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All Journal Jurnal Sport Science Program Kreativitas Mahasiswa - Pengabdian Kepada Masyarakat Folia Medica Indonesiana The Indonesian Biomedical Journal Health Notions Molecular and Cellular Biomedical Sciences (MCBS) JBN (Jurnal Bedah Nasional) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Keperawatan BSI Journal Medical Informatics Technology

Lukman Hakim

Department Of Pharmacology, Faculty Of Medicine, Universitas Airlangga, Surabaya

Author-ID : 446354

Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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REVITALISASI PERAN KARANG TARUNA SEBAGAI KOMUNITAS PENGGERAK ANTIMADAT DAN SEKS BEBAS (KOMPAS) REMAJA DI KAWASAN LOKALISASI DOLLY, SURABAYA Sulistiawan, Dedik; Hakim, Lukman; Mahenda, Adelia Ratri; Bikatofani, Ryan Rizky; Ibad, Mursyidul
Program Kreativitas Mahasiswa - Pengabdian Kepada Masyarakat PKM-M 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Issues related to adolescent sexual deviation cases and drug abuse in Indonesia continues to increase. A total of 75 % of the 3.2 million drug users in Indonesia was a teenager . Of the 84 respondents who had experienced adolescent unwanted pregnancy , 60 % of whom have an abortion . The case with the teenagers in the Localization Dolly , Surabaya . The existence of Dolly contribute 71 % of the adolescent premarital sexual behavior in the vicinity. Meanwhile , youth are expected to play a role in movement and free sex antimadat in the region has not seen the real Dolly . This community service program aimed at restoring the role of youth organizations as an active community and helpless in society in movement and free sex antimadat promotive and preventive centered community -based approach , through the formation of peer educators . The method used is based on a theoretical framework Precede - PROCEED as a frame work development of health education programs . This program is proven to improve cognition in the Dolly teen population at risk as cases of sexual perversion and drug abuse . This activity produces an output in the form of the Youth Center as youth centers , triggering a re- active youth organizations in the target area . The key point of this program s success is the involvement of the subject s empowerment in decision-making that aims to arouse the internal motivation that makes the subject of empowerment as a necessity . Revitalization Role as Community Youth Activator Antimadat and Free Sex ( COMPASS ) Localization Region Youth Dolly , Surabaya is expected to be a best practice implementation of the empowerment of adolescent reproductive health , especially in the area of prostitution

EFEK PEMBERIAN KOPI TERHADAP GLUKOSA DARAH DAN LAKTAT DARAH SELAMA DAN SESUDAH AKTIFITAS FISIK SUBMAKSIMAL Lukman Khakim
Jurnal Sport Science Vol 4, No 3 (2015): Volume 4, Nomor 3, Juni 2015
Publisher : Jurnal Sport Science

Abstract: The study aimed at finding out the effect of coffee on blood glucose and blood lactate before and after sub maximal physical activities. The design of the study was ex-perimental laboratories. The subject of the study was 21-to-23-year-old and healthy students of Sport Science of Surabaya State University. The result of the analysis showed that paired test of blood glucose level (K1) posttest 1 - posttest (3) p=0,014 (p<0,05), K2 posttest 1 - posttest 3 p=0,073 (p>0,05) whereas lactate acid posttest 1 - posttest 3 p=0,00 (p<0,05), K2 posttest 1 - posttest 3 p=0,00 (p<0,05). The independent T-test of glucose level right after 20-minute-exercise was p=0,014 (p<0,05) showing that there was a significant difference and the lactate acid level after 20-minute-exercise was p= 0,008 (p<0,05) also showing that there was a significant difference. In conclusion, coffee could reduce the over decrease of blood glucose as a result of doing physical activities or after. Meanwhile, coffee could also reduce the over increase of lactate acid.Key words: MDA, submaximal exercise Shorinji Kempo, at night.Abstrak: Penelitian untuk mengetahui efek pemberian kopi terhadap glukosa darah dan laktat darah selama dan sesudah aktivitas fisik submaksimal. Penelitian dilakukan dengan metode experimental laboratoris. Subyek penelitian mahasiswa Ilmu Keolahragaan Uni-versitas Negeri Surabaya dengan usia 21-23 tahun dalam kondisi sehat. Hasil analisis menunjukkan uji berpasangan kadar glukosa darah (K1) postest 1 - postest (3) p=0,014 (p<0,05), K2 postest 1 - postest 3 p=0,073 (p>0,05) sedangkan asam laktat postest 1 - postest 3 p=0,00 (p<0,05), K2 postest 1 - postest 3 p=0,00 (p<0,05). Uji t bebas glukosa 20 menit segera selesai exercise p=0,014 (p<0,05) menunjukkan data signifikan ada perbedaan yang bermakna sedangkan asam laktat 20 menit segera selesai exercise p= 0,008 (p<0,05) menunjukkan data signifikan ada perbedaan yang bermakna. Dengan pemberian kopi dapat mengurangi penurunan glukosa darah yang terlalu besar pada saat melakukan aktifitas fisik maupun segera setelah melakukan aktivitas fisik sedang-kan pemberian kopi terhadap asam laktat dapat mengurangi peningkatan asam laktat terlalu tinggi.Kata kunci: kadar mda, latihan submaksimal shorinji kempo, di malam hari.

Type of Dominant Personality in Coronary Artery Heart Disease Patients Beny Prastyo; Abdurrachman Abdurrachman; Yunias Setiawati; Rerdin Julario; Lukman Hakim Andira
Health Notions Vol 3, No 11 (2019): November
Publisher : Humanistic Network for Science and Technology (HNST)

Coronary heart disease is one of the leading causes of death in Indonesia. Personality is one of the risk factors of coronary heart disease. The aim of the study was to investigate the dominant personality according to Big Five Personality in patients with coronary heart disease. We used an analytical descriptive study with cross-sectional design. The samples taken were patients with coronary heart disease in Dr. Soetomo General Hospital Surabaya in May 2019. Data of personality were collected using the Big Five Personality questionnaire. The result showed that the dominant personality according to Big Five Personality in patients with coronary heart disease was conscientiousness. Keywords: big five personality; coronary heart disease; personality type

Dedifferentiation of MCF-7 Breast Cancer Continuous Cell Line, Development of Breast Cancer Stem Cells (BCSCs) Enriched Culture and Biomarker Analysis Ami Ashariati Prayogo; Andi Yasmin Wijaya; Winona May Hendrata; Steven Sheng Looi; Reny I’tishom; Lukman Hakim; Fedik Abdul Rantam; I Ketut Sudiana; Abdurachman Abdurachman
The Indonesian Biomedical Journal Vol 12, No 2 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i2.977

BACKGROUND: Cancer stem cells (CSCs) eradication might serve as a robust approach for cancer eradication. MCF-7 as breast cancer continuous cell line is known to contain breast CSCs (BCSCs) for its capability to maintain its original tumor population. CSCs enriched culture is a fundamental tool for CSCs targeted therapy development. Effective and unsophisticated CSCs dedifferentiation protocol for producing CSCs enriched culture is needed.METHODS: MCF-7 cells were cultured initially in Dulbecco's Modified Eagle Medium (DMEM) low glucose medium then changed to DMEM:F12. Serum starvation was performed during each medium refreshment gradually with fetal bovine serum (FBS) concentration of 10%, 5%, 2.5% until reaching 1% FBS concentration. Stable MCF-7 culture was then adapted to serum free culture system, containing DMEM:F12, epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and B27 supplement as dedifferentiation protocol for 18 days. Cluster of differentiation (CD)44 and CD24 double staining immunocytochemistry was performed to evaluate cell stemness.RESULTS: The population of cells expressing BCSCs markers (CD44+/CD24low) in non-adherent single cells subpopulation was significantly increased after the dedifferentiation procedure (70.39%) compared to control groups (0.71%) (p<0.05). In contrast, the expression of BCSCs marker in adherent single cells subpopulation and for both adherent and non-adherent mammosphere the BCSCs markers showed a stable expression.CONCLUSION: BCSCs enrichment of breast cancer cell cultures from MCF-7 breast cancer cell line can be performed. Breast cancer cell plasticity is observed during the dedifferentiation protocol. Development of dedifferentiation inducing protocols can serve as an important foundation for breast cancer therapy development through BCSCs elimination.KEYWORDS: breast neoplasms, cell line, dedifferentiation, immunohistochemistry, neoplastic stem cells

The Prognostic Role of Neutrophil-to-Lymphocyte Ratio (NLR) in Testicular Germ Cell Tumor (GCT) Haviv Muris Saputra; Lukman Hakim
Folia Medica Indonesiana Vol. 58 No. 1 (2022): March
Publisher : Universitas Airlangga

Highlights:Neutrophil to lymphocyte ratio (NLR) has been reported by several studies for its role as a biomarker in various diseases, however, the role of NLR in testicular GCT is still unclear.The characteristics and responses of testicular GCT patients among Indonesian men show similarity to other reports worldwide.As a parameter, NLR shows promise to be used as a potential biomarker for prognosis in testicular GCT.Abstract:The global incidence of testicular cancer is 1-2% from all cancers. The attempts to maintain high therapeutic rates while decreasing the treatment-related side effects and toxicity have become the current concern. However, the reports regarding testicular germ cell tumors (GCT) in Indonesia are limited. Thus, we aimed to evaluate the clinical characteristics of testicular GCT patients undergoing bleomycin, etoposide, and cisplatin (BEP) chemotherapy, as well as their chemotherapy response and side effects. We reported the data of patients with Testicular Germ Cell Tumor from January 2015 to December 2019. Several data were retrieved, including patient demographics, tumor characteristics, treatment, and prognosis outcome. A total of 67 patients with testicular germ cell tumors were included in this study. The mean age was 28.9 years old. The chemotherapy regimens used were four cycles of (BEP) in 36 patients (53.7%), followed by three cycles of BEP in 22 patients (32.8%). Patients with seminoma GCT mostly had a complete response (54.1%), whereas most patients with non-seminoma GCT had progressive disease (47.8%). The multiple logistic regression analysis showed that NLR and S staging were independently associated with the patient’s response to chemotherapy (OR 2.14, 95% CI 1.22, 3.78, p <0.01,OR 9.43, 95% CI 1.81, 49.14, p < 0.01). The clinical characteristics and response of testicular GCT patients among Indonesian men showed similarity with the current worldwide data. The NLR could be used as a potential biomarker for prognosis.

Correlation of Serum Nitric Oxide and Urine Malondialdehyde Levels in Non-Hemodialysis Chronic Kidney Disease Patients Dinda Dwi Purwati; Arifa Mustika; Lukman Hakim; Mochammad Thaha
Molecular and Cellular Biomedical Sciences Vol 6, No 1 (2022)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v6i1.226

Background: In 2017, about 1.2 million people died because of Chronic Kidney Disease (CKD). Patients with CKD are known to have increased levels of oxidative stress which leads to decrease in NO production. NO is a highly reactive signaling molecule and a major determinant of vascular homeostasis. Thus, the decreased NO can be a risk factor for the development of atherosclerosis and increased cardiovascular risk. Meanwhile, Malondialdehyde (MDA) is known as excellent biomarker for oxidative stress. This study aims to determine the correlation of serum total nitric oxide (NO) and urine MDA levels in non-hemodialysis CKD patients.Materials and Methods: This study was an observational clinical study with a cross sectional design. Fourty-nine CKD subjects were selected by consecutive sampling. The samples for laboratory tests were collected from urine. MDA concentration was measured using the High-Performance Liquid Chromatography (HPLC) kit. NO concentration was measured with Griess reaction method and Total Nitric Oxide Parameter kit. The data were analyzed using the Statistic Package for Social Science (SPPS) software version 16.Results: The data showed significant negative correlations between MDA with NO (r=-0.294; p=0.041).Conclusion: There was a correlation between serum total NO and urine MDA levels in non-hemodialysis CKD patients.Keywords: chronic kidney disease, malondialdehyde, nitric oxide, non-hemodialysis

PENGALAMAN BELAJAR MAHASISWA KEDOKTERAN DALAM PENGGUNAAN REKAMAN KULIAH SEBAGAI MEDIA PEMBELAJARAN Lukman Hakim; Fundhy Sinar Ikrar Prihatanto; Musofa Rusli
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 8, No 3 (2019): November
Publisher : Asosiasi Institusi Pendidikan Kedokteran Indonesia

Background: Recorded lecture is a type of learning media which the lecturers record their voices when lecturing. This type of media is popular in many universities outside Indonesia. Faculty of Medicine Universitas Airlangga is developing electronic learning using recorded lecture in 2016. This study aimed to learn the experience of college student about the usage of recorded lecture, the impact to their learning style, and their hopes about the implementation of recorded lecture in Faculty of Medicine Universitas Airlangga. Method: This qualitative study applied content analysis design. The variable used are age, gender, intelligence quotient, learning style, learning equipment, experience when using learning media, and busyness in student affairs. Results: Eleven subjects are interviewed. The results are variably different between the subject. There are seven themes arise from the analysis results, for instance: 1) classical class alone was not enough, need another alternative; 2) the recorded lecture was similar with the one in internet; 3) used recorded lecture just for a few times; 4) recorded lecture was very beneficial; 5) the recorded lecture was too long; 6) college students are very busy outside the class; 7) a wish for the improvement og the recorded lectures, both quality and quality. Conclusion: The experience felt by medical education students on the use of recordings still varies. In general, students feel helped by the recording of lectures, on the other hand there are students who are not satisfied with the quality and quantity of lecture recordings provided by the campus. Massive and comprehensive improvements are needed in all aspects of providing lecture records, both in terms of teachers and in terms of technology support Keywords: recorded lecture, content analysis, qualitative research, medical student, electronic learning.

Testicular Seminoma: Correlation Between Staging and Chemotherapy Response, Two Years Overall Survival Rate Ida Bagus Putra Pramana; Lukman Hakim; Wahjoe Djatisoesanto; Sunaryo Hardjowijoto
JBN (Jurnal Bedah Nasional) Vol 3 No 1 (2019): JBN (Jurnal Bedah Nasional)
Publisher : Program Studi Ilmu Bedah, Fakultas Kedokteran Universitas Udayana

Objective: to determine the patient’s characteristics, correlation between staging and chemotherapy response, furthermore two years overall survival rate. Methods: a retrospective analytic study was conducted. Data were obtained from medical records in January 2008 to December 2014 and analyzed using SPSS 17.0. All of correlation between staging and chemotherapy response, primary tumor staging (pT) and metastasis (M), regional lymph nodes staging (N) and metastasis (M), serum tumor marker and chemotherapy response were tested by Spearman correlation test. Two years overall survival rate was analyzed by Kaplan-Meier. Data ratio with normal distribution was tested by Paired T-test. Results: the mean age of patients were 31.03 ± 13.751 years, with seven patients (15.6%) had previous history of undescended testis. Based on TNM staging, we found that most patients had already develop into stage pT3 (46.7%), N3 (57.7%), and M0 (57.7%). A significant correlation between staging and chemotherapy response was shown with stage I of testicular seminoma had completely chemotherapy response (100%) and two years overall survival rate in stage I was 100%, whereas in metastatic seminoma (stage II and III) was 60%, with Hazard Ratio 0.63 (p=0.294; 95%CI 0.276-1.476). Conclusion: patients in early stage of testicular seminoma will give a better response to chemotherapy and will have better survival rate compared to those with metastatic seminoma.

SYSTEMATIC REVIEW: KOMUNITAS WANITA LANSIA DAN FAKTOR RISIKO INKONTINENSIA URIN DI WILAYAH ASIA Alya Shafira Hewiz; Novira Widajanti; Lukman Hakim; Rwahita Satyawati
Jurnal Keperawatan BSI Vol 10 No 2 (2022): Jurnal Keperawatan BSI
Publisher : LPPM Universitas BSI

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Knowledge of how the condition of elderly women in the community, especially in the Asian region, is interesting to know. Especially related to the study of risk factors and the relationship with urinary incontinence. This study aims to determine the risk factors and association with urinary incontinence in elderly women in particular in the Asian region. The method used is the PRISMA guidelines to be used as a systematic review. Sources of research data obtained from the data center. PubMed and Science Direct research in the period 2000-2020 with exclusion and inclusion criteria. Assessments are carried out for quality and risk using a standardized scoring system. Based on research in the Asian region, 3 articles were selected. Information obtained in communities in the Asian region in elderly women that the prevalence of urinary incontinence ranges from 19%–31.3%. Urinary incontinence is influenced by many factors, namely age, BMI, and smoking habits. The conclusion is that urinary incontinence is often experienced by elderly women in the Asian region and many factors can cause urinary incontinence. Awareness about urinary incontinence in elderly women can help better management.

Systematic Review: Risk Factors and Prevalence of Urinary Incontinence in Elderly Women, a Case Study in Japan and Taiwan Alya Shafira Hewiz; Novira Widajanti; Lukman Hakim; Rwahita Satyawati
Journal Medical Informatics Technology Volume 1 No. 2, June 2023
Publisher : SAFE-Network

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37034/medinftech.v1i2.9

Knowledge of the conditions of elderly women in Japanese and Taiwanese communities, particularly in relation to risk factors and their association with urinary incontinence, is of interest. This study aimed to identify risk factors and prevalence of urinary incontinence in elderly women in the community of the Japanese and Taiwanese case study areas. The research method used was a systematic review based on PRISMA guidelines. Data sources were obtained from PubMed and Science Direct for the period 2000-2020 using specific inclusion and exclusion criteria. Evaluation was conducted for quality and bias risk using a standardized assessment system. Results showed that the prevalence of urinary incontinence in elderly women in Japanese and Taiwanese communities ranged from 29.8% to 31.3%. Many factors influenced urinary incontinence, such as age, body mass index (BMI), and smoking habits. From the two selected articles in Japan and Taiwan, it was concluded that urinary incontinence was commonly experienced by elderly women in the community, and awareness of this condition could help improve management.

Co-Authors Abdurachman Abdurachman Abdurrachman Abdurrachman Adelia Ratri Mahenda Alya Shafira Hewiz Ami Ashariati Andi Yasmin Wijaya Arifa Mustika Beny Prastyo Dedik Sulistiawan Dinda Dwi Purwati Fedik Abdul Rantam Fundhy Sinar Ikrar Prihatanto, Fundhy Sinar Ikrar Haviv Muris Saputra I Ketut Sudiana I'tishom, Reny Ida Bagus Putra Pramana MOCHAMMAD THAHA Mursyidul Ibad Musofa Rusli Novira Widajanti, Novira Rerdin Julario Rwahita Satyawati Ryan Rizky Bikatofani Steven Sheng Looi Sunaryo Hardjowijoto wahjoe djatisoesanto Winona May Hendrata Yunias Setiawati

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