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All Journal Journal Syifa Sciences and Clinical Research (JSSCR)
Mahdalena Sy. Pakaya
Jurusan Farmasi, Fakultas Olahraga dan Kesehatan, Universitas Negeri Gorontalo, Jl. Jenderal Sudirman No. 06 Kota Gorontalo 96128, Indonesia
Chemistry Medicine & Pharmacology

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Efektivitas Penurunan Kadar Glukosa Darah Daun Lamtoro (Leucaena leucocephala L.) Pada Mencit Jantan (Mus muscullus L.) Juliyanty Akuba; Endah Nurrohwinta Djuwarno; Faramita Hiola; Mahdalena Sy. Pakaya
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14913

Abstract

Diabetes mellitus (DM) is defined as a disease or metabolic disorder characterized by high blood glucose levels. The management of diabetes mellitus therapy in the community is diverse, ranging from synthetic drugs to herbal medicines. Many people assume that herbal medicines are relatively cheaper and safer compared to synthetic drugs. One of the plants commonly used as herbal medicine is Lamtoro. This research aimed to determine the effectiveness of Lamtoro leaves (LeucaenaleucocephalaL) on decreasing blood glucose levels on lab mice (Mus musculus L). This study used 27 male house mice divided into nine groups; each group consisted of three male house mice, i.e., glucose control (group I), negative control Na-CMC 1% w/v (group II), Positive control of chlamyd Gliben 1.56% w/v (group III), administered N-Hexan extract of Lamtoro leave 1% w/v (group IV), the extract of N-Heksan Lamtoro leaf 2.5% w/v (group V),  the extract of N-Heksan Lamtoro leaf 5% w/v (group VI), ethanol extract of Lamtoro leaf 1% w/v (group VII), ethanol extract of Lamtoro leaf 2.5% b/v (group VIII), and ethanol extract of Lamtoro leaves 5% w/v (group IX). The results were analyzed using the One Way ANOVA test. It showed that N-Hexane and Ethanol extract of Lamtoro leaves with a concentration of 1% w/v, 2.5% w/v and 5% w/v was able to reduce the blood glucose levels. The extract which had the best activity in reducing blood glucose levels was found in ethanol extract 96% at a concentration of 5% w/v with a decrease in the percentage by 59%. This was because the 96% ethanol extract contained a number of secondary metabolite compounds, i.e., flavonoids, alkaloids and tannins as blood glucose levels reducer
Isolasi dan Karakterisasi Bakteri Endofit dari Akar Pare (Momordica charantia L.) Mahdalena Sy. Pakaya; Julianty Akuba; Dizky Ramadani Putri Papeo; Andi Makkulawu; Ade Ari Puspitadewi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.15536

Abstract

Endophytic bacteria are microbes that grow on plant tissue and can form a colony on plant tissue without producing a negative effect on the host. The endophytic bacteria have the potential to have the same activity and produce secondary metabolite as their host. The root of bitter melon (momordica charantia L.) has been known to have antibacterial activity, thus enabling the presence of endophytic bacteria, which also have antibacterial potential.This present research aims to isolate and characterize endophytic bacteria found in bitter melon (Momordica charantia L. The method used in the isolation stage is direct lanting so that the endophytic bacteria are obtained from plant tissue; macroscopic and microscopic characterization stage; inhibition test stage; inhibition test stage using disc method (Kirby-Bauer). In accordance with the results of macroscopic and microscopic characterization, the two bacteria indicate different characteristics.
Formulasi Dan Evaluasi Fisik Sediaan Mouthwash Ekstrak Etanol Kulit Buah Matoa (Pometia Pinnata) Nur Ain Thomas; Mahdalena Sy. Pakaya; Ariani H. Hutuba; Yayah Rachmatiyah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15538

Abstract

Matoa peels contained phenolic, saponin, tannin, flavonoid and terpenoid which functions as anti-bacterias to Streptococcus mutans that can cause dental caries and active ingridients for mouthwash preparations. Mouthwash is a solution to be used as a cleansing agent that can improve mouth hygiene, esthetics and breath freshness. This study aimed to identify the etanol extract of Matoa peels to be formulated mouthwash preprations and its physical evalutions. This study employed methods that includes peels extraction, extract phytochemical screening, mouthwash preparation productions and mouthwash preparations evluations consisting of organoleptic, pH and viscosity test. The testing was conducted in day 0, 7, 14, 21 and 28. The findings revealed formula 2 as the best formula with 10% of glycerin concentration.
Isolasi, Karakterisasi, dan Uji Antioksidan Fungi Endofit dari Tanaman Batang Kunyit (Curcuma domestica Val.,) Mahdalena Sy. Pakaya; Nur Ain Thomas; Hamsidar Hasan; Ariani H. Hutuba; Grasela Mbae
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20341

Abstract

Endophytic fungi live in mutualistic symbiosis and can produce secondary metabolites similar to their host. This research aims to isolate, characterize, and test the antioxidant activity of secondary metabolites from turmeric stems. This research is experimental research where the method used for endophytic fungi isolation is the direct planting method, and antioxidant activity is tested using qualitative and quantitative methods with DPPH (1.1-diphenyl-2-picylhydrazyl). One fungal isolate was obtained with the fungal isolate code (BK). Based on macroscopic and microscopic characterization, the BK fungal isolate indicates the Deuteromycota class's characteristics. The qualitative antioxidant test results indicate that the fraction of BK endophytic fungal isolate indicates antioxidant activity, indicated by the yellow color against a purple background on the TLC plate observed under visible light. The respective ICso values for the ethyl acetate and n-hexane fractions were 52.989 µg/ml and 89.725 µg/ml, categorized as strong antioxidants. The methanol fraction had an ICso value of 119.02 µg/ml, categorized as moderate, while the pure supernatant fraction had an ICso value of 156.86 µg/ml, categorized as weak antioxidant activity.
Co-Authors Ade Ari Puspitadewi Andi Makkulawu Ariani H. Hutuba Dizky Ramadani Putri Papeo Endah Nurrohwinta Djuwarno Faramita Hiola Grasela Mbae Hamsidar Hasan Julianty Akuba NUR AIN THOMAS Yayah Rachmatiyah