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Anik Puryatni
Division Of Nutrition And Metabolic Diseases, Department Of Pediatrics, Faculty Of Medicine, Universitas Brawijaya, Saiful Anwar Hospital, Malang, East Java, Indonesia
Health Professions Public Health

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Relationship of Epidermal Growth Factor (EGF) and Insulin-Like Growth Factor-1 (IGF-1) levels in breast milk colostrum with the occurrence of necrotizing enterocolitis in neonates Anik Puryatni; Prasetya Ismail; Fireka Juniantika; Bayu Kurniawan
Pediatric Sciences Journal Vol. 2 No. 2 (2021): (Available online 1 December 2021)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.636 KB) | DOI: 10.51559/pedscij.v2i2.30

Abstract

Background: Colostrum contains various bioactive compounds that have various roles and potentials in preventing the occurrence of necrotizing enterocolitis (NEC). EGF and IGF-1 are growth factors found in breast milk colostrum in the form of polypeptides that play a role in regulating and stimulating cell proliferation and differentiation processes. The purpose of this study was to determine the relationship between EGF and IGF-1 levels in breast milk colostrum with the occurrence of NEC in neonates. Methods: This analytical observational study was conducted at Saiful Anwar Hospital Malang during June-August 2019 on mothers and neonates who were breastfed. Maternal colostrum was collected at 72 hours postpartum, while NEC incidence in infants was determined prospectively. EGF and IGF-1 levels in colostrum were examined using the ELISA method. The data were processed by SPSS 21 program and analyzed using Spearman’s test and logistic regression. Results: 24 mother and baby pair samples were included in the study. The mean level of EGF in maternal colostrum was 466±304 ng/ml, and the mean level of IGF-1 was 1.99±0.96 ng/ml with no significant difference in levels based on gestational age. There is a strong negative correlation between the levels of EGF (r = -0.630; p=0.001) and IGF-1 (r = -0.646; p=0.001) on the occurrence of NEC. With the regression test, there was no significant effect between the levels of IGF-1 (p=0.995) and EGF (p=0.997) on NEC occurrence. Conclusion: EGF and IGF-1 levels have a significant relationship to the occurrence of NEC. The higher levels of EGF and IGF-1 contained in breast milk colostrum reduced the incidence of necrotizing enterocolitis in neonates.
Relationship between vitamin D levels with nutritional status and children's obesity in Saiful Anwar Hospital, Malang Anik Puryatni; Harjoedi Adji Tjahjono; Hanna Tetty
Pediatric Sciences Journal Vol. 4 No. 1 (2023): (Available online: 1 June 2023)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v4i1.59

Abstract

Background: Obesity is a condition marked by an excessive buildup of body fat tissue and is characterized by a recognizable clinical picture. An imbalance between energy intake and energy output leads to obesity. Both obesity and vitamin D insufficiency are serious health issues of the present. It was claimed that the mobilization of free fatty acids from adipose tissue might be impacted by active vitamin D (1,25-dihydroxy vitamin D). This study aimed to find a relationship between vitamin D levels with nutritional status and children's obesity in Saiful Anwar Hospital. Methods: This study used a cross-sectional approach with a consecutive sampling method. Seventy-five subjects met the inclusion criteria in the Saiful Anwar Hospital Malang pediatric ward in February-March 2022. The samples were then examined for vitamin D levels. Subjects were grouped based on good nutritional status, overweight, and obesity. The basic characteristics of the research subjects included gender, age, anthropometric status, nutritional status, and vitamin D levels. Results: The results showed that vitamin D levels were lower in overweight and obese children (median 17.6 and 14.08 kg/m2) than in normal nutrition children (median 34 kg/m2). Vitamin D and children's nutritional status had a significant relationship (p=0.001). Conclusion: Vitamin D levels and children's nutritional status were significantly correlated, with vitamin D levels being lower in overweight and obese children than in children with normal nutrition.
Co-Authors Bayu Kurniawan Fireka Juniantika Hanna Tetty Harjoedi Adji Tjahjono Prasetya Ismail