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Nurul Windi Anggraini
Program Studi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya, Palembang, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Peranan Stres Oksidatif pada Preeklampsi Subandrate -; Mia EPA Faisal; Nurul Windi Anggraini
Cermin Dunia Kedokteran Vol 44, No 6 (2017): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v44i6.800

Abstract

Preeklampsi merupakan sindrom pada kehamilan yang ditandai dengan peningkatan tekanan darah dan proteinuri. Salah satu teori patofisiologi preeklampsi adalah teori stres oksidatif. Stres oksidatif bermula dari kegagalan invasi trofoblas saat implantasi sehingga menyebabkan hipoksi atau iskemik plasenta, selanjutnya menyebabkan berbagai kerusakan sel termasuk disfungsi sel endotel plasenta. Disfungsi sel endotel plasenta bersama kerusakan sel lain memicu manisfestasi klinis preeklampsi.Preeclampsia is pregnancy-related syndrome characterized by high blood pressure and protenuria. According to oxidative stress theory, preeclampsia is started by failure of trophoblast invasion in implantation process causing placental hypoxia or ischemia. These conditions will lead to different mechanisms of cell damage, including placental endothelial cell dysfunction. Endothelial placental cell dysfunction and other cell damage caused by oxidative stress will trigger the clinical manifestations of preeclampsia.
Co-Authors Mia EPA Faisal Subandrate