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EFEK EKSTRAK METANOL DAUN SELEDRI (Apium graveolens Linn.) SEBAGAI INSEKTISIDA TERHADAP NYAMUK Akuba,M.Sc.,Apt, Juliyanty; Thomas, Nurain; Dwy Jayanto Palay, Rendy
Journal Syifa Sciences and Clinical Research Vol 1, No 1 (2019): March
Publisher : State University of Gorontalo

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The ability of mosquitoes as a vector of various diseases such as dengue and malaria. One of the most commonly used methods of eradicating mosquitoes is chemical insecticides aimed at killing adult mosquitoes, which also creates its own problems, namely the emergence of mosquito resistance and toxic effects on humans. Therefore, alternative insecticides that are safer for the environment are needed from plants. One of them uses celery plants (Apium graveolens Linn.). Celery contains essential oils which act as respiratory poisons that can repel or kill mosquitoes. This study aims to see the effect of methanol extract of celery leaves as insecticides on mosquitoes, carried out by spraying on mosquitoes in confinement. Spraying using water as a negative control, baygon as a positive control and each extract solution 5% b / v, 10% b / v and 15% b / v. Spraying on each cage is done 8 times, ie 2 times from the left side of the cage, 2 times from the right side of the cage, 2 times from the front of the cage and 2 times from the back of the cage. The results showed that testing of methanol extract of celery leaves at a concentration of 5%, 10% and 15% could work as a mosquito-killing insecticide.

UJI EFEKTIVITAS SEDIAAN PATCH EKSTRAK DAUN CENGKEH (Syzygium aromaticum) SEBAGAI REPELLENT NYAMUK Sy. Pakaya, M.Si.,Apt, Mahdalena; Thomas, Nurain; Arista Idris, Pinkan
Journal Syifa Sciences and Clinical Research Vol 1, No 1 (2019): March
Publisher : State University of Gorontalo

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Clove (Syzygium aromaticumL.) leaf has efficacy as repellent because it contains terpenoid eugenol. This study aimed to determine how the effectiveness of clove leaf extract patch dosage as a mosquito repellent. This research was started with extraction using maceration method with 96% ethanol solvent. Furthermore, making the dosage of patch of clove leaf extract using matrix method with variation of the clove leaf extract concentration. Then, the effectiveness of mosquito repellent patch was tested by using rabbit that divided into 5 treatment groups namely K- (base patch), K+ (mosquito repellent patch), 3 groups of clove leaf extract patch with variation of concentration of F1a (concentration of 1%), F1b (concentration of 3%), and F1c (concentration of 5%). Each group was attached to the clothes of the rabbit and put into the experimental box that had been put by mosquito as many as 20 tails. Based on result of ANNOVA statistic test showed that clove (Syzygium aromaticumL.) leaf patch dosage against the rabbit gave a significant effect against mosquito repellent, where at 5% concentration of clove leaf extract could give mosquito repellent efficacy better than concentration 1% and 3%.

UJI EFEKTIVITAS SEDIAAN PATCH EKSTRAK DAUN CENGKEH (Syzygium aromaticum) SEBAGAI REPELLENT NYAMUK Sy. Pakaya, M.Si.,Apt, Mahdalena; Thomas, Nurain; Arista Idris, Pinkan
Journal Syifa Sciences and Clinical Research Vol 1, No 1 (2019): March
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.51 KB)

Clove (Syzygium aromaticumL.) leaf has efficacy as repellent because it contains terpenoid eugenol. This study aimed to determine how the effectiveness of clove leaf extract patch dosage as a mosquito repellent. This research was started with extraction using maceration method with 96% ethanol solvent. Furthermore, making the dosage of patch of clove leaf extract using matrix method with variation of the clove leaf extract concentration. Then, the effectiveness of mosquito repellent patch was tested by using rabbit that divided into 5 treatment groups namely K- (base patch), K+ (mosquito repellent patch), 3 groups of clove leaf extract patch with variation of concentration of F1a (concentration of 1%), F1b (concentration of 3%), and F1c (concentration of 5%). Each group was attached to the clothes of the rabbit and put into the experimental box that had been put by mosquito as many as 20 tails. Based on result of ANNOVA statistic test showed that clove (Syzygium aromaticumL.) leaf patch dosage against the rabbit gave a significant effect against mosquito repellent, where at 5% concentration of clove leaf extract could give mosquito repellent efficacy better than concentration 1% and 3%.

EFEK EKSTRAK METANOL DAUN SELEDRI (Apium graveolens Linn.) SEBAGAI INSEKTISIDA TERHADAP NYAMUK Akuba,M.Sc.,Apt, Juliyanty; Thomas, Nurain; Dwy Jayanto Palay, Rendy
Journal Syifa Sciences and Clinical Research Vol 1, No 1 (2019): March
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (552.775 KB)

The ability of mosquitoes as a vector of various diseases such as dengue and malaria. One of the most commonly used methods of eradicating mosquitoes is chemical insecticides aimed at killing adult mosquitoes, which also creates its own problems, namely the emergence of mosquito resistance and toxic effects on humans. Therefore, alternative insecticides that are safer for the environment are needed from plants. One of them uses celery plants (Apium graveolens Linn.). Celery contains essential oils which act as respiratory poisons that can repel or kill mosquitoes. This study aims to see the effect of methanol extract of celery leaves as insecticides on mosquitoes, carried out by spraying on mosquitoes in confinement. Spraying using water as a negative control, baygon as a positive control and each extract solution 5% b / v, 10% b / v and 15% b / v. Spraying on each cage is done 8 times, ie 2 times from the left side of the cage, 2 times from the right side of the cage, 2 times from the front of the cage and 2 times from the back of the cage. The results showed that testing of methanol extract of celery leaves at a concentration of 5%, 10% and 15% could work as a mosquito-killing insecticide.

FORMULASI DAN UJI EFEKTIVITAS GEL EKSTRAK BUAH PARE (Momordica charantia L) Terhadap BAKTERI Staphylococcusepidermidis dan Propionibacterium acnes PENYEBAB JERAWAT Thomas, Nur Ain; Abdulkadir, Widy Susanti; Mohi, Mega Agustiwi
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 2, No 1 (2019)
Publisher : Sam Ratulangi University

FORMULASI DAN UJI EFEKTIVITAS GEL EKSTRAK BUAH PARE (Momordica charantia L) Terhadap BAKTERI Staphylococcusepidermidis dan Propionibacterium acnes PENYEBAB JERAWATÂ Nur Ain Thomas1), Widysusanti Abdulkadir1), Mega Agustiwi Mohi1) 1)Jurusan Farmasi, Fakultas Olahraga dan KesehatanUniversitas Negeri GorontaloÂ ABSTRACTÂ Acne is a skin disease in the form of inflammation in the layer of polysebaseus triggered by the bacteria Staphyloccoccus epidermidis and Propionibacterium acnes. One plant that is empirically and based on scientific data has anti-acne properties is bitter melon (Momordica charantia L). In pare fruit extract contains flavonoids which are thought to be able to act as active compounds in the form of anti-acne. This study aims to formulate bitter melon extract as an anti-acne gel and determine the inhibition of bitter melon extract gel against acne-causing bacteria, namely Staphylococcus epidermidis and Propionibacterium acne. Pare fruit extract gel with 3 variations of extract concentration, namely 5%, 7.5% and 10%. Evaluation of gel preparations included organoleptic test, homogeneity, spreadability, pH, viscosity, and irritation test. Data analysis using Oneway ANOVA. Based on the results of the research conducted, it can be concluded that bitter fruit extract (Momordica charantia L) can be formulated as an anti-acne gel, and the preparation of bitter fruit extract gel (Momordica charantia L) at a concentration of 10% has a inhibition of 10 mm against Staphylococcus epidermidis and 7, 1 mm against the bacterium Propionibacterium acne which is included in the medium category.Â Keywords: Acne, Extract, Gel , Stahpylococcus epidermidis, Propionibacterium acnesÂ Â ABSTRAKÂ Jerawat merupakan penyakit kulit berupa peradangan pada lapisan polisebaseus yang dipicu oleh bakteri Staphyloccoccus epidermidis dan Propionibacterium acnes. Salah satu tanaman yang secara empiris dan berdasarkan data ilmiah memiliki khasiat antijerawat adalah buah pare (Momordica charantia L). Dalam ekstrak buah pare terkandung flavonoid yang diduga dapat berperanÂ sebagai senyawa aktif sedian antijerawat. Penelitian ini bertujuan untukÂ memformulasikan ekstrak buah pare sebagai gel antijerawat dan menentukan daya hambat gel ekstrak buah pare terhadap bakteri penyebab jerawat yaitu Staphylococcus epidermidis dan Propionibacterium acne. Gel ekstrak buah pare dengan 3 variasi konsentrasi ekstrak yaitu 5%, 7,5% dan 10%. Evaluasi sediaan gel meliputi uji organoleptik, homogenitas, daya sebar, pH, viskositas, dan uji iritasi.Analisis data menggunakan ANOVA Oneway. Berdasarkan hasil penelitian yang dilakukan maka dapat disimpulkan bahwa ekstrak buah pare (Momordica charantia L) dapat diformulasikan sebagai gel antijerawat, dan sediaan gel ekstrak buah pare (Momordica charantia L) pada konsentrasi 10% mempunyai daya hambat 10 mm terhadap bakteri Staphylococcus epidermidis dan 7,1 mm terhadap bakteri Propionibacterium acne yang termasuk dalam kategori sedang.Kata Kunci :Jerawat, Ekstrak Buah Pare, Gel, Stahpylococcus epidermidis, Propionibacterium acnes Â

Pemanfaatan Ubi Ungu Sebagai Makanan Kesehatan Dalam Upaya Peningkatan Derajat Kesehatan dan Kesejahteraan Masyarakat Petani di Desa Mekar Jaya Kecamatan Duhiadaa Kabupaten Pohowato Madania, Madania; Hasan, Hamsidar; Thomas, Nur Ain
JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat) Vol 1 No 2 (2017): JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat)
Publisher : Dewan Pimpinan Daerah (DPD) Forum Dosen Indonesia JATIM

The potency of purple sweet potatoes cultivation in Mekar Jaya Village, Duhiadaa Sub-district, PohowatoRegency is abundant but only sold in the form of tuber. Average selling price of the tuber is Rp. 7,000, - which is stillincluded in the very low price category and the demand is still small. To be able to increase the selling point, it isnecessary to inform the community in the village both knowledges and skills in terms of raw management of the tuber intoflour and subsequently it can be made into a healthy food with high nutritional value and also to increase the sellingvalue so as to improve the welfare of the community. This activity aims to improve the knowledges and skills of thecommunity in making healthy food from the tuber. This health foods such as ice cream with high nutritional value,brownies and low carbohydrate bread, and potato sticks with high antioxidant content is one of the alternative fooddestined for diabetics, cholesterol due to the nutritional content and fiber. The empowerment model in transferringknowledges and technology to the group of Pembinaan Kesejahteraan Keluarga (PKK) in the village is using directpractice method in the field, starting from the process of making products from the tuber to product marketing. Thisactivity involves the supervisors (Dosen Pembimbing Lapangan, DPL), students, extension workers as partners in KKNPPM (Kuliah Kerja Nyata - Pembelajaran Pemberdayaan Masyarakat) activities that is a very important institution related to the activities undertaken and involved in the development of agricultural commodities development.  The form of the implemented program are socialization by the students about the benefits of the tuber and direct practice about how tomake healthy products such as making bread, brownies, ice cream and potato sticks, packaging and marketing accordingto the needs. The method used is empowerment of PKK Mekar Jaya group with instructional techniques and directpractice by providing knowledges about how to produce a high quality products from the purple sweet potatoes which iscapable to compete in the market

UJI BAKTERIOLOGIS MINUMAN RINGAN BERKARBONASI YANG BEREDAR DI BEBERAPA SEKOLAH DASAR DI MANADO THOMAS, NUR AIN
Jurnal Entropi Vol4, No 2, 2009
Publisher : Jurnal Entropi

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Penelitian ini bertujuan untuk mengetahui kondisi bakteriologis minuman ringan berkarbonasi yang beredar di beberapa Sekolah Dasar di Manado. Penelitian ini menggunakan metode SPC (Standard Plate Count) untuk menghitung jumlah total bakteri,dan Most Probable Number (MPN) untuk mengetahui total bakteri koliform dan identifikasi bakteri pathogen yaitu Salmonella sp,Eschericia coli dan Staphylococcus sp dengan menggunakan media selektif. Minuman ringan berkarbonasi diambil dari empat wilayah sekolah dasar yang mewakili wilayah Barat,Timur,Utara dan Selatan. Minuman ringan yang diperiksa yaitu tanpa Es dan dengan es. Hasil penelitian jumlah total bakteri yang diperoleh pada sample minuman ringan tanpa es yaitu : Al (7,0 X 101 koloni/ml), All (1 X 101koloni/ml) All (2,4X102koloni/ml), AIV (1,7X102)koloni/ml), sedangkan pada sample minuman ringan dengan es yaitu :BI (1,7X103koloni/ml), BII (4,3X102 koloni/ml) BIII (2,1X103 koloni/ml), BIV (1,8X103koloni/ml), dan persyartan angka lempeng total adlah maksimal 5X102koloni/ml.sedangkan untuk jumlah bakteri koliform pada sample tanpa es yaitu : AI (

FORMULASI SEDIAAN SAMPO ANTIKETOMBE EKSTRAK ETANOL SELEDRI (Apium graveous L.) DAN UJI AKTIVITASNYA TERHADAP JAMUR Malassezia furfur Ain Thomas, Nur; Adam Mustapa, Mohamad; Abto, Nazarudin
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022 (in press)
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.10772

Ketombe merupakan salah satu masalah kulit kepala yang disebabkan oleh jamur Malassezia furfur. Tanaman seledri (Apium graveolus L.) merupakan salah satu tanaman yang diketahui memiliki aktivitas sebagai antijamur. Tujuan dari penelitian ini adalah untuk memformulasikan ekstrak etanol seledri (Apium graveolus L.) menjadi sampo dan uji aktivitas antijamur terhadap jamur penyebab ketombe yaitu Malassezia furfur. Penelitian diawali dengan proses ekstraksi seledri dengan metode maserasi, kemudian dilakukan optimasi basis sampo dengan variasi konsentrasi cocamidopropyl betain 4%, 6%, 8% dan 10% sebagai surfaktan sekunder dan peningkat viskositas. Basis optimum yang terpilih yaitu basis dengan cocamidopropyl betain 10% kemudian diformulasikan dengan ekstrak etanol seledri (Apium graveolus L.) dengan konsentrasi 0,5%, 1% dan 2,5%. Setelah itu dilakukan evaluasi yang meliputi uji organoleptis, uji pH, uji viskositas, uji ketinggian busa, uji ketahanan busa seta uji kesukaan (hedonic). Pengujian aktivitas antijamur dilakukan dengan metode difusi cakram untuk melihat zona hambat. Hasil uji menunjukan sampo antiketombe ekstrak etanol seledri (Apium graveolus L.) menghasilkan diameter rata-rata area hambat masing-masing untuk F4a sebesar 4,3 mm, F4b 4,6 mm, dan F4c sebesar 6,6 mm. Hasil uji aktivitas antijamur diolah dengan metode One Way Anova dengan taraf kepercayaan 99% (Î±=0,01). Hasil penelitian menunjukkan bahwa sampo dengan ekstrak etanol seledri 0,5%, 1% dan 2,5% aktif dalam menghambat jamur Malassezia furfur dengan hasil analisis One Way Anova menunjukkan p=0,000 (sigÎ±).

Pemberdayaan Masyarakat Kabupaten Boalemo Melalui Pelatihan Dan Pembuatan Produk Sediaan Herbal Dari Tanaman Obat Dalam Rangka Pencapaian Sy. Pakaya, Mahdalena; Thomas, Nur Ain
Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Vol 11, No 1 (2022): Jurnal Sibermas (Sinergi Bersama Masyarakat)
Publisher : Univeristas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/sibermas.v11i1.12043

Indonesia memilki potensi sebagai sentra penghasil obat tradisional. Biodiversiti tumbuhan yang melimpah, menjadi pendukung utama untuk dikembangkannya produk obat herbal. Sehingga bisa menjadi lahan pembuka lapangan pekerjaan baru di masyrakat.Â Oleh karena itu diperlukan adanya berbagai program pembinaan dengan memanfaatkan dan mengelola tumbuhan maupun tanaman obat yang ditanam disekitar pekarangan rumah untuk dioah sebaga obat tradisional. Tujuan dari pengabdian ini adalah meningkatkan pendapatan masyarakatÂ dengan memberikan pelatihan pembuatan produk herbal. Adapun delapan produk yang dipraktikan secara langsung yakniÂ Serbuk Jahe Instan, Serbuk Kunyit Asam Instan, Kapsul Jahe/Kunyit/Temulawak/Sereh, Susu Jagung Jahe, Susu Rempah, Lemonggrass Tea, Teh Herbal, Permen Jahe dan Minyak Balur. Metode yang digunakan adalah ceramah dan praktik atau demonstrasi. Sehingga masyarakat dapat mempraktikkan secara langsung dan menerapkan dalamÂ rumah tangga.

Formulasi, Karakterisasi, Dan Evaluasi Drops Liquid Self Nano-Emulsifying Drug Delivery System (SNEDDS) Astaxanthin Robert Tungadi; Nur Ain Thomas; Wanda Gita Van Gobel
Indonesian Journal of Pharmaceutical Education Vol 1, No 3 (2021): September-Desember 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i3.11400

SNEDDS are isotropic mixtures of oil, surfactant, and cosurfactant that produce spontaneous nanoemulsions once they make contact with gastric juices in order to increase the solubility of active pharmaceutical ingredients. One of the active pharmaceutical ingredients with low solubility is Astaxanthin. This research aims at formulating, characterizing, and evaluating SNEDDS containing Astaxanthin in the form of droplets. This research is a laboratory experiment. SNEDDS containing Astaxanthin droplets are made in 3 formulas using the ratio of surfactants and co-surfactants which are characterized to produce F1, F2, and F3 transmittance values of 91%, 90%, and 95%, respectively. Furthermore, the F1 particle size value of 183.75 nm obtains a PDI value of 0.272, the F2 particle sizevalue of 195.25 nm obtains a PDI value of 0.341, and the F3 particle size value of 105.75 nm obtains a PDI value of 0.392. This signifies that the absorption efficiency of F1, F2, and F3 are 94.62%, 94.35%, and 95.57%, respectively. The evaluation reveals the insignificant changes in the emulsion viscosities of SNEDDS containing Astaxanthin liquid drop after having received a stability test for 28 days using Paired T. Test data analysis (p0.05). The research findings show that the F3 of 72% surfactant and 18% co-surfactant concentrations are the best formula in producing SNEDDS. It concludes thar the higher the surfactant concentration produced, the greater the ability to, oil droplets resulting in obtaining small partidles and high absorption efficiency.

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