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All Journal International Journal of Public Health Science (IJPHS) Pharmaciana: Jurnal Kefarmasian Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Iin Narwanti
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Arts Humanities Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Other

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TLC-Bioautography Profile of Ethyl Acetate Extract of 5 Bacteria Isolated from Ficus carica L Rhizosphere Nanik Sulistyani; Iin Narwanti
International Journal of Public Health Science (IJPHS) Vol 4, No 2: June 2015
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.711 KB) | DOI: 10.11591/ijphs.v4i2.4716

Abstract

Research has been conducted on the 5 isolates of bacteria isolated from the rhizosphere of Ficus carica L as a producer of antibiotics. The previous study showed they have NRPS gene profiles that differ from each other. This study aims to determine the TLC Rf spots having inhibition activity against the growth of Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922. The study was conducted using the 5 bacteria isolates, namely T19, T24, T25, T37 and T41. All isolates were fermented at room temperature for 14 days. Further the each broth culture was filtered and extracted using ethyl acetate. Components in the extract were separated by thin layer chromatography (TLC) with the mobile phase of chloroformmethanol (7: 3), followed by bioautography test against the S. aureus and E. coli to determine the chromatogram spots containing antibiotics. TLC results showed all isolates had different chromatogram profiles. The bioautography results showed that only isolate T25 can produce antibiotics against S. aureus. The antibiotic spot was at Rf 0.9 in the use of chloroform-methanol (7: 3) solvent system.
UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEME (1)-N-(2-NITROBENZIL)-1,10- FENANTROLINIUM IODIDA DAN (1)-N-(4-NITROBENZIL)-1,10- FENANTROLINIUM IODIDA SECARA IN VITRO Laela Hayu Nurani; Dwi Utami; Wahyu Widyaningsih; Iin Narwanti; Eti Nurwening; Jumina Jumina
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (145.12 KB) | DOI: 10.12928/pharmaciana.v4i2.1575

Abstract

The inhibitory activity of heme polymerization of (1)-N-(2-nitrobenzyl)-1,10- phenantrolinium iodide and (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide have been done. This study aims to analyse the (1)-N-(2-nitrobenzyl)-1,10-phenantrolinium iodide and (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide as inhibitory of polimerization heme. Analysis of heme inhibtory polimerization activity used the experimental in vitro method. The activity showed by IC50 (the capable concentration of extract to inhibiting polymerization heme by 50% ). The IC50 value acquired by probit analysis. Assess IC50 of (1)-N-(2-nitrobenzyl)- 1,10-phenantrolinium iodide not to be identified, (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide and chloroquine by successively are 0,571±0,071; 25,498±1,876 mg/mL. The result showed the (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide had the highest value of the heme polymerization inhibitory activity than chloroquin, (1)-N-(2-nitrobenzyl)-1,10- phenantrolinium iodide hadn’t the heme polymerization inhibitory activity.
PEMBINAAN KESADARAN PANGAN THOYIB YANG AMAN PENGAWET SINTETIS PADA PENGURUS CABANG ‘AISYIYAH WIROBRAJAN Amalya Nurul Khairi; Titisari Juwitaningtyas; Iin Narwanti
Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Vol. 2 No. 2 (2018)
Publisher : Universitas Ahmad Dahlan, Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jp.v2i2.446

Abstract

Ibu-ibu anggota PCA Wirobrajan sebagian besar adalah pengusaha makanan dan minuman yang terampil dalam pengolahan panganan basah tradisional maupun street food. Kondisi ini merupakan akibat dari banyaknya jumlah sekolah dan adanya Pasar Klitihikan yang khusus menjual makanan jenis camilan di Kecamatan Wirobrajan. Pengabdian ini bertujuan untuk meningkatkan kesadaran Ibu-ibu anggota PCA Wirobrajan terhadap bahaya penggunaan pengawet sintetis sekaligus membekali dengan keterampilan membuat pengawet dari bahan alami dan deteksi sederhana kandungan formalin. Metode yang dilakukan adalah dengan pelatihan dan pemaparan materi. Kegiatan tersebut dilaksanakan dalam tiga kali sesi. Dari hasil pembinaan yang dilakukan diperoleh hasil antusiasme keikutsertaan Ibu-ibu PCA Wirobrajan dan semangat mereka untuk memperbaiki proses pengolahan pangan dengan meminimalisir penggunaan bahan tambahan pangan (BTP) sintetis yang berbahaya. 
SUBCRONIC TOXICITY TEST COMBINATION OF Phyllanthus niruri AND Centella asiatica EXTRACT AT HEMATOLOGY IN RATS Siti Fatmawati Fatimah; Endang Darmawan; Iin Narwanti; Dzulhaifa Dzulhaifa; Ira Aprilia Wulandari; Ria Putri Salma
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art8

Abstract

Background: Meniran (Phyllathus niruri) and pegagan (Centella asiatica) are well-known medicinal plants in Indonesia. Uses of meniran and pegagan as herbal medicines need to be examined for their subchronic activity to assure their safety. Objective: This study aimed to evaluate subchronic effects of a combination of extracted meniran and pegagan on Wistar rats through haematological parameters (erythrocytes, haemoglobin, haematocrit, MCV, MCH, and MCHC).Methods: Animal models used were 56 male and female Wistar rats and were divided randomly into 4 groups. Group 1 received CMC-Na 1% (control group). Group 2 received extracts of meniran and pegagan (50:50 mg/kgBW). Group 3 received extracts of meniran and pegagan (250:250 mg/kgBW). Group 4 received extracts of meniran and pegagan (1250:1250 mg/kgBW). Subchronic test of meniran and pegagan was conducted by providing treatments for the Wistar rats for 28 days. Their haematological substances were analysed statistically by using one way ANOVA and Kruskal-Wallis method with confidence interval of 95% and post-hoc. Results: This study found that the haematological substances in male Wistar rats were normal and did not significantly change (p>0,05). It also showed that haemoglobin and haematocrit substances in female rats were normal and did not significantly change (p>0,05). Erythrocytes, MCV, MCH, and MCHC in female rats indicated significant change (p<0,05), but they were still in normal ranges.Conclusion: It could be concluded that administration of the combination of extracted meniran and pegagan was not toxic to haematology of the rats in all doses.
Co-Authors Amalya Nurul Khairi DWI UTAMI Dzulhaifa Dzulhaifa Endang Darmawan Ira Aprilia Wulandari Jumina Jumina Laela Hayu Nurani Nanik Sulistyani Ria Putri Salma Siti Fatmawati Fatimah, Siti Fatmawati Titisari Juwitaningtyas Wahyu Widyaningsih Yoga Yuniadi