data showed the molecular weight of fractionated peptides were 1514 and 2029 Da. We assumed that both peptides have the same affinity as previous peptides in inhibiting HMG-CoA reductase.

Pengaruh Ekstrak Etanol 90% Daun Kelor (Moringa oleifera Lam.) Terhadap Fertilitas Tikus Putih Jantan (Sprague-Dawley) Azrifitria Azrifitria; Suci Ahda Novitri; Vishilpy Dimalia; Ratih Dara Syadillah
Jurnal Sains Farmasi & Klinis Vol 8, No 3 (2021): J Sains Farm Klin 8(3), Desember 2021
Publisher : Fakultas Farmasi Universitas Andalas

Kelor (Moringa oleifera Lam.) banyak digunakan sebagai obat tradisional dan sumber nutrisi yang baik. Penelitian daun kelor tentang fertilitas telah pernah dilakukan, namun adanya perbedaan hasil menjadi hal yang menarik untuk diteliti lebih lanjut. Penelitian ini bertujuan untuk mengetahui efek ekstrak etanol 90% daun kelor (EEDK) terhadap fertilitas dengan parameter spermatogenesis dan afrodisiak pada tikus putih jantan (Sprague-Dawley). Tikus putih jantan dibagi secara acak menjadi kelompok normal (NaCMC 0,5%), kelompok uji (EEDK dosis 50, 200 dan 800 mg/kgBB). Pemberian EEDK diberikan secara oral selama 15 hari. Hasil penelitian ini menunjukkan bahwa EEDK dapat meningkatkan serum testosteron namun tidak bermakna (p>0,05), masih dalam konsentrasi normal (0,66-0,54 µg/ml). Konsentrasi spermatozoa meningkat secara bermakna (p<0,05) pada dosis 800mg/kgBB, namun diameter tubulus seminiferus dan bobot testis tidak berbeda bermakna (p>0,05) pada semua dosis kelompok uji. Pemberian EEDK tidak mempengaruhi efek mounting frequency dan latency serta intromission latency dan frequency pada tikus jantan secara bermakna (p>0,05). Berdasarkan hasil tersebut, dapat disimpulkan bahwa pemberian EEDK pada tikus putih jantan (Sprague-Dawley) selama 15 hari memiliki potensi terhadap efek spermatogenesis dibandingkan dengan efek afrodisiak

The Impact of Pharmacists’ Interventions to Prevent Medication Errors at a Tertiary Hospital in Central Jakarta, Indonesia Azrifitria Azrifitria; Siti Fauziyah; Apriliana Nur
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 1, No 1 (2019)
Publisher : UIN Syarif Hidayatullah Jakarta

To promote the safety and quality of pharmaceutical services are still an issue in Indonesia. One way of doing so is to implement pharmaceutical care standards and prevent medication errors. The aim of this study was to evaluate if the intervention that conducts before and after the socialization in the standard of pharmacy service could cause a decrease in medication errors. The study was conducted by using a quasi-experimental design without a control group in outpatient pharmacy services of a tertiary hospital in central Jakarta, Indonesia. A total of 7627 prescriptions were collected prospectively by the total sampling method in April and May 2016. The observation was conducted in two stages of prescribing and dispensing. A total of 2541 medication errors identified, error rates of 16% and 33.3% were found during the prescribing and dispensing stages before socialization (April 2016), respectively. After the socialization in May 2016, the error rates of 15.2% and 20.2% were found in the prescribing and dispensing stages, respectively. However, the differences pre- and post-socialization were not significant (p>0.05). The greatest decrease in medication error was found on drug labels, which fell from 721(21%) to 458 (11%). Observations on near-miss events based on a risk matrix showed that these were dominated by a low-degree of risk. Based on these results, it could be concluded that the intervention given to pharmacists could decline medication errors. Nevertheless, further study with a greater amount of time and better pharmacist socialization is required.

Co-Authors Aldi Octavio Apriliana Nur Benny Manulang Chairul . Muhardi Ritonga Ratih Dara Syadillah Sandra Hermanto Siti Fauziyah Sri Purwaningsih Suci Ahda Novitri Supandi Supandi Susi Kusumaningrum Syaikhul Aziz Vishilpy Dimalia

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