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All Journal Indonesian Journal of Tropical and Infectious Disease Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology

Musofa Rusli

Faculty Of Medicine, Universitas Airlangga, Surabaya. Department Of Internal Medicine, Faculty Of Medicine, RSUD Dr. Soetomo, Surabaya

Author-ID : 3298107

Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Articles

Predictor of Mortality COVID-19 in Two Referral Hospital in Surabaya, Indonesia Usman Hadi; Bramanton; Tri Pudy Asmarawati; Musofa Rusli; Nasronudin; Brian Eka Rachman; M. Vitanata Arfijanto
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17659

Introduction: World Health Organization had identified COVID-19 in January 2019. This disease is caused by SARS-CoV-2, which spread throughout the world and became a pandemic on March 20, 2020. COVID-19 is still a health problem because it has not clear whether the patients will be cured and survive from the disease or not. This study aims to determine the predictors of mortality from COVID-19 at Dr. Soetomo General Academic Hospital and Universitas Airlangga Hospital in Surabaya, Indonesia.Method: This study was conducted in Dr. Soetomo General Academic Hospital (referral hospital for COVID-19, 1500 beds) and Universitas Airlangga Hospital (Referal Hospital for COVID-19, 600 beds). The study used data on patients with confirmed COVID-19 who were hospitalized at these two referral hospitals. Predictors of mortality were analyzed using logistic regressions.Result: There were 247 COVID-19 patients enrolled in this study, all patients were tested positive PCR SARS-CoV-2. The main complaints were cough, nasal congestion, dyspnea, and fever. Significant predictor mortality in this study were age >60 years old (OR: 3.24, 95% CI, 1.36 - 7.70), chronic kidney disease (OR: 5.71, 95% CI, 2.05 - 15.89), obesity (OR: 8.22, 95% CI,1.5 - 54.17), malignancy (OR: 6.025, 95% CI, 1.1- 33.00), coronary heart disease (OR: 5.31, 95% CI, 1.28 - 21.98) , and C-reactive protein >10 mg/L (OR 4.603, 95% CI, 2.03 - 10.44).Conclusions: Obesity and the presence of malignancy, chronic kidney disease, heart disease and age >60 yearsold are the strongest predictors of mortality in people with COVID-19, despite high CRP results.

Profile of Pneumocystis JiroveciiPneumoia in HIV/AIDS Patients in Dr. Soetomo General Hospital of East Java Province Pius Sebastian Ginting; Bramantono; RestiYudhawati Meliana; Musofa Rusli
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 2 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i2.17933

Background: Human immunodeficiency virus (HIV)-infected patients if not treated will experienceacquired immunodeficiency syndrome (AIDS). People with AIDS will suffer opportunistic infection.One of the common opportunistic infections is Pneumocystis jirovecii pneumonia (PCP). PCP is aninfection caused by the fungus Pneumocystis jirovecii which infects patient’s lungs. The purpose of thisstudy is to analyze the profile of HIV/AIDS patients with PCP in Dr. Soetomo Hospital.Methods: This is a retrospective descriptive study based on medical records obtained from the inpatientward of Dr. Soetomo General Hospital Surabaya. A total 21 patients enrolled in this study who met theinclusion criteria. The data are retrospectively described by demographic characteristics, CD4 count,clinical symptoms, blood gas, and lungs radiographic features.Conclusion:Major findings of PCP in HIV/AIDS patients was in the group of age 25-49 years (85,7%),male (85,7%), high school graduate (71,4%), employed and unmarried (66,7%). The most commonclinical symptoms were dyspnea (100%), PaO2 ≥70 mmHg (61,97%), CD4 count <50 cells/μL (76,2%)and the most common radiographic features was bilateral interstitial infiltrates (95,2%).

Diagnostic Problems in Leptospirosis Patients : A Case Report Megawati; Musofa Rusli
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 2 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i2.17969

Leptospirosis is a zoonosis infection found in almost every part of the world but is mostly endemic in tropical and subtropical countries. In 2013 there were 640 new cases reported with 60 death cases (CFR 9.37%). An increase in new cases had caused an outbreak in Sampang, Madura due to a flood following a high rainfall. A male patient aged 45 years old with Leptospirosis. The diagnosis was made based on the epidemiology, clinical manifestations, and Microscopic Agglutination Test (MAT) examination data. In the early treatment, the examination of IgM and IgG Leptospira showed negative results a confirmation with MAT examination was done subsequently. Diagnosis using MAT also provides information about an outbreak in a region. Upon receiving antibiotic and symptomatic treatments and clinical recovery, the patient’s condition continued to improve.

PLASMA LEAKAGE PROFILES OF DENGUE HEMORRHAGIC FEVER PATIENTS IN RSUD Dr. SOETOMO, SURABAYA, EAST JAVA, INDONESIA JANUARY – JUNE 2014 Ferdian Rizaliansyah; Aryati Aryati; Musofa Rusli
Indonesian Journal of Tropical and Infectious Disease Vol. 6 No. 4 (2017)
Publisher : Institute of Topical Disease Universitas Airlangga

Plasma leakage is one crucial point of dengue hemorrhagic fever (DHF) that differentiates it from dengue fever (DF). DHF has to meet 4 criteria which are 2 – 7 days of acute fever, hemorrhagic manifestation, thrombocytopenia (≤100.000 cells/mm3) and evidence of plasma leakage. Plasma leakage consists of increasing hematocrit ≥20%, hypoalbuminemia or evidence of pleural effusion or ascites. Often doctors only base their DHF diagnosis on the presence of thrombocytopenia. This study analyzed the presence of plasma leakage between adult and pediatric patients with a DHF diagnosis in RSUD Dr. Soetomo in order to make the diagnosis and healthcare services better in the future. This was a retrospective study which used medical records of DHF patients admitted from January to June 2014. 78 cases were included, 24 adult patients (31%) and 54 pediatric patients (69%). 29/78 (37%) patients had no evidence of plasma leakage. No adult patients had ascites whereas 11/54 (20%) pediatric patients presented with ascites. No adult patients had pleural effusion whereas 25/54 (53%) pediatric patients did. Most adult patients that had serum albumin checked had normal albumin levels (12/14 [86%]) while only 14/28 (52%) pediatric patients had normal albumin level. 5/22 (23%) adult patients versus 32/53 (60%) pediatric patients showed hematocrit increments ≥20%. Patients admitted with dengue virus infection may currently be often misclassified as DHF because there are no plasma leakage manifestation in some patients.. There are significant differences in plasma leakage manifestations between adult and pediatric patients which poses a theory that pediatric patients are more susceptible to have plasma leakage manifestations than adult patients.

LOWER PERCEIVED-STIGMATIZATION BY HEALTH WORKERS AMONG HIV-AIDS PATIENTS OF KEY POPULATION BACKGROUNDS Jihan Qonitatillah; Samsriyaningsih Handayani; Ernawati Ernawati; Musofa Rusli
Indonesian Journal of Tropical and Infectious Disease Vol. 8 No. 2 (2020)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i2.15425

The stigma of people living with HIV-AIDS (PLWHA) by health workers may have a broad impact, so it is necessary to identify the factors that influence the occurrence of stigma. Identification of factors that cause a decrease in stigmatization by health workers will have an impact on improving the quality of life of people with HIV, increasing compliance with medication, and ultimately reducing the incidence of HIV infection itself. The purpose of this study was to analyze factors related to PLWHA’s perception of stigma among health workers in the community health center. This research applied a cross-sectional design using interviews. Ninety-four patients from the Infectious Disease Intermediate Care of Dr. Soetomo Hospital Surabaya, a tertiary level hospital, were interviewed. The stigma perception was assessed using a questionnaire modified from the Standardized Brief Questionnaire by Health Policy Project with Cronbach’s Alpha of 0.786. The data were simultaneously analyzed with binary multiple regressions on IBM SPSS Statistics 22.0 for Windows software. There were 30 out of 94 patients with key population backgrounds, and most population was injecting drug users (IDUs) and female sex workers (FSWs). PLWHA perceived most stigmatized community health workers when they drew blood, provided care, and considered they were involved in irresponsible behavior. There were relationships between age(p=0.008), marital status(p=0.013), and the history of key population (p=0.006)to people living with HIV-AIDS (PLWHA)’s perception of stigma among health workers in East Java community health center. Future research on factors influencing HIV-related stigma is needed to improve patients’ quality of life.

Correlation between ESBL-Producing Bacteria Infection with Sepsis Severity of Patient in Medical Ward of Internal Medicine Department Dr. Soetomo General Hospital in 2016 Asri Dhea Pratiwi; Musofa Rusli; Budi Utomo
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 10 No. 2 (2019): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: Sepsis is life-threatening condition that begins with infections that trigger pro-inflammation overresponse. Delaying antibiotic treatment in sepsis can cause serious condition. In ESBL-producing bacteria, the antibiotic resistance is common and it might cause harm to sepsis patient. This research aims to analyze the correlation between infections of ESBL-producing bacteria with sepsis severity. Methods: This study was observational analytic on sepsis patient in Internal Medicine Ward of Dr. Soetomo General Hospital. The data were taken from medical records of the patient. The severity of sepsis was based on Surviving Sepsis Campaign 2012. Results: A total 72 sepsis patients were included in this study, which consist of 40 patients with non-producing ESBL GNB and 32 patients with ESBL-producing bacteria. The most common bacteria in ESBL infection is Escherichia coli ESBL+ (75%) and non ESBL infection is Acinetobacter baumanii (27.5%). Septic shock is more common in patient with ESBL-producing bacteria (53.1% vs 22.5%). The correlation between ESBL infection and sepsis severity is significant and the power of correlation is low (p = 0.048; r = 0.234). Conclusion: There is a correlation between ESBL-producing bacteria infection with sepsis severity and the power of correlation is low (p = 0.048, r = 0.234).

Sepsis: Antibiotic Resistances of Gram-Positive and Gram-Negative Bacterial in a Tertiary Care Hospital Siti Nurul Jannah; Muhammad Vitanata Arfijanto; Musofa Rusli; Agung Dwi Wahyu Widodo
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 12 No. 1 (2021): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V12I12021.29-37

Introduction: Sepsis is a systemic infection that causes multiorgan failure and death. The death rate that is caused by sepsis is increasing. This high value of death has a correlation with the resistance of antibiotics. However, increased antibiotic resistance is not balanced with new research about antibiotics. As a consequence, it causes difficulties in handling sepsis patients who need antibiotic 1-2 hours after diagnosis is enforced. Methods: This was a descriptive study with case study design to analyze medical records of the patients, evaluating the pattern of bacterial resistance to antibiotic in 221 patients with sepsis with 240 blood isolates to identify. Results: From 221 patients identified as sepsis, there were 97 male patients (43.9%) and 124 female patients (56.1%), mostly between 18-59 years old (63.8%), with the highest level in female (54.8 %) and elderly (66.3%). The bacteria that caused the most sepsis were gram-positive. The most species in gram-positive are Staphylococcus haemolyticus (16.3%) and Staphylococcus aureus (12.5%), and the most species in gram-negative is Escheriichia coli (13.3%). The most sensitive antibiotics in gram-positive bacteria were Piperacillin-Tazobactam (100%), Daptomycin (99.2%), and Clindamycin (99.2%). The sensitive antibiotics in gram-negative bacteria were Amikacin (85.9%), Cefoperazone (84.6%), and Piperacillin-Tazobactam (84.1%). Conclusion: The most sensitive antibiotics in gram-positive bacteria were Piperacillin-Tazobactam, Daptomycin, and Clindamycin. The sensitive antibitics in gram-negative bacteria were Amikacin, Cefoperazone, and Piperacillin-Tazobactam.

PENGALAMAN BELAJAR MAHASISWA KEDOKTERAN DALAM PENGGUNAAN REKAMAN KULIAH SEBAGAI MEDIA PEMBELAJARAN Lukman Hakim; Fundhy Sinar Ikrar Prihatanto; Musofa Rusli
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 8, No 3 (2019): November
Publisher : Asosiasi Institusi Pendidikan Kedokteran Indonesia

Background: Recorded lecture is a type of learning media which the lecturers record their voices when lecturing. This type of media is popular in many universities outside Indonesia. Faculty of Medicine Universitas Airlangga is developing electronic learning using recorded lecture in 2016. This study aimed to learn the experience of college student about the usage of recorded lecture, the impact to their learning style, and their hopes about the implementation of recorded lecture in Faculty of Medicine Universitas Airlangga. Method: This qualitative study applied content analysis design. The variable used are age, gender, intelligence quotient, learning style, learning equipment, experience when using learning media, and busyness in student affairs. Results: Eleven subjects are interviewed. The results are variably different between the subject. There are seven themes arise from the analysis results, for instance: 1) classical class alone was not enough, need another alternative; 2) the recorded lecture was similar with the one in internet; 3) used recorded lecture just for a few times; 4) recorded lecture was very beneficial; 5) the recorded lecture was too long; 6) college students are very busy outside the class; 7) a wish for the improvement og the recorded lectures, both quality and quality. Conclusion: The experience felt by medical education students on the use of recordings still varies. In general, students feel helped by the recording of lectures, on the other hand there are students who are not satisfied with the quality and quantity of lecture recordings provided by the campus. Massive and comprehensive improvements are needed in all aspects of providing lecture records, both in terms of teachers and in terms of technology support Keywords: recorded lecture, content analysis, qualitative research, medical student, electronic learning.

Diagnostic Patterns of Suspected Covid-19 Patients Using Scor Covid-19, PCR Test and Serological Test in Dr. Soetomo Hospital Surabaya, Indonesia Usman Hadi; Bramantono Bramantono; M Vitanata; Musofa Rusli; Brian Eka Rahman; Tripudi Asmarawati; Erika Marfiani; Erwin Astha Triyono
Current Internal Medicine Research and Practice Surabaya Journal Vol. 2 No. 2 (2021): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v2i2.28956

Objective: To find out the diagnostic pattern of COVID-19 using RT-PCR or a rapid antibody test in the suspected group of patients.Method: The study was conducted in Dr. Soetomo General Hospital (referral hospital for covid-19, 1500 beds). The study used data on patients with suspected covid-19 who were hospitalized at the Dr. Soetomo General Hospital in Surabaya.Result: There were 200 suspected COVID-19 patients enrolled in this study, the main complaints of cough, fever, dyspnoea, around 69.5%, 75%, and 76.5%, respectively. Although not a common symptom, it seems that anosmia (14%) is typical for COVID-19. Based on this scoring system, a total of 196 patients had a high risk of being infected with COVID-19, and 125 (64%) of them finally showed a positive PCR test. PCR test mostly positive (62.5%), while serological test (rapid immunoglobulin test) mostly nonreactive, but there were no significant differences between PCR and Serological test (p=0.16 OR: 1.5(0.84-71). Furthermore, if we compare the various existing variables, namely the covid-19 score, immunoglobulin rapid test, and radiological examination, only the radiological examination results can be used as a strong predictor of positive PCR results (p=0.005, OR: 1.68 (0.17-16.43).In this study, we found that abnormal chest radiographs are a good parameter for diagnosing COVID-19, (OR: 2.92; 95% CI, 1.34 -6.34).Conclusion: The initial radiological examination combined with the clinical symptoms of Covid-19 is the most important thing to predict the presence of this disease.

BACTERIAL PATTERN AMONG SEPSIS PATIENTS IN INTERNAL MEDICINE INPATIENT WARD DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA Ilma Dzurriyyatan Toyyibah; Musofa Rusli; Juniastuti Juniastuti
Majalah Biomorfologi Vol. 32 No. 2 (2022): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v32i1.2022.52-58

Highlights:1. Bacteria remain a major cause of bacterial sepsis.2. The most common causal agent in bacterial septicaemia was the gram-positive bacterium. Abstract: Background: Bacteria remain the primary cause of bacterial sepsis. Gram-negative bacteria are the most commonly isolated from sepsis patients. However, gram-positive bacterial infections have also increased recently. Objective: To identify the pattern of bacterial infection in sepsis patients in Internal Medicine inpatient ward Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Material and Method: This retrospective study reviewed the medical records of all sepsis patients in Internal Medicine Ward Dr. Soetomo General Academic Hospital, Surabaya, Indonesia from January 1 – December 31, 2016. All patients were divided according to bacterial species into two groups: patients with gram-positive and gram-negative infection. The collected data were statistically analyzed using SPSS ver. 16.0 to find out the frequency. Result: From 179 eligible data reviewed, there were 103 (57.5%) patients with gram-positive bacterial infection and 76 (43.5%) patients with a gram-negative bacterial infection. The major isolates of gram-positive bacteria were Staphylococcus hominins (30 isolates) and gram-negative bacteria was Escherichia coli (30 isolates), 43 isolates showed multi-drug resistant organisms; Escherichia coli ESBL 23 isolates, Klebsiella pneumoniae ESBL 3 isolates, Klebsiella oxytoca ESBL 2 isolates and Methilcillin Resistance Staphylococcus aureus 5 isolates. Conclusion: The most common causative agent in bacterial sepsis was gram-positive bacteria. The major isolated gram-positive bacteria are Staphylococcus hominis and gram-negative bacteria were Escherichia coli. The species of multi-drug resistant organisms found are Methilcillin-Resistant Staphylococcus aureus (MRSA), Escherichia coli ESBL, Klebsiella pneumonia ESBL and Klebsiella oxytoca ESBL. Among the patients with multi-drug resistant organism infection, Escherichia coli ESBL were the most prevalent one.

Co-Authors Agung Dwi Wahyu Widodo Aryati Aryati Asmarawati, Tri Pudy Asri Dhea Pratiwi Bramanton Bramantono - Brian Eka Rachman Brian Eka Rahman Budi Utomo Erika Marfiani Ernawati Ernawati Erwin Astha Triyono Ferdian Rizaliansyah Fundhy Sinar Ikrar Prihatanto, Fundhy Sinar Ikrar Ilma Dzurriyyatan Toyyibah Jihan Qonitatillah Juniastuti Juniastuti Lukman Hakim M Vitanata Marissa Jayawinata Megawati Muhammad Vitanata Arfijanto Nasronudin Pius Sebastian Ginting Resti Yudhawati Samsriyaningsih Handayani Siti Nurul Jannah Subagyo Yotopranoto Tripudi Asmarawati Usman Hadi

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